G protein-coupled receptor 48 upregulates estrogen receptor α expression via cAMP/PKA signaling in the male reproductive tract

Development

Volumn 137, Issue 1, 2010, Pages 151-157

  Li, Xiao Ying ^a   Lu, Yan ^a   Sun, Hai Yan ^a   Wang, Ji Qiu ^a   Yang, Jun ^a   Zhang, Hui Jie ^a   Fan, Neng Guang ^a   Xu, Jia ^a   Jiang, Jing Jing ^a   Liu, Ru Ya ^a   Li, Da Li ^b   Liu, Ming Yao ^b   Ning, Guang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Creb; Epididymis; ER (Esr1); Gpr48; Infertility; Mouse

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTROGEN RECEPTOR ALPHA; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 48; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; EMBRYO; EPIDIDYMIS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; ION TRANSPORT; MALE; MALE GENITAL SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EPIDIDYMIS; ESTROGEN RECEPTOR ALPHA; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FOLLICLE STIMULATING HORMONE; IMMUNOHISTOCHEMISTRY; INFERTILITY, MALE; LUTEINIZING HORMONE; MALE; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TESTIS;

MUS;

EID: 73649092120     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.040659     Document Type: Article

References (42)

1. Avenel, J., Humphrey, Y. and Barry, T. H. (2009). Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns. Dev. Biol. 325, 6-14.
2. Bahr, J. M., Dalponte, M., Janssen, S., Bunick, D. and Nakai, M. (2006). Ion transporters for fluid reabsorption in the rooster (Gallus domesticus) epididymal region. Anim. Reprod. Sci. 95, 331-337.
3. Brooks, D. E. (1983). Epididymal functions and their hormonal regulation. Aust. J. Biol. Sci. 36, 205-221.
4. Chew, S. B., Leung, G. P., Leung, P. Y., Tse, C. M. and Wong, P. Y. D. (2000). Polarized distribution of NHE1 and NHE2 in the rat epididymis. Biol. Reprod. 62, 755-758.
5. Clulow, J., Jones, R. C., Hansen, L. A. and Man, S. Y. (1998). Fluid and electrolyte reabsorption in the ductuli efferentes testis. J. Reprod. Fertil. Suppl. 53, 1-14.
6. Couse, J. F. and Korach, K. S. (1999). Estrogen receptor null mice: what have we learned and where will they lead us? Endocr. Rev. 20, 358-417.
7. Frasor, J. and Gibori, G. (2003). Prolactin regulation of estrogen receptor expression. Trends Endocrinol. Metab. 14, 118-123.
8. Frasor, J., Barkai, U., Zhong, L., Fazleabas, A. T. and Gibori, G. (2001). PRL-induced ERalpha gene expression is mediated by Janus kinase 2 (Jak2) while signal transducer and activator of transcription 5b (Stat5b) phosphorylation involves Jak2 and a second tyrosine kinase. Mol. Endocrinol. 15, 1941-1952.
9. Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori, T. and Oda, T. (2006a). Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 66, 11623-11631.
10. Gao, Y., Kitagawa, K., Shimada, M., Uchida, C., Hattori, T., Oda, T. and Kitagawa, M. (2006b). Generation of a constitutively active mutant of human GPR48/LGR4,a G-protein-coupled receptor. Hokkaido Igaku Zasshi 81, 101-105, 107, 109.
11. Hess, R. A., Bunick, D., Lee, K. H., Bahr, J., Taylor, J. A., Korach, K. S. and Lubahn, D. B. (1997). A role of oestrogen in the male reproductive tract. Nature 390, 509-512.
12. Hinton, B. T., Palladino, M. A., Rudolph, D. and Labus, J. C. (1995). The epididymis as protector of maturing spermatozoa. Reprod. Fertil. Dev. 7, 731-745.
13. Hoshii, T., Takeo, T., Nakagata, N., Takeya, M., Araki, K. and Yamamura, K. (2007). LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice. Biol. Reprod. 76, 303-313.
14. Hsu, S. Y., Liang, S. G. and Hsueh, A. J. (1998). Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Mol. Endocrinol. 12, 1830-1845.
15. Ilio, K. Y. and Hess, R. A. (1994). Structure and function of the ductuli efferentes. Microsc. Res. Tech. 29, 432-467.
16. Kipp, J. L., Kilen, S. M., Woodruff, T. K. and Mayo, K. E. (2007). Activin regulates estrogen receptor gene expression in the mouse ovary. J. Biol. Chem. 282, 36755-36765.
17. Kos, M., O'Brien, S., Flouriot, G. and Gannon, F. (2000). Tissue-specific expression of multiple mRNA variants of the mouse estrogen receptor α gene. FEBS Lett. 477, 15-20.
18. Kos, M., Reid, G., Denger, S. and Gannon, F. (2001). Minireview: genomic organization of the human ERalpha gene promoter region. Mol. Endocrinol. 15, 2057-2063.
19. Krege, J. H., Hodgin, J. B., Couse, J. F., Enmark, E. and Warner, M. (1998). Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc. Natl. Acad. Sci. USA 95, 15677-15682.
20. Leung, G. P., Tse, C. M., Chew, S. B. and Wong, P. Y. (2001). Expression of multiple Na+/H+ exchanger isoforms in cultured epithelial cells from rat efferent duct and cauda epididymidis. Biol. Reprod. 64, 482-490.
