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Volumn 6, Issue 8, 2009, Pages 478-487

Immunotherapeutic strategies in kidney cancer-when TKIs are not enough

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AS 1409; BEVACIZUMAB; CANCER VACCINE; CARBONATE DEHYDRATASE IX; DENILEUKIN DIFTITOX; HYPOXIA INDUCIBLE FACTOR 1; INTERLEUKIN 2; IPILIMUMAB; ISOTRETINOIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MODIFIED VACCINIA VIRUS ANKARA 5T4 VACCINE; MONOCLONAL ANTIBODY G250; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLACEBO; RENIALE; SORAFENIB; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; VITESPEN; ANGIOGENESIS INHIBITOR; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; CYTOKINE; PROTEIN KINASE INHIBITOR; TUMOR ANTIGEN; TUMOR MARKER; TUMOR PROTEIN;

EID: 70350010317     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2009.91     Document Type: Review
Times cited : (45)

References (95)
  • 1
    • 73849129531 scopus 로고    scopus 로고
    • [online]
    • UK Kidney Cancer statistics. Cancer Research UK [online], http://info.cancerresearchuk.org/ cancerstats/types/kidney/ (2008).
    • (2008) UK Kidney Cancer Statistics
  • 2
    • 73849099699 scopus 로고    scopus 로고
    • Cancer facts & figures 2008
    • [online]
    • Cancer Facts & Figures 2008. American Cancer Society [online], http://www.cancer.org/ downloads/sTT/2008CAFFfinalsecured.pdf (2008).
    • (2008) American Cancer Society
  • 3
    • 3142765935 scopus 로고    scopus 로고
    • Renal Cell carcinoma: Etiology, incidence and epidemiology
    • Murai, M. & Oya, M. renal Cell carcinoma: etiology, incidence and epidemiology. Curr. Opin. Urol. 14, 229-233 (2004).
    • (2004) Curr. Opin. Urol. , vol.14 , pp. 229-233
    • Murai, M.1    Oya, M.2
  • 4
    • 0017361999 scopus 로고
    • The role of adjunctive nephrectomy in patients with metastatic renal cell carcinoma
    • Montie, J. e. et al. The role of adjunctive nephrectomy in patients with metastatic renal cell carcinoma. J. Urol. 117, 272 (1977).
    • (1977) J. Urol. , vol.117 , pp. 272
    • Montie, J.E.1
  • 5
    • 0018121304 scopus 로고
    • The natural history of metastatic renal cell carcinoma: A computer analysis
    • Dekernion, J. B., ramming, K. P. & smith, r. B. The natural history of metastatic renal cell carcinoma: a computer analysis. J. Urol. 120, 148-152 (1978).
    • (1978) J. Urol. , vol.120 , pp. 148-152
    • Dekernion, J.B.1    Ramming, K.P.2    Smith, R.B.3
  • 6
    • 0027279710 scopus 로고
    • Regression of metastatic renal cell carcinoma after cytoreductive nephrectomy
    • Marcus, s. G. et al. regression of metastatic renal cell carcinoma after cytoreductive nephrectomy. J. Urol. 150, 463-466 (1993).
    • (1993) J. Urol. , vol.150 , pp. 463-466
    • Marcus, S.G.1
  • 7
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe, G. et al. results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J. Clin. Oncol. 13, 688-696 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 688-696
    • Fyfe, G.1
  • 8
    • 0035134688 scopus 로고    scopus 로고
    • Interferon in oncological practice: Review of interferon biology, clinical applications, and toxicities
    • Jonasch, e. & Haluska, F. G. interferon in oncological practice: review of interferon biology, clinical applications, and toxicities. Oncologist 6, 34-55 (2001).
    • (2001) Oncologist , vol.6 , pp. 34-55
    • Jonasch, E.1    Haluska, F.G.2
  • 9
    • 18844386435 scopus 로고    scopus 로고
    • Histologic predictors of renal cell carcinoma response to interleukin-2 based therapy
    • Upton, M. P., Parker, r. A., Youmans, A., McDermott, D. F. & Atkins. M. B. Histologic predictors of renal cell carcinoma response to interleukin-2 based therapy. J. Immunother. 28, 488-495 (2005).
    • (2005) J. Immunother. , vol.28 , pp. 488-495
    • Upton, M.P.1    Parker, R.A.2    Youmans, A.3    McDermott, D.F.4    Atkins, M.B.5
  • 10
    • 21044442672 scopus 로고    scopus 로고
    • Carbonic anhydrase iX expression predicts outcome of interleukin 2 therapy for renal cancer
    • Atkins, M. et al. Carbonic anhydrase iX expression predicts outcome of interleukin 2 therapy for renal cancer. Clin. Cancer. Res. 11, 3714-3721 (2005).
