Uncertainty in Clinical Medicine

Philosophy of Medicine

Volumn , Issue , 2011, Pages 299-356

  Djulbegovic, Benjamin ^a   Hozo, Iztok ^b   Greenland, Sander ^c  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b INDIANA UNIVERSITY NORTHWEST   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84878294530     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-444-51787-6.50011-8     Document Type: Chapter

References (248)

1. P.E. Achinstein (2004) Science rules. A historical introduction to scientific methods Baltimore: The John Hopkins University Press
2. P.E. Achinstein (2005) Science evidence. Philosophical theories and applications Baltimore: The John Hopkins University Press
3. M. Allais (1953) Le compartment de l'homme rationnel devant le risque. Critque des postulates et axiomes de l'ecole Americaine. Econometrica 21 503-546.
4. D. Altman (1994) The scandal of poor medical research. BMJ 308 283-284.
5. D. Altman (2002) Poor-Quality Medical Research: What Can Journals Do? JAMA 287(21), 2765-2767.
6. D. Altman, K.F. Schultz, D. Moher and for the CONSORT group (2001) The revised CONSORT statement: explanation and elaboration. Ann Intern Med 134 663-694.
7. R. Audi (2003) Epistemology. A contemporary introduction to the theory of knowledge 2nd New York: Routledge
8. J. Baron (2000) Thinking and deciding 3rd ed Cambridge: Cambridge University Press
9. J. Baron (2007) Thinking and deciding 4th ed Cambridge: Cambridge University Press
10. P. Basch (2005) Electronic health records and the national health information network: affordable, adoptable, and ready for prime time? Ann Intern Med 143(3), 227-228.
11. T. Bayes (1764) An assay toward solving a problem in the doctrine of chances. Philosphical Transactions of the Royal Society of London 53 370-418.
12. M. Behera, A. Kumar, H.P. Soares, L. Sokol and B. Djulbegovic (2007) Evidence-based medicine for rare diseases: implications for data interpretation and clinical trial design. Cancer Control 14(2), 160-166.
13. D. Bell (1982) Regret in Decision Making under Uncertainty. Operations Research 30 961-981.
14. D. Bell, H. Raiffa and A. Tversky (1988) Decision making. Descriptive, normative, and prescriptive interactions Cambridge: Cambridge University Press
15. K. Benson and A.J. Hartz (2000) A comparison of observational studies and randomized, controlled trials. N Engl J Med 342(25), 1878-1886.
16. E. Berner and M. Graber (2008) Overconfidence as a cause of diagnostic error in medicine. Am J Med 121(5 Suppl), S2-23.
17. S. Bikchandani, D. Hirshfleifer and I. Welch (1998) Learning from behavior of others: conformity, fads, and informational cascades. J Econ Perspectives 12 151-170.
18. M. Birnbaum (1999) Paradoxes of Allais, stochastic dominance, and decision weights. B. Shanteau, A. Mellers, D.A. Schum (Eds) Decision science and technology: Reflections on the contributions of Ward Edwards Norwell MA:: Kluwer Academic Publishers 27-52.
19. M. Birnbaum (1999) Testing critical properties of decision making on the Internet. Psychological Science 10 399-407.
20. M. Birnbaum (2008) New paradoxes of risky decision making. Psychological Review 115 463-501.
21. M. Birnbaum and J. Navarrete (1998) Testing descriptive utility theories: Violations of stochastic dominance and cumulative independence. Journal of Risk and Uncertainty 17 49-78.
22. M. Birnbaum, J. Patton and M. Lott (1999) Evidence against Rank-Dependent Utility Theories: Tests of Cumulative Independence, Interval Independence, Stochastic Dominance, and Transitivity. Organ Behav Hum Decis Process 77(1), 44-83.
23. P. Bossuyt, J. Reitsma, D. Bruns, C. Gatsonis, P. Glasziou, L. Irwig, D. Moher, D. Rennie, H. de Vet and J. Lijmer (2003) The STARD Statement for reporting of studies of diagnostic accuracy: explanation and elaboration. Clin Chem 49 7-18.
24. I. Boutron, D. Moher, D. Altman, K. Schulz, P. Ravaud and C.G. for the (2003) Extending the CONSORT Statement to Randomized Trials of Nonpharmacologic Treatment: Explanation and Elaboration. Ann Intern Med 148(4), 295-309.
25. C. Boyd, J. Darer, C. Boult, L. Fried, L. Boult and A. Wu (2005) Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases: Implications for Pay for Performance. JAMA 294(6), 716-724.
26. E. Brandstatter and G. Gigerenzer (2006) The Priority Heuristic: Making Choices Without Trade-Offs. Psychological Review 113 409-432.
