메뉴 건너뛰기




Volumn 48, Issue 12-13, 2011, Pages 1477-1483

Somatic hypermutation targeting is influenced by location within the immunoglobulin V region

Author keywords

AID; B cells; Germinal centers; Hypermutation; Immunoglobulin; Selection

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN RECEPTOR;

EID: 79957835550     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.04.002     Document Type: Article
Times cited : (22)

References (37)
  • 2
    • 73349126428 scopus 로고    scopus 로고
    • Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells
    • Anderson S.M., Khalil A., Uduman M., Hershberg U., Louzoun Y., Haberman A.M., Kleinstein S.H., Shlomchik M.J. Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells. J. Immunol. 2009, 183:7314-7325.
    • (2009) J. Immunol. , vol.183 , pp. 7314-7325
    • Anderson, S.M.1    Khalil, A.2    Uduman, M.3    Hershberg, U.4    Louzoun, Y.5    Haberman, A.M.6    Kleinstein, S.H.7    Shlomchik, M.J.8
  • 3
    • 0027499308 scopus 로고
    • Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots
    • Betz A.G., Rada C., Pannell R., Milstein C., Neuberger M.S. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:2385-2388.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 2385-2388
    • Betz, A.G.1    Rada, C.2    Pannell, R.3    Milstein, C.4    Neuberger, M.S.5
  • 4
    • 0030026711 scopus 로고    scopus 로고
    • Affinity maturation and hypermutation in a simulation of the humoral immune response
    • Celada F., Seiden P.E. Affinity maturation and hypermutation in a simulation of the humoral immune response. Eur. J. Immunol. 1996, 26:1350-1358.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1350-1358
    • Celada, F.1    Seiden, P.E.2
  • 5
    • 52949111532 scopus 로고    scopus 로고
    • Ongoing somatic hypermutation of the rearranged VH but not of the V-lambda gene in EBV-transformed rheumatoid factor-producing lymphoblastoid cell line
    • Chezar I., Lobel-Lavi L., Steinitz M., Laskov R. Ongoing somatic hypermutation of the rearranged VH but not of the V-lambda gene in EBV-transformed rheumatoid factor-producing lymphoblastoid cell line. Mol. Immunol. 2008, 46:80-90.
    • (2008) Mol. Immunol. , vol.46 , pp. 80-90
    • Chezar, I.1    Lobel-Lavi, L.2    Steinitz, M.3    Laskov, R.4
  • 6
    • 33846404877 scopus 로고    scopus 로고
    • DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
    • Delbos F., Aoufouchi S., Faili A., Weill J.C., Reynaud C.A. DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J. Exp. Med. 2007, 204:17-23.
    • (2007) J. Exp. Med. , vol.204 , pp. 17-23
    • Delbos, F.1    Aoufouchi, S.2    Faili, A.3    Weill, J.C.4    Reynaud, C.A.5
  • 7
    • 34249790004 scopus 로고    scopus 로고
    • Molecular mechanisms of antibody somatic hypermutation
    • Di Noia J.M., Neuberger M.S. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 2007, 76:1-22.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 1-22
    • Di Noia, J.M.1    Neuberger, M.S.2
  • 8
    • 0021711720 scopus 로고
    • Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
    • Griffiths G.M., Berek C., Kaartinen M., Milstein C. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 1984, 312:271-275.
    • (1984) Nature , vol.312 , pp. 271-275
    • Griffiths, G.M.1    Berek, C.2    Kaartinen, M.3    Milstein, C.4
  • 9
    • 0025823716 scopus 로고
    • Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites
    • Kabat E.A., Wu T.T. Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites. J. Immunol. 1991, 147:1709-1719.
    • (1991) J. Immunol. , vol.147 , pp. 1709-1719
    • Kabat, E.A.1    Wu, T.T.2
  • 10
    • 0030978963 scopus 로고    scopus 로고
    • Codon bias and plasticity in immunoglobulins
    • Kepler T.B. Codon bias and plasticity in immunoglobulins. Mol. Biol. Evol. 1997, 14:637-643.
    • (1997) Mol. Biol. Evol. , vol.14 , pp. 637-643
    • Kepler, T.B.1
  • 11
    • 0142149019 scopus 로고    scopus 로고
    • Estimating hypermutation rates from clonal tree data
    • Kleinstein S.H., Louzoun Y., Shlomchik M.J. Estimating hypermutation rates from clonal tree data. J. Immunol. 2003, 171:4639-4649.
    • (2003) J. Immunol. , vol.171 , pp. 4639-4649
    • Kleinstein, S.H.1    Louzoun, Y.2    Shlomchik, M.J.3
  • 13
    • 1642369951 scopus 로고    scopus 로고
    • IMGT, The international ImMunoGeneTics information system
    • Lefranc M.P. IMGT, The international ImMunoGeneTics information system. Methods Mol. Biol. 2004, 248:27-49. http://imgt.cines.fr/.
    • (2004) Methods Mol. Biol. , vol.248 , pp. 27-49
    • Lefranc, M.P.1
  • 15
    • 66649099262 scopus 로고    scopus 로고
    • V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment
    • MacCarthy T., Kalis S.L., Roa S., Pham P., Goodman M.F., Scharff M.D., Bergman A. V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:8629-8634.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 8629-8634
