Toxin-antitoxin systems: Classification, biological function and application in biotechnology

Current Issues in Molecular Biology

Volumn 16, Issue 1, 2014, Pages 9-14

  Ghafourian, Sobhan ^a,b   Raftari, Mohammad ^a   Sadeghifard, Nourkhoda ^b   Sekawi, Zamberi ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b ILAM UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITOXIN; UNTRANSLATED RNA; BACTERIAL PROTEIN; BACTERIAL SECRETION SYSTEM; BACTERIAL TOXIN;

APOPTOSIS; ARTICLE; BACTERIAL CELL; BACTERIAL GENOME; BACTERIAL MEMBRANE; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIAL SURVIVAL; BACTERIOPHAGE; BIOFILM; BIOTECHNOLOGY; CELL SURVIVAL; DEGRADATION KINETICS; DRUG TARGETING; GENE CONTROL; MEMBRANE FORMATION; NONHUMAN; PLASMID; PROTEIN SYNTHESIS; REPORTER GENE; TOXIN ANALYSIS; TYPE I TOXIN ANTITOXIN SYSTEM; TYPE II TOXIN ANTITOXIN SYSTEM; TYPE III TOXIN ANTITOXIN SYSTEM; TYPE IV TOXIN ANTITOXIN SYSTEM; ANTAGONISTS AND INHIBITORS; BACTERIAL SECRETION SYSTEM; BIOSYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HUMAN; LACTOBACILLUS CASEI; LISTERIA MONOCYTOGENES; METABOLISM; PROCEDURES; STAPHYLOCOCCUS SAPROPHYTICUS;

ANTITOXINS; BACTERIAL PROTEINS; BACTERIAL SECRETION SYSTEMS; BACTERIAL TOXINS; BIOTECHNOLOGY; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; LACTOBACILLUS CASEI; LISTERIA MONOCYTOGENES; STAPHYLOCOCCUS SAPROPHYTICUS;

