메뉴 건너뛰기




Volumn 15, Issue 3, 2013, Pages 224-231

Novel immunotherapies in GU malignancies

Author keywords

Bladder cancer; Combination strategies; CTLA 4 antibody; Immunotherapy; PD 1 antibody; Prostate cancer; Renal cell carcinoma; Targeted therapy

Indexed keywords

AGS 003; ANTINEOPLASTIC AGENT; AXITINIB; BCG VACCINE; BEVACIZUMAB; CYCLOPHOSPHAMIDE; EVEROLIMUS; GIRENTUXIMAB; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; IMA 901; IMP 321; INTERFERON; IPILIMUMAB; MAGE A 3; MONOCLONAL ANTIBODY HUJ 591; MONOCLONAL ANTIBODY MNL 2704; NIVOLUMAB; NY ESO 1; PAZOPANIB; PLACEBO; RECOMBINANT INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 21; RILIMOGENE GALVACIREPVEC; SIPULEUCEL T; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TICILIMUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84877924000     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-013-0306-8     Document Type: Article
Times cited : (3)

References (72)
  • 1
    • 42649145828 scopus 로고    scopus 로고
    • Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): A literature review
    • 18313224 10.1016/j.ctrv.2007.12.001
    • Gupta K, Miller JD, Li JZ, et al. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev. 2008;34:193-205.
    • (2008) Cancer Treat Rev , vol.34 , pp. 193-205
    • Gupta, K.1    Miller, J.D.2    Li, J.Z.3
  • 2
    • 65949115921 scopus 로고    scopus 로고
    • Sequential therapy in renal cell carcinoma
    • 19402067 10.1002/cncr.24241 1:CAS:528:DC%2BD1MXmtVOktr8%3D
    • Escudier B, Goupil MG, Massard C, et al. Sequential therapy in renal cell carcinoma. Cancer. 2009;115:2321-6.
    • (2009) Cancer , vol.115 , pp. 2321-2326
    • Escudier, B.1    Goupil, M.G.2    Massard, C.3
  • 3
    • 84865554296 scopus 로고    scopus 로고
    • Emerging immunotherapies for renal cell carcinoma.
    • Escudier B. Emerging immunotherapies for renal cell carcinoma. Ann Oncol. 2012;23:S8.
    • (2012) Ann Oncol , vol.23 , pp. 8
    • Escudier, B.1
  • 4
    • 70350010317 scopus 로고    scopus 로고
    • Immunotherapeutic strategies in kidney cancer-when TKIs are not enough
    • 19546865 10.1038/nrclinonc.2009.91 1:CAS:528:DC%2BD1MXpsFyhtr4%3D
    • Biswas S, Eisen T. Immunotherapeutic strategies in kidney cancer-when TKIs are not enough. Nat Rev Clin Oncol. 2009;6:478-87.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 478-487
    • Biswas, S.1    Eisen, T.2
  • 5
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • 7884429 1:STN:280:DyaK2M7ptVGiuw%3D%3D
    • Fyfe G, Fisher RI, Rosenberg SA, et al. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol. 1995;13:688-96.
    • (1995) J Clin Oncol , vol.13 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3
  • 6
    • 0033847587 scopus 로고    scopus 로고
    • Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma
    • Fisher RI, Rosenberg SA, Fyfe G. Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma. Cancer J Sci Am. 2000;S1:55-7.
    • (2000) Cancer J Sci Am , vol.1 , pp. 55-57
    • Fisher, R.I.1    Rosenberg, S.A.2    Fyfe, G.3
  • 8
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • 11773181 10.1200/JCO.20.1.289 1:CAS:528:DC%2BD38XnsFeqtg%3D%3D
    • Motzer RJ, Bacik J, Murphy BA, et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol. 2002;20:289-96.
    • (2002) J Clin Oncol , vol.20 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3
  • 10
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • 16757724 10.1001/jama.295.21.2516 1:CAS:528:DC%2BD28XlsV2rtLk%3D
    • Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA. 2006;295:2516-24.
