Neuronal expression of glutamine synthetase in Alzheimer's disease indicates a profound impairment of metabolic interactions with astrocytes

Neurochemistry International

Volumn 36, Issue 4-5, 2000, Pages 471-482

  Robinson, Stephen R ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Beta amyloid; Cerebral cortex; GFAP; Glutamate; Human; Oligodendrocyte

Indexed keywords

AMYLOID BETA PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; GLYCOGEN;

ADULT; AGED; ALZHEIMER DISEASE; ASTROCYTE; BEHAVIOR DISORDER; BRAIN CORTEX; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; NORMAL HUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SENILE PLAQUE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ASTROCYTES; CADAVER; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE-AMMONIA LIGASE; HUMANS; MIDDLE AGED; NEURONS; PYRAMIDAL CELLS; REFERENCE VALUES; SENILE PLAQUES; TEMPORAL LOBE; TISSUE DISTRIBUTION;

EID: 0033963901     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(99)00150-3     Document Type: Conference Paper

References (63)

1. Aksenov M.Y., Aksenova M.V., Carney J.M., Butterfield D.A. Oxidative modification of glutamine synthetase by amyloid beta peptide. Free Radical Research. 27:1997;267-281.
2. Aksenov M., Aksenova M.V., Harris M.E., Hensley K., Butterfield D.A., Carney J.M. Enhancement of beta-amyloid peptide A beta(1-40)-mediated neurotoxicity by glutamine synthetase. Journal of Neurochemistry. 65:1995;1899-1902.
3. Alexander G.M., Grothusen J.R., Gordon S.W., Schwartzman R.J. Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats. Brain Research. 766:1997;1-10.
4. Barnett N.L., Pow D.V., Plenderleith M.B., Robinson S.R. Inhibition of glutamine synthetase suppresses the electroretinogram B-wave in the rat. Society for Neuroscience Abstracts. 22:1996;121.
5. Basun H., Forssell L.G., Almkvist O., Cowburn R.F., Eklof R., Winblad B., Wetterberg L. Amino acid concentrations in cerebrospinal fluid and plasma in Alzheimer's disease and healthy control subjects. Journal of Neural Transmission, Parkinson's Disease and Dementia Section. 2:1990;295-304.
6. Batton C.I., O'Dowd B.S., Noone D.F., Kril J., Robinson S.R. Ferritin-rich microglia are concentrated within β-amyloid plaques. Alzheimer's Research. 3:1997;23-28.
7. Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica. 82:1991;239-259.
8. Browning E.T., Nicklas W.J. Induction of glutamine synthetase by dibutyryl cyclic AMP in C-6 glioma cells. Journal of Neurochemistry. 39:1982;336-341.
9. Butterfield D.A. beta-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease. Chemical Research and Toxicology. 10:1997;495-506.
10. Butterfield D.A., Hensley K., Cole P., Subramaniam R., Aksenov M., Aksenova M., Bummer P.M., Haley B.E., Carney J.M. Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease. Journal of Neurochemistry. 68:1997;2451-2457.
11. Csernansky J.G., Bardgett M.E., Sheline Y.I., Morris J.C., Olney J.W. CSF excitatory amino acids and severity of illness in Alzheimer's disease. Neurology. 46:1996;1715-1720.
12. D'Amelio F., Eng L.F., Gibbs M.A. Glutamine synthetase immunoreactivity is present in oligodendroglia of various regions of the central nervous system. Glia. 3:1990;335-341. [see comments].
13. Delorme P., Hevor T.K. Glycogen particles in methionine sulfoximine epileptogenic rodent brain and liver after the administration of methionine and actinomycin D. Neuropathology and Applied Neurobiology. 11:1985;117-128.
14. Ereciñska M., Silver I.A. Metabolism and role of glutamate in mammalian brain. Progress in Neurobiology. 35:1990;245-296.
15. Folbergrova J., Passonneau J.V., Lowry O.H., Schulz D.W. Glycogen, ammonia and related metabolities in the brain during seizures evoked by methionine sulphoximine. Journal of Neurochemistry. 16:1969;191-203.
16. Fonnum F. Glutamate: a neurotransmitter in mammalian brain. Journal of Neurochemistry. 42:1984;1-11.
17. Gaitonde M., Richter D. Changes with age in the utilisation of glucose carbon in liver and brain. Journal of Neurochemistry. 13:1996;1309-1318.
18. Gibbs M.E., O'Dowd B.S., Hertz L., Robinson S.R., Sedman G.L., Ng K.T. Inhibition of glutamine synthetase activity prevents memory consolidation. Cognitive Brain Research. 4:1996;57-64.
