Fluorine-Protein Interactions and 19F NMR Isotropic Chemical Shifts: An Empirical Correlation with Implications for Drug Design

ChemMedChem

Volumn 6, Issue 1, 2011, Pages 104-114

  Dalvit, Claudio ^a   Vulpetti, Anna ^b  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Drug design; Fluorinated fragments; Fluorine chemistry; NMR spectroscopy; Protein ligand interactions

Indexed keywords

CARBON; FLUORINE; LIGAND; PROTEIN; RECEPTOR;

ARTICLE; ATOM; CRYSTAL STRUCTURE; DATA BASE; DRUG DESIGN; ELECTRON; EXPERIMENT; FLUORINATION; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM CHEMISTRY;

BINDING SITES; DATABASES, PROTEIN; DRUG DESIGN; FLUORINE; HUMANS; HYDROGEN BONDING; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, IMMUNOLOGIC;

EID: 78650552642     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000412     Document Type: Article

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