27. D. Brock (1990) When competent patients make irrational choices. N Engl J Med 322 1595-1599.
28. C. Camerer and M. Weber (1992) Recent develpments in modeling preferences:uncertainty and ambiguity. J Risk Uncertainty 5 325-370.
29. J. Carter (2008) Electronic Health Records 2nd ed Philadelphia: ACP Press
30. I. Chalmers (2001) Using systematic reviews and registers of ongoing trials for scientific and ethical trial design, monitoring, and reporting. M. Egger, G.D. Smith, D.G. Altman (Eds) Systematic reviews in health care. Meta-analysis in context London: BMJ 429-443.
31. I. Chalmers (2004) Well informed uncertainties about the effects of treatments. BMJ 328(7438), 475-476.
32. I. Chalmers (2004) Why comparisons must address genuine uncertainties http://www.jameslindlibrary.org/essays/comparisons/genuine_uncertainties.html
33. I. Chalmers (2006) Why fair tests are needed: a brief history. ACP Journal Club. Jul-Aug 145 A8-A9.
34. I. Chalmers (2007) Addressing uncertainties about the effects of treatments offered to NHS patients: whose responsibility? J R Soc Med 100(10), 440-441.
35. I. Chalmers, L.V. Hedges and H. Cooper (2002) A brief history of research synthesis. Eval Health Prof 25 12-37.
36. N. Christakis (2001) Death Foretold. Prophecy and prognosis in medical care Vol. 11 Chicago: The University of Chicago Press
37. M. Clarke (2004) Doing new research? Don't forget the old, PLoS Med 1(2), e35.
38. M. Clarke, P. Alderson and I. Chalmers (2002) Discussion sections in reports of controlled trials published in general medical journals. JAMA 287 2799-2801.
39. R. Collins and S. McMahon (2001) Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials. Lancet 357 373-380.
40. M. Colyvan (2008) Is probability the only coherent approach to uncertainty? Risk Anal 28(3), 645-652.
41. Commitee on Quality of Health Care in America. Institute of Medicine. Crossing the quality chasm (2001) A New Health System for the 21st Century Washington, DC: National Academy Press
42. J. Concato, N. Shah and R.I. Horwitz (2000) Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 342(25), 1887-1892.
43. J. Covey (2007) A meta-analysis of the effects of presenting treatment benefits in different formats. Med Decis Making 27(5), 638-654.
44. H. Cruse, M. Winiarek, J. Marshburn, O. Clark and B. Djulbegovic (2002) Quality and methods of developing practice guidelines. BMC Health Service Research 2(1), http://www.biomedcentral.com/1472-6963/2/1 2002
45. S. Curley (2007) The application of Dempster-Shafer theory demonstrated with justification provided by legal evidence. Judgment and Decision Making 5 257-276.
46. P. Cutler (1985) Problem solving in medicine Baltimore: Williams & Wilkins
47. A. Dagli, R. Morse, C. Dalton, J. Owen and G. Hayden (2003) Formulating clinical questions during community preceptorships: a first step in utilizing evidence-based medicine. Fam Med 35 619-621.
48. J. Daley (1999) Medical uncertainty and practice variation get personal: what should I do about hormone replacement therapy? Ann Intern Med 130 602-603.
49. Dartmouth Institute for Health Policy and Clinical Practice. The Dartmouth Atlas of Health Care cited. Available from http://www.dartmouthatlas.org/
50. K. Davies (2007) The information-seeking behavior of doctors: a review of the evidence. Health Info Libr J 24(2), 78-94.
51. R. Dawes, D. Faust and P. Meehl (1989) Clinical versus actuarial judgment. Science 243(4899), 1668-1674.
52. J.P.M. De SA (2008) Chance. The life of games and the game of life Berlin: Springer
53. B. DeFinetti (1974) The theory of probability New York: Wiley
54. D. Detmer (2003) Building the national health information infrastructure for personal health, health care services, public health, and research. BMC Med Inform Decis Mak 3 1.
55. G. Diamond and J. Forrester (1983) Metadiagnosis. An epistemologic model of clinical judgment. Am J Med. 75 129-137.
56. A. Dijksterhuis, M. Bos, L. Nordgren and R. van Baaren (2006) On Making the Right Choice: The Deliberation-Without-Attention Effect. Science 311(5763), 1005-1007.
57. B. Djulbegovic (2001) Acknowledgment of Uncertainty: A Fundamental Means to Ensure Scientific and Ethical Validity in Clinical Research. Current Oncology Reports 3 389-395.
58. B. Djulbegovic (2003) Principles of research synthesis. M. Perry (Eds) ASCO Educational Session, 39 Annual Meeting Washington, DC: ASCO 737-750.
