메뉴 건너뛰기




Volumn 15, Issue 2, 2012, Pages 188-197

Clinical and therapeutic relevance of PIM1 kinase in gastric cancer

Author keywords

Amplification; Gastric cancer; PIM1; Targeted therapy

Indexed keywords

1 [3 [6 (CYCLOPROPYLMETHYLAMINO)IMIDAZO[1,2]PYRIDAZIN 3 YL]PHENYL]ETHANONE; ANTINEOPLASTIC AGENT; K 00135; MESSENGER RNA; PROTEIN KINASE PIM 1; UNCLASSIFIED DRUG;

EID: 84861530026     PISSN: 14363291     EISSN: 14363305     Source Type: Journal    
DOI: 10.1007/s10120-011-0097-2     Document Type: Article
Times cited : (35)

References (36)
  • 3
    • 77950859162 scopus 로고    scopus 로고
    • Gastric cancer: Trastuzumab trial results spur search for other targets
    • Hede K. Gastric cancer: trastuzumab trial results spur search for other targets. J Natl Cancer Inst. 2009;101:1306-7.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1306-1307
    • Hede, K.1
  • 4
    • 0025806308 scopus 로고
    • The human PIM-1 gene product is a protein serine kinase
    • Padma R, Nagarajan L. The human PIM-1 gene product is a protein serine kinase. Cancer Res. 1991;51:2486-9.
    • (1991) Cancer Res , vol.51 , pp. 2486-2489
    • Padma, R.1    Nagarajan, L.2
  • 5
    • 0021233675 scopus 로고
    • Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region
    • Cuypers HT, Selten G, Quint W, Zijlstra M, Maandag ER, Boelens W, et al. Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell. 1984;37:141-50. (Pubitemid 14079845)
    • (1984) Cell , vol.37 , Issue.1 , pp. 141-150
    • Cuypers, H.T.1    Selten, G.2    Quint, W.3
  • 6
    • 29244464759 scopus 로고    scopus 로고
    • The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C
    • DOI 10.1016/j.biocel.2005.10.010, PII S1357272505003092
    • Bachmann M, Kosan C, Xing PX, Montenarh M, Hoffmann I, Moroy T. The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol. 2006;38:430-43. (Pubitemid 41821890)
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , Issue.3 , pp. 430-443
    • Bachmann, M.1    Kosan, C.2    Xing, P.X.3    Montenarh, M.4    Hoffmann, I.5    Moroy, T.6
  • 7
    • 48549096958 scopus 로고    scopus 로고
    • Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels
    • Morishita D, Katayama R, Sekimizu K, Tsuruo T, Fujita N. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res. 2008;68:5076-85.
    • (2008) Cancer Res , vol.68 , pp. 5076-5085
    • Morishita, D.1    Katayama, R.2    Sekimizu, K.3    Tsuruo, T.4    Fujita, N.5
  • 8
    • 3343007095 scopus 로고    scopus 로고
    • 112 gatekeeper site
    • DOI 10.1016/j.febslet.2004.06.050, PII S0014579304008026
    • Aho TL, Sandholm J, Peltola KJ, Mankonen HP, Lilly M, Koskinen PJ. Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett. 2004;571:43-9. (Pubitemid 38992921)
    • (2004) FEBS Letters , vol.571 , Issue.1-3 , pp. 43-49
    • Aho, T.L.T.1    Sandholm, J.2    Peltola, K.J.3    Mankonen, H.P.4    Lilly, M.5    Koskinen, P.J.6
  • 9
    • 41249100545 scopus 로고    scopus 로고
    • The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells
    • Xie Y, Xu K, Linn DE, Yang X, Guo Z, Shimelis H, et al. The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells. J Biol Chem. 2008;283:3349-56.
    • (2008) J Biol Chem , vol.283 , pp. 3349-3356
    • Xie, Y.1    Xu, K.2    Linn, D.E.3    Yang, X.4    Guo, Z.5    Shimelis, H.6
  • 10
    • 49749092649 scopus 로고    scopus 로고
    • A role for polyploidy in the tumorigenicity of Pim-1- expressing human prostate and mammary epithelial cells
