Functional genomics of pain in analgesic drug development and therapy

Pharmacology and Therapeutics

Volumn 139, Issue 1, 2013, Pages 60-70

  Lötsch, Jörn ^a,c   Doehring, Alexandra ^a   Mogil, Jeffrey S ^b   Arndt, Torsten ^a,c   Geisslinger, Gerd ^a,c   Ultsch, Alfred ^d  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b MCGILL UNIVERSITY   (Canada)

^c FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Computational biology; Drug discover; Gene ontology; Knowledge discovery; Models; Pain

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; ABT 712; ADRENERGIC RECEPTOR; AJULEMIC ACID; ALO 02; ANALGESIC AGENT; AZD 1386; AZD 2066; AZD 2423; AZD 2516; AZD 9056; BMS 741672; CE 2240535; EVT 401; FASINUMAB; FLUPIRTINE; FULRANUMAB; G PROTEIN COUPLED RECEPTOR; GABAPENTIN; GABAPENTIN ENACARBIL; GALACTOSIDASE; GRC 15300; GRC 17536; GSK 1482160; KDS 2000; KETAMINE; LY 2828360; LY 2935585; MAVATREP; MEDI 578; N METHYL DEXTRO ASPARTIC ACID; NALOXONE; NERVE GROWTH FACTOR BETA SUBUNIT; NGX 1998; OMEGA CONOTOXIN MVIIA; OPIATE; PF 04531083; PF 05089771; PF 4136309; PF 4457845; PF 4586881; PG 110; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; PREGABALIN; PROSTAGLANDIN; PROTEIN KINASE WNK1; RETIGABINE; SEROTONIN RECEPTOR; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.7; SOFINICLINE; TEZAMPANEL; UNCLASSIFIED DRUG; V 158866; Z 160;

3' UNTRANSLATED REGION; ALLELE; ANALGESIA; ANATOMICAL CONCEPTS; FUNCTIONAL GENOMICS; GAIN OF FUNCTION MUTATION; GENETIC ASSOCIATION; HUMAN; INTRACELLULAR SIGNALING; ION TRANSPORT; LOSS OF FUNCTION MUTATION; NEUROPATHY; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW;

ANALGESICS; ANIMALS; GENOMICS; HUMANS; MICRORNAS; PAIN; SYSTEMS BIOLOGY;

EID: 84877926843     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.04.004     Document Type: Review

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