메뉴 건너뛰기




Volumn 345, Issue 3, 2013, Pages 483-491

Ezetimibe increases hepatic iron levels in mice fed a high-fat diets

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A OXIDASE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; CD71 ANTIGEN; CHOLESTEROL; EZETIMIBE; FAS ANTIGEN; FERRITIN; FERRITIN H; FERRITIN L; HEMOJUVELIN; HEPCIDIN; HEPHAESTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; IRON; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NEOGENIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 84878061834     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.203448     Document Type: Article
Times cited : (6)

References (53)
  • 1
    • 84873522131 scopus 로고    scopus 로고
    • Dietary fat level affects tissue iron levels but not the iron regulatory gene HAMP in rats
    • Ahmed U and Oates PS (2013) Dietary fat level affects tissue iron levels but not the iron regulatory gene HAMP in rats. Nutr Res 33:126-135.
    • (2013) Nutr Res , vol.33 , pp. 126-135
    • Ahmed, U.1    Oates, P.S.2
  • 5
    • 83355169559 scopus 로고    scopus 로고
    • Diet-induced obesity leads to decreased hepatic iron storage in mice
    • Chung J, Kim MS, and Han SN (2011) Diet-induced obesity leads to decreased hepatic iron storage in mice. Nutr Res 31:915-921.
    • (2011) Nutr Res , vol.31 , pp. 915-921
    • Chung, J.1    Kim, M.S.2    Han, S.N.3
  • 6
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP and James OF (1998) Steatohepatitis: A tale of two "hits"? Gastroenterology 114:842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 7
    • 84859929103 scopus 로고    scopus 로고
    • Ezetimibe: Its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic fatty liver disease
    • de Bari O, Neuschwander-Tetri BA, Liu M, Portincasa P, and Wang DQ (2012) Ezetimibe: Its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic fatty liver disease. J Lipids 2012:302847 .
    • (2012) J Lipids , vol.2012 , pp. 302847
    • De Bari, O.1    Neuschwander-Tetri, B.A.2    Liu, M.3    Portincasa, P.4    Wang, D.Q.5
  • 8
    • 0036838570 scopus 로고    scopus 로고
    • Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice
    • Dupic F, Fruchon S, Bensaid M, Loreal O, Brissot P, Borot N, Roth MP, and Coppin H (2002) Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice. Gut 51:648-653.
    • (2002) Gut , vol.51 , pp. 648-653
    • Dupic, F.1    Fruchon, S.2    Bensaid, M.3    Loreal, O.4    Brissot, P.5    Borot, N.6    Roth, M.P.7    Coppin, H.8
  • 10
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, and Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 19
    • 1442314640 scopus 로고    scopus 로고
    • Body iron stores in relation to risk of type 2 diabetes in apparently healthy women
    • Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, and Hu FB (2004) Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 291: 711-717.
    • (2004) JAMA , vol.291 , pp. 711-717
    • Jiang, R.1    Manson, J.E.2    Meigs, J.B.3    Ma, J.4    Rifai, N.5    Hu, F.B.6
  • 20
    • 4644243396 scopus 로고    scopus 로고
    • Serum ferritin and risk of the metabolic syndrome in U.S. adults
    • Jehn M, Clark JM, and Guallar E (2004) Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care 27:2422-2428.
    • (2004) Diabetes Care , vol.27 , pp. 2422-2428
    • Jehn, M.1    Clark, J.M.2    Guallar, E.3
  • 21
    • 65549134351 scopus 로고    scopus 로고
    • Inhibition of constitutively activated nuclear factor-kB induces reactive oxygen species-and iron-dependent cell death in cutaneous T-cell lymphoma
    • Kiessling MK, Klemke CD, Kaminski MM, Galani IE, Krammer PH, and Gülow K (2009) Inhibition of constitutively activated nuclear factor-kB induces reactive oxygen species-and iron-dependent cell death in cutaneous T-cell lymphoma. Cancer Res 69:2365-2374.
    • (2009) Cancer Res , vol.69 , pp. 2365-2374
    • Kiessling, M.K.1    Klemke, C.D.2    Kaminski, M.M.3    Galani, I.E.4    Krammer, P.H.5    Gülow, K.6
  • 22
    • 33751020540 scopus 로고    scopus 로고
    • Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease
    • Kirsch R, Sijtsema HP, Tlali M, Marais AD, and Hall PdeL (2006) Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease. Liver Int 26: 1258-1267.