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 11
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • 17215529 10.1056/NEJMoa065044 1:CAS:528:DC%2BD2sXksVGqsw%3D%3D
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356:115-24.
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 12
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • 17215530 10.1056/NEJMoa060655 1:CAS:528:DC%2BD2sXksVKitg%3D%3D
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356:125-34.
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 13
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • 19451442 10.1200/JCO.2008.19.5511 1:CAS:528:DC%2BD1MXpvFejt7w%3D
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol. 2009;27:3312-8.
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 14
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • 18156031 10.1016/S0140-6736(07)61904-7
    • Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet. 2007;370:2103-11.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 15
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • 18936475 10.1200/JCO.2008.16.9847 1:CAS:528:DC%2BD1MXhslClsA%3D%3D
    • Rini BI, Halabi S, Rosenberg JE, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol. 2008;26:5422-8.
    • (2008) J Clin Oncol , vol.26 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 16
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
    • 20368558 10.1200/JCO.2009.26.5561 1:CAS:528:DC%2BC3cXpsFSgsbw%3D
    • Rini BI, Halabi S, Rosenberg JE, et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol. 2010;28:2137-43.
    • (2010) J Clin Oncol , vol.28 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 17
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • 17538086 10.1056/NEJMoa066838 1:CAS:528:DC%2BD2sXmtVKkurs%3D
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356:2271-81.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 18
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • 18653228 10.1016/S0140-6736(08)61039-9 1:CAS:528:DC%2BD1cXps1GmsLY%3D
    • Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet. 2008;372:449-56.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 19
    • 77952301116 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and everolimus in patients with advanced renal cell carcinoma
    • 20368560 10.1200/JCO.2009.26.3152 1:CAS:528:DC%2BC3cXpsFSgsb4%3D
    • Hainsworth JD, Spigel DR, Burris 3rd HA, et al. Phase II trial of bevacizumab and everolimus in patients with advanced renal cell carcinoma. J Clin Oncol. 2010;28:2131-6.
    • (2010) J Clin Oncol , vol.28 , pp. 2131-2136
    • Hainsworth, J.D.1    Spigel, D.R.2    Burris Iii., H.A.3
  • 20
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • 20100962 10.1200/JCO.2009.23.9764 1:CAS:528:DC%2BC3cXktF2lt78%3D
    • Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol. 2010;28:1061-8.
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 21
    • 84865506371 scopus 로고    scopus 로고
    • Patient preference between pazopanib (Paz) and sunitinib (Sun): Results of a randomized double-blind, placebo-controlled, cross-over study in patients with metastatic renal cell carcinoma (mRCC) - PISCES study, NCT 01064310 [abstract CRA4502]
    • Chicago, USA; June 1-5
    • Escudier B, Porta C, Bono P, et al. Patient preference between pazopanib (Paz) and sunitinib (Sun): Results of a randomized double-blind, placebo-controlled, cross-over study in patients with metastatic renal cell carcinoma (mRCC) - PISCES study, NCT 01064310 [abstract CRA4502]. Presented at the American Society of Clinical Oncology Annual Meeting, Chicago, USA; June 1-5, 2012.
    • (2012) Presented at the American Society of Clinical Oncology Annual Meeting
    • Escudier, B.1    Porta, C.2    Bono, P.3
  • 22
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial
    • 22056247 10.1016/S0140-6736(11)61613-9 1:CAS:528:DC%2BC3MXhsFGqsL%2FP
    • Rini BI, Escudier B, Tomczak P, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet. 2011;378:1931-9.
    • (2011) Lancet , vol.378 , pp. 1931-1939
    • Rini, B.I.1    Escudier, B.2    Tomczak, P.3
  • 23
    • 79960345429 scopus 로고    scopus 로고
    • Immunotherapy for renal cell carcinoma
    • 10.1016/j.hoc.2011.04.010
    • Rosenblatt J, Mcdermott DF. Immunotherapy for renal cell carcinoma. Hematol Oncol Clin N Am. 2011;25:793-812.