59. B. Djulbegovic (2004) Lifting the fog of uncertainty from the practice of medicine. BMJ 329(7480), 1419-1420.
60. B. Djulbegovic (2004) Well informed uncertainties about the effects of treatment: Paradox exists in dealing with uncertainty. BMJ 328(7446), 1018.
61. B. Djulbegovic (2006) Evidence and decision-making. J Eval Clin Practice 12 248-256.
62. B. Djulbegovic (2007) Articulating and responding to uncertainties in clinical research. J Med Philosophy 32 79-98.
63. B. Djulbegovic, A. Frohlich and C. Bennett (2005) Acting on Imperfect Evidence: How Much Regret Are We Ready to Accept? J Clin Oncol 23(28), 6822-6825.
64. B. Djulbegovic, G. Guyatt and R. Aschroft (2009) Epistemological inquiries in evidence-based medicine. Cancer Control 16 158-169.
65. B. Djulbegovic and I. Hozo (2008) When Should Potentially False Research Findings Be Considered Acceptable? PLoS Medicine 4(2), e26.
66. B. Djulbegovic, I. Hozo and G. Lyman (2000) Linking evidence-based medicine therapeutic summary measures to clinical decision analysis, MedGen-Med http://www.medscape.com/Medscape/GeneralMedicine/journal/2000/v2002.n2001/mgm0113.djul/mgm0113.djul-2001.html
67. B. Djulbegovic, I. Hozo, A. Schwartz and K. McMasters (1999) Acceptable regret in medical decision making. Med Hypotheses 53 253-259.
68. B. Djulbegovic, T.P. Loughran Jr., C.A. Hornung, G. Kloecker, E.N. Efthimiadis, T.J. Hadley, J. Englert, M. Hoskins and G.H. Goldsmith (1999) The quality of medical evidence in hematology-oncology. The American Journal of Medicine 106(2), 198-205.
69. B. Djulbegovic and G. Lyman (2006) Screening mammography at 40-49 years: regret or no regret? Lancet 368(9552), 2035-2037.
70. B. Djulbegovic, G. Lyman and J. Ruckdeschel (2000) Why Evidence-based Oncology. Evidence-based Oncology 1 2-5.
71. B. Djulbegovic, H. Soares and A. Kumar.What kind of evidence do patients and practitioners need: Evidence profiles based on 5 key evidence-based principles to summarize data on benefits and harms, Cancer Treatment Reviews 32 (7):572-576.
72. B. Djulbegovic and D.S. Sullivan (Eds) (1997) Decision Making in Oncology. Evidence-based management New York: Churchill Livingstone, Inc
73. J. Douard (1996) Is risk neutrality rational? Med Decis Making 16 10-11.
74. D. Eddy (1990) Comparing benefits and harms: the balance sheet. JAMA 263 2493-2505.
75. D. Eddy (1990) Variations in physician practice: the role of uncertainty. Health Aff 3(2), 74-89.
76. D. Eddy (1990) Practice polices: guidelines for methods. JAMA 263 1839-1841.
77. D. Eddy and J. Billings (1988) The quality of medical evidence: implications for quality of care. Health Aff 7(1), 19-32.
78. W. Edwards, R. Miles Jr. and D. von Winterfeld (2007) Advances in decision analysis. From foundations to applications New York: Cambridge University Press
79. D. Ellsberg (1961) Risk, ambiguity, and the Savage axioms. Quart J Economics 75 643-669.
80. E. Emanuel, V. Fuchs and A. Garber (2007) Essential Elements of a Technology and Outcomes Assessment Initiative. JAMA 298(11), 1323-1325.
81. I. Evans, H. Thornton and I. Chalmers (2006) Testing Treatments: better research for better healthcare London: British Library
82. T. Fahey, S. Griffiths and T.J. Peters (1995) Evidence-based purchasing:understanding results of clinical trials and systemetic reviews. BMJ 311 1053-1056.
83. M. Field and K. Lohr (1990) Clinical practice guidelines:directions for a new agency Washigton: Institute of Medicine, National Academy Press
84. E. Fisher, D. Wennberg, T. Stukel, D. Gottlieb, F. Lucas and E. Pinder (2003) The implications of regional variations in Medicare spending. Part 1: the content, quality, and accessibility of care. Ann Intern Med 138(4), 273-287.
85. E. Fisher (2003) The implications of regional variations in Medicare spending. Part 2: health outcomes and satisfaction with care. Ann Intern Med 138(4), 288-298.