19. Hansson E. Regulation of glutamine synthetase synthesis and activity by glucocorticoids and adrenoceptor activation in astroglial cells. Neurochemistry Research. 14:1989;585-587.
20. Hansson E., Ronnback L. Regulation of glutamate and GABA transport by adrenoceptors in primary astroglial cell cultures. Life Science. 44:1989;27-34.
21. Hensley K., Carney J.M., Mattson M.P., Aksenova M., Harris M., Wu J.F., Floyd R.A., Butterfield D.A. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proceedings of the National Academy of Sciences, USA. 91:1994;3270-3274.
22. Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., Aksenova M., Gabbita S.P., Wu J.F., Carney J.M., et al. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. Journal of Neurochemistry. 65:1995;2146-2156.
23. Hertz L. Is Alzheimer's disease an anterograde degeneration, originating in the brainstem, and disrupting metabolic and functional interactions between neurons and glial cells? Brain Research and Brain Research Reviews. 14:1989;335-353.
24. Hertz L., Peng L. Energy metabolism at the cellular level of the CNS. Canadian Journal of Physiology and Pharmacology. 70:1992;S145-157.
25. Hertz L., Dringen R., Schousboe A., Robinson S.R. Astrocytes: glutamate producers for neurons. Journal of Neuroscience Research. 57:1999;417-428.
26. Hevor T.K., Delorme P., Gayet J. Glycogen content and fructose-1, 6-biphosphatase activity in methionine sulfoximine epileptogenic mouse brain and liver after protein synthesis inhibition. Neuropathology and Applied Neurobiology. 11:1985;129-139.
27. Huang R., Peng L., Chen Y., Hajek I., Zhao Z., Hertz L. Signalling effect of elevated potassium concentrations and monoamines on brain energy metabolism at the cellular level. Developmental Neuroscience. 16:1994;337-351.
28. Humphrey M.F., Chu Y., Mann K., Rakoczy P. Retinal GFAP and bFGF expression after multiple argon laser photocoagulation injuries assessed by both immunoreactivity and mRNA levels. Experimental Eye Research. 64:1997;361-369.
29. Jimenez-Jimenez F.J., Molina J.A., Gomez P., Vargas C., de Bustos F., Benito-Leon J., Tallon-Barranco A., Orti-Pareja M., Gasalla T., Arenas J. Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease. Journal of Neural Transmission. 105:1998;269-277.
30. Le Prince G., Delaere P., Fages C., Lefrancois T., Touret M., Salanon M., Tardy M. Glutamine synthetase (GS) expression is reduced in senile dementia of the Alzheimer type. Neurochemistry Research. 20:1995;859-862.
31. Mandybur T.I., Chuirazzi C.C. Astrocytes and the plaques of Alzheimer's disease. Neurology. 40:1990;635-639.
32. Mann D.M.A., Sumpter P.Q., Davies C.A., Yates P.O. Glycogen accumulations in the cerebral cortex in Alzheimer's disease. Acta Neuropathologica. 73:1987;181-184.
33. Miyake T., Kitamura T. Glutamine synthetase immunoreactivity in two types of mouse brain glial cells. Brain Research. 586:1992;53-60.
34. Morris J.C., Heyman A., Mohs R.C., Hughes J.P., van Belle G., Fillenbaum G., Mellits E.D., Clark C. The consortium to establish a registry for alzheimer's disease (CERAD) - Part I: clinical and neuropsychological assessment of Alzheimer's disease. Neurology. 39:1989;1159-1165.
35. Ng K.T., O'Dowd B.S., Rickard N.S., Robinson S.R., Gibbs M.E., Rainey C., Zhao W.Q., Sedman G.L., Hertz L. Complex roles of glutamate in the Gibbs-Ng model of one-trial aversive learning in the new-born chick. Neuroscience and Biobehavioural Reviews. 21:1997;45-54.
36. Norenberg M.D. Astroglial dysfunction in hepatic encephalopathy. Metabolic Brain Disorders. 13:1998;319-335.
37. Norenberg M.D., Martinez-Hernandez A. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Research. 161:1979;303-310.
38. Ong W.Y., Garey L.J., Reynolds R. Distribution of glial fibrillary acidic protein and glutamine synthetase in human cerebral cortical astrocytes - a light and electron microscopic study. Journal of Neurocytology. 22:1993;893-902.
39. O'Dowd B.S., Ng K.T., Robinson S.R. Distribution of glutamine synthetase in the chick forebrain: implications for passive avoidance memory formation. Journal fur Hirnforschung. 38:1997;147-152.