    • (2011) Hematol Oncol Clin N Am , vol.25 , pp. 793-812
    • Rosenblatt, J.1    McDermott, D.F.2
  • 24
    • 0029120245 scopus 로고
    • Pillars article: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • J Immunol 2011, 187:3459-3465
    • Krummel MF, Allison JP. Pillars article: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. j exp med. 1995. 182: 459-465. J Immunol 2011, 187:3459-3465.
    • (1995) J Exp Med. , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 25
    • 0034984740 scopus 로고    scopus 로고
    • VEGF as a mediator of tumor-associated immunodeficiency
    • 11444391 10.1385/IR:23:2-3:263 1:CAS:528:DC%2BD3MXltFWqtro%3D
    • Ohm JE, Carbone DP. VEGF as a mediator of tumor-associated immunodeficiency. Immunol Res. 2001;23:263-72.
    • (2001) Immunol Res , vol.23 , pp. 263-272
    • Ohm, J.E.1    Carbone, D.P.2
  • 26
    • 84879606383 scopus 로고    scopus 로고
    • Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer
    • in press
    • Tang AP, Heng DYC. Programmed death 1 pathway inhibition in metastatic renal cell cancer and prostate cancer. Curr Oncol Rep 2012, in press.
    • (2012) Curr Oncol Rep
    • Tang, A.P.1    Dyc, H.2
  • 27
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • 11015443 10.1084/jem.192.7.1027 1:CAS:528:DC%2BD3cXntFSlt7o%3D
    • Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000;192:1027-34.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 28
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • 22437870 10.1038/nrc3239 1:CAS:528:DC%2BC38XksVegtrw%3D
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252-64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 29
    • 34250177269 scopus 로고    scopus 로고
    • PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma
    • 17363529 10.1158/1078-0432.CCR-06-2599 1:CAS:528:DC%2BD2sXivV2gt7k%3D
    • Thompson RH, Dong H, Lohse CM, et al. PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma. Clin Cancer Res. 2007;13:1757-61.
    • (2007) Clin Cancer Res , vol.13 , pp. 1757-1761
    • Thompson, R.H.1    Dong, H.2    Lohse, C.M.3
  • 30
    • 33645736792 scopus 로고    scopus 로고
    • Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • 16585157 10.1158/0008-5472.CAN-05-4303 1:CAS:528:DC%2BD28XjtVOkt7w%3D
    • Thompson RH, Kuntz SM, Leibovich BC, et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res. 2006;66:3381-5.
    • (2006) Cancer Res , vol.66 , pp. 3381-3385
    • Thompson, R.H.1    Kuntz, S.M.2    Leibovich, B.C.3
  • 31
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • 20516446 10.1200/JCO.2009.26.7609 1:CAS:528:DC%2BC3cXpslajtLw%3D
    • Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28:3167-75.
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 32
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • 22658127 10.1056/NEJMoa1200690 1:CAS:528:DC%2BC38XhtV2rs7fN This is a landmark study revealing the role of anti-PD-1 in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-54. This is a landmark study revealing the role of anti-PD-1 in cancer.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 33
    • 84872514622 scopus 로고    scopus 로고
    • Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
    • in press
    • Lipson EJ, Sharfman WH, Drake CG et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res 2013, in press.
    • (2013) Clin Cancer Res
    • Lipson, E.J.1    Sharfman, W.H.2    Drake, C.G.3
  • 34
    • 84877922992 scopus 로고    scopus 로고
    • A phase i study to evaluate safety and antitumor activity of biweekly BMS-936558 (Anti-PD-1, MDX-1106/ONO-4538) in patients with RCC and other advanced refractory malignancies [abstract 331]
    • Orlando, USA; February 17-19
    • McDermott DF, Drake CG, Sznol M, et al. A phase I study to evaluate safety and antitumor activity of biweekly BMS-936558 (Anti-PD-1, MDX-1106/ONO-4538) in patients with RCC and other advanced refractory malignancies [abstract 331]. Presented at the Genitourinary Cancers Symposium, Orlando, USA; February 17-19, 2011.
