Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 12, 2013, Pages 3592-3598

  Hurley, Christopher A ^a   Blair, Wade S ^c   Bull, Richard J ^a   Chang, Christine ^c   Crackett, Peter H ^a   Deshmukh, Gauri ^c   Dyke, Hazel J ^a   Fong, Rina ^c   Ghilardi, Nico ^c   Gibbons, Paul ^c   Hewitt, Peter R ^a   Johnson, Adam ^c   Johnson, Tony ^a   Kenny, Jane R ^c   Kohli, Pawan Bir ^c   Kulagowski, Janusz J ^a   Liimatta, Marya ^c   Lupardus, Patrick J ^c   Maxey, Robert J ^a   Mendonca, Rohan ^c   Narukulla, Raman ^a   Pulk, Rebecca ^c   Ubhayakar, Savita ^c   Van Abbema, Anne ^c   Ward, Stuart I ^a   Waszkowycz, Bohdan ^b   Zak, Mark ^c   more..

^a Argenta Discovery Ltd   (United Kingdom)

^b Genentech Inc ^*  (United Kingdom)

^c GENENTECH INC   (United States)

Author keywords

JAK1; JAK1 inhibitor; JAK2; Janus; kinase

Indexed keywords

IMIDAZOPYRROLOPYRIDINE; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE INHIBITOR; PYRIDINE DERIVATIVE; TOFACITINIB; TRIAZOLOPYRROLOPYRIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG EXPOSURE; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; RAT; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; JANUS KINASE 1; JANUS KINASE 2; KINETICS; MODELS, MOLECULAR; PYRIDINES; PYRROLES; RATS;

RATTUS;

EID: 84878114913     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.018     Document Type: Article

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