메뉴 건너뛰기




Volumn 7, Issue 1, 2013, Pages

Tumour dormancy and clinical implications in breast cancer

Author keywords

Angiogenesis; Breast cancers; Immune surveillance; Microenvironment; Tumor dormancy

Indexed keywords

ANGIOSTATIN; ENDOSTATIN; FIBROBLAST GROWTH FACTOR; HEAT SHOCK PROTEIN 27; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MATRIX METALLOPROTEINASE; MICRORNA; VASCULOTROPIN;

EID: 84878120607     PISSN: None     EISSN: 17546605     Source Type: Journal    
DOI: 10.3332/ecancer.2013.320     Document Type: Review
Times cited : (33)

References (77)
  • 2
    • 79961087495 scopus 로고    scopus 로고
    • Controversies in clinical cancer dormancy
    • DOI: 10.1073/pnas.1106613108 PMID: 21746894 PMCID: 3145712
    • Uhr JW and Pantel K (2011) Controversies in clinical cancer dormancy Proc Natl Acad Sci USA 108 12396-400 DOI: 10.1073/pnas.1106613108 PMID: 21746894 PMCID: 3145712
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 12396-12400
    • Uhr, J.W.1    Pantel, K.2
  • 3
    • 68549137924 scopus 로고    scopus 로고
    • Cancer micrometastases
    • DOI: 10.1038/nrclinonc.2009.44 PMID: 19399023
    • Pantel K, Alix-Panabieres C and Riethdorf S (2009) Cancer micrometastases Nat Rev Clin Oncol 6 339-51 DOI: 10.1038/nrclinonc.2009.44 PMID: 19399023
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 339-351
    • Pantel, K.1    Alix-Panabieres, C.2    Riethdorf, S.3
  • 5
    • 0034860222 scopus 로고    scopus 로고
    • Solitary cancer cells as a possible source of tumour dormancy?
    • DOI 10.1006/scbi.2001.0382
    • Naumov GN, MacDonald IC, Chambers AF and Groom AC (2001) Solitary cancer cells as a possible source of tumour dormancy? Semin Cancer Biol 11 271-6 DOI: 10.1006/scbi.2001.0382 PMID: 11513562 (Pubitemid 32799904)
    • (2001) Seminars in Cancer Biology , vol.11 , Issue.4 , pp. 271-276
    • Naumov, G.N.1    MacDonald, I.C.2    Chambers, A.F.3    Groom, A.C.4
  • 6
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases
    • Luzzi KJ, MacDonald IC, Schmidt EE, et al (1998) Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases Am J Pathol 153(3) 865-73 DOI: 10.1016/S0002-9440(10)65628-3 PMID: 9736035 (Pubitemid 28419039)
    • (1998) American Journal of Pathology , vol.153 , Issue.3 , pp. 865-873
    • Luzzi, K.J.1    MacDonald, I.C.2    Schmidt, E.E.3    Kerkvliet, N.4    Morris, V.L.5    Chambers, A.F.6    Groom, A.C.7
  • 7
    • 0028951043 scopus 로고
    • Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • DOI: 10.1038/nm0295-149 PMID: 7585012
    • Holmgren L, O'Reilly MS and Folkman J (1995) Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression Nat Med 1 149-53 DOI: 10.1038/nm0295-149 PMID: 7585012
    • (1995) Nat Med , vol.1 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 11
    • 59149083473 scopus 로고    scopus 로고
    • Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype
    • DOI: 10.1158/0008-5472.CAN-08-2590 PMID: 19176381
    • Almog N, Ma L, Raychowdhury R, et al (2009) Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype Cancer Res 69 836-44 DOI: 10.1158/0008-5472.CAN-08-2590 PMID: 19176381
    • (2009) Cancer Res , vol.69 , pp. 836-844
    • Almog, N.1    Ma, L.2    Raychowdhury, R.3
  • 12
    • 0038662614 scopus 로고    scopus 로고