    • Roh M, Franco OE, Hayward SW, van der Meer R, Abdulkadir SA. A role for polyploidy in the tumorigenicity of Pim-1- expressing human prostate and mammary epithelial cells. PLoS ONE. 2008;3:e2572.
    • (2008) PLoS ONE , vol.3
    • Roh, M.1    Franco, O.E.2    Hayward, S.W.3    Van Der Meer, R.4    Abdulkadir, S.A.5
  • 14
    • 33644515323 scopus 로고    scopus 로고
    • Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas [13]
    • DOI 10.1038/sj.leu.2404094, PII 2404094
    • Sivertsen EA, Galteland E, Mu D, Holte H, Meza-Zepeda L, Myklebost O, et al. Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas. Leukemia. 2006;20:539-42. (Pubitemid 43291765)
    • (2006) Leukemia , vol.20 , Issue.3 , pp. 539-542
    • Sivertsen, E.A.1    Galteland, E.2    Mu, D.3    Holte, H.4    Meza-Zepeda, L.5    Myklebost, O.6    Patzke, S.7    Smeland, E.B.8    Stokke, T.9
  • 19
    • 41149093037 scopus 로고    scopus 로고
    • Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase
    • DOI 10.1021/jm701248t
    • Pierce AC, Jacobs M, Stuver-Moody C. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J Med Chem. 2008;51:1972-5. (Pubitemid 351438879)
    • (2008) Journal of Medicinal Chemistry , vol.51 , Issue.6 , pp. 1972-1975
    • Pierce, A.C.1    Jacobs, M.2    Stuver-Moody, C.3
  • 20
    • 52049122136 scopus 로고    scopus 로고
    • Isoxazolo[3,4-b]quinoline-3,4(1H, 9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim- 2 kinases: Chemistry, biological activities, and molecular modeling
    • Tong Y, Stewart KD, Thomas S, Przytulinska M, Johnson EF, Klinghofer V, et al. Isoxazolo[3,4-b]quinoline-3,4(1H, 9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim- 2 kinases: chemistry, biological activities, and molecular modeling. Bioorg Med Chem Lett. 2008;18:5206-8.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 5206-5208
    • Tong, Y.1    Stewart, K.D.2    Thomas, S.3    Przytulinska, M.4    Johnson, E.F.5    Klinghofer, V.6
  • 24
    • 12844276658 scopus 로고    scopus 로고
    • Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization
    • DOI 10.1002/gcc.20136
    • Gorringe KL, Boussioutas A, Bowtell DD. Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization. Genes Chromosomes Cancer. 2005;42:247-59. (Pubitemid 40171189)
    • (2005) Genes Chromosomes and Cancer , vol.42 , Issue.3 , pp. 247-259
    • Gorringe, K.L.1    Boussioutas, A.2    Bowtell, D.D.L.3
  • 25
    • 77952221559 scopus 로고    scopus 로고
    • Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition
    • Okamoto W, Okamoto I, Yoshida T, Okamoto K, Takezawa K, Hatashita E, et al. Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition. Mol Cancer Ther. 2010;9: 1188-97.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1188-1197
    • Okamoto, W.1    Okamoto, I.2    Yoshida, T.3    Okamoto, K.4    Takezawa, K.5    Hatashita, E.6
  • 26
    • 77749251829 scopus 로고    scopus 로고
    • Pathology of gastric intestinal metaplasia: Clinical implications
    • Correa P, Piazuelo MB, Wilson KT. Pathology of gastric intestinal metaplasia: clinical implications. Am J Gastroenterol. 2010;105:493-8.
    • (2010) Am J Gastroenterol , vol.105 , pp. 493-498
    • Correa, P.1    Piazuelo, M.B.2    Wilson, K.T.3
  • 27
    • 34547599505 scopus 로고    scopus 로고
    • PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation
    • DOI 10.1038/ncb1618, PII NCB1618
