Insights into the activity and specificity of trypanosoma cruzi trans -Sialidase from molecular dynamics simulations

Biochemistry

Volumn 52, Issue 21, 2013, Pages 3740-3751

  Mitchell, Felicity L ^a   Neres, João ^a,b   Ramraj, Anitha ^a   Raju, Rajesh K ^a   Hillier, Ian H ^a   Vincent, Mark A ^a   Bryce, Richard A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL SIMULATION; MOLECULAR DYNAMICS SIMULATIONS; NEGLECTED TROPICAL DISEASE; OPEN CONFORMATION; POTENTIAL DRUG TARGETS; PROTEIN FLEXIBILITY; SOLVENT ACCESSIBILITY; TRYPANOSOMA CRUZI;

HYDROLYSIS; MOLECULAR DYNAMICS; PROTEINS; SUGARS;

SUBSTRATES;

HYMECROMONE; LACTOSE; SIALIDASE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HYDROLYSIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DATA BANK; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIALYLATION; TRYPANOSOMA CRUZI;

ANIMALS; GLYCOPROTEINS; MOLECULAR DYNAMICS SIMULATION; NEURAMINIDASE; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 84878342023     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301112p     Document Type: Article

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