Camphor modulates TRPV3 cation channels activity by interacting with critical pore-region cysteine residues

Pakistan Journal of Pharmaceutical Sciences

Volumn 26, Issue 3, 2013, Pages 431-438

  Sherkheli, Muhammad Azhar ^a,b   Vogt Eisele, Angela K ^b   Weber, Kirsten ^b   Hatt, Hanns ^b  

^a HAZARA UNIVERSITY   (Pakistan)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Camphor modulates; Cysteine; Dermatitis; Inflammation; Nociception; Transient receptor potential (TRP)

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; CALCIUM ION; CAMPHOR; CARVEOL; COMPLEMENTARY DNA; CYSTEINE; MUTANT PROTEIN; VANILLOID RECEPTOR 3;

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; ELECTRIC POTENTIAL; FEMALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; VOLTAGE CLAMP;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BORON COMPOUNDS; CALCIUM; CAMPHOR; CYSTEINE; DNA, COMPLEMENTARY; MICE; MOLECULAR SEQUENCE DATA; MONOTERPENES; TRPV CATION CHANNELS; XENOPUS;

EID: 84878099119     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Asakawa M, Yoshioka T, Matsutani T, Hikita I, Suzuki M, Oshima I, Tsukahara K, Arimura A, Horikawa T, Hirasawa T and Sakata T(2006). Association of a mutation in TRPV3 with defective hair growth in rodents. J. Invest. Dermatol., 126: 2664-2672.
2. Boukalova S, Marsakova L, Teisinger J and Vlachova V (2010). Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels. J. Biol. Chem., 285: 41455-41462.
3. Brauchi S, Orta G, Mascayano C, Salazar M, Raddatz N, Urbina H, Rosenmann E, Gonzalez-Nilo F and Latorre R (2007). Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc. Natl. Acad. Sci. USA, 104: 10246-10251.
4. Carreno O, Corominas R, Fernandez-Morales J, Camina M, Sobrido MJ, Fernandez-Fernandez JM, Pozo-Rosich P, Cormand B and Macaya A (2012). SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population. Am. J. Med. Genet B. Neuropsychiatr. Genet., 159: 94-103.
5. Caterina MJ (2007). Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am. J. Physiol Regul. Integr. Comp. Physiol., 292: 64-76.
6. Cheng W, Yang F, Liu S, Colton C.K, Wang C, Cui Y, Cao X, Zhu MX, Sun C, Wang KW and Zheng J (2012). Heteromeric heat-sensitive TRP channels exhibit distinct temperature and chemical response. J Biol Chem 287(10):7279-7288.
7. Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE and Xu H (2010). TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell., 141: 331-343.
8. Chung MK, Lee H, Mizuno A, Suzuki M and Caterina MJ (2004a). 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J. Neurosci., 24: 5177-5182.
9. Chung MK, Lee H, Mizuno A, Suzuki M and Caterina MJ (2004b). TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J. Biol. Chem., 279: 21569-21575.
10. Clapham DE (2003). TRP channels as cellular sensors, Nature, 426: 517-524.
11. Clapham DE, Runnels LW and Strubing C (2001). The TRP ion channel family. Nat. Rev. Neurosci., 2: 387-396.
12. Gavva NR, Klionsky L, Qu YS, Shi LC, Tamir R, Edenson S, Zhang TJ, Viswanadhan VN, Toth A, Pearce LV, Vanderah TW, Porreca F, Blumberg PM, Lile J, Sun Y, Wildt K, Louis JC and Treanor JJS (2004). Molecular determinants of vanilloid sensitivity in TRPV1. J. Biol Chem, 279: 20283-20295.
13. Grandl J, Hu H, Bandell M, Bursulaya B, Schmidt M, Petrus M and Patapoutian A (2008). Pore region of TRPV3 ion channel is specifically required for heat activation. Nat. Neurosci., 11(9):1007-1013.
14. Harks EGA, Camina JP, Peters PHJ, Ypey DL, Scheenen WJJM, Van Zoelen EJJ and Theuvenet APR (2003). Besides affecting intracellular calcium signaling, 2-APB reversibly blocks gap junctional coupling in confluent monolayers, thereby allowing the measurement of single-cell membrane currents in undissociated cells. Faseb Journal, 17: 941.
15. Ho SN, Hunt HD, Horton RM, Pullen JK and Pease LR (1989). Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene, 77: 51-59.
16. Hu H, Grandl J, Bandell M, Petrus M and Patapoutian A (2009). Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc. Natl. Acad. Sci. USA, 106: 1626-1631.
17. Hu H.Z, Xiao R, Wang C, Gao N, Colton C.K, Wood J.D and Zhu M.X (2006). Potentiation of TRPV3 channel function by unsaturated fatty acids, J.Cell Physiol., 208: 201-212.
18. Imura K, Yoshioka T, Hirasawa T and Sakata T (2009). Role of TRPV3 in immune response to development of dermatitis. J. Inflamm., (Lond), 6: 17.
