In vivo-in vitro relationship of methotrexate 7-hydroxylation by aldehyde oxidase in four different strain rats.

Drug metabolism and pharmacokinetics

Volumn 21, Issue 6, 2006, Pages 485-491

  Moriyasu, Aya ^a   Sugihara, Kazumi ^a   Nakatani, Keiko ^a   Ohta, Shigeru ^a   Kitamura, Shigeyuki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYMETHOTREXATE; 7-HYDROXYMETHOTREXATE; ALDEHYDE OXIDASE; DRUG DERIVATIVE; FOLIC ACID ANTAGONIST; METHOTREXATE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BILE; CHEMISTRY; CYTOSOL; ENZYMOLOGY; FECES; LIVER; MALE; METABOLISM; RAT; RAT STRAIN; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; URINE; WISTAR RAT;

ALDEHYDE OXIDASE; ANIMALS; BILE; CYTOSOL; FECES; FOLIC ACID ANTAGONISTS; LIVER; MALE; METHOTREXATE; RATS; RATS, INBRED STRAINS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SPECIES SPECIFICITY;

EID: 33847709895     PISSN: 13474367     EISSN: None     Source Type: Journal    
DOI: 10.2133/dmpk.21.485     Document Type: Article

References (0)