86. C. Foster (2001) The ethics of medical research on humans Cambridge: Cambridge University Press
87. R. Fox (1957) Training for uncertainty. R. Merton, G.C. Reader, P. Kendall (Eds) The student-physician: introductory studies in the sociology of medical education Cambridge, MA: Harvard University Press
88. R. Fox (1957) The evolution of medical uncertainty. Milbank Mem Fund Quaterly/Health and Soc 58 1-49.
89. J. Gabbay and A. le May (2004) Evidence based guidelines or collectively constructed mindlines? Ethnographic study of knowledge management in primary care. BMJ 329(7473), 1013. 1010
90. General Medical Council (2007) Good Medical Practice London: GMC
91. J. George, S. Woolf, G. Rakob, et al. (1996) Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 88 3-40.
92. M. Gerrity, R. DeVellis and J. Earp (1990) Physicians' reaction to uncertainty in patient care. A new measure and new insights. Med Care 28 724-736.
93. M. Gerrity, R. DeVellis and J. Earp (1990) Physicians' reactions to uncertainty in patient care. A new measure and new insights. Med Care 28(8), 724-736.
94. M. Gerrity, M. White, R. DeVellis and R. Dittus (1995) Physicians' reaction to uncertainty: refining the constructs and scales. Motivation and Emotion. 3 175-191.
95. G. Gigerenzer and U. Hoffrage (1995) How to improve Bayesian reasoning without instruction: Frequency formats. Psychology Review 102 4-704.
96. G. Gigerenzer, P. Todd and the ABC Research Group (1999) Simple Heuristics That Make Us Smart New York: Oxford University Press
97. C. Gill, L. Sabin and C. Schmid (2005) Why clinicians are natural bayesians. Bmj 330(7499), 1080-1083.
98. P. Glasziou, I. Chalmers, M. Rawlins and P. McCulloch (2007) When are randomised trials unnecessary? Picking signal from noise. BMJ 334(7589), 349-351.
99. P. Glasziou and L.M. Irwig (1995) An evidence based approach to individualising treatment. BMJ 311 1356-1359.
100. A. Glenny, D. Altman, F. Song, C. Sakarovitch, J. Deeks, R. D'Amico, M. Bradburn and A. Eastwood (2005) Indirect comparisons of competing interventions. Health Technol Assess 9(26), 1-134. iii-iv
101. L. Goble (2001) The Blackwell Guide to Philosophical Logic Oxford: Blackwell Publishing
102. I. Good (1967) On the principle of total evidence. Br J Phil Sci 17 319-321.
103. S. Goodman (1999) Probability at the bedside: the knowing of chances or the chances of knowing. Ann Intern Med 130 604-606.
104. S. Goodman (1999) Toward evidence-based medical statistics. 2: the Bayes factor. Ann Intern Med 130 1005-1013.
105. S. Goodman (1999) Toward evidence-based medical statitistics. 1: the p value fallacy. Ann Intern Med 130 995-1004.
106. S. Greenland (1998) Probability logic and probabilistic induction. Epidemiology 9 322-332.
107. S. Greenland (2005) Multiple-bias modeling for analysis of observational data. J R Statist Soc 168(Part 2(A)), 267-306.
108. S. Greenland (2006) Bayesian perspectives for epidemiological research: I. Foundations and basic methods. Int J Epidemiol 35(3), 765-775.
109. S. Greenland (2007) Bayesian perspectives for epidemiological research. II. Regression analysis. Int J Epidemiol 36(1), 195-202.
110. S. Greenland (2008) Bayesian interpretation and analysis of research results. Semin Hematol 45(3), 141-149.
111. S. Greenland (2009) Accounting for uncertainty about investigator bias: disclosure is informative. J Epidemiol Community Health 63(8), 593-598.
112. S. Greenland (2009) Bayesian perspectives for epidemiologic research: III. Bias analysis via missing-data methods. Int J Epidemiol 38 1662-1673.
113. S. Greenland and T.L. Lash (2008) Bias analysis. K.J. Rothman, S. Greenland, T.L. Lash (Eds) Modern Epidemiology 3rd ed. Philadelphia: Lippincott-Williams-Wilkins 345-380.
114. F. Grodstein, M. Stampfer, J. Manson, G. Colditz, W. Willett, B. Rosner, F. Speizer and C. Hennekens (1996) Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med 335(7), 453-461.
115. G. Guyatt (1991) Evidence-Based Medicine. ACP J Club A-16 114.
116. G. Guyatt and D. Rennie Users' Guidees to the Medical Literature. A Manual for Evidence-based Clinical Practice. Chicago: American Medical Association.
117. G. Guyatt, A. Oxman, R. Kunz, Y. Falck-Ytter, G. Vist, A. Liberati, H. Schunemann and G. for the Going from evidence to recommendations (2008) BMJ 336(7652), 1049-1051.
