Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology

Neuroscience Letters

Volumn 383, Issue 1-2, 2005, Pages 33-38

  Wharton, Stephen B ^a   Williams, Gareth H ^b   Stoeber, Kai ^b   Gelsthorpe, Catherine H ^a   Baxter, Lynne ^a   Johnson, Anthony L ^c   Ince, Paul G ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Alzheimer's disease; Cell cycle; Glia; Ki67; Mcm2; Neurodegeneration; PCNA

Indexed keywords

BIOLOGICAL MARKER; CYCLINE; KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN 2;

AGING; ALZHEIMER DISEASE; ANTIGEN DETECTION; ARTICLE; CELL CYCLE; CHROMOSOME REPLICATION; COHORT ANALYSIS; CONTROLLED STUDY; GLIA CELL; GRAY MATTER; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NERVE CELL; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCORING SYSTEM; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; WHITE MATTER;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; CELL COUNT; CELL CYCLE PROTEINS; GENE EXPRESSION; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; NEUROGLIA; NUCLEAR PROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; STATISTICS, NONPARAMETRIC;

EID: 20344384232     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.04.019     Document Type: Article

References (39)

1. I. Akiguchi, H. Tomimoto, T. Suenaga, H. Wakita, and H. Budka Alterations in glia and axons in the brains of Binswanger's disease patients Stroke 28 1997 1423 1429
2. G. Bartzokis Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease Neurobiol. Aging 25 2004 5 18
3. E.M. Blalock, J.W. Geddes, K.C. Chuen, N.M. Porter, W.R. Markesbery, and P.W. Landfield Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses Proc. Natl. Acad. Sci. U.S.A. 101 2004 2173 2178
4. I. Blasko, M. Stampfer-Kountchev, P. Robatscher, R. Veerhuis, P. Eikelenboom, and B. Grubeck-Loebenstein How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes Aging Cell 3 2004 169 176
5. H. Braak, and E. Braak Neuropathological staging of Alzheimer-related changes Acta Neuropathol. 82 1991 239 259
6. A. Brun, and E. Englund A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study Ann. Neurol. 19 1986 253 262
7. J. Busser, D.S. Geldmacher, and K. Herrup Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain J. Neurosci. 18 1998 2801 2807
8. S.M. De la Monte, Y.K. Sohn, N. Ganju, and J.R. Wands p53- and CD95-associated apoptosis in neurodegenerative disease Lab. Invest. 78 1998 401 411
9. X.-L. Ding, J. Husseman, A. Tomashevski, D. Nochlin, L.-W. Jin, and I. Vincent The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease Am. J. Pathol. 157 2000 1983 1990
10. E. Endl, and J. Gerdes The Ki-67 protein: fascinating forms and an unknown function Exp. Cell Res. 257 2000 231 237
11. J. Gerdes, H. Lemke, H. Baisch, H.H. Wacker, U. Schwab, and H. Stein Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67 J. Immunol. 133 1984 1710 1715
12. M. Guo, and B.A. Hay Cell proliferation and apoptosis Curr. Opin. Cell Biol. 11 1999 745 752
13. J.J.M. Hoozemans, M.K. Brückner, A.J.M. Rozemuller, R. Veerhuis, P. Eikelenboom, and T. Arendt Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex J. Neuropathol. Exp. Neurol. 61 2002 678 688
14. K.L. Jordan-Sciutto, L.M. Malaiyandi, and R. Bowser Altered distribution of cell cycle transcriptional regulators during Alzheimer disease J. Neuropathol. Exp. Neurol. 61 2002 358 367
15. R. Kalaria Microglia and Alzheimer's disease Curr. Opin. Hematol. 6 1999 15 24
16. K. Kobayashi, M. Hayashi, H. Nakano, Y. Fukutani, K. Sasaki, M. Shimazaki, and Y. Koshino Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease Neuropathol. Appl. Neurobiol. 28 2002 238 251
17. M. Koistinaho, S. Lin, X. Wu, M. Esterman, D. Koger, J. Hanson, R. Higgs, F. Liu, S. Malkani, K.R. Bales, and S.M. Paul Apolipoprotein E promotes astrocyte colocalisation and degradation of deposited amyloid-β peptides Nat. Med. 10 2004 719 726
