The neuroimmune system in Alzheimer's disease: The glass is half full

Advances in Alzheimer's Disease

Volumn 3, Issue , 2012, Pages 295-302

  Hickman, Suzanne E ^a   El Khoury, Joseph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; amyloid ; chemokines; microglia; mononuclear phagocytes; scavenger receptors

Indexed keywords

AMYLOID BETA PROTEIN; CD36 ANTIGEN; CHEMOKINE RECEPTOR CCR2; COMPLEMENT COMPONENT C1Q; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; SCAVENGER RECEPTOR A; SCAVENGER RECEPTOR A1; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; BLOOD BRAIN BARRIER; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; INFLAMMATION; MICROGLIA; MONONUCLEAR PHAGOCYTE; NERVE DEGENERATION; NEUROIMMUNOLOGY; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RECEPTOR BINDING;

EID: 84877974951     PISSN: 22105727     EISSN: 22105735     Source Type: Book Series    
DOI: 10.3233/978-1-61499-154-0-295     Document Type: Article

References (53)

1. Lawson LJ, Perry VH, Dri P, Gordon S (1990) Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39, 151-170
2. ClayW(1900) A Textbook of Pathology in Relation to Mental Disease, Edinburgh
3. Rezaie P, Male D (2002) Mesoglia & microglia-A historical review of the concept of mononuclear phagocytes within the central nervous system. J Hist Neurosci 11, 325-374
4. Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318
5. Chan WY, Kohsaka S, Rezaie P (2007) The origin and cell lineage of microglia: New concepts. Brain Res Rev 53, 344-354
6. Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, Capecchi MR (2010) Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell 141, 775-785
7. Priller J, Prinz M, Heikenwalder M, Zeller N, Schwarz P, Heppner FL, Aguzzi A (2006) Early and rapid engraftment of bone marrow-derived microglia in scrapie. J Neurosci 26, 11753-11762
8. Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwalder M, BruckW, Priller J, PrinzM(2007) Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci 10, 1544-1553
9. El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD (2003) CD36 mediates the innate host response to beta-Amyloid. J Exp Med 197, 1657-1666
10. Webster SD, ParkM,Fonseca MI,Tenner AJ (2000) Structural and functional evidence for microglial expression of C1qR(P), the C1q receptor that enhances phagocytosis. J Leukoc Biol 67, 109-116
11. Ulvestad E, Williams K, Bjerkvig R, Tiekotter K, Antel J, Matre R (1994) Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells. J Leukoc Biol 56, 732-740
12. Ribes S, Ebert S, Regen T, Agarwal A, Tauber SC, Czesnik D, Spreer A, Bunkowski S, Eiffert H, Hanisch UK, Hammerschmidt S, Nau R (2009) Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia. Infect Immun 78, 865-871
13. Takahashi K, Rochford CD, Neumann H (2005) Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med 201, 647-657
14. Beauvillain C, Donnou S, Jarry U, Scotet M, Gascan H, Delneste Y, Guermonprez P, Jeannin P, Couez D (2008) Neonatal and adult microglia cross-present exogenous antigens. Glia 56, 69-77
15. Guillemin GJ, Brew BJ (2004) Microglia, macrophages, perivascular macrophages, and pericytes:Areviewof function and identification. J Leukoc Biol 75, 388-397
16. Fabriek BO,Van Haastert ES, Galea I, PolflietMM,Dopp ED, Van Den Heuvel MM, Van Den Berg TK, De Groot CJ, Van Der Valk P, Dijkstra CD (2005) CD163-positive perivascular macrophages in the humanCNSexpress molecules for antigen recognition and presentation. Glia 51, 297-305
17. Kim WK, Alvarez X, Fisher J, Bronfin B, Westmoreland S, McLaurin J, Williams K (2006) CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood. Am J Pathol 168, 822-834
18. Audoy-Remus J, Richard JF, Soulet D, Zhou H, Kubes P, Vallieres L (2008) Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2. J Neurosci 28, 10187-10199
19. Bechmann I, Priller J, Kovac A, Bontert M, Wehner T, Klett FF, Bohsung J, Stuschke M, Dirnagl U, Nitsch R (2001) Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages. Eur J Neurosci 14, 1651-1658
20. Frautschy SA,Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM (1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol 152, 307-317
21. Tooyama I, Kimura H, Akiyama H, McGeer PL (1990) Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease. Brain Res 523, 273-280
22. McGeer EG, McGeer PL (2010) Neuroinflammation in Alzheimer's disease and mild cognitive impairment: A field in its infancy. J Alzheimers Dis 19, 355-361
23. Meda L, Cassatella MA, Szendrei GI, Otvos L Jr, Baron P, Villalba M, Ferrari D, Rossi F (1995) Activation of microglial cells by beta-Amyloid protein and interferon-gamma. Nature 374, 647-650
24. Fraser I, Hughes D, Gordon S (1993) Divalent cationindependent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor. Nature 364, 343-346
