Aldehyde oxidase and its importance in novel drug discovery: Present and future challenges

Expert Opinion on Drug Discovery

Volumn 8, Issue 6, 2013, Pages 641-654

  Garattini, Enrico ^a   Terao, Mineko ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Aldehyde oxidase; Drug discovery; Drug metabolism; Environmental pollutants; Molybdo enzymes

Indexed keywords

ALDEHYDE OXIDASE; CAFFEINE; CITALOPRAM; CYTOCHROME P450; MERCAPTOPURINE; METHOTREXATE; PHTHALAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; PROLINTANE; PYRROLIDINE DERIVATIVE; RESORUFIN; RETINAL; TAMOXIFEN; VANILLIN; XANTHINE OXIDASE; XENOBIOTIC AGENT;

AMINO TERMINAL SEQUENCE; BIOTRANSFORMATION; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; CHROMOSOME; COMPUTER MODEL; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; CYTOSOLIC FRACTION; DRUG METABOLISM; ELECTRON; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; EXPERIMENTAL STUDY; GENE DUPLICATION; HUMAN; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; LIVER; MISSENSE MUTATION; NONHUMAN; NUCLEOPHILICITY; POLLUTANT; PRIORITY JOURNAL; PSEUDOGENE; REVIEW; SYNTHESIS; WESTERN BLOTTING;

ALDEHYDE OXIDASE; ANIMALS; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; FLAVOPROTEINS; HUMANS; MOLYBDENUM; SUBSTRATE SPECIFICITY;

EID: 84877967554     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2013.788497     Document Type: Review

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