    • (2011) Presented at the Genitourinary Cancers Symposium
    • McDermott, D.F.1    Drake, C.G.2    Sznol, M.3
  • 35
    • 0035056017 scopus 로고    scopus 로고
    • CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
    • 11244047 10.1146/annurev.immunol.19.1.565 1:CAS:528:DC%2BD3MXivFKgurc%3D
    • Chambers CA, Kuhns MS, Egen JG, Allison JP. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol. 2001;19:565-94.
    • (2001) Annu Rev Immunol , vol.19 , pp. 565-594
    • Chambers, C.A.1    Kuhns, M.S.2    Egen, J.G.3    Allison, J.P.4
  • 36
    • 84869787349 scopus 로고    scopus 로고
    • Immunotherapies: The blockade of inhibitory signals
    • 23197939 10.7150/ijbs.5273 1:CAS:528:DC%2BC38XhvVGjt7rI
    • Wu YL, Liang J, Zhang W, et al. Immunotherapies: the blockade of inhibitory signals. Int J Biol Sci. 2012;8:1420-30.
    • (2012) Int J Biol Sci , vol.8 , pp. 1420-1430
    • Wu, Y.L.1    Liang, J.2    Zhang, W.3
  • 37
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • 20525992 10.1056/NEJMoa1003466 1:CAS:528:DC%2BC3cXhtVCrtrbN Ipilimumab pivotal trial that describes first immunotherapy to improve survival in patients with solid tumors
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711-23. Ipilimumab pivotal trial that describes first immunotherapy to improve survival in patients with solid tumors.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 38
    • 37349072460 scopus 로고    scopus 로고
    • Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
    • 18049334 10.1097/CJI.0b013e318156e47e 1:CAS:528:DC%2BD2sXhtlGqs7fO
    • Yang JC, Hughes M, Kammula U, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother. 2007;30:825-30.
    • (2007) J Immunother , vol.30 , pp. 825-830
    • Yang, J.C.1    Hughes, M.2    Kammula, U.3
  • 39
    • 79551717184 scopus 로고    scopus 로고
    • Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma
    • 20922784 10.1002/cncr.25639 1:CAS:528:DC%2BC3MXislensr4%3D
    • Rini BI, Stein M, Shannon P, et al. Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma. Cancer. 2011;117:758-67.
    • (2011) Cancer , vol.117 , pp. 758-767
    • Rini, B.I.1    Stein, M.2    Shannon, P.3
  • 40
    • 70349669259 scopus 로고    scopus 로고
    • A phase i pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma
    • 19755389 10.1158/1078-0432.CCR-09-0068 1:CAS:528:DC%2BD1MXhtF2lurvL
    • Brignone C, Escudier B, Grygar C, et al. A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma. Clin Cancer Res. 2009;15:6225-31.
    • (2009) Clin Cancer Res , vol.15 , pp. 6225-6231
    • Brignone, C.1    Escudier, B.2    Grygar, C.3
  • 41
    • 42949139835 scopus 로고    scopus 로고
    • Phase i study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma
    • 18347008 10.1200/JCO.2007.14.5193 1:CAS:528:DC%2BD1cXlvFaqs7k%3D
    • Thompson JA, Curti BD, Redman BG, et al. Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma. J Clin Oncol. 2008;26:2034-9.
    • (2008) J Clin Oncol , vol.26 , pp. 2034-2039
    • Thompson, J.A.1    Curti, B.D.2    Redman, B.G.3
  • 42
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • 19276286 10.1158/1078-0432.CCR-08-1332 1:CAS:528:DC%2BD1MXjtF2rurY%3D Preclinical evidence that sunitinib enhances the effect of the immune system, leading to the design of clinical trials with goal to further investigate this concept
    • Ko JS, Zea AH, Rini BI. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res. 2009;15:2148-57. Preclinical evidence that sunitinib enhances the effect of the immune system, leading to the design of clinical trials with goal to further investigate this concept.
    • (2009) Clin Cancer Res , vol.15 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.I.3
  • 43
    • 84877923715 scopus 로고    scopus 로고
    • A phase II study testing the safety and activity of AGS-003 as an immunotherapeutic in subjects with newly diagnosed advanced stage renal cell carcinoma (RCC) in combination with sunitinib [abstract 4588]
    • Chicago, USA; June 4-8
    • Amin A, Dudek A, Logan T, et al. A phase II study testing the safety and activity of AGS-003 as an immunotherapeutic in subjects with newly diagnosed advanced stage renal cell carcinoma (RCC) in combination with sunitinib [abstract 4588]. Presented at the American Society of Clinical Oncology Annual Meeting, Chicago, USA; June 4-8, 2010.