    • Metastasis suppressor gene: Basic biology and potential clinical use
    • Steeg PS, Ouatas T, Halverson D, et al (2003) Metastasis suppressor genes: basic biology and potential clinical use Clin Breast Cancer 4(1) 51-62 DOI: 10.3816/CBC.2003.n.012 PMID: 12744759 (Pubitemid 36621624)
    • (2003) Clinical Breast Cancer , vol.4 , Issue.1 , pp. 51-62
    • Steeg, P.S.1    Quatas, T.2    Halverson, D.3    Palmieri, D.4    Salerno, M.5
  • 13
    • 84865641870 scopus 로고    scopus 로고
    • Consensus micro RNAs governing the switch of dormant tumors to the fast-growing angiogenic phenotype
    • DOI: 10.1371/journal.pone.0044001 PMCID: 3432069
    • Almog N, Ma L, Schwager C, et al (2012) Consensus micro RNAs governing the switch of dormant tumors to the fast-growing angiogenic phenotype PLoS One 7(8) e44001 DOI: 10.1371/journal.pone.0044001 PMCID: 3432069
    • (2012) PLoS One , vol.7 , Issue.8
    • Almog, N.1    Ma, L.2    Schwager, C.3
  • 14
    • 53949097593 scopus 로고    scopus 로고
    • Epigenetic silencing contributes to the loss of BRMS 1 expression in breast cancer
    • DOI: 10.1007/s10585-008-9187-x
    • Metge BJ, Frost AR, King JA, et al (2008) Epigenetic silencing contributes to the loss of BRMS 1 expression in breast cancer Clin Exp Met 25 753-63 DOI: 10.1007/s10585-008-9187-x
    • (2008) Clin Exp Met , vol.25 , pp. 753-763
    • Metge, B.J.1    Frost, A.R.2    King, J.A.3
  • 15
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • DOI: 10.1093/jnci/82.1.4 PMID: 1688381
    • Folkman J (1990) What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82 4-6 DOI: 10.1093/jnci/82.1.4 PMID: 1688381
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 16
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • DOI 10.1016/S0092-8674(00)80108-7
    • Hanahan D and Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis Cell 86 353-64 DOI: 10.1016/S0092- 8674(00)80108-7 PMID: 8756718 (Pubitemid 26272076)
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 18
    • 33748940402 scopus 로고    scopus 로고
    • Role of angiogenesis in human tumor dormancy: Animal models of the angiogenic switch
    • Naumov GN, Akslen LA and Folkman J (2006) Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch Cell Cycle 5 1779-87 DOI: 10.4161/cc.5.16.3018 PMID: 16931911 (Pubitemid 44435320)
    • (2006) Cell Cycle , vol.5 , Issue.16 , pp. 1779-1787
    • Naumov, G.N.1    Akslen, L.A.2    Folkman, J.3
  • 19
    • 84871611946 scopus 로고    scopus 로고
    • Clinical opportunities and challenges in targeting tumour dormancy
    • DOI: 10.1038/nrclinonc.2012.207 PMID: 23183631
    • Hensel JA, Flaig WA and Theodorescu D (2012) Clinical opportunities and challenges in targeting tumour dormancy Nat Rev Clin Oncol 10(1) 41-51 DOI: 10.1038/nrclinonc.2012.207 PMID: 23183631
    • (2012) Nat Rev Clin Oncol , vol.10 , Issue.1 , pp. 41-51
    • Hensel, J.A.1    Flaig, W.A.2    Theodorescu, D.3
  • 20
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • DOI 10.1038/339058a0
    • Folkman J, Watson K, Ingber D and Hanahan D (1989) Induction of angiogenesis during the transition from hyperplasia to neoplasia Nature 339 58-61 DOI: 10.1038/339058a0 PMID: 2469964 (Pubitemid 19115892)
    • (1989) Nature , vol.339 , Issue.6219 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 23
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ and Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis J Clin Oncol 23(5) 1011-27 DOI: 10.1200/JCO.2005.06.081 (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 24
    • 0033994361 scopus 로고    scopus 로고
    • Extrinsic regulators of epithelial tumor progression: Metalloproteinases
    • DOI: 10.1016/S0959-437X(99)00043-X PMID: 10679388
    • Bergers G and Coussens LM (2000) Extrinsic regulators of epithelial tumor progression: metalloproteinases Curr Opin Genet Dev 10 120-7 DOI: 10.1016/S0959-437X(99)00043-X PMID: 10679388
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 120-127
    • Bergers, G.1    Coussens, L.M.2
  • 25
    • 84861868696 scopus 로고    scopus 로고
    • Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer
    • DOI: 10.1073/pnas.1017909109 PMID: 22589302 PMCID: 3365195
    • Straume O, Shimamura T, Lampa MJ, et al (2012) Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer Proc Natl Acad Sci USA 109 8699-704 DOI: 10.1073/pnas.1017909109 PMID: 22589302 PMCID: 3365195
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 8699-8704
    • Straume, O.1    Shimamura, T.2    Lampa, M.J.3
  • 26
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: From immunosurveillance to tumor escape
    • DOI 10.1038/ni1102-991
    • Dunn GP, Bruce AT, Ikeda H, et al (2002) Cancer immunoediting: from immunosurveillance to tumor escape Nat Immunol 3 991-8 DOI: 10.1038/ni1102-991 PMID: 12407406 (Pubitemid 35363648)
    • (2002) Nature Immunology , vol.3 , Issue.11 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2    Ikeda, H.3    Old, L.J.4    Schreiber, R.D.5
  • 27
    • 2542430341 scopus 로고    scopus 로고
    • The three Es of cancer immunoediting
    • DOI 10.1146/annurev.immunol.22.012703.104803
    • Dunn GP, Old LJ and Schreiber RD (2004) The three Es of cancer immunoediting Annu Rev Immunol 22 329-60 DOI: 10.1146/annurev.immunol.22.012703. 104803 (Pubitemid 38680426)
    • (2004) Annual Review of Immunology , vol.22 , pp. 329-360
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 28
    • 0028968004 scopus 로고
    • Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice
    • DOI: 10.1084/jem.181.4.1539 PMID: 7535341
    • Racila E, Scheuermann RH, Picker LJ, et al (1995) Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice J Exp Med 181 1539-50 DOI: 10.1084/jem.181.4.1539 PMID: 7535341
    • (1995) J Exp Med , vol.181 , pp. 1539-1550
    • Racila, E.1    Scheuermann, R.H.2    Picker, L.J.3
  • 29
    • 53549123079 scopus 로고    scopus 로고
    • Immune-mediated dormancy: An equilibrium with cancer
    • DOI: 10.1189/jlb.1107774
    • Teng MWL, Swann JB, Koebel CM, et al (2008) Immune-mediated dormancy: an equilibrium with cancer J Leukocyte Bio 84 988-993 DOI: 10.1189/jlb.1107774
    • (2008) J Leukocyte Bio , vol.84 , pp. 988-993
    • Teng, M.W.L.1    Swann, J.B.2    Koebel, C.M.3
  • 31
    • 67349109903 scopus 로고    scopus 로고
    • B7-H1 up-regulation on dendritic-like leukemia cells suppresses T cell immune function through modulation of IL-10/IL-12 production and generation of Treg cells
    • DOI: 10.1016/j.leukres.2009.01.007 PMID: 19233469
    • Ge W, Ma X, Li X, et al (2009) B7-H1 up-regulation on dendritic-like leukemia cells suppresses T cell immune function through modulation of IL-10/IL-12 production and generation of Treg cells Leuk Res 33 948-957 DOI: 10.1016/j.leukres.2009.01.007 PMID: 19233469
    • (2009) Leuk Res , vol.33 , pp. 948-957
    • Ge, W.1    Ma, X.2    Li, X.3
  • 33
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • DOI: 10.1038/nri1806 PMID: 16557261
    • Zou W (2006) Regulatory T cells, tumour immunity and immunotherapy Nat Rev Immunol 6 295-307 DOI: 10.1038/nri1806 PMID: 16557261
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 34
    • 72849141569 scopus 로고    scopus 로고
    • Immune cells and angiogenesis
    • DOI: 10.1111/j.1582-4934.2009.00810.x PMID: 19538473
    • Ribatti D and Crivellato E (2009) Immune cells and angiogenesis J Cell Mol Med 13 2822-33 DOI: 10.1111/j.1582-4934.2009.00810.x PMID: 19538473
    • (2009) J Cell Mol Med , vol.13 , pp. 2822-2833
    • Ribatti, D.1    Crivellato, E.2
  • 35
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • DOI: 10.1083/jcb.147.1.89 PMID: 10508858
    • Aguirre-Ghiso JA, Kovalski K and Ossowski L (1999) Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling J Cell Biol 147 89-104 DOI: 10.1083/jcb.147.1.89 PMID: 10508858
    • (1999) J Cell Biol , vol.147 , pp. 89-104
    • Aguirre-Ghiso, J.A.1    Kovalski, K.2    Ossowski, L.3
  • 36
    • 84860595935 scopus 로고    scopus 로고
    • Microenvironments dictating tumor cell dormancy
    • DOI: 10.1007/978-3-642-28160-0-3 PMID: 22527492 PMCID: 3516301
    • Bragado P, Sosa MS, Keely P, et al (2012) Microenvironments dictating tumor cell dormancy Recent Results Cancer Res 195 25-39 DOI: 10.1007/978-3-642-28160-0-3 PMID: 22527492 PMCID: 3516301
    • (2012) Recent Results Cancer Res , vol.195 , pp. 25-39
    • Bragado, P.1    Sosa, M.S.2    Keely, P.3
  • 38
    • 0035172910 scopus 로고    scopus 로고
    • Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo
    • PMID: 11294892 PMCID: 32272
    • Aguirre-Ghiso JA, Liu D, Mignatti A, et al (2001) Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo Mol Biol Cell 12 863-79 PMID: 11294892 PMCID: 32272
    • (2001) Mol Biol Cell , vol.12 , pp. 863-879
    • Aguirre-Ghiso, J.A.1    Liu, D.2    Mignatti, A.3
  • 39
    • 52049093658 scopus 로고    scopus 로고
    • The urokinase receptor [u-PAR] - A link between tumor cell dormancy and minimal residual disease in bone marrow?
    • DOI: 10.1111/j.1600-0463.2008.00997.x PMID: 18834405
    • Allgayer H and Aguirre-Ghiso JA (2008) The urokinase receptor [u-PAR]-a link between tumor cell dormancy and minimal residual disease in bone marrow? APMIS 116 602-14 DOI: 10.1111/j.1600-0463.2008.00997.x PMID: 18834405
    • (2008) APMIS , vol.116 , pp. 602-614
    • Allgayer, H.1    Aguirre-Ghiso, J.A.2
  • 40
    • 5144235557 scopus 로고    scopus 로고
    • Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
    • DOI 10.1016/j.ccr.2004.06.025, PII S1535610804002077
    • White DE, Kurpios NA, Zuo D, et al (2004) Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction Cancer Cell 6 159-70 DOI: 10.1016/j.ccr.2004.06.025 PMID: 15324699 (Pubitemid 39485688)
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 159-170
    • White, D.E.1    Kurpios, N.A.2    Zuo, D.3    Hassell, J.A.4    Blaess, S.5    Mueller, U.6    Muller, W.J.7
  • 42
    • 0037379794 scopus 로고    scopus 로고
    • SAPK
    • Aguirre-Ghiso JA, Estrada Y, Liu D and Ossowski L (2003) ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38 (SAPK) Cancer Res 63 1684-95 PMID: 12670923 (Pubitemid 36373662)
    • (2003) Cancer Research , vol.63 , Issue.7 , pp. 1684-1695
    • Aguirre-Ghiso, J.A.1    Estrada, Y.2    Liu, D.3    Ossowski, L.4
  • 43
    • 48749105093 scopus 로고    scopus 로고
    • A TF6alpha-Rheb-mTOR signalling promotes survival of dormant tumor cells in vivo
    • DOI: 10.1073/pnas.0800939105 PMID: 18650380
    • Schewe DM and Aguirre-Ghiso JA (2008) A TF6alpha-Rheb-mTOR signalling promotes survival of dormant tumor cells in vivo Proc Natl Acad Sci USA 105 10519-24 DOI: 10.1073/pnas.0800939105 PMID: 18650380
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10519-10524
    • Schewe, D.M.1    Aguirre-Ghiso, J.A.2
  • 44
    • 33745700206 scopus 로고    scopus 로고
    • Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases
    • DOI: 10.1158/0008-5472.CAN-04-0297 PMID: 16778188
    • Houghton AM, Grisolano JL, Baumann ML, et al (2006) Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases Cancer Res 66 6149-55 DOI: 10.1158/0008-5472.CAN-04-0297 PMID: 16778188
    • (2006) Cancer Res , vol.66 , pp. 6149-6155
    • Houghton, A.M.1    Grisolano, J.L.2    Baumann, M.L.3
  • 45
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • DOI: 10.1146/annurev.pathol.1.110304.100224
    • Tlsty TD and Coussens LM (2006) Tumor stroma and regulation of cancer development Annu Rev Pathol 1 119-50 DOI: 10.1146/annurev.pathol.1.110304.100224
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 46
    • 65549086081 scopus 로고    scopus 로고
    • Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer
    • DOI: 10.1200/JCO.2008.18.0497 PMID: 19332733
    • Xenidis N, Ignatiadis M, Apostolaki S, et al (2009) Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer J Clin Oncol 27 2177-84 DOI: 10.1200/JCO.2008.18.0497 PMID: 19332733
    • (2009) J Clin Oncol , vol.27 , pp. 2177-2184
    • Xenidis, N.1    Ignatiadis, M.2    Apostolaki, S.3
  • 47
    • 0037102125 scopus 로고    scopus 로고
    • Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: Evaluation of their prognostic significance
    • DOI: 10.1200/JCO.2002.08.135 PMID: 12177100
    • Stathopoulou A, Vlachonikolis I, Mavroudis D, et al (2002) Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: Evaluation of their prognostic significance J Clin Oncol 20 3404-12 DOI: 10.1200/JCO.2002.08.135 PMID: 12177100
    • (2002) J Clin Oncol , vol.20 , pp. 3404-3412
    • Stathopoulou, A.1    Vlachonikolis, I.2    Mavroudis, D.3
  • 48
    • 79958181044 scopus 로고    scopus 로고
    • Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients with operable breast cancer: Prognostic relevance for late relapse
    • DOI: 10.1186/bcr2897 PMCID: 3218949
    • Saloustros E, Perraki M, Apostolaki S, et al (2011) Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients with operable breast cancer: prognostic relevance for late relapse Breast Cancer Res 13(3) R60 DOI: 10.1186/bcr2897 PMCID: 3218949
    • (2011) Breast Cancer Res , vol.13 , Issue.3
    • Saloustros, E.1    Perraki, M.2    Apostolaki, S.3
  • 49
    • 79955491864 scopus 로고    scopus 로고
    • Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse - A european pooled analysis
    • DOI: 10.1158/1078-0432.CCR-10-2515 PMID: 21415211
    • Janni W, Vogl FD, Wiedswang G, et al (2011) Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse - a european pooled analysis Clin Cancer Res 17(9) 2967-76 DOI: 10.1158/1078-0432.CCR-10-2515 PMID: 21415211
    • (2011) Clin Cancer Res , vol.17 , Issue.9 , pp. 2967-2976
    • Janni, W.1    Vogl, F.D.2    Wiedswang, G.3
  • 51
    • 67349111353 scopus 로고    scopus 로고
    • Migration rules: Tumours are conglomerates of self metastases
    • DOI: 10.1038/sj.bjc.6605071 PMID: 19455139 PMCID: 2714240
    • Enderling H, Hlatky L and Hahnfeldt P (2009) Migration rules: tumours are conglomerates of self metastases Br J Cancer 100 1917-25 DOI: 10.1038/sj.bjc.6605071 PMID: 19455139 PMCID: 2714240
    • (2009) Br J Cancer , vol.100 , pp. 1917-1925
    • Enderling, H.1    Hlatky, L.2    Hahnfeldt, P.3
  • 52
    • 33846239456 scopus 로고    scopus 로고
    • Beyond tumorigenesis: Cancer stem cells in metastasis
    • DOI 10.1038/sj.cr.7310118, PII 7310118
    • Li F, Tiede B, Massague J and Kang Y (2007) Beyond tumorigenesis: cancer stem cells in metastasis Cell Res 17 3-14 DOI: 10.1038/sj.cr.7310118 (Pubitemid 46096419)
    • (2007) Cell Research , vol.17 , Issue.1 , pp. 3-14
    • Li, F.1    Tiede, B.2    Massague, J.3    Kang, Y.4
  • 53
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • DOI 10.1038/35102167
    • Reya T, Morrison SJ, Clarke MF and Weissman IL (2001) Stem cells, cancer, and cancer stem cells Nature 414 105-11 DOI: 10.1038/35102167 PMID: 11689955 (Pubitemid 33041634)
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 54
    • 0242721548 scopus 로고    scopus 로고
    • L with Nonpeptidic Small-Molecule Antagonists
    • Wang S, Yang D and Lippman ME (2003) Targeting Bcl-2 and Bcl-XL with non peptidic small-molecule antagonists Semin Oncol 30 133-42 DOI: 10.1053/j.seminoncol.2003.08.015 PMID: 14613034 (Pubitemid 37433404)
    • (2003) Seminars in Oncology , vol.30 , Issue.5 SUPPL. 16 , pp. 133-142
    • Wang, S.1    Yang, D.2    Lippman, M.E.3
  • 55
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signalling and BMi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • DOI: 10.1158/0008-5472.CAN-06-0054 PMID: 16778178
    • Liu S, Dontu G, Mantle ID, et al (2006) Hedgehog signalling and BMi-1 regulate self-renewal of normal and malignant human mammary stem cells Cancer Res 66 6063-71 DOI: 10.1158/0008-5472.CAN-06-0054 PMID: 16778178
    • (2006) Cancer Res , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3
  • 56
    • 33646428091 scopus 로고    scopus 로고
    • Normal stem cells and cancer stem cells: The niche matters
    • DOI: 10.1158/0008-5472.CAN-05-3986 PMID: 16651403
    • Li L and Neaves WB (2006) Normal stem cells and cancer stem cells: the niche matters Cancer Res 66 4553-4557 DOI: 10.1158/0008-5472.CAN-05-3986 PMID: 16651403
    • (2006) Cancer Res , vol.66 , pp. 4553-4557
    • Li, L.1    Neaves, W.B.2
  • 57
    • 33847296106 scopus 로고    scopus 로고
    • Targeted therapy for cancer stem cells: The patched pathway and ABC transporters
    • DOI 10.1038/sj.onc.1210200, PII 1210200
    • Lou H and Dean M (2007) Targeted therapy for cancer stem cells: the patched pathway and ABC transporters Oncogene 26 1357-60 DOI: 10.1038/sj.onc.1210200 PMID: 17322922 (Pubitemid 46328461)
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1357-1360
    • Lou, H.1    Dean, M.2
  • 58
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • DOI: 10.1038/onc.2010.215 PMID: 20531305
    • Singh A and Settleman J (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer Oncogene 29 4741-51 DOI: 10.1038/onc.2010.215 PMID: 20531305
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 59
    • 77953362501 scopus 로고    scopus 로고
    • Molecular mechanisms underlying tumor dormancy
    • DOI: 10.1016/j.canlet.2010.03.004 PMID: 20363069
    • Almog N (2010) Molecular mechanisms underlying tumor dormancy Cancer Lett 294(2) 139-46 DOI: 10.1016/j.canlet.2010.03.004 PMID: 20363069
    • (2010) Cancer Lett , vol.294 , Issue.2 , pp. 139-146
    • Almog, N.1
  • 60
    • 0042972556 scopus 로고    scopus 로고
    • Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis
    • DOI 10.1016/S1535-6108(03)00030-8
    • Watnick RS, Cheng YN, Rangarajan A, et al (2003) Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis Cancer Cell 3 219-31 DOI: 10.1016/S1535-6108(03)00030-8 PMID: 12676581 (Pubitemid 37443878)
    • (2003) Cancer Cell , vol.3 , Issue.3 , pp. 219-231
    • Watnick, R.S.1    Cheng, Y.-N.2    Rangarajan, A.3    Ince, T.A.4    Weinberg, R.A.5
  • 61
    • 84859994398 scopus 로고    scopus 로고
    • Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer
    • DOI: 10.1371/journal.pone.0035569 PMCID: 3329481
    • Kim RS, Avivar-Valderas A, Estrada Y, Bragado P, et al (2012) Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer PLoS One 7(4) e35569 DOI: 10.1371/journal.pone.0035569 PMCID: 3329481
    • (2012) PLoS One , vol.7 , Issue.4
    • Kim, R.S.1    Avivar-Valderas, A.2    Estrada, Y.3    Bragado, P.4
  • 62
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG) PMID: 15894097
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials Lancet 365 1687-717 PMID: 15894097
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 64
    • 80052142418 scopus 로고    scopus 로고
    • Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases
    • DOI: 10.1073/pnas.1103125108 PMID: 21844363 PMCID: 3161545
    • Carlsson A, Wingren C, Kristensson M, et al (2011) Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases Proc Natl Acad Sci USA 108 14252-7 DOI: 10.1073/pnas. 1103125108 PMID: 21844363 PMCID: 3161545
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14252-14257
    • Carlsson, A.1    Wingren, C.2    Kristensson, M.3
  • 66
    • 84856529459 scopus 로고    scopus 로고
    • A multinational, randomized phase III study of bevacizumab (Bev) with FOLFOX4 or XELOX versus FOLFOX4 alone as adjuvant treatment for colon cancer (CC): Subgroup analyses from the AVANT trial
    • PMID: 21343554
    • Andre T, Van Cutsem E, Schmoll H, et al (2011) A multinational, randomized phase III study of bevacizumab (Bev) with FOLFOX4 or XELOX versus FOLFOX4 alone as adjuvant treatment for colon cancer (CC): subgroup analyses from the AVANT trial J Clin Oncol 29 PMID: 21343554
    • (2011) J Clin Oncol , vol.29
    • Andre, T.1    Van Cutsem, E.2    Schmoll, H.3
  • 67
    • 79551521053 scopus 로고    scopus 로고
    • Overall survival (OS) and updated disease-free survival (DFS) results of the NSABP C-08 trial assessing bevacizumab (B) in stage II and III colon cancer
    • DOI: 10.1200/JCO.2010.30.0855 PMID: 21969501 PMCID: 3188282
    • Allegra CJ, Yothers GA, O'Connell MJ, et al (2011) Overall survival (OS) and updated disease-free survival (DFS) results of the NSABP C-08 trial assessing bevacizumab (B) in stage II and III colon cancer J Clin Oncol 29 DOI: 10.1200/JCO.2010.30.0855 PMID: 21969501 PMCID: 3188282
    • (2011) J Clin Oncol , vol.29
    • Allegra, C.J.1    Yothers, G.A.2    O'Connell, M.J.3
  • 68
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • DOI: 10.1016/S0140-6736(00)49915-0
    • Paget S (1889) The distribution of secondary growths in cancer of the breast Lancet 1 571-3 DOI: 10.1016/S0140-6736(00)49915-0
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 69
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • DOI: 10.1056/NEJMra030831 PMID: 15084698
    • Roodman GD (2004) Mechanisms of bone metastasis N Engl J Med 350(16) 1655-64 DOI: 10.1056/NEJMra030831 PMID: 15084698
    • (2004) N Engl J Med , vol.350 , Issue.16 , pp. 1655-1664
    • Roodman, G.D.1
  • 70
    • 79951842507 scopus 로고    scopus 로고
    • Anticancer evidence for zoledronic acid across the cancer continuum
    • DOI: 10.1016/S1040-8428(11)70006-3
    • Costa L, Harper P, Coleman RE and Lipton A (2011) Anticancer evidence for zoledronic acid across the cancer continuum Crit Rev Oncol Hematol 77(11) S31-7 DOI: 10.1016/S1040-8428(11)70006-3
    • (2011) Crit Rev Oncol Hematol , vol.77 , Issue.11
    • Costa, L.1    Harper, P.2    Coleman, R.E.3    Lipton, A.4
  • 71
    • 60549097419 scopus 로고    scopus 로고
    • Endocrine therapy plus zoledronic acid in premenopausal breast cancer
    • DOI: 10.1056/NEJMoa0806285
    • Gnant M, Mlineritsch B, Schippinger W, et al (2009) Endocrine therapy plus zoledronic acid in premenopausal breast cancer N Eng J Med 360(7) 679-91 DOI: 10.1056/NEJMoa0806285
    • (2009) N Eng J Med , vol.360 , Issue.7 , pp. 679-691
    • Gnant, M.1    Mlineritsch, B.2    Schippinger, W.3
  • 72
    • 80054035939 scopus 로고    scopus 로고
    • Breast cancer adjuvant therapy with zoledronic acid
    • on behalf of the AZURE Investigators DOI: 10.1056/NEJMoa1105195 PMID: 21995387
    • Coleman RE, Marshall H, Cameron D, et al on behalf of the AZURE Investigators (2011) Breast cancer adjuvant therapy with zoledronic acid N Engl J Med 365(15) 1396-405 DOI: 10.1056/NEJMoa1105195 PMID: 21995387
    • (2011) N Engl J Med , vol.365 , Issue.15 , pp. 1396-1405
    • Coleman, R.E.1    Marshall, H.2    Cameron, D.3
  • 75
    • 2942538264 scopus 로고    scopus 로고
    • Dissecting the metastatic cascade
    • Pantel K, Brakenhoff RH (2004) Dissecting the metastatic cascade Nat Rev Cancer 4 448-56 DOI: 10.1038/nrc1370 (Pubitemid 38745530)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.6 , pp. 448-456
    • Pantel, K.1    Brakenhoff, R.H.2
  • 76
    • 78649467513 scopus 로고    scopus 로고
    • Does tumour dormancy offer a therapeutic target?
    • DOI: 10.1038/nrc2933 PMID: 21048784
    • Goss PE and Chambers AF (2010) Does tumour dormancy offer a therapeutic target? Nat Rev Cancer 10(12) 871-7 DOI: 10.1038/nrc2933 PMID: 21048784
    • (2010) Nat Rev Cancer , vol.10 , Issue.12 , pp. 871-877
    • Goss, P.E.1    Chambers, A.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.