Genetic determinants of voluntary exercise

Trends in Genetics

Volumn 29, Issue 6, 2013, Pages 348-357

  Kelly, Scott A ^a   Pomp, Daniel ^b  

^a OHIO WESLEYAN UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Collaborative cross; Expression quantitative trait loci (eQTL); Genomics; Physical activity; Quantitative trait loci (QTL); Wheel running

Indexed keywords

ANIMAL BEHAVIOR; EPIGENETICS; EXERCISE; GENE EXPRESSION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENOMICS; HUMAN; LOCOMOTION; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REGULATORY MECHANISM; REVIEW; TRANSCRIPTOMICS;

ANIMALS; EPIGENESIS, GENETIC; EXERCISE; GENE EXPRESSION; GENE REGULATORY NETWORKS; GENETIC DETERMINISM; GENOME-WIDE ASSOCIATION STUDY; HUMANS; QUANTITATIVE TRAIT LOCI;

EID: 84878173696     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2012.12.007     Document Type: Review

References (97)

1. Bramble D.M., Lieberman D.E. Endurance running and the evolution of Homo. Nature 2004, 432:345-352.
2. Lieberman D.E., Bramble D.M. The evolution of marathon running: capabilities in humans. Sports Med. 2007, 37:288-290.
3. Iwaniuk A.N., et al. Do big-brained animals play more? Comparative analyses of play and relative brain size in mammals. J. Comp. Psychol. 2001, 115:29-41.
4. Fox J. The Ball 2012, Harper Collins.
5. Kelly S.A., Garland T. Phenotypic plasticity and experimental evolution. J. Exp. Biol. 2006, 209:2344-2361.
6. Mechikoff R. A History and Philosophy of Sport and Physical Education: From Ancient Civilizations to the Modern World 2010, McGraw Hill.
7. Gotaas T. The jogging revolution. Running: A Global History 2009, Reaktion Books, 240-261.
8. Bowerman W.J. Jogging: A Physical Program for All Ages 1967, Ace Books.
9. Cooper K.H. Aerobics 1977, Bantam Books.
10. Ng S.W., Popkin B.M. Time use and physical activity: a shift away from movement across the globe. Obes. Rev. 2012, 10.1111/j.1467-789X.2011.00982.x.
11. Westerterp K.R., Speakman J.R. Physical activity energy expenditure has not decline since the 1980s and matches energy expenditures wild mammals. Int. J. Obes. 2008, 32:1256-1263.
12. Centers for Disease Control, Prevention (CDC) Physical activity levels among children aged 9-13 years - United States, 2002. MMWR Morb. Mortal. Wkly. Rep. 2003, 52:785-788.
13. Centers for Disease Control, Prevention (CDC) Physical activity levels of high school students - United States, 2010. MMWR Morb. Mortal. Wkly. Rep. 2011, 60:773-777.
14. Garland T., et al. The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives. J. Exp. Biol. 2011, 214:206-229.
15. Novak C.M., et al. The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward. Neurosci. Biobehav. Rev. 2012, 36:1001-1014.
16. Mathes W.F., et al. Architecture of energy balance traits in emerging lines of the Collaborative Cross. Am. J. Physiol. Endocrinol. Metab. 2011, 300:E1124-E1134.
17. De Moor M.H., et al. Genome-wide association study of exercise behavior in Dutch and American adults. Med. Sci. Sports Exerc. 2009, 41:1887-1895.
18. Bouchard C. Genomic predictors of trainability. Exp. Physiol. 2012, 97:347-352.
19. Eriksson M., et al. Genetic factors in physical activity and the equal environment assumption - the Swedish young male twins study. Behav. Genet. 2006, 36:238-247.
20. Joosen A.M., et al. Genetic analysis of physical activity in twins. Am. J. Clin. Nutr. 2005, 82:1253-1259.
21. Stubbe J.H., de Geus E.J.C. Genetics of exercise behavior. Handbook of Behavior Genetics 2009, 343-358. Springer Science and Business Media. Y.-K. Kim (Ed.).
22. Swallow J.G., et al. Artificial selection for increased wheel-running behavior in house mice. Behav. Genet. 1998, 28:227-237.
23. Kelly S.A., et al. Genetic architecture of voluntary exercise in an advanced intercross line of mice. Physiol. Genomics 2010, 42:190-200.
24. Cai G., et al. A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children. Obesity 2006, 14:1596-1604.
25. Leamy L.J., et al. Genetic variation for body weight change in mice in response to physical exercise. BMC Genet. 2009, 10:58.
26. Leamy L.J., et al. Genetic variation in the pleiotropic association between physical activity and body weight in mice. Genet. Sel. Evol. 2009, 41:41.
27. Kelly S.A., et al. Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture Physiol. Genomics 2011, 43:199-212.
