Immunization of mice with a newly identified thyroid-stimulating hormone receptor splice variant induces Graves'-like disease

Journal of Autoimmunity

Volumn 43, Issue , 2013, Pages 18-25

  Endo, Toyoshi ^a   Kobayashi, Teturo ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Antigenicity; Graves' disease; Splice variant; Thyroid stimulating antibody; Thyroid stimulating hormone receptor

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; CYCLIC AMP; IODINE 123; MESSENGER RNA; THYROTROPIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTROPORATION; EXON; GOITER; GRAVES DISEASE; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; THYROID GLAND; THYROTOXICOSIS;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; BASE SEQUENCE; CLONING, MOLECULAR; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; FEMALE; GRAVES DISEASE; HEK293 CELLS; HUMANS; IMMUNIZATION; MICE; MICE, INBRED BALB C; PROTEIN ISOFORMS; RECEPTORS, THYROTROPIN; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER;

EID: 84878349986     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2013.02.004     Document Type: Article

References (34)

1. Kohn L.D., Harii N. Thyrotropin receptor autoantibodies (TSHRAbs): epitopes, origins and clinical significance. Autoimmunity 2003, 36:331-337.
2. Endo T., Ohta K., Haraguchi K., Onaya T. Cloning and functional expression of a thyrotropin receptor cDNA from rat fat cells. J Biol Chem 1995, 270:10833-10837.
3. Inoue M., Tawata M., Yokomori N., Endo T., Onaya T. Expression of thyrotropin receptor on clonal osteoblast-like rat osteosarcoma cell. Thyroid 1998, 8:1059-1064.
4. Abe E., Marians R.C., Yu W., Wu X.B., Ando T., Li Y., et al. TSH is a negative regulator of skeletal remodeling. Cell 2003, 115:151-162.
5. Davies T., Marians R., Latif R. The TSH receptor reveals itself. J Clin Invest 2002, 110:161-164.
6. Moyle W.R., Lin W., Myers R.V., Cao D., Kerrigan J.E., Bernard M.P. Models of glycoprotein hormone receptor interaction. Endocrine 2005, 26:189-205.
7. Sanders J., Chirgadze D.Y., Sanders P., Baker S., Sullivan A., Bhardwaja A., et al. Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody. Thyroid 2007, 17:395-410.
8. Graves P.N., Tomer Y., Davies T.F. Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain. Biochem Biophys Res Commun 1992, 18:1135-1143.
9. Takeshita A., Nagayama Y., Fujiyama K., Yokoyama N., Namba H., Yamashita S., et al. Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript. Biochem Biophys Res Commun 1992, 188:1214-1219.
10. Endo T., Kobayashi T. Thyroid-stimulating hormone receptor in brown adipose tissue is involved in the regulation of thermogenesis. Am J Physiol Endocrinol Metab 2008, 295:E514-E518.
11. Mizutori Y., Chen C.R., McLachlan S.M., Rapoport B. The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction. Mol Endocrinol 2008, 22:1171-1182.
12. Endo T., Ohmori M., Ikeda M., Kotani S., Onaya T. Rabbit antibodies against two different extracellular domains of human thyrotropin receptor possess thyroid stimulating activities. Biochem Biophys Res Commun 1991, 179:1548-1553.
13. Navas P., Nowack D.D., Morré D.J. Isolation of purified plasma membranes from cultured cells and hepatomas by two-phase partition and preparative free-flow electrophoresis. Cancer Res 1989, 49:2147-2156.
14. +-activated p-nitrophenylphosphatase activities of NaI-treated microsomes from young rat cerebrum. J Biol Chem 1979, 254:4577-4584.
15. Latif R., Graves P., Davies T.F. Oligomerization of the human thyrotropin receptor: fluorescent protein-tagged hTSHR reveals post-translational complexes. J Biol Chem 2001, 276:45217-45224.
16. Kaneda T., Honda A., Hakozaki A., Fuse T., Muto A., Yoshida T. An improved Graves' disease model established by using in vivo electroporation exhibited long-term immunity to hyperthyroidism in BALB/c mice. Endocrinology 2007, 148:2335-2344.
17. Kaithamana S., Fan J., Osuga Y., Liang S.G., Prabhakar B.S. Induction of experimental autoimmune Graves' disease in BALB/c mice. J Immunol 1999, 163:5157-5164.
18. Shimojo N., Kohno Y., Yamaguchi K., Kikuoka S., Hoshioka A., Niimi H., et al. Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule. Proc Natl Acad Sci U S A 1996, 93:11074-11079.
19. Costagliola S., Many M.C., Denef J.F., Pohlenz J., Refetoff S., Vassart G. Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease. J Clin Invest 2000, 105:803-811.
20. Nagayama Y., Kita-Furuyama M., Ando T., Nakao K., Mizuguchi H., Hayakawa T., et al. A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J Immunol 2002, 168:2789-2794.
21. O'Shaughnessy P.J., Marsh P., Dudley K. Follicle-stimulating hormone receptor mRNA in the mouse ovary during post-natal development in the normal mouse and in the adult hypogonadal (hpg) mouse: structure of alternate transcripts. Mol Cell Endocrinol 1994, 101:197-201.
22. Rajapaksha W.R., Robertson L., O'Shaughnessy P.J. Expression of follicle-stimulating hormone-receptor mRNA alternate transcripts in bovine granulosa cells during luteinization in vivo and in vitro. Mol Cell Endocrinol 1996, 120:25-30.
23. Song G.J., Park Y.S., Lee Y.S., Lee C.C., Kang I.S. Alternatively spliced variants of the follicle-stimulating hormone receptor gene in the testis of infertile men. Fertil Steril 2002, 77:499-504.
24. Apaja P.M., Tuusa J.T., Pietilä E.M., Rajaniemi H.J., Petäjä-Repo U.E. Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum. Mol Biol Cell 2006, 17:2243-2255.
25. Chen C.R., McLachlan S.M., Rapoport B. Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation. Endocrinology 2010, 15:1940-1947.
26. Rees Smith B., McLachlan S.M., Furmaniak J. Autoantibodies to the thyrotropin receptor. Endocr Rev 1988, 9:106-121.
27. Rapoport B., Chazenbalk G.D., Jaume J.C., McLachlan S.M. The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr Rev 1998, 19:673-716.
28. Kleinau G., Jäschke H., Neumann S., Lättig J., Paschke R., Krause G. Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface. J Biol Chem 2004, 279:51590-51600.
29. Mueller S., Kleinau G., Jaeschke H., Paschke R., Krause G. Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation. J Biol Chem 2008, 283:18048-18055.
30. Sanders P., Young S., Sanders J., Kabelis K., Baker S., Sullivan A., et al. Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody. J Mol Endocrinol 2011, 46:81-99.
31. Latif R., Teixeira A., Michalek K., Ali M.R., Schlesinger M., Baliram R., et al. Antibody protection reveals extended epitopes on the human TSH receptor. PLoS One 2012, 7:e44669.
32. Nakahara A., Mitsutake N., Sakamoto H., Nayayama Y. Abstract P-YIA-3. Folia Endocrinologica Japonica 2010, 89:256.
33. Yang F., Chen I.H., Xiong Z., Yan Y., Wang H., Yang X.F. Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens. Clin Immunol 2006, 121:121-133.
34. Ng B., Yang F., Huston D.P., Yan Y., Yang Y., Xiong Z., et al. Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes. J Allergy Clin Immunol 2004, 114:1463-1470.