Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors

Journal of Biomolecular Screening

Volumn 18, Issue 5, 2013, Pages 599-609

  Southern, Craig ^a   Cook, Jennifer M ^a   Neetoo Isseljee, Zaynab ^a   Taylor, Debra L ^a   Kettleborough, Catherine A ^a   Merritt, Andy ^a   Bassoni, Daniel L ^b   Raab, William J ^b   Quinn, Elizabeth ^b   Wehrman, Tom S ^b   Davenport, Anthony P ^c   Brown, Andrew J ^d   Green, Andrew ^b,d   Wigglesworth, Mark J ^d   Rees, Steve ^d  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b DiscoverRx Corporation   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

arrestin recruitment; natural ligand; orphan G protein coupled receptor

Indexed keywords

BETA ARRESTIN; CHOLESTEROL; CORTISTATIN; ESTRADIOL; EZETIMIBE; FLUNARIZINE; G PROTEIN COUPLED RECEPTOR; KYNURENIC ACID; LIGAND; LYSOPHOSPHATIDIC ACID; PROTON; SOMATOSTATIN; SPHINGOSINE 1 PHOSPHATE; ZAPRINAST; ZERANOL;

ABSORPTION; ARTICLE; CELL COMPARTMENTALIZATION; CELL INTERACTION; CONCENTRATION RESPONSE; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MEASUREMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; VALIDATION PROCESS;

Β-ARRESTIN RECRUITMENT; NATURAL LIGAND; ORPHAN G-PROTEIN-COUPLED RECEPTOR;

ANIMALS; ARRESTINS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DISCOVERY; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; SACCHAROMYCES CEREVISIAE; SMALL MOLECULE LIBRARIES;

EID: 84878172571     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113475480     Document Type: Article

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