메뉴 건너뛰기




Volumn 36, Issue 6-7, 2003, Pages 331-337

Thyrotropin receptor autoantibodies (TSHRAbs): Epitopes, origins and clinical significance

Author keywords

Blocking TSHRAbs; Graves' disease; Hashimoto's disease; Primary myxedema; Stimulating TSHRAbs; Thyrotropin binding inhibiting immunoglobulin (TBIIs)

Indexed keywords

ARACHIDONIC ACID; AUTOANTIBODY; CALCIUM ION; CYCLIC AMP; EPITOPE; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENT; INOSITOL PHOSPHATE; PROPYLTHIOURACIL; RADIOACTIVE IODINE; THIAMAZOLE; THYROTROPIN; THYROTROPIN BINDING INHIBITION ANTIBODY; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

EID: 0141816819     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.1080/08916930310001604199     Document Type: Review
Times cited : (38)

References (52)
  • 1
    • 0006469852 scopus 로고
    • Graves' disease: A paradigm for autoimmunity
    • In: Pinchera, A., Ingbar, S.H., McKenzie, J.M. and Fenzi, G.F., eds; (Plenum Press, New York)
    • Adams, D.D., Knight, A., Knight, J.G. and Laing, P. (1987) "Graves' disease: A paradigm for autoimmunity", In: Pinchera, A., Ingbar, S.H., McKenzie, J.M. and Fenzi, G.F., eds, Thyroid Autoimmunity (Plenum Press, New York), pp 1-10.
    • (1987) Thyroid Autoimmunity , pp. 1-10
    • Adams, D.D.1    Knight, A.2    Knight, J.G.3    Laing, P.4
  • 2
    • 0003127304 scopus 로고
    • Antireceptor immunity
    • In: Rayner, D. and Champion, B., eds; (R G Landes Biomedical Publishers, Austin/Georgetown, Texas)
    • Kohn, L.D., Giuliani, C., Montani, V., Napolitano, G., Ohmori, M., Ohta, M., et al. (1995) "Antireceptor immunity", In: Rayner, D. and Champion, B., eds. Thyroid Immunity (R G Landes Biomedical Publishers, Austin/Georgetown, Texas), pp 115-170.
    • (1995) Thyroid Immunity , pp. 115-170
    • Kohn, L.D.1    Giuliani, C.2    Montani, V.3    Napolitano, G.4    Ohmori, M.5    Ohta, M.6
  • 4
    • 0030819082 scopus 로고    scopus 로고
    • Thyrotropin-receptor-mediated diseases: A paradigm for receptor autoimmunity
    • Prabhakar, B.S., Fan, J.-L. and Seetharamaiah, G.S. (1997) "Thyrotropin-receptor-mediated diseases: A paradigm for receptor autoimmunity", Immunol. Today 18, 437-442.
    • (1997) Immunol. Today , vol.18 , pp. 437-442
    • Prabhakar, B.S.1    Fan, J.-L.2    Seetharamaiah, G.S.3
  • 6
    • 0032247323 scopus 로고    scopus 로고
    • The thyrotropin (TSH)-releasing hormone receptor: Interaction with TSH and autoantibodies
    • Rapoport, B., Chazenbalk, G.D., Jaume, J.C. and McLachlan, S.M. (1998) "The thyrotropin (TSH)-releasing hormone receptor: Interaction with TSH and autoantibodies", Endocr. Rev. 19, 673-716.
    • (1998) Endocr. Rev. , vol.19 , pp. 673-716
    • Rapoport, B.1    Chazenbalk, G.D.2    Jaume, J.C.3    McLachlan, S.M.4
  • 8
    • 0028014390 scopus 로고
    • Meta-analysis evaluation of the impact of thyrotropin receptor antibodies on long term remission after medical therapy of Graves' disease
    • Feldt-Rasmussen, U., Schleusener, H. and Carayon, P. (1994) "Meta-analysis evaluation of the impact of thyrotropin receptor antibodies on long term remission after medical therapy of Graves' disease", J. Clin. Endocrinol. Metab. 78, 98-102.