118. G. Guyatt, A. Oxman, G. Vist, R. Kunz, Y. Falck-Ytter, P. Alonso-Coello, H. Schunemann and G. for the GRADE: an emerging consensus on rating quality of evidence and strength of recommendations (2008) BMJ 336(7650), 924-926.
119. S. Haack. Evidence and inquiry. Oxford: Blackwell.
120. A. Hajek. Probability, logic, and probability logic in L. Goble (ed.), The Blackwell Guide to Philosophical Logic., Oxford: Blackwell Publishing.
121. A. Hajek. Interpretations of Probability. http://plato.stanford.edu/entries/probability-interpret/.
122. M. Hall (1995) Perception of risk is affected by presentation. BMJ 311 1229.
123. S.O. Hansson (2007) Risk http://www.science.uva.nl/∼seop/entries/risk/
124. N. Harris, E. Jaffe, J. Diebold, G. Flandrin, H. Muller-Hermelink, J. Vardiman, T. Lister and C. Bloomfield (1999) World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 17(12), 3835-3849.
125. R. Hastie (2001) Problems for judgment and decision making. Annu Rev Psychol 52 653-683.
126. R. Hastie and R. M. Dawes. Rational choice in an uncertain world. London: Sage Publications, Inc.
127. R. Haynes, C. Cotoi, J. Holland, L. Walters, N. Wilczynski, D. Jedraszewski, J. McKinlay, R. Parrish, K. McKibbon and for the McMaster Premium Literature Service (2006) (2006) Second-Order Peer Review of the Medical Literature for Clinical Practitioners. JAMA 295(15), 1801-1808. P
128. G. Heiss, R. Wallace, G.L. Anderson, A. Aragaki, S. Beresford, R. Brzyski, R. Chlebowski, M. Gass, A. LaCroix, J. Manson, R. Prentice, J. Rossouw and M. Stefanick (2008) for the Health Risks and Benefits 3 Years After Stopping Randomized Treatment With Estrogen and Progestin 1036-1045. W.H.I.I
129. M. Henry (2006) Uncertainty, responsibility, and the evolution of the physician/patient relationship. J Med Ethics 32(6), 321-323.
130. J. Higgins and S. Green (2008) Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 updated February 2008. The Cochrane Collaboration
131. A. Hill (1952) The clinical trial. N Engl J Med 113-119. (247)
132. B.E. Hillner and T.J. Smith (2007) Do the Large Benefits Justify the Large Costs of Adjuvant Breast Cancer Trastuzumab? J Clin Oncol 25(6), 611-613.
133. D. Hirshleifer and S. Teoh (2003) Herd behaviour and cascading in captial markets: a review and synthesis. Eur Financial Management 9 25-66.
134. J. Hitt (2001) The Year in Ideas:A to Z New York Times: Evidence-based Medicine
135. R. Howard (2007) The foundations of decision analysis revisited. W. Edwards, R.F.J. Miles, D. von Winterfeldt (Eds) Advances in decision analysis: from foundtaions to applications New York: Cambridge University 32-56.
136. R. Howard (1988) Uncertainty about probability: a decision analysis perspective. Risk Analysis 8 91-98.
137. W. Howell and S. Burnett (1978) Uncertainty measurement: a cognitive taxonomy. Organ Behav Hum Performance 22 45-68.
138. I. Hozo and B. Djulbegovic (2008) When is diagnostic testing inappropriate or irrational? Acceptable regret approach, Med Decis Making 28(4), 540-553.
139. I. Hozo and B. Djulbegovic (2009) Will insistence on practicing medicine according to expected utility theory lead to an increase in diagnostic testing? Medical Decision Making 29 320-324.
140. I. Hozo, M. Schell and B. Djulbegovic (2008) Decision-making when data and inferences are not conclusive: risk-benefit and acceptable regret approach. Semin Hematol 45(3), 150-159.
141. M. Hunink and P. Glasziou (2001) Decision-making in health and medicine. Integrating evidence and values Cambridge: Cambridge University Press
142. D. Hunter, M. Khoury and J. Draze (2008) Letting the genome out of the bottle-will we get our wish? N Engl J Med 358(2), 105-107.
143. D. Hyde (2005) Sorites Paradox
144. International Myeloma Working Group (2003) Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 121 749-757.
145. J. Ioannidis (2005) Why most published research findings are false. PLoS Med 2(8), e124.
146. J. Ioannidis (2005) Contradicted and Initially Stronger Effects in Highly Cited Clinical Research. JAMA 294(2), 218-228.
