Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO

Phytomedicine

Volumn 20, Issue 8-9, 2013, Pages 699-704

  Tang, Yuhan ^a   Tian, Hongtao ^a   Shi, Yanru ^a   Gao, Chao ^a   Xing, Mingyou ^a   Yang, Wei ^a   Bao, Wei ^a   Wang, Di ^a   Liu, Liegang ^a   Yao, Ping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Carbon monoxide (CO); CYP2E1; Ethanol; Heme oxygenase 1 (HO 1); Quercetin

Indexed keywords

ALCOHOL; CARBON MONOXIDE; CYTOCHROME P450 2E1; HEME; HEME OXYGENASE 1; QUERCETIN;

ALCOHOL LIVER CIRRHOSIS; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; INCUBATION TIME; LIVER CELL; LIVER MICROSOME; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; CARBON MONOXIDE; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GENE EXPRESSION REGULATION; HEME; HEME OXYGENASE-1; HEPATOCYTES; HUMANS; LIPID PEROXIDATION; LIVER; MALE; OXIDATIVE STRESS; PROTECTIVE AGENTS; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84878111805     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.03.010     Document Type: Article

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