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , pp. 98-102
    • Feldt-Rasmussen, U.1    Schleusener, H.2    Carayon, P.3
  • 10
    • 0019466939 scopus 로고
    • Monoclonal antibodies to the thyrotropin receptor: Implications for receptor structure and the action of autoantibodies in Graves' disease
    • Yavin, E., Yavin, Z., Schneider, M.D., et al. (1981) "Monoclonal antibodies to the thyrotropin receptor: Implications for receptor structure and the action of autoantibodies in Graves' disease", Proc. Natl Acad. Sci. USA 78, 3180-3184.
    • (1981) Proc. Natl Acad. Sci. USA , vol.78 , pp. 3180-3184
    • Yavin, E.1    Yavin, Z.2    Schneider, M.D.3
  • 11
    • 0020358828 scopus 로고
    • Monoclonal antibodies to the thyrotropin receptor: The identification of blocking and stimulating antibodies
    • Valente, W.A., Yavin, Z., Yavin, E., et al. (1982) "Monoclonal antibodies to the thyrotropin receptor: The identification of blocking and stimulating antibodies", J. Endocrinol. Invest. 5, 293-301.
    • (1982) J. Endocrinol. Invest. , vol.5 , pp. 293-301
    • Valente, W.A.1    Yavin, Z.2    Yavin, E.3
  • 12
    • 0006500345 scopus 로고
    • Monoclonal antibodies to the thyrotropin receptor: The identification of blocking and stimulating antibodies
    • Valente, W.A., Vitti, P., Yavin, Z., et al. (1982) "Monoclonal antibodies to the thyrotropin receptor: The identification of blocking and stimulating antibodies", Proc. Natl Acad. Sci. USA 79, 6680-6684.
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 6680-6684
    • Valente, W.A.1    Vitti, P.2    Yavin, Z.3
  • 13
    • 0022556761 scopus 로고
    • Monoclonal antibody studies defining the origin and properties of autoantibodies in Graves' disease
    • In: Schwartz, R. and Rose, N., eds
    • Kohn, L.D., Alvarez, F., Marcocci, C., et al. (1986) "Monoclonal antibody studies defining the origin and properties of autoantibodies in Graves' disease", In: Schwartz, R. and Rose, N., eds, Autoimmunity: Experimental and Clinical Aspects Ann. NY Acad. Sci. 475, pp 157-173.
    • (1986) Autoimmunity: Experimental and Clinical Aspects Ann. NY Acad. Sci. , vol.475 , pp. 157-173
    • Kohn, L.D.1    Alvarez, F.2    Marcocci, C.3
  • 14
    • 9844219737 scopus 로고    scopus 로고
    • Characterization of monoclonal thyroid stimulating and thyrotropin binding inhibiting autoantibodies from a Hashimoto's patient whose children had intrauterine and neonatal thyroid disease
    • Kohn, L.D., Hoffman, W.H., Tombaccini, D., Marcocci, C., Shimojo, N., Watanabe, Y., et al. (1997) "Characterization of monoclonal thyroid stimulating and thyrotropin binding inhibiting autoantibodies from a Hashimoto's patient whose children had intrauterine and neonatal thyroid disease", J. Clin. Endocrinol. Metab. 82, 3998-4009.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 3998-4009
    • Kohn, L.D.1    Hoffman, W.H.2    Tombaccini, D.3    Marcocci, C.4    Shimojo, N.5    Watanabe, Y.6
  • 15
    • 0032752930 scopus 로고    scopus 로고
    • Signaling pathways involved in thyroid hyperfunction and growth in Graves' disease
    • Ci Cerbo, A. and Corda, D. (1999) "Signaling pathways involved in thyroid hyperfunction and growth in Graves' disease", Biochimie 81, 415-424.
    • (1999) Biochimie , vol.81 , pp. 415-424
    • Ci Cerbo, A.1    Corda, D.2
  • 16
    • 0034853157 scopus 로고    scopus 로고
    • Studies using recombinant fragments of human TSH receptor reveal apparent diversity in the binding specificities of antibodies that block TSH binding to its receptor or stimulate thyroid hormone production
    • Cundiff, J.G., Kaithamana, S., Seetharamaiah, G.S., Baker, J.R. Jr and Prabhakar, B.S. (2001) "Studies using recombinant fragments of human TSH receptor reveal apparent diversity in the binding specificities of antibodies that block TSH binding to its receptor or stimulate thyroid hormone production", J. Clin. Endocrinol. Metab. 86, 3998-4009.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 3998-4009
    • Cundiff, J.G.1    Kaithamana, S.2    Seetharamaiah, G.S.3    Baker J.R., Jr.4    Prabhakar, B.S.5
  • 17
    • 0025951486 scopus 로고
    • Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients
    • Tahara, K., Ban, T., Minegishi, T. and Kohn, L.D. (1991) "Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients", Biochem. Biophys. Res. Commun. 179, 70-77.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 70-77
    • Tahara, K.1    Ban, T.2    Minegishi, T.3    Kohn, L.D.4
  • 18
    • 0025831943 scopus 로고
    • Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/chorionic gonadotropin receptors
    • Nagayama, Y., Wadsworth, H.L., Russo, D., Chazenbalk, G.D. and Rapoport, B. (1991) "Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/chorionic gonadotropin receptors", J. Clin. Investig. 88, 336-340.