19. Jordt S.E and Julius D (2002). Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell., 108: 421-430.
20. Lee H and Caterina MJ (2005). TRPV channels as thermosensory receptors in epithelial cells. Pflugers Arch., 451: 160-167.
21. Liu B, Yao J, Zhu MX and Qin F (2011). Hysteresis of gating underlines sensitization of TRPV3 channels. J. Gen. Physiol., 138: 509-520.
22. Lumpkin EA and Caterina MJ (2007). Mechanisms of sensory transduction in the skin. Nature, 445: 858-865.
23. Mandadi S, Sokabe T, Shibasaki K, Katanosaka K, Mizuno A, Moqrich A, Patapoutian A, Fukumi-Tominaga T, Mizumura K and Tominaga M (2009). TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch., 458: 1093-1102.
24. Maruyama T and Takeuchi H (1997). Water accessibility to the tryptophan indole N-H sites of gramicidin A transmembrane channel: detection of positional shifts of tryptophans 11 and 13 along the channel axis upon cation binding. Biochemistry, 36(36): 10993-1001.
25. Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN, Spencer KS, Andahazy M, Story GM and Patapoutian A (2005). Impaired thermosensation in mice lacking TRPV3: A heat and camphor sensor in the skin. Sci., 307: 1468-1472.
26. Nilius B (2007). TRP channels in disease. Biochimica Et Biophysica Acta-Molecular Basis of Dis., 1772: 805-812.
27. Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, Mcintyre P, Bevan S and Patapoutian A (2002). A heat-sensitive TRP channel expressed in keratinocytes. Science, 296: 2046-2049.
28. Phelps CB, Wang RR, Choo SS and Gaudet R (2010). Differential regulation of TRPV1 TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J. Biol. Chem., 285: 731-740.
29. Sherkheli MA, Gisselman G, Mitchell R, Vogt-Eisele AK and Hatt H (2007). Selective TRPM8 agonists: A novel group of neurophathic analgesics. FEBS J., 274: 232.
30. Sherkheli MA (2010). Trip through the pharmacology of hot-and cold sensing TRP ion channels: A hope for better painkillers and anti-inflammatory drugs. Saarbruecken, Germany VDM Verlag, pp. 45-76.
31. Sherkheli MA, Benecke H, Doerner JF, Kletke O, Vogt-Eisele AK, Gisselmann G and Hatt H (2009). Monoterpenoids induce agonist-specific desensitization of transient receptor potential vanilloid-3 (TRPV3) ion channels. J. Pharm Pharm Sci., 12: 116-128.
32. Sherkheli MA, Gisselmann G, Ak VE, Jf D and Hatt H (2008). Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak. J. Pharm Sci., 21: 370-378.
33. Sherkheli MA, Gisselmann G and Hatt H (2012). Supercooling agent icilin blocks awarmth-sensing ion channel TRPV3. The Scientific World Journal, vol. 2012, Article ID 982725, 8 pages, doi:10.1100/2012/982725.
34. Sherkheli MA, Vogt-Eisele AK, Bura D, Beltran Marques LR, Gisselmann G and Hatt H (2010). Characterization of selective TRPM8 ligands and their structure activity response (SAR) relationship. J. Pharm Pharm Sci., 13: 242-253.
35. Smith GD, Gunthorpe J, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P and Davis JB (2002). TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature, 418: 186-190.
36. Villmann C, Bull L and Hollmann M (1997). Kainate binding proteins possess functional ion channel domains. J. Neurosci., 17: 7634-7643.
37. Vogt-Eisele AK, Weber K, Sherkheli MA, Vielhaber G, Panten J, Gisselmann G and Hatt H (2007). Monoterpenoid agonists of TRPV3. Br. J. Pharmacol., 151: 530-540.
38. Xiao R, Tang J, Wang C, Colton CK, Tian J and Zhu MX (2008a). Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J. Biol. Chem., 283: 6162-6174.
39. Xiao R, Tian J, Tang J and Zhu MX (2008b). The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active. Cell Calcium., 43: 334-343.
40. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, Distefano PS, Curtis R and Clapham DE (2002). TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature, 418: 181-186.
41. Yang F, Cui Y, Wang K and Zheng J (2010). Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc. Natl. Acad. Sci. USA, 107: 7083-7088.
42. Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y and Mori Y (2006). Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat. Chem. Biol., 2: 596-607.
43. Yoshioka T, Imura K, Asakawa M, Suzuki M, Oshima I, Hirasawa T, Sakata T, Horikawa T and Arimura A (2009). Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice. J. Invest Dermatol., 129: 714-722.