Modulation of catalytic function by differential plasticity of the active site: Case study of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase

Biochemistry

Volumn 48, Issue 15, 2009, Pages 3398-3406

  Demir, Özlem ^a   Roitberg, Adrian E ^a  

^a University of Florida ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES; CATALYTIC FUNCTIONS; CATALYTIC MECHANISMS; CAUSATIVE AGENTS; CHAGAS' DISEASE; HOST CELLS; HYDROLASE; IMMUNE SYSTEMS; MOLECULAR DYNAMICS SIMULATIONS; SIALIDASE; SOLVENT EXPOSURES; THERAPEUTIC TARGETS; TRANS-SIALIDASE; TRYPANOSOMA; TRYPANOSOMA CRUZI;

ENZYME ACTIVITY; ENZYMES; LIGANDS; MOLECULAR DYNAMICS; PLASTICITY;

DYNAMICS;

APOENZYME; HOLOENZYME; SIALIDASE;

ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; SIMULATION; TRYPANOSOMA; TRYPANOSOMA CRUZI;

ANIMALS; APOPROTEINS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GLYCOPROTEINS; HOLOENZYMES; LIGANDS; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS; TRYPANOSOMA; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI; TRYPANOSOMA RANGELI;

EID: 65249119681     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802230y     Document Type: Article

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