    • (1991) J. Clin. Investig. , vol.88 , pp. 336-340
    • Nagayama, Y.1    Wadsworth, H.L.2    Russo, D.3    Chazenbalk, G.D.4    Rapoport, B.5
  • 19
    • 0027319614 scopus 로고
    • Structure-function studies of the human thyrotropin receptor. Inhibition of binding of labeled thyrotropin (TSH) by synthetic human TSH receptor peptides
    • Morris, J.C., Bergert, E.R. and McCormick, D.J. (1993) "Structure-function studies of the human thyrotropin receptor. Inhibition of binding of labeled thyrotropin (TSH) by synthetic human TSH receptor peptides", J. Biol. Chem. 268, 10900-10905.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10900-10905
    • Morris, J.C.1    Bergert, E.R.2    McCormick, D.J.3
  • 20
    • 0028788720 scopus 로고
    • Presence of heterogeneous thyroid-stimulating antibodies in sera from individual Graves' patients as shown by synthesized thyrotropin receptor peptide application: Evidence showing two independent epitopes and a possible recognition of two epitopic regions by one antibody molecule
    • Sugawa, H., Akamizu, T., Kosugi, S., Ueda, Y., Ohta, C., Okuda, J. and Mori, T. (1995) "Presence of heterogeneous thyroid-stimulating antibodies in sera from individual Graves' patients as shown by synthesized thyrotropin receptor peptide application: Evidence showing two independent epitopes and a possible recognition of two epitopic regions by one antibody molecule", Eur. J. Endocrinol. 133, 283-293.
    • (1995) Eur. J. Endocrinol. , vol.133 , pp. 283-293
    • Sugawa, H.1    Akamizu, T.2    Kosugi, S.3    Ueda, Y.4    Ohta, C.5    Okuda, J.6    Mori, T.7
  • 21
    • 0028961403 scopus 로고
    • Thyroid-stimulating antibodies in sera from patients with Grave's disease are heterogeneous in epitope recognition
    • Ueda, Y., Sugawa, H., Akamizu, T., Okuda, J., Ueda, M., Kosugi, S., Ohta, C., Kihou, Y. and Mori, T. (1995) "Thyroid-stimulating antibodies in sera from patients with Grave's disease are heterogeneous in epitope recognition", Eur. J. Endocrinol. 132, 62-68.
    • (1995) Eur. J. Endocrinol. , vol.132 , pp. 62-68
    • Ueda, Y.1    Sugawa, H.2    Akamizu, T.3    Okuda, J.4    Ueda, M.5    Kosugi, S.6    Ohta, C.7    Kihou, Y.8    Mori, T.9
  • 22
    • 0029937902 scopus 로고    scopus 로고
    • Epitopes for thyroid-stimulating antibodies in Graves' sera: A possible link of heterogeneity to differences in response to antithyroid drug treatment
    • Kim, W.B., Cho, B.Y., Park, H.Y., Lee H.K., Kohn, L.D., Tahara, K. and Koh, C.S. (1996) "Epitopes for thyroid-stimulating antibodies in Graves' sera: A possible link of heterogeneity to differences in response to antithyroid drug treatment", J. Clin. Endocrinol. Metab. 81, 1758-1767.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 1758-1767
    • Kim, W.B.1    Cho, B.Y.2    Park, H.Y.3    Lee, H.K.4    Kohn, L.D.5    Tahara, K.6    Koh, C.S.7
  • 23
    • 0031154048 scopus 로고    scopus 로고
    • Changes in epitopes for thyroid-stimulating antibodies in Graves' disease sera during treatment of hyperthyroidism: Therapeutic implications
    • Kim, W.B., Chung, H.K., Lee, H.K., Kohn, L.D., Tahara, K. and Cho, B.Y. (1997) "Changes in epitopes for thyroid-stimulating antibodies in Graves' disease sera during treatment of hyperthyroidism: Therapeutic implications", J. Clin. Endocrinol. Metab. 82, 1953-1959.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1953-1959
    • Kim, W.B.1    Chung, H.K.2    Lee, H.K.3    Kohn, L.D.4    Tahara, K.5    Cho, B.Y.6
  • 24
    • 0031000765 scopus 로고    scopus 로고
    • Subtypes of anti-TSH receptor antibodies classified by various assays using CHO cells expressing wild-type or chimeric human TSH receptor
    • Watanabe, Y., Tahara, K., Hirai, A., Tada, H., Kohn, L.D. and Amino, N. (1997) "Subtypes of anti-TSH receptor antibodies classified by various assays using CHO cells expressing wild-type or chimeric human TSH receptor", Thyroid 7, 13-19.