    • (2005) Clin. Cancer. Res. , vol.11 , pp. 3714-3721
    • Atkins, M.1
  • 11
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer, r. J. et al. sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 356, 115-124 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , pp. 115-124
    • Motzer, R.J.1
  • 12
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes, G. et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N. Engl. J. Med. 356, 2271-2281 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2271-2281
    • Hudes, G.1
  • 13
    • 33947633432 scopus 로고    scopus 로고
    • From 'Hellstrom Paradox' to anti-adenosinergic cancer immunotherapy
    • Lukashev, D., sitkovsky, M. & Ohta, A. From 'Hellstrom Paradox' to anti-adenosinergic cancer immunotherapy. Purinergic Signal. 3, 129-134 (2007).
    • (2007) Purinergic Signal. , vol.3 , pp. 129-134
    • Lukashev, D.1    Sitkovsky, M.2    Ohta, A.3
  • 15
    • 34548211280 scopus 로고    scopus 로고
    • CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion
    • Pederson, A. e. & ronchese, F. CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion. J. Immune Based Ther. Vaccines 5, 1-6 (2007).
    • (2007) J. Immune Based Ther. Vaccines , vol.5 , pp. 1-6
    • Pederson, A.E.1    Ronchese, F.2
  • 16
    • 33744908300 scopus 로고    scopus 로고
    • Regulatory T cells and toll-like receptors in cancer therapy
    • wang, r. F. regulatory T cells and toll-like receptors in cancer therapy. Cancer Res. 66, 4987-4990 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 4987-4990
    • Wang, R.F.1
  • 17
    • 51349165526 scopus 로고    scopus 로고
    • CTLA-4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion
    • Kavanagh, B. et al. CTLA-4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion. Blood 112, 1175-1183 (2008).
    • (2008) Blood , vol.112 , pp. 1175-1183
    • Kavanagh, B.1
  • 18
    • 34247523605 scopus 로고    scopus 로고
    • Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma
    • siddiqui, s. A. et al. Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma. Clin. Cancer Res. 13, 2075-2081 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2075-2081
    • Siddiqui, S.A.1
  • 19
    • 25444454359 scopus 로고    scopus 로고
    • Regulation of immune cells by local-tissue oxygen tension: HiF1 alpha and adenosine receptors
    • sitkovsky, M. & Lukashev, D. regulation of immune cells by local-tissue oxygen tension: HiF1 alpha and adenosine receptors. Nat. Rev. Immunol. 5, 712-721 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 712-721
    • Sitkovsky, M.1    Lukashev, D.2
  • 20
    • 33749478922 scopus 로고    scopus 로고
    • Cancer's molecular sweet tooth and the warburg effect
    • Kim, J. w. & Dang, C. v. Cancer's molecular sweet tooth and the warburg effect. Cancer Res. 66, 8927-8930 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 8927-8930
    • Kim, J.W.1    Dang, C.V.2
  • 21
    • 23944498840 scopus 로고    scopus 로고
    • Lactate dehydrogenase 5 (LDH5) relates to upregulated hypoxia inducible factor pathway and metastasis in colorectal cancer
    • Koukourakis, M., Giatromanolaki, A., simopoulos, C., Polychronidis, A. & sivridis, e. Lactate dehydrogenase 5 (LDH5) relates to upregulated hypoxia inducible factor pathway and metastasis in colorectal cancer. Clin. Exp. Metastasis 22, 25-30 (2005).
    • (2005) Clin. Exp. Metastasis , vol.22 , pp. 25-30
    • Koukourakis, M.1    Giatromanolaki, A.2    Simopoulos, C.3    Polychronidis, A.4    Sivridis, E.5
  • 22
    • 34247352844 scopus 로고    scopus 로고
    • Inhibitory effect of tumor cellderived lactic acid on human T cells
    • Fischer, K. et al. inhibitory effect of tumor cellderived lactic acid on human T cells. Blood 109, 3812-3819 (2007).
    • (2007) Blood , vol.109 , pp. 3812-3819
    • Fischer, K.1
  • 23
    • 33748357735 scopus 로고    scopus 로고
    • A2A adenosine receptor protects tumors from antitumor T cells
    • Ohta, A. et al. A2A adenosine receptor protects tumors from antitumor T cells. Proc. Natl Acad. Sci. USA 103, 13132-13137 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 13132-13137
    • Ohta, A.1
  • 24
    • 52649138296 scopus 로고    scopus 로고
    • Adenosine receptors in regulation of dendritic cell differentiation and function
    • Novitskiy, s. v. et al. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112, 1822-1831 (2008).