147. C. Jaffe (2006) Measures of Response: RECIST, WHO, and New Alternatives. J Clin Oncol 24(20), 3245-3251.
148. T. Jefferson (2008) More cases, doctor? Yes please, Cases J 2008 1 38.
149. http://www.jointcommission.org/sentinelevents/sentineleventalert/sea_23.htm
150. P. Juni, D. Altman and M. Egger (2001) Assessing the quality of controlled clinical trials. BMJ 323 42-46.
151. P. Juni and M. Egger (2002) Allocation concealment in clinical trials. JAMA 288 2407-2408. discussion 2408-2409
152. P. Juni and M. Egger (2005) Commentary: empirical evidence of attrition bias in clinical trials. Int J Epidem 34 87-88.
153. D. Kahneman (2003) Maps of bounded rationality: psychology for behavioral economics. American Economic Review 93 1449-1475.
154. D. Kahneman (2006) Frames and brains: elicitation and control of response tendencies. Trends Cogn Sci
155. D. Kahneman, P. Slovic and A. Tversky (2005) Judgement under uncertainty: heuristics and biases New York: Cambridge University Press
156. D. Kahneman and A. Tversky (1979) Prospect theory:an analysis of decion under risk. Econometrica 47 263-291.
157. D. Kahneman and A. Tversky (1982) The psychology of preferences, Sci American 246 160-173.
158. D. Kahneman and A. Tversky (2000) Choices, values, and frames New York: Cambridge University Press
159. D. Kahneman and A. Tversky (1982) Variants of uncertainty. Cognition 11 143-157.
160. J. Kasser (2006) Philosophy of science Chantily: VA: The Teaching Company
161. J. Kasser (1989) Our stubborn quest for diagnostic certainty. A cause of excessive testing, N Engl J Med 320 1489-1491.
162. F. Knight (1921) Risk, uncertainty, and profit Boston: Hart, Schaffner & Mark; Houghton Mifflin Co
163. J. Knottnerus (2002) The evidence base of clinical diagnosis London: BMJ Books
164. L. Kohn, J. Corrigan and M. Donaldosn (2000) To err is human. Building a safer health system Washington, DC: National Academy Press
165. K. Kording (2007) Decision theory: what should the nervous system do? Science 318(5850), 606-610.
166. R. Kunz and A. Oxman (1998) The unpredictability paradox: review of empirical comparisons of randomized and non-randomized trials. BMJ 317 1185-1190.
167. L. Leape (1994) Error in medicine. JAMA 272 1851-1857.
168. F. Legare. Managing vriability and uncertainty, Encyclopedia of decision-making, in press.
169. J. Lexchin, L.A. Bero, B. Djulbegovic and O. Clark (2003) Pharmaceutical industry sponsorship and research outcome and quality: systematic review. BMJ 326(7400), 1167-1170.
170. S. Lichenstein and P. Slovic (2006) The Construction of Preference New York: Cambridge University Press
171. D. Lindley (2006) Making decisions 2nd ed New York: Wiley
172. I. Lipkus (2007) Numeric, verbal, and visual formats of conveying health risks: suggested best practices and future recommendations. Med Decis Making 27(5), 696-713.
173. G. Loomes and R. Sugden (1982) Regret theory: an alternative theory of rational choice. Economic J 92 805-824.
174. L. Lopes (1987) Between hope and fear: the psychology of risk. Advances in Experimental and Social Psychology 20 255-295.
175. K. Ludmerer (1999) Time to heal New York: Oxford Press
176. R. MacCoun (1998) Biases in the interpretation and use of research results. Annu Rev Psychol 49 259-287.
177. H. Mann and B. Djulbegovic (2003) Choosing a control intervention for a randomised clinical trial. BMC Med Res Methodol 3(1), 7.
178. H. Mann and B. Djulbegovic (2003) Why comparisons must address genuine uncertainties. Comparator bias. James Lind Library www.jameslindlibrary.org
179. J. Matthews (1995) Quantification and Quest for Medical Certainty Princeton, NJ: Princeton University Press
180. M. McClellan, J. McGinnis, E. Nabel and L. Olsen (2008) Evidence-based medicine and the Changing Nature of Health Care: Workshop Summary (IOM Roundtable on Evidence-Based Medicine)N Washington, DC: National Academy of Sciences
181. B. McNei (2001) Hidden Barriers to Improvement in the Quality of Care. N Engl J Med 345(22), 1612-1620.
182. L. McShane, D. Altman, W. Sauerbrei, S. Taube, M. Gion and G. Clark (2005) Reporting recommendations for tumor marker prognostic studies (REMARK). J Natl Cancer Inst 97(16), 1180-1184.