EID: 84877936018     PISSN: 14673037     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Aridani, O. R., Nikravesh, A., Pandey, D.P., Gerdes, K., and Good, L. (2006). Competitive inhibition of natural antisense Sok-RNA interactions activates Hok-mediated cell killing in Escherichia coli. Nucleic Acids Res. 34, 5915-22.
2. Aizenman, E., Engelberg-Kulka, H., and Glaser, G. (1996). An Escherichia coli chromosomal 'addiction module' regulated by guanosine 30,50-bispyrophosphate: a model for programmed bacterial cell death. Proc. Natl Acad. Sci, 93, 6059-6063.
3. Bernard, P., and Couturier, M. (1992). Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes. J. Mol. Biol. 226, 735-45.
4. Bernard, P., Gabant, P., Bahassi, E.M., and Couturier, M. (1994). Positive-selection vectors using the F plasmid ccdB killer gene. Gene, 148, 71-74.
5. Blower, T.R., Pei, X.Y., Short, F.L., Fineran, P.C., Humphreys, D.P., Luisi, B.F., and Salmond, G.P.C. (2011). A processed noncoding RNA regulates an altruistic bacterial antiviral system. Nat Struct Mol Biol. 18, 185-190.
6. Chan, W.T., Nieto, C, Harikrishna, J.H., Khoo, S.K., Othman R.Y., Espinosa, M., and Yeo, C.C. (2011). Genetic Regulation of the yefM-yoeB Toxin-Antitoxin Locus of Streptococcus pneumoniae. J. Bacteriol. 193, 4612-4625.
7. Christensen-Dalsgaard, M., Overgaard, M., Winther, K.S., and Gerdes K. (2008). RNA decay by messenger RNA interferases. Meth Enzymol, 447, 521-35.
8. Durand, S., Jahn, N., Condon, C., and Brantl, S. (2012). Type I toxin-antitoxin systems in Bacillus subtilis. RNA Biol, 9.
9. Fineran, P.C., Blower, T.R., Foulds, I.J., Humphreys, D.P., Lilley, K.S., and Salmond, G.P. (2009). The phage abortive infection system, ToxIN, functions as a protein-RNA toxinantitoxin pair. Proc Natl Acad Sci, 106, 894-899.
10. Fozo, E.M., Hemm, M.R., and Storz, G. (2008). Small toxic proteins and the antisense RNAs that repress them. Microbiol Mol Bio Rev. 72, 579-89.
11. Fozo, E.M., Makarova, K.S., Shabalina, S.A., Yutin, N., Koonin, E.V., and Storz, G. (2010). Abundance of type Toxin-antitoxin Systems 13 I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of nove families. Nucleic Acids Res, 38, 3743-59.
12. Fozo, E.M. (2012). New type I toxin-antitoxin families from "wild" and laboratory strains of E. coli: Ibs-Sib, ShoB-OhsC and Zor-Orz. RNA Biol, 9.
13. Gross, M., Marianovsky, I., and Glaser, G. (2006). MazG - a regulator of programmed cell death in Escherichia coli. Mol Microbiol, 59, 590-601.
14. Gonzalez-Barrios, A.F. (2006). Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J Bacteriol, 188, 305-316.
15. Hayes, F. (2003). Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest. Science, 301, 1496-1499.
16. Hang, Y., Zhang, J., Hoeflich, K.P., Ikura, M., Qing, G., and Inouye, M. (2003). MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Mol. Cell 12, 913-23.
17. Harrison, J.J. (2009). The chromosomal toxin gene yafQ is a determinant of multidrug tolerance for Escherichia coli growing in a biofilm. Antimicrob. Agents Chemother, 53, 2253-2258.
18. Kawano, M. (2012). Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli: hok/sok, ldr/rdl, symE/symR. RNA Biol, 9.
19. Kim, Y., Wang, X., Ma, Q., Zhang, X.S., and Wood, T.K. (2009). Toxin-antitoxin systems in Escherichia coli influence biofilm formation through YjgK (TabA) and fimbriae. J Bacteriol, 191, 1258-1267.
20. Leplae, R., Geeraerts, D., Hallez, R., Guglielmini, J., Dreze, P., and Van Melderen, L. (2011). Diversity of bacterial type II toxinantitoxin systems: a comprehensive search and functional analysis of novel families. Nucleic Acids Res, 39, 5513-5525.
21. Lewis, K. (2008). Multidrug tolerance of biofilms and persister cells, p. 107-131. In T. Romeo (ed.), Bacterial biofilms. Springer-Verlag, Berlin, Germany.
22. Loris, R. (2003). Crystal structure of the intrinsically flexible addiction antidote MazE. J. Biol. Chem. 278, 28252-28257.
23. Maisonneuve, E., Shakespeare, L.J., Jorgensen, M.G., and Gerdes, K. (2011). Bacterial persistence by RNA endonucleases. Proc Natl Acad Sci, 108, 13206-13211.
24. Melderen, L.V., and Saavedra De Bast, M. (2009). Bacterial toxin-antitoxin systems: more than selfish entities? PLoS Genetics, 5, 1-6.
25. Ochman, H., and Davalos, L.M. (2006). The nature and dynamics of bacterial genomes. Science, 311, 1730-1733.
26. Pandey, D.P., and Gerdes, K. (2005). Toxin-antitoxin loci are highly abundant in free-living but lost from hostassociated prokaryotes. Nucleic Acids Res, 33, 966-976.
27. Pecota, D.C, and Wood, T.K. (1996). Exclusion of T4 phage by the hok/sokkiller locus from plasmid R1. J Bacteriol, 178, 2044-2050.
28. Pedersen, K., Christensen, S.K, and Gerdes, K. (2002). Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins. Mol Microbiol. 45, 501-510.
29. Stone, B.F., Cowie, M.R., Kerr, J.D., and Binnington, K.C. (1982). Improved toxin/antitoxin assays for studies on the Australian paralysis tick Ixodes holocyclus. Aust J Exp Biol Med Sci. 60. 309-18.
30. Tieber, D., Gabant, P., and Szpirer, C. (2008). The art of selective killing: plasmid toxin/antitoxin systems and their technological applications. BioTechniques. 45, 344-6.
31. Van Melderen, L., and Saavedra De Bast, M. (2009). Bacterial Toxin-Antitoxin Systems: More Than Selfish Entities? PLoS Genet. 5, e1000437.
32. Wang, X., and Wood, T.K. (2011). Toxin-antitoxin systems influence biofilm and persister cell formation and the general stress response. Appl Environ Microbiol. 77, 5577-5583.
33. Wang, X., Lord, D.M., Cheng, H.Y., Osbourne, D.O., Hong, S.H., and Sanchez-Torres, V. (A)(2012). A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nat. Chem. Biol. 8, 855-861.
34. Wang, X., Lord, D.M., Hong, S.H., Peti, W., Benedik, M.J., and Wood, T.K. (B) (2012). Type II Toxin/Antitoxin MqsR/MqsA Controls Type V Toxin/Antitoxin GhoT/GhoS. Applied Microbiol.
35. Wagner, E. G. H., and Unoson, C. (2012).The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes. RNA Biol. 9.
36. Yamaguchi, Y., Park, J., and Inouye, M. (2011). Toxinantitoxin systems in bacteria and archaea. Ann. Rev Genet. 45, 61-79.