Discovery of a highly potent series of TLR7 agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5939-5943

  Jones, Peter ^a   Pryde, David C ^a   Tran, Thien Duc ^a   Adam, Fiona M ^a   Bish, Gerwyn ^a   Calo, Frederick ^a   Ciaramella, Guiseppe ^a   Dixon, Rachel ^b   Duckworth, Jonathan ^a   Fox, David N A ^a   Hay, Duncan A ^a   Hitchin, James ^b   Horscroft, Nigel ^a   Howard, Martin ^a   Laxton, Carl ^a   Parkinson, Tanya ^a   Parsons, Gemma ^a   Proctor, Katie ^a   Smith, Mya C ^a   Smith, Nicholas ^a   Thomas, Amy ^a   more..

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b SRG   (United Kingdom)

Author keywords

Aldehyde oxidase; Deazapurine; HCV; Pyridine oxidation; TLR7 agonists

Indexed keywords

ALDEHYDE OXIDASE; PURINE DERIVATIVE; PYRIDINE DERIVATIVE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 7 AGONIST; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; NONHUMAN; OXIDATION; RAT; STRUCTURE ACTIVITY RELATION;

ALDEHYDE OXIDASE; ANIMALS; ANTIVIRAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HEPACIVIRUS; HEPATITIS C; HUMANS; INJECTIONS, INTRAVENOUS; INTERFERON INDUCERS; INTERFERONS; MICROSOMES, LIVER; MOLECULAR TARGETED THERAPY; MOLECULAR WEIGHT; PURINES; RATS; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 7;

HEPATITIS C VIRUS; RATTUS;

EID: 80052583341     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.076     Document Type: Article

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