    • (1997) Thyroid , vol.7 , pp. 13-19
    • Watanabe, Y.1    Tahara, K.2    Hirai, A.3    Tada, H.4    Kohn, L.D.5    Amino, N.6
  • 25
    • 0042744788 scopus 로고    scopus 로고
    • The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim
    • Chen, C.-R., Pichurin, P., Nagayama, Y., Latrofa, F., Rapoport, B. and McLachlan, S.M. (2003) "The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim", J. Clin. Investig. 111, 1897-1904.
    • (2003) J. Clin. Investig. , vol.111 , pp. 1897-1904
    • Chen, C.-R.1    Pichurin, P.2    Nagayama, Y.3    Latrofa, F.4    Rapoport, B.5    McLachlan, S.M.6
  • 26
    • 0026522437 scopus 로고
    • Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid stimulating antibodies and with thyroid stimulating blocking antibodies in idiopathic myxedema: These determinants have no homologous sequence on gonadotropin receptors
    • Kosugi, S., Ban, T., Akamizu, T. and Kohn, L.D. (1992) "Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid stimulating antibodies and with thyroid stimulating blocking antibodies in idiopathic myxedema: These determinants have no homologous sequence on gonadotropin receptors", Mol. Endocrinol. 6, 168-180.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 168-180
    • Kosugi, S.1    Ban, T.2    Akamizu, T.3    Kohn, L.D.4
  • 27
    • 0027532027 scopus 로고
    • Identification of thyroid stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor
    • Kosugi, S., Ban, T. and Kohn, L.D. (1993) "Identification of thyroid stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor", Mol. Endocrinol. 7, 114-130.
    • (1993) Mol. Endocrinol. , vol.7 , pp. 114-130
    • Kosugi, S.1    Ban, T.2    Kohn, L.D.3
  • 28
    • 0026002412 scopus 로고
    • Site directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors: Relationship of functional and immunogenic domains
    • Kosugi, S., Ban, T., Akamizu, T., et al. (1991) "Site directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors: Relationship of functional and immunogenic domains", J. Biol. Chem. 266, 19413-19418.
    • (1991) J. Biol. Chem. , vol.266 , pp. 19413-19418
    • Kosugi, S.1    Ban, T.2    Akamizu, T.3
  • 29
    • 0025721846 scopus 로고
    • Further characterization of a high-affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Grave's patients
    • Kosugi, S., Ban, T., Akamizu, T., et al. (1991) "Further characterization of a high-affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Grave's patients", Biochem. Biophys. Res. Commun. 180, 1118-1124.
    • (1991) Biochem. Biophys. Res. Commun. , vol.180 , pp. 1118-1124
    • Kosugi, S.1    Ban, T.2    Akamizu, T.3
  • 30
    • 0027015541 scopus 로고
    • Molecular basis for the autoreactivity against thyroid stimulating hormone receptor
    • Kohn, L.D., Kosugi, S., Ban, T., et al. (1992) "Molecular basis for the autoreactivity against thyroid stimulating hormone receptor", Intern. Rev. Immunol. 9, 135-165.