28. Swallow J.G., et al. Phenotypic and evolutionary plasticity of organ masses in response to voluntary exercise in house mice. Integr. Comp. Biol. 2005, 45:426-437.
29. Leamy L.J., et al. A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice. BMC Genet. 2010, 11:83.
30. Svenson K.L. High-resolution genetic mapping using the Mouse Diversity outbred population. Genetics 2012, 190:437-447.
31. Lightfoot J.T., et al. Strain screen and haplotype association mapping of wheel running in inbred mouse strains. J. Appl. Physiol. 2010, 109:623-634.
32. Lightfoot J.T., et al. Quantitative trait loci for physical activity traits in mice. Physiol. Genomics 2008, 32:401-408.
33. Nehrenberg D.L., et al. QTL underlying voluntary exercise in mice: interactions with the 'mini muscle' locus and sex. J. Hered. 2010, 101:42-53.
34. Leamy L.J., et al. An epistatic genetic basis for physical activity traits in mice. J. Hered. 2008, 99:639-646.
35. Fisher R.A. The Genetical Theory of Natural Selection 1930, Oxford University Press.
36. de Vilhena E., Santos D.M., et al. Genetics of physical activity and physical inactivity in humans. Behav. Genet. 2012, 42:559-578.
37. Shephard R.J., Vuillemin A. Limits to the measurement of habitual physical activity by questionnaires. Br. J. Sports Med. 2003, 37:197-206.
38. De Moor M.H., et al. Genome-wide linkage scan for exercise participation in Dutch sibling pairs. Eur. J. Hum. Genet. 2007, 15:1252-1259.
39. Trevaskis J., et al. Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. Endocrinology 2005, 146:3757-3764.
40. Park K.S., et al. Polymorphisms in the leptin receptor (LEPR) - putative association with obesity and T2DM. J. Hum. Genet. 2006, 51:85-91.
41. Verdugo R.A., et al. Serious limitations of the QTL/microarray approach for QTL gene discovery. BMC Biol. 2010, 8:96.
42. Jansen R.C., Nap J.P. Genetical genomics: the added value from segregation. Trends Genet. 2001, 17:388-391.
43. Davis R.C., et al. Systems genetics of susceptibility to obesity-induced diabetes in mce. Physiol. Genomics 2012, 44:1-13.
44. Kelly S.A., et al. Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain. Genetics 2012, 191:643-654.
45. Hitzemann R., et al. A strategy for the integration of QTL, gene expression, and sequence analysis. Mamm. Genome 2003, 14:733-747.
46. Leygraf A., et al. Rgs2 gene polymorphisms as modulators of anxiety in humans?. J. Neural. Transm. 2006, 113:1921-1925.
47. Mathes W.F., et al. Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity. Behav. Brain Res. 2010, 210:155-163.
48. Keller P., et al. A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J. Appl. Physiol. 2011, 110:46-59.
49. Bray M.S., et al. The human gene map for performance and health related fitness phenotypes: the 2006-2007 update. Med. Sci. Sports Exerc. 2009, 41:35-73.
50. Roth S.M., et al. Advances in exercise, fitness, and performance genomics in 2011. Med. Sci. Sports Exerc. 2012, 44:809-817.
51. Yang H.S., et al. High-resolution mapping of a novel genetic locus regulating voluntary physical activity in mice. Genes Brain Behav. 2012, 11:113-124.
52. Pedersen B.K. Muscles and their myokines. J. Exp. Biol. 2011, 214:337-346.
53. Pedersen B.K., Febbraio M.A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 2012, 8:457-465.
54. Pedersen B.K. A muscular twist on the fate of fat. N. Engl. J. Med. 2012, 366:1544-1545.
55. Bostrom P., et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012, 481:463-468.
56. Kobilo T., et al. Endurance factors improve hippocampal neurogenesis and spatial memory in mice. Learn. Mem. 2012, 18:103-107.
57. Pomp D., et al. Complex genetics of obesity in mouse models. Annu. Rev. Nutr. 2008, 28:331-345.
58. Kivela R., et al. Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB J. 2010, 24:4565-4574.
59. Wisloff U., et al. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science 2005, 307:418-420.
60. Girard I., et al. Leptin levels and body composition of mice selectively bred for high voluntary activity. Physiol. Biochem. Zool. 2007, 80:568-579.
61. Vaanholt L.M., et al. Plasma adiponectin is increased in mice selectively bred for high wheel-running activity, but not by wheel running per sé. Horm. Metab. Res. 2007, 39:377-383.
62. Pedersen B.K., Saltin B. Evidence for prescribing exercise as therpy in chronic disease. Scand. J. Med. Sports 2006, 16(Suppl. 1):3-63.
63. Leskinen T., et al. Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs. PLoS ONE 2010, 5:e12609.