    • Zippo A, De Robertis A, Serafini R, Oliviero S. PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYCdependent transcriptional activation and oncogenic transformation. Nat Cell Biol. 2007;9:932-44. (Pubitemid 47190448)
    • (2007) Nature Cell Biology , vol.9 , Issue.8 , pp. 932-944
    • Zippo, A.1    De Robertis, A.2    Serafini, R.3    Oliviero, S.4
  • 28
    • 32944458740 scopus 로고    scopus 로고
    • Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL
    • Macdonald A, Campbell DG, Toth R, McLauchlan H, Hastie CJ, Arthur JS. Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. BMC Cell Biol. 2006;7:1.
    • (2006) BMC Cell Biol , vol.7 , pp. 1
    • MacDonald, A.1    Campbell, D.G.2    Toth, R.3    McLauchlan, H.4    Hastie, C.J.5    Arthur, J.S.6
  • 29
    • 33744774483 scopus 로고    scopus 로고
    • Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity
    • Aho TL, Sandholm J, Peltola KJ, Ito Y, Koskinen PJ. Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity. BMC Cell Biol. 2006;7:21.
    • (2006) BMC Cell Biol , vol.7 , pp. 21
    • Aho, T.L.1    Sandholm, J.2    Peltola, K.J.3    Ito, Y.4    Koskinen, P.J.5
  • 31
    • 9144225473 scopus 로고    scopus 로고
    • 2TM cell cycle checkpoint
    • DOI 10.1074/jbc.M404440200
    • Bachmann M, Hennemann H, Xing PX, Hoffmann I, Moroy T. The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. J Biol Chem. 2004;279:48319-28. (Pubitemid 39540988)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.46 , pp. 48319-48328
    • Bachmann, M.1    Hennemann, H.2    Pei, X.X.3    Hoffmann, I.4    Moroy, T.5
  • 32
    • 77953030981 scopus 로고    scopus 로고
    • Altered subcellular localization of c-Myc protein identifies aggressive B-cell lymphomas harboring a c-MYC translocation
    • Ruzinova MB, Caron T, Rodig SJ. Altered subcellular localization of c-Myc protein identifies aggressive B-cell lymphomas harboring a c-MYC translocation. Am J Surg Pathol. 2010;34:882-91.
    • (2010) Am J Surg Pathol , vol.34 , pp. 882-891
    • Ruzinova, M.B.1    Caron, T.2    Rodig, S.J.3
  • 33
    • 77957905244 scopus 로고    scopus 로고
    • Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion
    • Santio NM, Vahakoski RL, Rainio EM, Sandholm JA, Virtanen SS, Prudhomme M, et al. Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion. Mol Cancer. 2010;9:279.
    • (2010) Mol Cancer , vol.9 , pp. 279
    • Santio, N.M.1    Vahakoski, R.L.2    Rainio, E.M.3    Sandholm, J.A.4    Virtanen, S.S.5    Prudhomme, M.6
  • 34
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235:177-82. (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 35
    • 77956945071 scopus 로고    scopus 로고
    • A study of HER2 gene amplification and protein expression in gastric cancer
    • Yan B, Yau EX, Bte Omar SS, Ong CW, Pang B, Yeoh KG, et al. A study of HER2 gene amplification and protein expression in gastric cancer. J Clin Pathol. 2010;63:839-42.
    • (2010) J Clin Pathol , vol.63 , pp. 839-842
    • Yan, B.1    Yau, E.X.2    Bte Omar, S.S.3    Ong, C.W.4    Pang, B.5    Yeoh, K.G.6
  • 36
    • 17144410021 scopus 로고    scopus 로고
    • Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway
    • DOI 10.1158/1541-7786.MCR-04-0192
    • Shay KP, Wang Z, Xing PX, McKenzie IF, Magnuson NS. Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway. Mol Cancer Res. 2005;3:170-81. (Pubitemid 40524900)
    • (2005) Molecular Cancer Research , vol.3 , Issue.3 , pp. 170-181
    • Shay, K.P.1    Wang, Z.2    Xing, P.-X.3    McKenzie, I.F.C.4    Magnuson, N.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.