Nicorandil inhibits hypoxia-induced apoptosis in human pulmonary artery endothelial cells through activation of mitoKATP and regulation of eNOS and the NF-κB pathway

International Journal of Molecular Medicine

Volumn 32, Issue 1, 2013, Pages 187-194

  Wang, Hui ^a,b   Zuo, Xiangrong ^a   Wang, Qiang ^a   Yu, Yanzhe ^a   Xie, Lijun ^a   Wang, Hong ^a   Wu, Hongcheng ^b   Xie, Weiping ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Lihuili Hospital   (China)

Author keywords

Endothelial nitric oxide synthase; Mitochondrial adenosine triphosphate sensitive potassium channel; Nicorandil; Nuclear factor B; Pulmonary hypertension

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 5 HYDROXYDECANOIC ACID; CASPASE 3; CASPASE 9; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; N(G) NITROARGININE METHYL ESTER; NICORANDIL; POTASSIUM CHANNEL; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RECEPTOR DOWN REGULATION; STAINING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL HYPOXIA; CELL SURVIVAL; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; NF-KAPPA B; NICORANDIL; NITRIC OXIDE SYNTHASE TYPE III; POTASSIUM CHANNELS; PROTO-ONCOGENE PROTEINS C-BCL-2; PULMONARY ARTERY; SIGNAL TRANSDUCTION;

EID: 84878245179     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1379     Document Type: Article

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