    • (2010) Presented at the American Society of Clinical Oncology Annual Meeting
    • Amin, A.1    Dudek, A.2    Logan, T.3
  • 44
    • 84883201891 scopus 로고    scopus 로고
    • Results of a randomized phase II study investigating multipeptide vaccination with IMA901 in advanced renal cell carcinoma (RCC) [4529]
    • Chicago, USA; June 4-8
    • Reinhardt C, Zdrojowy R, Szczylik C, et al. Results of a randomized phase II study investigating multipeptide vaccination with IMA901 in advanced renal cell carcinoma (RCC) [4529]. Presented at the American Society of Clinical Oncology Annual Meeting, Chicago, USA; June 4-8, 2010.
    • (2010) Presented at the American Society of Clinical Oncology Annual Meeting
    • Reinhardt, C.1    Zdrojowy, R.2    Szczylik, C.3
  • 45
    • 78751650361 scopus 로고    scopus 로고
    • A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-alpha-2a in metastatic renal cell carcinoma patients
    • 20512580 10.1007/s00345-010-0570-2 1:CAS:528:DC%2BC3MXptVyitw%3D%3D
    • Siebels M, Rohrmann K, Oberneder R, et al. A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-alpha-2a in metastatic renal cell carcinoma patients. World J Urol. 2011;29:121-6.
    • (2011) World J Urol , vol.29 , pp. 121-126
    • Siebels, M.1    Rohrmann, K.2    Oberneder, R.3
  • 47
    • 84859768467 scopus 로고    scopus 로고
    • Immunotherapy of genitourinary malignancies
    • in press
    • Inamoto T, Azuma H. Immunotherapy of genitourinary malignancies. J Oncol 2012, in press.
    • (2012) J Oncol
    • Inamoto, T.1    Azuma, H.2
  • 48
    • 0028884557 scopus 로고
    • Angiogenesis in bladder cancer: Relationship between microvessel density and tumor prognosis
    • 7563203 10.1093/jnci/87.21.1603 1:STN:280:DyaK28%2Fis1altQ%3D%3D
    • Bochner BH, Cote RJ, Weidner N, et al. Angiogenesis in bladder cancer: relationship between microvessel density and tumor prognosis. J Natl Cancer Inst. 1995;87:1603-12.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1603-1612
    • Bochner, B.H.1    Cote, R.J.2    Weidner, N.3
  • 49
    • 79955006416 scopus 로고    scopus 로고
    • Phase II trial of cisplatin, gemcitabine, and bevacizumab as first-line therapy for metastatic urothelial carcinoma: Hoosier Oncology Group GU 04-75
    • 21422406 10.1200/JCO.2010.31.6067 1:CAS:528:DC%2BC3MXntVCnsbw%3D
    • Hahn NM, Stadler WM, Zon RT, et al. Phase II trial of cisplatin, gemcitabine, and bevacizumab as first-line therapy for metastatic urothelial carcinoma: Hoosier Oncology Group GU 04-75. J Clin Oncol. 2011;29:1525-30.
    • (2011) J Clin Oncol , vol.29 , pp. 1525-1530
    • Hahn, N.M.1    Stadler, W.M.2    Zon, R.T.3
  • 50
    • 70149124507 scopus 로고    scopus 로고
    • Phase 2 trial of sorafenib in patients with advanced urothelial cancer: A trial of the Eastern Cooperative Oncology Group
    • 19536901 10.1002/cncr.24467 1:CAS:528:DC%2BD1MXhtF2ktbnL
    • Dreicer R, Li H, Stein M, et al. Phase 2 trial of sorafenib in patients with advanced urothelial cancer: a trial of the Eastern Cooperative Oncology Group. Cancer. 2009;115:4090-5.