40. Orrego F., Villanueva S. The chemical nature of the main central excitatory transmitter: a critical appraisal based upon release studies and synaptic vesicle localization. Neuroscience. 56:1993;539-555.
41. Phelps C.H. An ultrastructural study of methionine sulphoximine-induced glycogen accumulation in astrocytes of the mouse cerebral cortex. Journal of Neurocytology. 4:1975;479-490.
42. Pike C.J., Cummings B.J., Cotman C.W. Early association of reactive astrocytes with senile plaques in Alzheimer's disease. Experimental Neurology. 132:1995;172-179.
43. Pike C.J., Ramezan-Arab N., Miller S., Cotman C.W. beta-Amyloid increases enzyme activity and protein levels of glutamine synthetase in cultured astrocytes. Experimental Neurology. 139:1996;167-171.
44. Pow D.V., Robinson S.R. Glutamate in some retinal neurons is derived solely from glia. Neuroscience. 60:1994;355-366.
45. Redjems-Bennani N., Jeandel C., Lefebvre E., Blain H., Vidailhet M., Gueant J.L. Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 44:1998;300-304.
46. Reichenbach A., Siegel A., Rickmann M., Wolff J.R., Noone D., Robinson S.R. Distribution of Bergmann glial somata and processes: implications for function. Journal fur Hirnforschung. 36:1995;509-517.
47. Robinson S.R. Relationships between Müller cells and neurons in a primitive tetrapod, the Australian lungfish. Visual Neuroscience. 14:1997;795-800.
48. Robinson S.R., Noone D.F., Kril J., Halliday G.M. Most amyloid plaques contain ferritin-rich cells. Alzheimer's Research. 1:1995;191-196.
49. Robinson S.R., Schousboe A., Dringen R., Magistretti P., Coles J., Hertz L. Metabolic trafficking between neurons and glia. Laming P.R., Sykova E., Reichenbach A., Hatton G.I., Bauer H. Glial Cells: Their Role in Behaviour. 1998;83-106 Cambridge University Press, Cambridge.
50. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J.P., Welty D.F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686.
51. Schor N.F. Inactivation of mammalian brain glutamine synthetase by oxygen radicals. Brain Research. 456:1988;17-21.
52. Schousboe A., Westergaard N., Sonnewald U., Petersen S.B., Huang R., Peng L., Hertz L. Glutamate and glutamine metabolism and compartmentation in astrocytes. Dev. Neurosci. 15:1993;359-366.
53. Seiler N. Is ammonia a pathogenetic factor in Alzheimer's disease? Neurochemistry Research. 18:1993;235-245.
54. Smith C.C., Bowen D.M., Francis P.T., Snowden J.S., Neary D. Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia. Journal of Neurology Neurosurgery and Psychiatry. 48:1985;469-471.
55. Smith C.D., Carney J.M., Starke-Reed P.E., Oliver C.N., Stadtman E.R., Floyd R.A., Markesbery W.R. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proceedings of the National Academy of Sciences, USA. 88:1991;10,540-10,543.
56. Stone E.A., Ariano M.A. Are glial cells targets of the central noradrenergic system? A review of the evidence. Brain Research and Brain Research Reviews. 14:1989;297-309.
57. Subbarao K.V., Hertz L. Effect of adrenergic agonists on glycogenolysis in primary cultures of astrocytes. Brain Research. 536:1990;220-226.
58. Subbarao K.V., Hertz L. Noradrenaline induced stimulation of oxidative metabolism in astrocytes but not in neurons in primary cultures. Brain Research. 527:1990;346-349.
59. Tansey F.A., Farooq M., Cammer W. Glutamine synthetase in oligodendrocytes and astrocytes: new biochemical and immunocytochemical evidence. Journal of Neurochemistry. 56:1991;266-272.
60. Tholey G., Ghandour M.S., Bloch S., Ledig M., Mandel P. Glutamine synthetase and energy metabolism enzymes in cultivated chick neurons and astrocytes: modulation by serum and hydrocortisone. Brain Research. 428:1987;73-81.
61. Tiffany-Castiglioni E., Roberts J.A., Sheeler-Gough L.V. Reduction of glutamine synthetase specific activity in cultured astroglia by ferrous chloride. Journal of Neuroscience Research. 24:1989;508-516.
62. Walz W., Lang M.K. Immunocytochemical evidence for a distinct GFAP-negative subpopulation of astrocytes in the adult rat hippocampus. Neurosci. Lett. 257:1998;127-130.
63. Yamamoto T., Iwasaki Y., Sato Y., Yamamoto H., Konno H. Astrocytic pathology of methionine sulfoximine-induced encephalopathy. Acta Neuropathologica. 77:1989;357-368.