    • (2008) Blood , vol.112 , pp. 1822-1831
    • Novitskiy, S.V.1
  • 25
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalysed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio, s. et al. Adenosine generation catalysed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204, 1257-1265 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1257-1265
    • Deaglio, S.1
  • 26
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HiF-1) and HiF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • raval, r. r. et al. Contrasting properties of hypoxia-inducible factor 1 (HiF-1) and HiF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol. Cell. Biol. 25, 5675-5686 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5675-5686
    • Raval, R.R.1
  • 27
    • 28744435202 scopus 로고    scopus 로고
    • EDB fibronectin and angiogenesis: A novel mechanistic pathway
    • Khan, Z. A. et al. eDB fibronectin and angiogenesis: a novel mechanistic pathway. Angiogenesis 8, 183-196(2005).
    • (2005) Angiogenesis , vol.8 , pp. 183-196
    • Khan, Z.A.1
  • 28
    • 34748820827 scopus 로고    scopus 로고
    • 5T4-modified vaccinia Ankara: Progress in tumor-associated antigen-based immunotherapy
    • Amato, r. J. 5T4-modified vaccinia Ankara: progress in tumor-associated antigen-based immunotherapy. Expert Opin. Biol. Ther. 7, 1463-1469 (2007).
    • (2007) Expert Opin. Biol. Ther. , vol.7 , pp. 1463-1469
    • Amato, R.J.1
  • 29
    • 0037314709 scopus 로고    scopus 로고
    • Carbonic anhydrase iX is an independent predictor of survival in advanced renal clear cell carcinoma: Implications for prognosis and therapy
    • Bui, M. H. et al. Carbonic anhydrase iX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. Clin. Cancer Res. 9, 802-811 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 802-811
    • Bui, M.H.1
  • 30
    • 73849133580 scopus 로고    scopus 로고
    • Evaluation of the potential for targeted therapy of renal carcinoma and metastatic melanoma with huBC1-huiL12 (As1409), a potent immunocytokine [abstract]
    • Doran, B., rogers, P., Jones, D., Green, C. & Courtenay-Luck, N. evaluation of the potential for targeted therapy of renal carcinoma and metastatic melanoma with huBC1-huiL12 (As1409), a potent immunocytokine [abstract]. AACR Meeting Abstracts 922 (2007).
    • (2007) AACR Meeting Abstracts , vol.922
    • Doran, B.1    Rogers, P.2    Jones, D.3    Green, C.4    Courtenay-Luck, N.5
  • 31
    • 34047131797 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and immunosuppression in cancer: Current knowledge and potential for new therapy
    • Johnson, B. J., Clay, T. M., Hobeika, A. C., Lyerly, H. K. & Morse, M. A. vascular endothelial growth factor and immunosuppression in cancer: current knowledge and potential for new therapy. Expert Opin. Biol. Ther. 7, 449-460 (2007).
    • (2007) Expert Opin. Biol. Ther. , vol.7 , pp. 449-460
    • Johnson, B.J.1    Clay, T.M.2    Hobeika, A.C.3    Lyerly, H.K.4    Morse, M.A.5
  • 32
    • 3242733235 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (veGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (sTATs) via veGF receptor-2 (KDr) in human hemopoietic progenitor cells
    • Ye, F. et al. vascular endothelial growth factor (veGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (sTATs) via veGF receptor-2 (KDr) in human hemopoietic progenitor cells. Gynecol. Oncol. 94, 125-133 (2004).
    • (2004) Gynecol. Oncol. , vol.94 , pp. 125-133
    • Ye, F.1
  • 33
    • 42149111675 scopus 로고    scopus 로고
    • Inhibition of sTAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma
    • Fujita, M. et al. inhibition of sTAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma. J. Immunol. 180, 2089-2098 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 2089-2098
    • Fujita, M.1
  • 34
    • 10344220548 scopus 로고    scopus 로고
    • Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
    • Thompson, r. H. et al. Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target. Proc. Natl Acad. Sci. USA 101, 17174-17179 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 17174-17179
    • Thompson, R.1    Et Al., H.2
  • 35
    • 52649160243 scopus 로고    scopus 로고
    • Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma
    • Crispen, P. L. et al. Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma. Clin. Cancer Res. 14, 5150-5157 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5150-5157
    • Crispen, P.L.1
  • 36
    • 42149099408 scopus 로고    scopus 로고
    • Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms
    • Biswas, s. K., sica, A. & Lewis, C. e. Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J. Immunol. 180, 2011-2017 (2007).
