Alternatively spliced variants of the follicle-stimulating hormone receptor gene in the testis of infertile men

Fertility and Sterility

Volumn 77, Issue 3, 2002, Pages 499-504

  Song, Gyun Jee ^a,d   Park, Yong Seog ^a   Lee, You Sik ^c   Lee, Chung Choo ^b   Kang, Inn Soo ^c  

^a Research Laboratory of Reproductive Biology and Infertility   (South Korea)

^b Seoul National University   (South Korea)

^c Department of Urology ^*  (South Korea)

^d Samsung Advanced Institute of Technology (SAIT)   (South Korea)

Author keywords

FSH receptor; Infertility; Spermatogenic defects; Splicing variant

Indexed keywords

FOLLITROPIN RECEPTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; FOLLITROPIN BLOOD LEVEL; GENE MUTATION; HUMAN; MALE; MALE INFERTILITY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERTOLI CELL; SPERMATOGENESIS; SPERMATOZOON ABNORMALITY; TESTIS;

ALTERNATIVE SPLICING; BASE SEQUENCE; BIOPSY; CASE-CONTROL STUDIES; DNA; ELECTROPHORESIS, AGAR GEL; FOLLICLE STIMULATING HORMONE; HUMANS; INFERTILITY, MALE; LUTEINIZING HORMONE; MALE; MOLECULAR SEQUENCE DATA; PROSPECTIVE STUDIES; RECEPTORS, FSH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TESTIS; TESTOSTERONE;

EID: 0036181612     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(01)03221-6     Document Type: Article

References (19)

1. Scope and goals of andrology
2. Reproductive impairments in the United States, 1965-1982
3. Abnormality of testicular FSH receptors in infertile men
4. Clinical manifestations of genetic defects gonadotrophins and their receptors
5. Expression of follicle-stimulating hormone receptor mRNA in rat testes and Sertoli cells
6. The testicular receptor for follicle stimulating hormone; structure and functional expression of cloned cDNA
7. Composite structure of the human thyrotropin receptor gene
8. The structure and organization of the human FSH receptor gene
9. Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10
10. Regulation of gonadotropin receptor gene expression
11. Alternative splicing of follicle-stimulating hormone receptor pre-mRNA; cloning and characterization of two alternatively spliced mRNA transcripts
12. Alternatively spliced mRNA transcripts encoding the extracellular domain of the FSH receptor gene
13. Follitropin signal transduction; alternative splicing of the FSH receptor gene produces a dominant negative form of receptor which inhibits hormone action
14. Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid; functional expression of altenatively exon 7 of the coding sequence
15. Expression of follicle stimulating hormone-receptor mRNA during gonadal
16. Men homozygous for an inactivating mutation of the FSH receptor gene present variable suppression of spermatogenesis and fertility
17. Mutational analysis of the follicle-stimulating hormone (FSH) receptor in normal and infertile men; identification and characterization of two discrete FSH receptor isoforms
18. Screening male intracytoplasmic sperm injection candidates for mutations of the follicle stimulating hormone receptor gene
19. Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor