Consensus Micro RNAs Governing the Switch of Dormant Tumors to the Fast-Growing Angiogenic Phenotype

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Almog, Nava ^a   Ma, Lili ^a   Schwager, Christian ^b   Brinkmann, Bastian G ^c   Beheshti, Afshin ^a   Vajkoczy, Peter ^c   Folkman, Judah ^d   Hlatky, Lynn ^a   Abdollahi, Amir ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; CD11B ANTIGEN; EPHRIN RECEPTOR A5; GRANULOCYTE COLONY STIMULATING FACTOR; MICRORNA; MICRORNA 190; MICRORNA 580; MICRORNA 588; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BREAST CARCINOMA; CANCER DIAGNOSIS; CANCER GROWTH; CANCER PREVENTION; CANCER STAGING; CELL PROLIFERATION; CONTROLLED STUDY; DORMANCY; DOWN REGULATION; EARLY DIAGNOSIS; GENE CONTROL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; LIPOSARCOMA; MALE; MOUSE; NONHUMAN; OSTEOSARCOMA; PHENOTYPE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIGENS, CD11B; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DOWN-REGULATION; GASTROINTESTINAL HORMONES; HUMANS; MALE; MICE; MICRORNAS; MYELOID CELLS; NEOPLASM STAGING; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NEUROPEPTIDES; PHENOTYPE; TRANSCRIPTOME; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT;

EID: 84865641870     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044001     Document Type: Article

References (35)

1. Folkman J, Kalluri R, (2004) Cancer without disease. Nature 427: 787.
2. Aguirre-Ghiso JA, (2007) Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 7: 834-846.
3. Favaro E, Amadori A, Indraccolo S, (2008) Cellular interactions in the vascular niche: implications in the regulation of tumor dormancy. APMIS 116: 648-659.
4. Indraccolo S, Minuzzo S, Masiero M, Pusceddu I, Persano L, et al. (2009) Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy. Cancer Res 69: 1314-1323.
5. Tang Y, Wang MT, Chen Y, Yang D, Che M, et al. (2009) Downregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancer. Int J Cancer 124: 1545-1551.
6. Gilead A, Meir G, Neeman M, (2004) The role of angiogenesis, vascular maturation, regression and stroma infiltration in dormancy and growth of implanted MLS ovarian carcinoma spheroids. Int J Cancer 108: 524-531.
7. Naumov GN, Folkman J, Straume O (2008) Tumor dormancy due to failure of angiogenesis: role of the microenvironment. Clin Exp Metastasis.
8. Uhr JW, Scheuermann RH, Street NE, Vitetta ES, (1997) Cancer dormancy: opportunities for new therapeutic approaches. Nat Med 3: 505-509.
9. Brackstone M, Townson JL, Chambers AF, (2007) Tumour dormancy in breast cancer: an update. Breast Cancer Res 9: 208.
10. Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J, (1972) Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 136: 261-276.
11. Holmgren L, O'Reilly MS, Folkman J, (1995) Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1: 149-153.
12. Almog N (2010) Molecular mechanisms underlying tumor dormancy. Cancer Lett.
13. Townson JL, Chambers AF, (2006) Dormancy of solitary metastatic cells. Cell Cycle 5: 1744-1750.
14. Uhr JW, Pantel K, (2011) Controversies in clinical cancer dormancy. Proc Natl Acad Sci U S A 108: 12396-12400.
15. Almog N, Henke V, Flores L, Hlatky L, Kung AL, et al. (2006) Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis. FASEB J 20: 947-949.
16. Naumov GN, Bender E, Zurakowski D, Kang SY, Sampson D, et al. (2006) A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype. J Natl Cancer Inst 98: 316-325.
17. Almog N, Ma L, Raychowdhury R, Schwager C, Erber R, et al. (2009) Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype. Cancer Res 69: 836-844.
18. Bartel DP, (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
19. Carthew RW, Sontheimer EJ, (2009) Origins and Mechanisms of miRNAs and siRNAs. Cell 136: 642-655.
20. Shojaei F, Singh M, Thompson JD, Ferrara N, (2008) Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression. Proc Natl Acad Sci U S A 105: 2640-2645.
21. Shojaei F, Wu X, Zhong C, Yu L, Liang XH, et al. (2007) Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450: 825-831.
22. Zhang B, Pan X, Cobb GP, Anderson TA, (2007) microRNAs as oncogenes and tumor suppressors. Dev Biol 302: 1-12.
23. Ventura A, Jacks T, (2009) MicroRNAs and cancer: short RNAs go a long way. Cell 136: 586-591.
24. Lee TY, Muschal S, Pravda EA, Folkman J, Abdollahi A, et al. (2009) Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins. Blood 114: 1987-1998.
25. O'Reilly MS, Holmgren L, Chen C, Folkman J, (1996) Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med 2: 689-692.
26. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, et al. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79: 315-328.
27. Hirota K, Semenza GL, (2006) Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol 59: 15-26.
28. Abdollahi A, Hahnfeldt P, Maercker C, Grone HJ, Debus J, et al. (2004) Endostatin's antiangiogenic signaling network. Mol Cell 13: 649-663.
29. Abdollahi A, Schwager C, Kleeff J, Esposito I, Domhan S, et al. (2007) Transcriptional network governing the angiogenic switch in human pancreatic cancer. Proc Natl Acad Sci U S A 104: 12890-12895.
30. Domhan S, Muschal S, Schwager C, Morath C, Wirkner U, et al. (2008) Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid. Mol Cancer Ther 7: 1656-1668.
31. Abdollahi A, Folkman J Evading tumor evasion: current concepts, perspectives of anti-angiogenic cancer therapy, (2010) Drug Resist Updat. 13: 16-28.
32. LeCouter J, Zlot C, Tejada M, Peale F, Ferrara N, (2004) Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization. Proc Natl Acad Sci U S A 101: 16813-16818.
33. Shaked Y, Voest EE, (2009) Bone marrow derived cells in tumor angiogenesis and growth: are they the good, the bad or the evil? Biochim Biophys Acta 1796: 1-4.
34. Fainaru O, Almog N, Wing Yung C, Nakai K, Montoya-Zavala M, et al. (2009) Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells. FASEB J.
35. McAllister SS, Gifford AM, Greiner AL, Kelleher SP, Saelzler MP, et al. (2008) Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 133: 994-1005.