18. M. Lei, and B.K. Tye Initiating DNA synthesis: from recruiting to activating the MCM complex J. Cell Sci. 114 2001 1447 1454
19. A. McShea, P.L. Harris, K.R. Webster, A.F. Wahl, and M.A. Smith Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease Am. J. Pathol. 150 1997 1933 1939
20. L. Meda, P. Baron, and G. Scarlato Glial activation in Alzheimer's disease: the role of Aβ and its associated proteins Neurobiol. Aging 22 2001 885 893
21. R.G. Nagele, J. Wegiel, V. Venkataraman, H. Imaki, K.-C. Wang, and J. Wegiel Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease Neurobiol. Aging 25 2004 663 674
22. Z. Nagy Cell cycle regulatory failure in neurones: causes and consequences Neurobiol. Aging 21 2000 761 769
23. Z. Nagy, M.M. Esiri, and A.D. Smith Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions Acta Neuropathol. 93 1997 294 300
24. Z.S. Nagy, M.M. Esiri, and A.D. Smith The cell division cycle and the pathophysiology of Alzheimer's disease Neuroscience 87 1998 731 739
25. Neuropathology group of the Medical Research Council cognitive function aging study (MRC-CFAS) Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales Lancet 357 2001 169 175
26. M. Noble The possible role of myelin destruction as a precipitating event in Alzheimer's disease Neurobiol. Aging 25 2004 25 31
27. G.C. Roman Senile dementia of the Binswanger type. A vascular form of dementia in the elderly J. Am. Med. Assoc. 258 1987 1782 1788
28. M.H.H. Schmidt, R. Broil, H.P. Bruch, O. Bogler, and M. Duchrow The proliferation marker pKI-67 organizes the nucleolus during the cell cycle depending on Ran and cyclin B J. Pathol. 199 2003 18 27
29. M. Sjöbeck, and E. Englund Glial levels determine severity of white matter disease in Alzheimer's disease: a neuropathological study of glial changes Neuropathol. Appl. Neurobiol. 29 2003 159 169
30. M.Z. Smith, Z.S. Nagy, and M.M. Esiri Cell cycle-related protein expression in vascular dementia and Alzheimer's disease Neurosci. Lett. 271 1999 45 48
31. K. Stoeber, T.D. Tlsty, L. Happerfield, G.A. Thomas, S. Romanov, L. Bobrow, E.D. Williams, and G.H. Williams DNA replication licensing and human cell proliferation J. Cell Sci. 114 2001 2027 2041
32. L. Toschi, and R. Bravo Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis J. Cell Biol. 107 1988 1623 1628
33. U. Ueberham, A. Hessel, and T. Arendt Cyclin C expression is involved in the pathogenesis of Alzheimer's disease Neurobiol. Aging 24 2003 427 435
34. R. Verheijen, H.J. Kuijpers, R. van Driel, J.L. Beck, J.H. van Dierendonck, G.J. Brakenhoff, and F.C. Ramaekers Ki67 detects a nuclear matrix-associated proliferation related antigen. II. Localisation in mitotic cells and association with chromosomes J. Cell Sci. 92 1989 531 540
35. R.A. Walker, and R.S. Camplejohn Comparison of monoclonal antibody Ki67 reactivity with grade and DNA flow cytometry of breast carcinomas Br. J. Cancer 57 1988 281 283
36. S.B. Wharton, K.K. Chan, J.R. Anderson, K. Stoeber, and G.H. Williams Replicative Mcm2 protein as a novel proliferation marker in oligodendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosis Neuropathol. Appl. Neurobiol. 27 2001 305 313
37. S.B. Wharton, S. Hibberd, K.L. Eward, D. Crimmins, D.A. Jellinek, D. Levy, K. Stoeber, and G.H. Williams DNA replication licensing and cell cycle kinetics of oligodendroglial tumours Br. J. Cancer 91 2004 262 269
38. Y. Yang, D.S. Geldmacher, and K. Herrup DNA replication precedes neuronal cell death in Alzheimer's disease J. Neurosci. 21 2001 2661 2668
39. Y. Yang, E.J. Mufson, and K. Herrup Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease J. Neurosci. 23 2003 2557 2563