    • (2009) Cancer , vol.115 , pp. 4090-4095
    • Dreicer, R.1    Li, H.2    Stein, M.3
  • 51
    • 84856851592 scopus 로고    scopus 로고
    • Double-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinum-pretreated metastatic urothelial cancer
    • 22184381 10.1200/JCO.2011.37.7002 1:CAS:528:DC%2BC38XkvVCit7w%3D
    • Choueiri TK, Ross RW, Jacobus S, et al. Double-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinum-pretreated metastatic urothelial cancer. J Clin Oncol. 2012;30:507-12.
    • (2012) J Clin Oncol , vol.30 , pp. 507-512
    • Choueiri, T.K.1    Ross, R.W.2    Jacobus, S.3
  • 52
    • 77950474660 scopus 로고    scopus 로고
    • Phase II study of sunitinib in patients with metastatic urothelial cancer
    • 20142593 10.1200/JCO.2009.25.3922 1:CAS:528:DC%2BC3cXksFSqurw%3D
    • Gallagher DJ, Milowsky MI, Gerst SR, et al. Phase II study of sunitinib in patients with metastatic urothelial cancer. J Clin Oncol. 2010;28:1373-9.
    • (2010) J Clin Oncol , vol.28 , pp. 1373-1379
    • Gallagher, D.J.1    Milowsky, M.I.2    Gerst, S.R.3
  • 53
    • 84864337145 scopus 로고    scopus 로고
    • Pazopanib in advanced and platinum-resistant urothelial cancer: An open-label, single group, phase 2 trial
    • 10.1016/S1470-2045(12)70294-2
    • Necchi A, Mariani L, Zaffaroni N, et al. Pazopanib in advanced and platinum-resistant urothelial cancer: an open-label, single group, phase 2 trial. Lancet Oncol. 2012;13:81081-6.
    • (2012) Lancet Oncol , vol.13 , pp. 81081-81086
    • Necchi, A.1    Mariani, L.2    Zaffaroni, N.3
  • 54
    • 77952337834 scopus 로고    scopus 로고
    • Preoperative CTLA-4 blockade: Tolerability and immune monitoring in the setting of a presurgical clinical trial
    • 20460488 10.1158/1078-0432.CCR-10-0569 1:CAS:528:DC%2BC3cXlvF2hsrY%3D
    • Carthon BC, Wolchok JD, Yuan J, et al. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res. 2010;16:2861-71.
    • (2010) Clin Cancer Res , vol.16 , pp. 2861-2871
    • Carthon, B.C.1    Wolchok, J.D.2    Yuan, J.3
  • 56
    • 63549129407 scopus 로고    scopus 로고
    • Immune responses detected in urothelial carcinoma patients after vaccination with NY-ESO-1 protein plus BCG and GM-CSF
    • 18833002 10.1097/CJI.0b013e3181891574 1:CAS:528:DC%2BD1cXht1OksL7L
    • Sharma P, Bajorin DF, Jungbluth AA, et al. Immune responses detected in urothelial carcinoma patients after vaccination with NY-ESO-1 protein plus BCG and GM-CSF. J Immunother. 2008;31:849-57.
    • (2008) J Immunother , vol.31 , pp. 849-857
    • Sharma, P.1    Bajorin, D.F.2    Jungbluth, A.A.3
  • 57
    • 0035136405 scopus 로고    scopus 로고
    • Immunotherapy of bladder cancer using autologous dendritic cells pulsed with human lymphocyte antigen-A24-specific MAGE-3 peptide
    • 11205913 1:CAS:528:DC%2BD3MXht1Whsb0%3D
    • Nishiyama T, Tachibana M, Horiguchi Y, et al. Immunotherapy of bladder cancer using autologous dendritic cells pulsed with human lymphocyte antigen-A24-specific MAGE-3 peptide. Clin Cancer Res. 2001;7:23-31.
    • (2001) Clin Cancer Res , vol.7 , pp. 23-31
    • Nishiyama, T.1    Tachibana, M.2    Horiguchi, Y.3
  • 58
    • 67650874081 scopus 로고    scopus 로고
    • Cancer statistics, 2009
    • 19474385 10.3322/caac.20006
    • Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225-49.