25. el Khoury J, Thomas CA, Loike JD, Hickman SE, Cao L, Silverstein SC (1994) Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors. J Biol Chem 269, 10197-10200
26. Jiang H, Burdick D, Glabe CG, CotmanCW,Tenner AJ (1994) beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol 152, 5050-5059
27. Christie RH, Freeman M, HymanBT(1996) Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. Am J Pathol 148, 399-403
28. El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD (1996) Scavenger receptor-mediated adhesion of microglia to beta-Amyloid fibrils. Nature 382, 716-719
29. Maxeiner H, Husemann J, Thomas CA, Loike JD, El Khoury J, Silverstein SC (1998) Complementary roles for scavenger receptor A and CD36 of human monocyte-derived macrophages in adhesion to surfaces coated with oxidized low-density lipoproteins and in secretion of H2O2. J Exp Med 188, 2257-2265
30. Coraci IS, Husemann J, Berman JW, Hulette C, Dufour JH, Campanella GK, Luster AD, Silverstein SC, El-Khoury JB (2002) CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to betaamyloid fibrils. Am J Pathol 160, 101-112
31. Means TK, Mylonakis E, Tampakakis E, Colvin RA, Seung E, Puckett L, Tai MF, Stewart CR, Pukkila-Worley R, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury J (2009) Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med 206, 637-653
32. Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, El Khoury J, Golenbock DT, Moore KJ (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 11, 155-161
33. Wilkinson K, Boyd JD, Glicksman M, Moore KJ, El Khoury J (2011) A high-content drug screen identifies ursolic acid as an inhibitor of amyloid-{beta} interactions with its receptor CD36. J Biol Chem 286(40), 34914-34922
34. Djukic M, Mildner A, Schmidt H, Czesnik D, BruckW, Priller J, Nau R, Prinz M (2006) Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice. Brain 129, 2394-2403
35. Charlier C, Nielsen K, Daou S, Brigitte M, Chretien F, Dromer F (2009) Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans. Infect Immun 77, 120-127
36. Chretien F, Lortholary O, Kansau I, Neuville S, Gray F, Dromer F (2002) Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia. J Infect Dis 186, 522-530
37. El Khoury J (2012) The blood brain barrier and pathogens: Hadrian's wall or a Dardanian gate? Virulence 3, 157-158
38. Remington LT, Babcock AA, Zehntner SP, Owens T (2007) Microglial recruitment, activation, and proliferation in response to primary demyelination. Am J Pathol 170, 1713-1724
39. Kokovay E, Cunningham LA (2005) Bone marrow-derived microglia contribute to the neuroinflammatory response and express iNOS in the MPTP mouse model of Parkinson's disease. Neurobiol Dis 19, 471-478
40. Viola A, Luster AD (2008) Chemokines and their receptors: Drug targets in immunity and inflammation. Annu Rev Pharmacol Toxicol 48, 171-197
41. Barlic J, Murphy PM (2007) Chemokine regulation of atherosclerosis. J Leukoc Biol 82, 226-236
42. Izikson L, Klein RS, Charo IF,Weiner HL, Luster AD (2000) Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med 192, 1075-1080
43. Ishizuka K, Kimura T, Igata-yi R, Katsuragi S, Takamatsu J, Miyakawa T (1997) Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin Neurosci 51, 135-138
44. Sokolova A, Hill MD, Rahimi F, Warden LA, Halliday GM, Shepherd CE (2009) Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease. Brain Pathol 19, 392-398
45. El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 13, 432-438
46. Hawkes CA, McLaurin J (2009) Selective targeting of perivascular macrophages for clearance of beta-Amyloid in cerebral amyloid angiopathy. Proc Natl Acad Sci U S A 106, 1261-1266
47. Kumar-Singh S, Pirici D, McGowan E, Serneels S, Ceuterick C, Hardy J, Duff K, Dickson D, Van Broeckhoven C (2005) Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. Am J Pathol 167, 527-543
48. Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19, 939-945
49. Jankowsky JL, Slunt HH, Ratovitski T, JenkinsNA, Copeland NG, Borchelt DR (2001) Co-expression of multiple transgenes in mouse CNS: A comparison of strategies. Biomol Eng 17, 157-165
50. Hickman SE, Allison EK, El Khoury J (2008) Microglial dysfunction and defective beta-Amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 28, 8354-8360
51. Fiala M, Lin J, Ringman J, Kermani-Arab V, Tsao G, Patel A, Lossinsky AS, Graves MC, Gustavson A, Sayre J, Sofroni E, Suarez T, Chiappelli F, BernardG(2005) Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients. J Alzheimers Dis 7, 221-232; discussion 255-262
52. Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T (2007) Interferon-gamma and tumor necrosis factor-Alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol 170, 680-692
53. Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS (2004) Tumor necrosis factor-Alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNKdependent MAPK pathway. J Biol Chem 279, 49523-49532