183. N. Meropol, K. Weinfurt, C. Burnett, A. Balshem, A. Benson 3rd, L. Castel, S. Corbett, M. Diefenbach, D. Gaskin, Y. Li, S. Manne, J. Marshall, J. Rowland, E. Slater, D. Sulmasy, D. Van Echo, S. Washington and K. Schulman (2003) Perceptions of patients and physicians regarding phase I cancer clinical trials: implications for physician-patient communication. J Clin Oncol 21(13), 2589-2596.
184. D. Michaels (2005) Doubt is their product. Sci Am 292(6), 96-101.
185. D. Michaels (2005) Manufactured uncertainty: protecting public health in the age of contested science and product defense. Ann N Y Acad Sci 1076 149-162.
186. M. Morgan and M. Henrion (1990) Uncertainty. A guide to dealing with uncertainty in quantitative and policy analysis UK: Cambridge: Cambridge University Press
187. E. Murphy (1997) Logic of medicine 2nd ed Baltimore: John University Press
188. C. Murray (2003) Human Accomplishment: The Pursuit of Excellence in the Arts and Sciences. 800 B.C. to 1950 New York: HarperCollins
189. W. Nelson, P. Han, A. Fagerlin, M. Stefanek and P. Ubel (2007) Rethinking the Objectives of Decision Aids: A Call for Conceptual Clarity. Med Decis Making 27(5), 609-618.
190. E. Nikolaidis, D. Ghiocel and S. Singhla (2005) Engineering design reliability handbook Boca Raton, FL: CRC Press
191. A. O'Connor (1997) Decisional Conflict Scale 2nd ed Ottawa Civic Hospital
192. A. O'Connor (1997) Validation of a decision conflict scale. Med Decis Making 15 25-30.
193. A. O'Connor, F. Legare and D. Stacey (2003) Risk communication in practice: the contribution of decision aids. BMJ 327(7417), 736-740.
194. A. O'Connor, D. Stacey, V. Entwistle, H. Llewellyn-Thomas, D. Rovner, M. Holmes-Rovner, V. Tait, J. Tetroe, V. Fiset, M. Barry and J. Jones (2003) Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst Rev CD001431. (2)
195. M. Parascandola (2007) A turning point for conflicts of interest: the controversy over the National Academy of Sciences' first conflicts of interest disclosure policy. J Clin Oncol 25(24), 3774-3779.
196. L. Perreault and J. Metzger (1999) A pragmatic framework for understanding clinical decision support. J Healthcare Inform Management System Society 2 5-21.
197. M. Politi, P. Han and N. Col (2007) Communicating the uncertainty of harms and benefits of medical interventions. Med Decis Making 27(5), 681-695.
198. K. Popper (2007) The logic of scientific discovery New York: Harper and Row
199. K. Popper (1959) The propensity interpretation of probability. Br J Phil Sci 10 25-42.
200. C. Ramsden (2006) Geriatric neologism. British Medical Journal 332 451.
201. D. Redelmeier, D. Koehler, V. Liberman and A. Tversky (1995) Probability judgement in medicine: discounting unspecified alternatives. Med Decis Making 15 227-231.
202. H. Regan, M. Colyvan and M. Burgman (2002) A taxonomy and treatment of uncertainty for ecology and conservation biology. Ecological Applications 12 618-628.
203. P. Rothwell (2007) Treating individuals: from randomized trials to personalized medicine Amsterdam: Elsevier
204. P. Rothwell (2006) Factors That Can Affect the External Validity of Randomised Controlled Trials. PLoS Clinical Trials 1(1), e9.
205. D. Sackett (1979) Bias in analytic research. J Chron Dis 32 51-63.
206. D. Sackett, S. Straus, W.S. Richardson, W. Rosenberg and B. Haynes (2000) Evidence-Based Medicine. How to Practice and Teach EBM 2nd ed New York: Churchill-Livingstone
207. L. Savage (1954) +The foundations of statistics New York: Wiley
208. A. Schwartz and G. Bergus (2008) Medical Decision Making: A Physician's Guide Cambridge: Cambridge University Press
209. B. Schwartz, A. Ward, J. Monterosso, S. Lyubomirsky, K. White and D. Lehman (2002) Maximizing versus satisficing: happiness is a matter of choice. J Pers Soc Psychol 83(5), 1178-1197.
210. G. Shaffer (1976) A mathematical theory of evidence Princeton, NJ: Princeton University Press
211. C. Shannon and W. Weaver (1962) The mathematical theory of communication Urbana: The University of Illinois Press
212. I. Sim, P. Gorman, R. Greenes, B. Haynes, B. Kaplan, H. Lehmann, P. Tan and g (2001) White paper: clinical decision support systems for the practice of evidence-based medicine. J Am Med Inform Assoc 8 527-534.
