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Volumn 311, Issue 5768, 2006, Pages 1730-1733

The nature and dynamics of bacterial genomes

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; DYNAMIC MECHANICAL ANALYSIS; DYNAMICS; ESCHERICHIA COLI; PROTEINS;

EID: 33645221999     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1119966     Document Type: Review
Times cited : (195)

References (50)
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    • note
    • The fraction of acquired genes that becomes dispensable is estimated by comparing the absolute numbers of acquired genes that are unique to E. coli K-12 to those shared among E. coli strains. Since its split from Salmonella, the E. coli lineage leading to strain K-12 acquired 394 genes, of which 91 are restricted to the genome of the K-12 strain (48). These 91 genes accumulated over a period spanning just under 5% of the history of the lineage, with the disproportionate representation of recent acquisitions attributable to the loss of older arrivals. If the acquisition rate has been relatively constant, only 303 genes remain from a total of 2093 that were introduced up to the time when K-12 diverged from other E. coli strains. Because most pseudogenes are of recent origin, the attrition rate of 85% can be applied to the 91 genes unique to E. coli K-12, yielding 77 expendable genes. In this regard, it is noteworthy that M. Taoka et al. (49) found that only a small fraction (∼10%) of genes mapping to E. coli regions specific to K-12 are translated into proteins.
  • 50
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    • Funded by NIH grant GM56120 to H.O. We thank N. Moran, A. Corthals, E. Groisman, and the three anonymous reviewers for their comments on the manuscript; E. Lerat for providing information about E. coli pseudogenes; P. Ng for assistance with SIFT; and S. Miller and B. Nankivell for technical support. The GenBank accession number for the E. coli MG1655 genome is U00096. Gene designations in tables 51 to 55 follow those in the most recent release (obtained from www.genome.wisc.edu/sequencing/updating.htm).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.