Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 4, 1999, Pages 411-418

  Jordan, C Geraldine M ^a,c   Rashidi, Mohammed R ^a   Laljee, Hussain ^a   Clarke, Stephen E ^b   Brown, John E ^a   Beedham, Christine ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYMETHOTREXATE; ALDEHYDE OXIDASE; ALLOPURINOL; CHLORPROMAZINE; FOLIC ACID ANTAGONIST; LIVER ENZYME; MENADIONE; METHOTREXATE;

ANIMAL EXPERIMENT; ARTICLE; DRUG METABOLISM; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER METABOLISM; NONHUMAN; OXIDATION; RABBIT;

ACYCLOVIR; ALDEHYDE OXIDASE; ALDEHYDE OXIDOREDUCTASES; ALLOPURINOL; ANIMALS; CHLORPROMAZINE; ENZYME INHIBITORS; GUINEA PIGS; HUMANS; KINETICS; LIVER; METHOTREXATE; OXIDATION-REDUCTION; RABBITS; SPECIES SPECIFICITY; STEREOISOMERISM; SUBSTRATE SPECIFICITY; VITAMIN K;

EID: 0032992164     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772619     Document Type: Article

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