21. Loh, E. D., Broussard, S. R., Liu, Q., Copeland, N. G., Gilbert, D. J., Jenkins, N. A. and Kolakowski, L. F., Jr (2000). Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping. Cytogenet. Cell Genet. 89, 2-5.
22. Loh, E. D., Broussard, S. R. and Kolakowski, L. F. (2001). Molecular characterization of a novel glycoprotein hormone G protein-coupled receptor. Biochem. Biophys. Res. Commun. 282, 757-764.
23. Longo, M., Peruzzi, B., Fortunati, D., De, L. V., Denger, S., Caselli, G., Migliaccio, S. and Teti, A. (2006). Modulation of human estrogen receptor alpha F promoter by a protein kinase C/c-Src-dependent mechanism in osteoblast-like cells. J. Mol. Endocrinol. 37, 489-502.
24. Mazerbourg, S., Bouley, D. M., Sudo, S., Klein, C. A., Zhang, J. V., Kawamura, K., Goodrich, L. V., Rayburn, H., Tessier-Lavigne, M. and Hsueh, A. J. (2004). Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol. Endocrinol. 18, 2241-2254.
25. McPherson, L. A., Baichwal, V. R. and Weigel, R. J. (1997). Identification of ERF-1 as a member of the AP2 transcription factor family. Proc. Natl. Acad. Sci. USA 94, 4342-4347.
26. Meistrich, M. L., Hughes, T. J. and Bruce, W. R. (1975). Alteration of epididymal sperm transport and maturation in mice by oestrogen and testosterone. Nature 258, 145-147.
27. Mendive, F., Laurent, P., Van, S. G., Skarnes, W., Pochet, R. and Vassart, G. (2006). Defective postnatal development of the male reproductive tract in LGR4 knockout mice. Dev. Biol. 290, 421-434.
28. Nicander, L., Osman, D. I., Ploen, L., Bugge, H. P. and Kvisgaard, K. N. (1983). Early effects of efferent ductule ligation on the proximal segment of the rat epididymis. Int. J. Androl. 6, 91-102.
29. Oliveira, C. A., Carnes, K., França, L. R., Hermo, L. and Hess, R. A. (2005). Aquaporin-1 and -9 are differentially regulated by oestrogen in the efferent ductule epithelium and initial segment of the epididymis. Biol. Cell 97, 385-395.
30. Pastor, S. N., Bagnis, C., Sabolic, I., Tyszkowski, R., McKee, M., Van, H. A., Breton, S. and Brown, D. (2001). Aquaporin 9 expression along the male reproductive tract. Biol. Reprod. 65, 384-393.
31. Preslock, J. P. and McCann, S. M. (1985). Short-term effects of vasoligation upon plasma follicle-stimulating hormone, luteinizing hormone, and prolactin in the adult rat: further evidence for a direct neural connection between the testes and the central nervous system. Biol. Reprod. 33, 1120-1125.
32. Robaire, B., Ewing, L. L., Zirkin, B. R. and Irby, D. C. (1977). Steroid 5α- reductase and 3α-hydroxysteroid dehydrogenase in the rat epididymis. Endocrinology 101, 1379-1390.
33. Ruz, R., Gregory, M., Smith, C. E., Cyr, D. G., Lubahn, D. B., Hess, R. A. and Hermo, L. (2006). Expression of aquaporins in the efferent ducts, sperm counts, and sperm motility in estrogen receptor-alpha deficient mice fed lab chow versus casein. Mol. Reprod. Dev. 73, 226-237.
34. Song, H., Luo, J., Luo, W., Weng, J., Wang, Z., Li, B., Li, D. and Liu, M. (2008). Inactivation of G-protein-coupled receptor 48 (Gpr48/ Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway. J. Biol. Chem. 283, 36687-36697.
35. Swider-Al-Amawi, M., Marchlewicz, M., Wiszniewska, B. and Wenda- Rozewicka, L. (2003). Effect of hCG on the morphology of rat epididymal epithelial cells in vitro. Folia Morphologica (Warszawa) 62, 489-491.
36. Van, S. G., Mendive, F., Pochet, R. and Vassart, G. (2005). Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse. Histochem. Cell Biol. 124, 35-50.
37. Weng, J., Luo, J., Cheng, X., Jin, C., Zhou, X., Qu, J., Tu, L., Ai, D., Li, D., Wang, J. et al. (2008). Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc. Natl. Acad. Sci. USA 105, 6081-6086.
38. Wong, C. H., Mruk, D. D., Lui, W. Y. and Cheng, C. Y. (2004). Regulation of blood-testis barrier dynamics: an in vivo study. J. Cell Sci. 117, 783-798.
39. Wong, P. Y. and Yeung, C. H. (1978). Absorptive and secretory functions of the perfused rat cauda epididymis. J. Physiol. 275, 13-26.
40. Wu, J. C., Gregory, C. W. and DePhilip, R. M. (1993). Expression of E-cadherin in immature rat and mouse testis and in rat Sertoli cell cultures. Biol. Reprod. 49, 1353-1361.
41. Yeh, S., Tsai, M. Y., Xu, Q., Mu, X. M., Lardy, H., Huang, K. E., Lin, H., Yeh, S. D., Altuwaijris, S., Zhou, X. et al. (2002). Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc. Natl. Acad. Sci. USA 99, 13498-13503.
42. Zhou, Q., Clarke, L., Nie, R., Carnes, K. and Lai, L. W. (2001). Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proc. Natl. Acad. Sci. USA 98, 14132-14137.