213. H. Simon (1955) A behavioral model of rational choice. Quart J Economics 69(99-118),
214. H. Simon (1955) Information processsing models of cognition. Ann Review Psychol 30(263-96),
215. B. Sirovich, D. Gottlieb, H. Welch and E. Fisher (2006) Regional Variations in Health Care Intensity and Physician Perceptions of Quality of Care. Ann Intern Med 144(9), 641-649.
216. R. Smith (1992) The ethics of ignorance. J Med Ethics 18(3), 117-118. 134
217. R. Sorenson (2006) Vagueness
218. H. Sox (2006) Better Care for Patients with Suspected Pulmonary Embolism. Ann Intern Med 144(3), 210-212.
219. H. Sox, M. Blatt, M. Higgins and M. Marton (1988) Medical Decision Making Boston: Butterworths
220. S. Tanenbaum (1993) What physicians know. N Engl J Med 329 1268-1271.
221. S. Tanenbaum (1993) Getting there from here: evidentiary quandaries of the US outcome movement. J Eval Clin Pract 1 97-103.
222. S. Tanenbaum (2005) Uncertainty, consultation, and the context of medical care. BMJ 330(7490), 515.
223. G. Taubes (1996) Looking for the evidence in medicine. Science 272 22-24.
224. S. Timmermans and A. Mauck (2005) The Promises And Pitfalls Of Evidence-Based Medicine. Health Aff 24(1), 18-28.
225. A. Tversky and D. Kahneman (1974) Judgements under uncertainty: heuristics and biases. Science 185 1124-1131.
226. A. Tversky and D. Kahneman (1974) Prospect theory. An analysis of decisions under risk. Econometrica 47 263-291.
227. A. Tversky and D. Kahneman (1986) Rational choice and the framing of decisions. Journal of Bussiness 59 5251-5278.
228. A. Tversky and D. Kahneman (1992) Advances in Prospect Theory: Cumulative Representation of Uncertainty. Journal of Risk and Uncertainty 5 297-323.
229. A. Tversky and D. Koehler (1994) Support theory: a nonextensional representation of subjective probability. Psychol Rev 101 547-567.
230. A. Tversky and P. Wakker (1995) Risk attitudes and decision weights, Econometrica 63 297-323.
231. J. Vandenbroucke (2008) Observational research, randomised trials, and two views of medical science. PLoS Med 5(3), e67.
232. A. Vickers, E. Basch and M. Kattan (2008) Against diagnosis. Ann Intern Med 149(3), 200-203.
233. J. Vickers (2006) The problem of induction http://plato.stanford.edu/entries/induction-problem/
234. S. Vincent and B. Djulbegovic (2005) Oncology treatment recommendations can be supported only by 1-2% of published high-quality evidence. Cancer Treat Rev 314 319-322.
235. R. von Mises (1957) Probability, Statistics and Truth 2n ed New York: Dover
236. P. Wakker (2008) Uncertainty. L. Blume, S.N. Durlauf (Eds) The New Palgrave: A Dictionary of Economics London: The MacMillan Press 6780-6791.
237. S. Watson and D. Buede (1987) Decision synthesis. The principles of & practice of decision analysis Cambridge: Cambridge University Press
238. K. Weinfurt (2007) Value of High-Cost Cancer Care: A Behavioral Science Perspective. J Clin Oncol 25(2), 223-227.
239. J. Wennberg (1986) Which rate is right? N Engl J Med 314 310-311.
240. T. Williamson (1994) Vagueness London: Routledge
241. E. Wilson (1998) Consilence. The unity of knowledge New York: Alfred A. Knopf
242. P. Wilson, R. D'Agostino, D. Levy, A. Belanger, H. Silbershatz and W. Kannel (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97 1837-1847.
243. R. Winn, W. Botnick and N. Dozier (1996) The NCCN guidelines development program. Oncology 10(supplement), 23-28.
244. J. Wipf, B. Lipsky, J. Hirschmann, E. Boyko, J. Takasugi, R. Peugeot and C. Davis (1999) Diagnosing pneumonia by physical examination: relevant or relic? Arch Intern Med 159(10), 1082-1087.
245. L. Wittgenstein (1969) On Certainty New York: Harper Torchbooks
246. S. Woolf (1992) Practice guidelines: a new reality in medicine. II. Methods of developing guidelines, Arch Intern Med 152 946-952.
247. H. Zimmerman (1996) Fuzzy set theory anf its applications 3rd ed Boston: Kluwer Academic
248. H. Zimmerman (2000) An application-oriented view of modeling uncertainty. European Journal of Operational Research 122 190-198.