    • (2006) Liver Int , vol.26 , pp. 1258-1267
    • Kirsch, R.1    Sijtsema, H.P.2    Tlali, M.3    Marais, A.D.4    Hall, PdeL.5
  • 23
    • 79956301571 scopus 로고    scopus 로고
    • The role of oxidative stress in non-alcoholic steatohepatitis
    • Koek GH, Liedorp PR, and Bast A (2011) The role of oxidative stress in non-alcoholic steatohepatitis. Clin Chim Acta 412:1297-1305.
    • (2011) Clin Chim Acta , vol.412 , pp. 1297-1305
    • Koek, G.H.1    Liedorp, P.R.2    Bast, A.3
  • 30
    • 79251532050 scopus 로고    scopus 로고
    • Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease
    • Nonalcoholic Steatohepatitis Clinical Research Network
    • Nelson JE, Wilson L, Brunt EM, Yeh MM, Kleiner DE, Unalp-Arida A, and Kowdley KV; Nonalcoholic Steatohepatitis Clinical Research Network (2011) Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease. Hepatology 53:448-457.
    • (2011) Hepatology , vol.53 , pp. 448-457
    • Nelson, J.E.1    Wilson, L.2    Brunt, E.M.3    Yeh, M.M.4    Kleiner, D.E.5    Unalp-Arida, A.6    Kowdley, K.V.7
  • 31
    • 73949151893 scopus 로고    scopus 로고
    • Synergistic influence of Abcb1 and Abcc2 on disposition and sterol lowering effects of ezetimibe in rats
    • Oswald S, May K, Rosin J, Lütjohann D, and Siegmund W (2010) Synergistic influence of Abcb1 and Abcc2 on disposition and sterol lowering effects of ezetimibe in rats. J Pharm Sci 99:422-429.
    • (2010) J Pharm Sci , vol.99 , pp. 422-429
    • Oswald, S.1    May, K.2    Rosin, J.3    Lütjohann, D.4    Siegmund, W.5
  • 32
    • 33747606815 scopus 로고    scopus 로고
    • Disposition and sterol-lowering effect of ezetimibe in multidrug resistanceassociated protein 2-deficient rats
    • Oswald S, Westrup S, Grube M, Kroemer HK, Weitschies W, and SiegmundW (2006) Disposition and sterol-lowering effect of ezetimibe in multidrug resistanceassociated protein 2-deficient rats. J Pharmacol Exp Ther 318:1293-1299.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1293-1299
    • Oswald, S.1    Westrup, S.2    Grube, M.3    Kroemer, H.K.4    Weitschies, W.5    Siegmund, W.6
  • 37
  • 38
    • 69249233513 scopus 로고    scopus 로고
    • Role of hepatic iron in non-alcoholic steatohepatitis
    • Sumida Y, Yoshikawa T, and Okanoue T (2009) Role of hepatic iron in non-alcoholic steatohepatitis. Hepatol Res 39:213-222.
    • (2009) Hepatol Res , vol.39 , pp. 213-222
    • Sumida, Y.1    Yoshikawa, T.2    Okanoue, T.3
  • 39
    • 84863554957 scopus 로고    scopus 로고
    • Ezetimibe ameliorates atherosclerotic and inflammatory markers, atherogenic lipid profiles, insulin sensitivity, and liver dysfunction in Japanese patients with hypercholesterolemia
    • Tamaki N, Ueno H, Morinaga Y, Shiiya T, and Nakazato M (2012) Ezetimibe ameliorates atherosclerotic and inflammatory markers, atherogenic lipid profiles, insulin sensitivity, and liver dysfunction in Japanese patients with hypercholesterolemia. J Atheroscler Thromb 19:532-538.
    • (2012) J Atheroscler Thromb , vol.19 , pp. 532-538
    • Tamaki, N.1    Ueno, H.2    Morinaga, Y.3    Shiiya, T.4    Nakazato, M.5
  • 40
    • 84868152812 scopus 로고    scopus 로고
    • Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice
    • Tanaka Y, Ikeda T, Yamamoto K, Ogawa H, and Kamisako T (2012) Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice. J Gastroenterol Hepatol 27:1711-1717.
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 1711-1717
    • Tanaka, Y.1    Ikeda, T.2    Yamamoto, K.3    Ogawa, H.4    Kamisako, T.5
  • 41
    • 24344434227 scopus 로고    scopus 로고
    • Pathways for the regulation of body iron homeostasis in response to experimental iron overload
    • Theurl I, Ludwiczek S, Eller P, Seifert M, Artner E, Brunner P, and Weiss G (2005) Pathways for the regulation of body iron homeostasis in response to experimental iron overload. J Hepatol 43:711-719.