    • (1992) Intern. Rev. Immunol. , vol.9 , pp. 135-165
    • Kohn, L.D.1    Kosugi, S.2    Ban, T.3
  • 31
    • 0027261234 scopus 로고
    • Chimeric studies of the extracellular domain of the rat thyrotropin (TSH) receptor: Amino acids 268-304 in the TSH receptor are involved in the ligand high-affinity, but not in TSH-receptor-specific signal transduction
    • Akamizu, T., Inoue, D., Kosugi, S., et al. (1993) "Chimeric studies of the extracellular domain of the rat thyrotropin (TSH) receptor: Amino acids 268-304 in the TSH receptor are involved in the ligand high-affinity, but not in TSH-receptor-specific signal transduction", Endocr. J. 40, 363-372.
    • (1993) Endocr. J. , vol.40 , pp. 363-372
    • Akamizu, T.1    Inoue, D.2    Kosugi, S.3
  • 32
    • 0028354607 scopus 로고
    • Further studies of amino acids(268-304) in thyrotropin (TSH)-lutropin/chorionic gonadotropin (LH/CG) chimeras: Cysteine-301 is important in TSH binding and tertiary structure
    • Akamizu, T., Inoue, D., Kosugi, S., et al. (1994) "Further studies of amino acids(268-304) in thyrotropin (TSH)-lutropin/chorionic gonadotropin (LH/CG) chimeras: Cysteine-301 is important in TSH binding and tertiary structure", Thyroid 4, 43-48.
    • (1994) Thyroid , vol.4 , pp. 43-48
    • Akamizu, T.1    Inoue, D.2    Kosugi, S.3
  • 33
    • 0031463319 scopus 로고    scopus 로고
    • Epitopes for thyroid stimulating and blocking autoantibodies on the extracellular domain of the human thyrotrophin receptor
    • Tahara, K., Ishikawa, N., Yamamoto, K., Hirai, A., Ito, K., Tamura, Y., et al. (1997) "Epitopes for thyroid stimulating and blocking autoantibodies on the extracellular domain of the human thyrotrophin receptor", Thyroid 7, 867-877.
    • (1997) Thyroid , vol.7 , pp. 867-877
    • Tahara, K.1    Ishikawa, N.2    Yamamoto, K.3    Hirai, A.4    Ito, K.5    Tamura, Y.6
  • 34
    • 0027174708 scopus 로고
    • Immunoglobulin G that interferes with thyroid stimulating antibody measurements can be eliminated specifically by incubation with synthetic peptides corresponding to partial sequences of the human thyrotropin receptor
    • Ueda, Y., Sugawa, H., Akamizu, T., et al. (1993) "Immunoglobulin G that interferes with thyroid stimulating antibody measurements can be eliminated specifically by incubation with synthetic peptides corresponding to partial sequences of the human thyrotropin receptor", Thyroid 3, 111-117.
    • (1993) Thyroid , vol.3 , pp. 111-117
    • Ueda, Y.1    Sugawa, H.2    Akamizu, T.3
  • 35
    • 0028961403 scopus 로고
    • Presence of heterogeneous thyroid stimulating antibodies in sera from individual Grave's patients as shown by synthesized TSH-R peptide application
    • Ueda, Y., Sugawa, H., Akamizu, T., et al. (1995) "Presence of heterogeneous thyroid stimulating antibodies in sera from individual Grave's patients as shown by synthesized TSH-R peptide application", Eur. J. Endocrinol. 132, 62-68.
    • (1995) Eur. J. Endocrinol. , vol.132 , pp. 62-68
    • Ueda, Y.1    Sugawa, H.2    Akamizu, T.3
  • 36
    • 0037244619 scopus 로고    scopus 로고
    • Prediction of outcome in patients with Graves' disease after antithyroid drug treatment according to epitope heterogeneity of thyroid-stimulating antibodies
    • Kim, T.Y., Park, Y.J., Park, D.J., Chung, H.-K., Kim, W.B., Kohn, L.D. and Cho, B.Y. (2003) "Prediction of outcome in patients with Graves' disease after antithyroid drug treatment according to epitope heterogeneity of thyroid-stimulating antibodies", J. Clin. Endocrinol. Metab. 88, 117-124.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 117-124
    • Kim, T.Y.1    Park, Y.J.2    Park, D.J.3    Chung, H.-K.4    Kim, W.B.5    Kohn, L.D.6    Cho, B.Y.7
  • 37
    • 0026464910 scopus 로고
    • Mutation of alanine 623 in the 3rd cytoplasmic loop of the rat TSH receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies
    • Kosugi, S., Okajima, F., Ban, T., et al. (1992) "Mutation of alanine 623 in the 3rd cytoplasmic loop of the rat TSH receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies", J. Biol. Chem. 267, 24153-24156.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24153-24156
    • Kosugi, S.1    Okajima, F.2    Ban, T.3
  • 38
    • 0026673198 scopus 로고
    • Thyroid stimulating immunoglobulins, like thyrotropin, activate both the cyclic AMP and the PIP2 cascade in CHO cells expressing the TSH receptor
    • Van Sande, J., Lejeune, C., Ludgate, M., et al. (1992) "Thyroid stimulating immunoglobulins, like thyrotropin, activate both the cyclic AMP and the PIP2 cascade in CHO cells expressing the TSH receptor", Mol. Cell. Endocrinol. 88, R1-R5.