    • MacCarthy, T.1    Kalis, S.L.2    Roa, S.3    Pham, P.4    Goodman, M.F.5    Scharff, M.D.6    Bergman, A.7
  • 16
    • 20444450849 scopus 로고    scopus 로고
    • Germinal centers still hold secrets
    • MacLennan I.C. Germinal centers still hold secrets. Immunity 2005, 22:656-657.
    • (2005) Immunity , vol.22 , pp. 656-657
    • MacLennan, I.C.1
  • 17
    • 27644489367 scopus 로고    scopus 로고
    • Immunoglobulin gene diversification
    • Maizels N. Immunoglobulin gene diversification. Annu. Rev. Genet. 2005, 39:23-46.
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 23-46
    • Maizels, N.1
  • 18
    • 0032559223 scopus 로고    scopus 로고
    • Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection
    • Melamed D., Benschop R.J., Cambier J.C., Nemazee D. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 1998, 92:173-182.
    • (1998) Cell , vol.92 , pp. 173-182
    • Melamed, D.1    Benschop, R.J.2    Cambier, J.C.3    Nemazee, D.4
  • 20
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000, 102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 21
  • 24
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham P., Bransteitter R., Petruska J., Goodman M.F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 2003, 424:103-107.
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 25
    • 0029164869 scopus 로고
    • Light chain replacement: a new model for antibody gene rearrangement
    • Prak E.L., Weigert M. Light chain replacement: a new model for antibody gene rearrangement. J. Exp. Med. 1995, 182:541-548.
    • (1995) J. Exp. Med. , vol.182 , pp. 541-548
    • Prak, E.L.1    Weigert, M.2
  • 27
    • 1542619234 scopus 로고    scopus 로고
    • Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
    • Rogozin I.B., Diaz M. Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process. J. Immunol. 2004, 172:3382-3384.
    • (2004) J. Immunol. , vol.172 , pp. 3382-3384
    • Rogozin, I.B.1    Diaz, M.2
  • 28
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • Rogozin I.B., Kolchanov N.A. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1992, 1171:11-18.
    • (1992) Biochim. Biophys. Acta , vol.1171 , pp. 11-18
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 29
    • 0035379581 scopus 로고    scopus 로고
    • Somatic mutation hotspots correlate with DNA polymerase eta error spectrum
    • Rogozin I.B., Pavlov Y.I., Bebenek K., Matsuda T., Kunkel T.A. Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Nat. Immunol. 2001, 2:530-536.
    • (2001) Nat. Immunol. , vol.2 , pp. 530-536
    • Rogozin, I.B.1    Pavlov, Y.I.2    Bebenek, K.3    Matsuda, T.4    Kunkel, T.A.5
  • 30
    • 0036449454 scopus 로고    scopus 로고
    • DNA target motifs of somatic mutagenesis in antibody genes
    • Shapiro G.S., Wysocki L.J. DNA target motifs of somatic mutagenesis in antibody genes. Crit. Rev. Immunol. 2002, 22:183-200.
    • (2002) Crit. Rev. Immunol. , vol.22 , pp. 183-200
    • Shapiro, G.S.1    Wysocki, L.J.2
  • 31
    • 0001578946 scopus 로고
    • The influence of somatic mutation on clonal expansion
    • Proceedings of the Seventh International Congress of Immunology
    • Shlomchik M.J., Litwin S., Weigert M. The influence of somatic mutation on clonal expansion. Prog. Immunol. 1990, VII:415.
    • (1990) Prog. Immunol. , vol.7 , pp. 415
    • Shlomchik, M.J.1    Litwin, S.2    Weigert, M.3
  • 32
    • 0029947265 scopus 로고    scopus 로고
    • Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells
    • Smith D.S., Creadon G., Jena P.K., Portanova J.P., Kotzin B.L., Wysocki L.J. Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells. J. Immunol. 1996, 156:2642-2652.
    • (1996) J. Immunol. , vol.156 , pp. 2642-2652
    • Smith, D.S.1    Creadon, G.2    Jena, P.K.3    Portanova, J.P.4    Kotzin, B.L.5    Wysocki, L.J.6
  • 34
    • 1342282983 scopus 로고    scopus 로고
    • DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine
    • Yu K., Huang F.T., Lieber M.R. DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine. J. Biol. Chem. 2004, 279:6496-6500.
    • (2004) J. Biol. Chem. , vol.279 , pp. 6496-6500
    • Yu, K.1    Huang, F.T.2    Lieber, M.R.3
  • 35
    • 0035377269 scopus 로고    scopus 로고
    • DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
    • Zeng X., Winter D.B., Kasmer C., Kraemer K.H., Lehmann A.R., Gearhart P.J. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat. Immunol. 2001, 2:537-541.
    • (2001) Nat. Immunol. , vol.2 , pp. 537-541
    • Zeng, X.1    Winter, D.B.2    Kasmer, C.3    Kraemer, K.H.4    Lehmann, A.R.5    Gearhart, P.J.6
  • 36
    • 18644366944 scopus 로고    scopus 로고
    • Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation
    • Zheng N.Y., Wilson K., Jared M., Wilson P.C. Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation. J. Exp. Med. 2005, 201:1467-1478.
    • (2005) J. Exp. Med. , vol.201 , pp. 1467-1478
    • Zheng, N.Y.1    Wilson, K.2    Jared, M.3    Wilson, P.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.