    • (2005) J Hepatol , vol.43 , pp. 711-719
    • Theurl, I.1    Ludwiczek, S.2    Eller, P.3    Seifert, M.4    Artner, E.5    Brunner, P.6    Weiss, G.7
  • 42
    • 50849134822 scopus 로고    scopus 로고
    • The intestine as a regulator of cholesterol homeostasis in diabetes
    • Tomkin GH (2008) The intestine as a regulator of cholesterol homeostasis in diabetes. Atheroscler Suppl 9:27-32.
    • (2008) Atheroscler Suppl , vol.9 , pp. 27-32
    • Tomkin, G.H.1
  • 43
    • 0002413872 scopus 로고
    • in Iron (Cook JD, ed, ed) , Livingstone, New York
    • Torrance JD and Bothwell TH (1980) Tissue iron stores, in Iron (Cook JD, ed, ed) pp 90-115, Livingstone, New York.
    • (1980) Tissue Iron Stores , pp. 90-115
    • Torrance, J.D.1    Bothwell, T.H.2
  • 46
    • 33745742487 scopus 로고    scopus 로고
    • Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
    • Vokurka M, Krijt J, Sulc K, and Necas E (2006) Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res 55:667-674.
    • (2006) Physiol Res , vol.55 , pp. 667-674
    • Vokurka, M.1    Krijt, J.2    Sulc, K.3    Necas, E.4
  • 47
    • 21044434748 scopus 로고    scopus 로고
    • First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
    • Wallace DF, Summerville L, Lusby PE, and Subramaniam VN (2005) First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut 54:980-986.
    • (2005) Gut , vol.54 , pp. 980-986
    • Wallace, D.F.1    Summerville, L.2    Lusby, P.E.3    Subramaniam, V.N.4
  • 48
    • 65949105929 scopus 로고    scopus 로고
    • Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor
    • Wang W, Reeves WB, and Ramesh G (2009) Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor. Am J Physiol Renal Physiol 296:F723-F729.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Wang, W.1    Reeves, W.B.2    Ramesh, G.3
  • 49
    • 78149246362 scopus 로고    scopus 로고
    • The hazards of iron loading
    • Weinberg ED (2010) The hazards of iron loading. Metallomics 2:732-740.
    • (2010) Metallomics , vol.2 , pp. 732-740
    • Weinberg, E.D.1
  • 50
    • 79954415297 scopus 로고    scopus 로고
    • Induction of microsomal triglyceride transfer protein expression is a candidate mechanism by which ezetimibe therapy might exert beneficial effects in patients with nonalcoholic steatohepatitis
    • author reply 417
    • Yoneda M, Fujita K, Imajo K,Mawatari H, Kirikoshi H, Saito S, and Nakajima A (2011) Induction of microsomal triglyceride transfer protein expression is a candidate mechanism by which ezetimibe therapy might exert beneficial effects in patients with nonalcoholic steatohepatitis. J Gastroenterol 46:415-416, author reply 417.
    • (2011) J Gastroenterol , vol.46 , pp. 415-416
    • Yoneda, M.1    Fujita, K.2    Imajo, K.3    Mawatari, H.4    Kirikoshi, H.5    Saito, S.6    Nakajima, A.7
  • 52
    • 69249118614 scopus 로고    scopus 로고
    • Hemojuvelinneogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression
    • Zhang AS, Yang F, Wang J, Tsukamoto H, and Enns CA (2009) Hemojuvelinneogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. J Biol Chem 284:22580-22589.
    • (2009) J Biol Chem , vol.284 , pp. 22580-22589
    • Zhang, A.S.1    Yang, F.2    Wang, J.3    Tsukamoto, H.4    Enns, C.A.5
  • 53
    • 41149120450 scopus 로고    scopus 로고
    • Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice
    • Zheng S, Hoos L, Cook J, Tetzloff G, Davis H, Jr, van Heek M, and Hwa JJ (2008) Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice. Eur J Pharmacol 584:118-124.
    • (2008) Eur J Pharmacol , vol.584 , pp. 118-124
    • Zheng, S.1    Hoos, L.2    Cook, J.3    Tetzloff, G.4    Davis Jr., H.5    Van Heek, M.6    Hwa, J.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.