    • (2009) CA Cancer J Clin , vol.59 , pp. 225-249
    • Jemal, A.1    Siegel, R.2    Ward, E.3
  • 59
    • 84872078210 scopus 로고    scopus 로고
    • Abiraterone in metastatic prostate cancer without previous chemotherapy
    • In press
    • Ryan CJ, Smith MR, de Bono JS, et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. N Engl J Med 2012, In press.
    • N Engl J Med 2012
    • Ryan, C.J.1    Smith, M.R.2    De Bono, J.S.3
  • 60
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • 20818862 10.1056/NEJMoa1001294 1:CAS:528:DC%2BC3cXhtVGlurrN This is the first study that proves that immunotherapy prolongs survival in prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411-22. This is the first study that proves that immunotherapy prolongs survival in prostate cancer.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 61
    • 34250223096 scopus 로고    scopus 로고
    • A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
    • 17363537 10.1158/1078-0432.CCR-06-2318 1:CAS:528:DC%2BD2sXivV2gtLs%3D
    • Small EJ, Tchekmedyian NS, Rini BI, et al. A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. Clin Cancer Res. 2007;13:1810-5.
    • (2007) Clin Cancer Res , vol.13 , pp. 1810-1815
    • Small, E.J.1    Tchekmedyian, N.S.2    Rini, B.I.3
  • 62
    • 77949895922 scopus 로고    scopus 로고
    • Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
    • 20100959 10.1200/JCO.2009.25.0597 1:CAS:528:DC%2BC3cXktF2ltLw%3D
    • Kantoff PW, Schuetz TJ, Blumenstein BA, et al. Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol. 2010;28:1099-105.
    • (2010) J Clin Oncol , vol.28 , pp. 1099-1105
    • Kantoff, P.W.1    Schuetz, T.J.2    Blumenstein, B.A.3
  • 63
    • 84877928185 scopus 로고    scopus 로고
    • Safety and antitumor activity of biweekly MDX-1106 (Anti-PD-1, BMS-936558/ONO-4538) in patients with advanced refractory malignancies [abstract 2506]
    • Chicago, USA; June 4-8
    • Sznol M, Powderly JD, Smith DC, et al. Safety and antitumor activity of biweekly MDX-1106 (Anti-PD-1, BMS-936558/ONO-4538) in patients with advanced refractory malignancies [abstract 2506]. Presented at the American Society of Clinical Oncology Annual Meeting, Chicago, USA; June 4-8, 2010.
    • (2010) Presented at the American Society of Clinical Oncology Annual Meeting
    • Sznol, M.1    Powderly, J.D.2    Smith, D.C.3
  • 64
    • 0242692683 scopus 로고    scopus 로고
    • Clinical use of monoclonal antibody HuJ591 therapy: Targeting prostate specific membrane antigen
    • 14610416 10.1097/01.ju.0000095151.97404.7c
    • Nanus DM, Milowsky MI, Kostakoglu L, et al. Clinical use of monoclonal antibody HuJ591 therapy: targeting prostate specific membrane antigen. J Urol. 2003;170:S84-8.
    • (2003) J Urol , vol.170
    • Nanus, D.M.1    Milowsky, M.I.2    Kostakoglu, L.3
  • 65
    • 4344618391 scopus 로고    scopus 로고
    • Phase i trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer
    • 15173215 10.1200/JCO.2004.09.154 1:CAS:528:DC%2BD2cXpsVWks74%3D
    • Milowsky MI, Nanus DM, Kostakoglu L, et al. Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer. J Clin Oncol. 2004;22:2522-31.
    • (2004) J Clin Oncol , vol.22 , pp. 2522-2531
    • Milowsky, M.I.1    Nanus, D.M.2    Kostakoglu, L.3
  • 66
    • 84877919932 scopus 로고    scopus 로고
    • Phase I/II trial of the prostate-specific membrane antigen (PSMA)-targeted immunoconjugate MLN2704 in patients (pts) with progressive metastatic castration resistant prostate cancer (CRPC) [abstract 4500]
    • Atlanta, USA; June 2-6
    • Milowsky MI, Galsky M, George DJ, et al. Phase I/II trial of the prostate-specific membrane antigen (PSMA)-targeted immunoconjugate MLN2704 in patients (pts) with progressive metastatic castration resistant prostate cancer (CRPC) [abstract 4500]. Presented at the American Society of Clinical Oncology Annual Meeting, Atlanta, USA; June 2-6, 2006.