64. Alegria-Torres J.A., et al. Epigenetics and lifestyle. Epigenomics 2011, 3:267-277.
65. Adamo K.B., et al. Can we modify the intrauterine environment to halt the intergenerational cycle of obesity?. Int. J. Environ. Res. Public Health 2012, 9:1263-1307.
66. Slomko H., et al. Minireview: epigenetics of obesity and diabetes in humans. Endocrinology 2012, 153:1025-1030.
67. Chong S., et al. Heritable germline epimutation is not the same as transgenerational epigenetic inheritance. Nat. Genet. 2007, 39:574-575.
68. Zhang F.F., et al. Physical activity and global genomic DNA methylation in a cancer free population. Epigenetics 2011, 6:293-299.
69. Barres R., et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012, 15:405-411.
70. de Mooji-van Malsen J.G., et al. Evidence for epigenetic interactions for loci on mouse chromosome 1 regulating open field activity. Behav. Genet. 2009, 39:176-182.
71. Kelly S.A., et al. Parent-of-origin effects on voluntary exercise levels and body composition in mice. Physiol. Genomics 2010, 40:111-120.
72. Good D.J., et al. Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity. Exerc. Sport Sci. Rev. 2008, 36:187-192.
73. Loos R.J., et al. Melanocortin-4 receptor gene and physical activity in the Quebec Family Study. Int. J. Obes. (Lond.) 2005, 29:420-428.
74. Hakimi P., et al. Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J. Biol. Chem. 2007, 282:32844-32855.
75. Narkar V.A., et al. AMPK and PPARdelta agonists are exercise mimetics. Cell 2008, 134:405-415.
76. Stensel D. Primary prevention of CVD: physical activity. Clin. Evid. (Online) 2009, 2009. pii 0218.
77. Gallanagh S., et al. Physical activity in the prevention and treatment of stroke. ISRN Neurol. 2011, 2011:953818.
78. Denlinger C.S., Engstrom P.F. Colorectal cancer survivorship: movement matters. Cancer Prev. Res. (Phila.) 2011, 4:502-511.
79. Physical activity reduces the incidient type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study. Diabetologia 2012, 55:1944-1952. The InterAct Consortium.
80. Wadden T.A., et al. Lifestyle modification for obesity: new developments in diet, physical activity, and behavior therapy. Circulation 2012, 125:1157-1170.
81. Winchester J., et al. Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year. Arch. Gerontol. Geriatr. 2013, 56:96-103.
82. Mustroph M.L., et al. Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL/6J mice. Neuroscience 2012, 219:62-71.
83. Church T.S., et al. Changes in weight, waist circumference and compensatory responses with different doses of exercise among sedentary, overweight postmenopausal women. PLoS ONE 2009, 4:e4515.
84. Tudor-Locke C., et al. How many steps/day are enough? For adults. Int. J. Behav. Nutr. Phys. Act. 2011, 8:79.
85. Chen R., et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 2012, 148:1293-1307.
86. Bouchard C., et al. Adverse metabolic response to regular exercise: is it a rare or common occurrence?. PLoS ONE 2012, 7:e37887.
87. Bowen R.S., et al. Sex hormone effects on physical activity levels: why doesn't Jane run as much as Dick?. Sports Med. 2011, 41:73-86.
88. Ricanati E.H.W., et al. Mitigating preventable chronic disease: progress report of the Cleveland Clinic's Lifestyle 180 program. Nutr. Metab. (Lond.) 2011, 8:83.
89. Bravata D.M., et al. Using pedometers to increase physical activity and improve health. JAMA 2007, 298:2296-2304.
90. Golbidi S., Laher I. Exercise and the cardiovascular system. Cardiol. Res. Pract. 2012, 2012:210852.
91. Nishi A., et al. QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains. Mamm. Genome 2010, 21:477-485.
92. de Ledesma A.M., et al. Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: congenic strains and candidate gene identification studies. Mamm. Genome 2006, 17:111-118.
93. Ways J., et al. Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypes. Physiol. Genomics 2007, 29:91-97.
94. Kotz C.M. Integration of feeding and spontaneous physical activity: role for orexin. Physiol. Behav. 2006, 88:294-301.
95. Levine J.A., et al. Effect of hyperthyroidism on spontaneous physical activity and energy expenditure in rats. J. Appl. Physiol. 2003, 94:165-170.
96. The genome architecture of the Collaborative Cross mouse reference population. Genetics 2012, 190:389-401. Collaborative Cross Consortium.
97. 2,max but not voluntary wheel running in mice. J. Exp. Biol. 2010, 213:510-519.