    • (1992) Mol. Cell. Endocrinol. , vol.88
    • Van Sande, J.1    Lejeune, C.2    Ludgate, M.3
  • 39
    • 0034517523 scopus 로고    scopus 로고
    • A novel mouse model of Graves' disease: Implications for a role in aberrant MHC class II expression in its pathogenesis
    • Shimojo, N., Arima, T., Yamaguchi, K.-I., Kikuoka, S., Kohn, L.D. and Kohno, Y. (2000) "A novel mouse model of Graves' disease: Implications for a role in aberrant MHC class II expression in its pathogenesis", Int. Rev. Immunol. 19, 619-631.
    • (2000) Int. Rev. Immunol. , vol.19 , pp. 619-631
    • Shimojo, N.1    Arima, T.2    Yamaguchi, K.-I.3    Kikuoka, S.4    Kohn, L.D.5    Kohno, Y.6
  • 40
    • 0032915936 scopus 로고    scopus 로고
    • Regulation and transfer of a murine model of thyrotropin receptor antibody mediated Graves' disease
    • Kita, M., Ahmad, L., Marians, R.C., Vlase, H., Unger, P., Graves, P.N. and Davies, T.F. (1999) "Regulation and transfer of a murine model of thyrotropin receptor antibody mediated Graves' disease", Endocrinology 140, 1392-1398.
    • (1999) Endocrinology , vol.140 , pp. 1392-1398
    • Kita, M.1    Ahmad, L.2    Marians, R.C.3    Vlase, H.4    Unger, P.5    Graves, P.N.6    Davies, T.F.7
  • 42
    • 0027325575 scopus 로고
    • Induction of TSH binding inhibitory immunoglobulins with the extracellular domain of the human thyrotropin receptor produced using a baculovirus expression system
    • Seetharamaiah, G.S., Desai, R.K., Dallas, J.S., et al. (1993) "Induction of TSH binding inhibitory immunoglobulins with the extracellular domain of the human thyrotropin receptor produced using a baculovirus expression system", Autoimmunity 14, 315-320.
    • (1993) Autoimmunity , vol.14 , pp. 315-320
    • Seetharamaiah, G.S.1    Desai, R.K.2    Dallas, J.S.3
  • 43
    • 0027319614 scopus 로고
    • Structure function studies of the human thyrotropin receptor: Inhibition of binding of labeled thyrotropin (TSH) by synthetic human TSH receptor peptides
    • Morris, J.C., Bergert, E.R. and McCormick, D.J. (1993) "Structure function studies of the human thyrotropin receptor: Inhibition of binding of labeled thyrotropin (TSH) by synthetic human TSH receptor peptides", J. Biol. Chem. 268, 10900-10905.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10900-10905
    • Morris, J.C.1    Bergert, E.R.2    McCormick, D.J.3
  • 44
    • 0025782892 scopus 로고
    • Localization and synthesis of the hormone binding regions of the human thyrotropin receptor
    • Atassi, M.Z., Manshouri, T. and Sakata, S. (1991) "Localization and synthesis of the hormone binding regions of the human thyrotropin receptor", Proc. Natl Acad. Sci. USA 88, 3613-3617.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 3613-3617
    • Atassi, M.Z.1    Manshouri, T.2    Sakata, S.3
  • 45
    • 0026074817 scopus 로고
    • Development of chicken antibodies toward the human thyrotropin receptor peptides and their bioactivities
    • Ohmori, M., Endo, T. and Onaya, T. (1991) "Development of chicken antibodies toward the human thyrotropin receptor peptides and their bioactivities", Biochem. Biophys. Res. Commun. 174, 399-403.