    • (2006) Presented at the American Society of Clinical Oncology Annual Meeting
    • Milowsky, M.I.1    Galsky, M.2    George, D.J.3
  • 67
    • 84871360414 scopus 로고    scopus 로고
    • Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-bispecific BiTE antibody cross-reactive with non-human primate antigens
    • 23041545 10.1158/1535-7163.MCT-12-0042 1:CAS:528:DC%2BC38XhvVSqt7bL
    • Friedrich M, Raum T, Lutterbuese R, et al. Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-bispecific BiTE antibody cross-reactive with non-human primate antigens. Mol Cancer Ther. 2012;11:2664-73.
    • (2012) Mol Cancer Ther , vol.11 , pp. 2664-2673
    • Friedrich, M.1    Raum, T.2    Lutterbuese, R.3
  • 68
    • 58349090027 scopus 로고    scopus 로고
    • Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF
    • 19147575 10.1158/0008-5472.CAN-08-3529 1:CAS:528:DC%2BD1MXltFShtQ%3D%3D
    • Fong L, Kwek SS, O'Brien S, et al. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. Cancer Res. 2009;69:609-15.
    • (2009) Cancer Res , vol.69 , pp. 609-615
    • Fong, L.1    Kwek, S.S.2    O'Brien, S.3
  • 69
    • 34547700498 scopus 로고    scopus 로고
    • Impact of androgen-deprivation therapy on the immune system: Implications for combination therapy of prostate cancer
    • 17569623 10.2741/2441 1:CAS:528:DC%2BD2sXosF2qsrk%3D
    • Aragon-Ching JB, Williams KM, Gulley JL. Impact of androgen-deprivation therapy on the immune system: implications for combination therapy of prostate cancer. Front Biosci. 2007;12:4957-71.
    • (2007) Front Biosci , vol.12 , pp. 4957-4971
    • Aragon-Ching, J.B.1    Williams, K.M.2    Gulley, J.L.3
  • 70
    • 51649128403 scopus 로고    scopus 로고
    • Analysis of overall survival in patients with nonmetastatic castration-resistant prostate cancer treated with vaccine, nilutamide, and combination therapy
    • 18628467 10.1158/1078-0432.CCR-07-5048 1:CAS:528:DC%2BD1cXosFGitLg%3D
    • Madan RA, Gulley JL, Schlom J, et al. Analysis of overall survival in patients with nonmetastatic castration-resistant prostate cancer treated with vaccine, nilutamide, and combination therapy. Clin Cancer Res. 2008;14:4526-31.
    • (2008) Clin Cancer Res , vol.14 , pp. 4526-4531
    • Madan, R.A.1    Gulley, J.L.2    Schlom, J.3
  • 71
    • 52049090425 scopus 로고    scopus 로고
    • Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer
    • 18646045 10.1002/cncr.23669 1:CAS:528:DC%2BD1cXhtFSlur3F
    • Higano CS, Corman JM, Smith DC, et al. Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer. Cancer. 2008;113:975-84.
    • (2008) Cancer , vol.113 , pp. 975-984
    • Higano, C.S.1    Corman, J.M.2    Smith, D.C.3
  • 72
    • 84860436621 scopus 로고    scopus 로고
    • Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: A phase 1 dose-escalation trial
    • 22326922 10.1016/S1470-2045(12)70007-4 Combination strategies strategies in the treatment of prostate cancer
    • van den Eertwegh AJ, Versluis J, van den Berg HP, et al. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol. 2012;13:509-17. Combination strategies strategies in the treatment of prostate cancer.
    • (2012) Lancet Oncol , vol.13 , pp. 509-517
    • Van Den Eertwegh, A.J.1    Versluis, J.2    Van Den Berg, H.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.