    • (1991) Biochem. Biophys. Res. Commun. , vol.174 , pp. 399-403
    • Ohmori, M.1    Endo, T.2    Onaya, T.3
  • 46
    • 0027451585 scopus 로고
    • Dual mechanism of perturbation of thyrotropin mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR derived peptides
    • Desai, R.K., Dallas, J.S., Gupta, M.K., et al. (1993) "Dual mechanism of perturbation of thyrotropin mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR derived peptides", J. Clin. Endocrinol. Metab. 77, 658-663.
    • (1993) J. Clin. Endocrinol. Metab. , vol.77 , pp. 658-663
    • Desai, R.K.1    Dallas, J.S.2    Gupta, M.K.3
  • 47
    • 0034886412 scopus 로고    scopus 로고
    • Epitope mapping of TSH receptor blocking antibodies in Graves' disease which appear during pregnancy
    • Kung, A.W.C., Lau, K.S. and Kohn, L.D. (2001) "Epitope mapping of TSH receptor blocking antibodies in Graves' disease which appear during pregnancy", J. Clin. Endocrinol. Metab. 86, 3647-3653.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 3647-3653
    • Kung, A.W.C.1    Lau, K.S.2    Kohn, L.D.3
  • 48
    • 0033769016 scopus 로고    scopus 로고
    • Characterization of thyroid-stimulating blocking antibodies which appeared during transient hypothyroidism after radioactive iodine therapy
    • Kung, A.WC., Lau, K.S. and Kohn, L.D. (2000) "Characterization of thyroid-stimulating blocking antibodies which appeared during transient hypothyroidism after radioactive iodine therapy", Thyroid 10, 909-917.
    • (2000) Thyroid , vol.10 , pp. 909-917
    • Kung, A.W.C.1    Lau, K.S.2    Kohn, L.D.3
  • 49
    • 2442731884 scopus 로고    scopus 로고
    • Two Graves' disease patients who spontaneously developed hypothyroidism after antithyroid drug treatment: Characteristics of epitopes for thyrotropin receptor antibodies
    • Chung, H.-K., Kim, W.B., Park, D.J., Kohn, L.D., Tahara, K. and Cho, B.Y. (1999) "Two Graves' disease patients who spontaneously developed hypothyroidism after antithyroid drug treatment: Characteristics of epitopes for thyrotropin receptor antibodies", Thyroid 9, 393-399.
    • (1999) Thyroid , vol.9 , pp. 393-399
    • Chung, H.-K.1    Kim, W.B.2    Park, D.J.3    Kohn, L.D.4    Tahara, K.5    Cho, B.Y.6
  • 50
    • 0033849505 scopus 로고    scopus 로고
    • The prevalence and clinical significance of blocking TSH receptor antibodies in untreated Graves' disease
    • Kim, W.B., Chung, H.K., Park, D.J., Lee, H.K., Tahara, K., Kohn, L.D. and Cho, B.Y. (2000) "The prevalence and clinical significance of blocking TSH receptor antibodies in untreated Graves' disease", Thyroid 10, 579-586.
    • (2000) Thyroid , vol.10 , pp. 579-586
    • Kim, W.B.1    Chung, H.K.2    Park, D.J.3    Lee, H.K.4    Tahara, K.5    Kohn, L.D.6    Cho, B.Y.7
  • 51
    • 0032985252 scopus 로고    scopus 로고
    • Epitope heterogeneity of TSH blocking antibodies in Graves' patients as detected with wild type versus chimeric TSH receptors
    • Grasso, Y.Z., Kim, M.R., Faiman, C., Kohn, L.D., Tahara, K. and Gupta, M.K. (1999) "Epitope heterogeneity of TSH blocking antibodies in Graves' patients as detected with wild type versus chimeric TSH receptors", Thyroid 9, 531-537.
    • (1999) Thyroid , vol.9 , pp. 531-537
    • Grasso, Y.Z.1    Kim, M.R.2    Faiman, C.3    Kohn, L.D.4    Tahara, K.5    Gupta, M.K.6
  • 52
    • 0031792560 scopus 로고    scopus 로고
    • Thyroid-stimulating antibodies predict hyperthyroidism
    • Davies, T.F. (1998) "Thyroid-stimulating antibodies predict hyperthyroidism", J. Clin. Endocrinol. Metab. 83, 3777-3781.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 3777-3781
    • Davies, T.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.