    • (2007) J. Immunol. , vol.180 , pp. 2011-2017
    • Biswas, S.K.1    Sica, A.2    Lewis, C.E.3
  • 37
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • Lin, e. Y. et al. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 66, 11238-11246 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 11238-11246
    • Lin, E.Y.1
  • 38
    • 0034650833 scopus 로고    scopus 로고
    • Autocrine production of iL-10 mediates defective iL-12 production and NF-kB activation in tumor-associated macrophages
    • sica, A. et al. Autocrine production of iL-10 mediates defective iL-12 production and NF-kB activation in tumor-associated macrophages. J. Immunol. 164, 762-767 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 762-767
    • Sica, A.1
  • 39
    • 42349094504 scopus 로고    scopus 로고
    • Tumor escape mechanism governed by myeloid-derived suppressor cells
    • Nagaraj, s. & Gabrilovich, D. i. Tumor escape mechanism governed by myeloid-derived suppressor cells. Cancer Res. 68, 2561-2563 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 2561-2563
    • Nagaraj, S.1    Gabrilovich, D.I.2
  • 40
    • 36849013036 scopus 로고    scopus 로고
    • Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    • shojaei, F. et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450, 825-831 (2007).
    • (2007) Nature , vol.450 , pp. 825-831
    • Shojaei, F.1
  • 41
    • 48649107126 scopus 로고    scopus 로고
    • Refractoriness to antivascular endothelial growth factor treatment: Role of myeloid cells
    • shojaei, F. & Ferrara, N. refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells. Cancer Res. 68, 5501-5504 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 5501-5504
    • Shojaei, F.1    Ferrara, N.2
  • 42
    • 32944474237 scopus 로고    scopus 로고
    • Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer
    • Karin, M., Lawrence, T. & Nizet, v. innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 124, 823-835 (2006).
    • (2006) Cell , vol.124 , pp. 823-835
    • Karin, M.1    Lawrence, T.2    Nizet, V.3
  • 43
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between inate immunity, inflammation, and cancer
    • Lin, w. w. & Karin, M. A cytokine-mediated link between inate immunity, inflammation, and cancer. J. Clin. Invest. 117, 1175-1183 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 44
    • 28044464696 scopus 로고    scopus 로고
    • Genes to vaccines for immunotherapy: How the molecular biology revolution has influenced cancer immunology
    • Laheru, D. A., Pardoll, D. M. & Jaffee, e. M. Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology. Mol. Cancer Ther. 4, 1645-1652 (2005).
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1645-1652
    • Laheru, D.A.1    Pardoll, D.M.2    Jaffee, E.M.3
  • 45
    • 0035794314 scopus 로고    scopus 로고
    • B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    • Tseng, s. Y. et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193, 839-846 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 839-846
    • Tseng, S.Y.1
  • 46
    • 34548453201 scopus 로고    scopus 로고
    • Interleukin 2 for patients with renal cancer
    • rosenberg, s. A. interleukin 2 for patients with renal cancer. Nat. Clin. Pract. Oncol. 4, 497 (2007).
    • (2007) Nat. Clin. Pract. Oncol. , vol.4 , pp. 497
    • Rosenberg, S.A.1
  • 47
    • 16644401873 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
    • McDermott, D. F. et al. randomized phase iii trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 23, 133-141 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 133-141
    • McDermott, D.F.1
  • 48
    • 0042914703 scopus 로고    scopus 로고
    • Randomized study of high-dose and low-dose interleukin-2 patients in patients with metastatic renal cell cancer
    • Yang, J. C. et al. randomized study of high-dose and low-dose interleukin-2 patients in patients with metastatic renal cell cancer. J. Clin. Oncol. 21, 3127-3132 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3127-3132
    • Yang, J.C.1
  • 49
    • 73849131640 scopus 로고    scopus 로고
    • Medroxyprogesterone, interferon alfa-2a, interferon-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: Results of a randomized controlled trial
    • Negrier, s. et al. Medroxyprogesterone, interferon alfa-2a, interferon-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: results of a randomized controlled trial. Cancer 110, 2460-2477 (2007).
    • (2007) Cancer , vol.110 , pp. 2460-2477
    • Negrier, S.1
  • 50
    • 18944385751 scopus 로고    scopus 로고
    • Immunotherapy for advanced renal cell cancer
    • Coppin, C. et al. immunotherapy for advanced renal cell cancer. Cochrane Database Syst. Rev. 1, CD001425 (2005).
    • (2005) Cochrane Database Syst. Rev. , vol.1
    • Coppin, C.1
  • 51
    • 0035818877 scopus 로고    scopus 로고
    • Nephrectomy followed by interferon-á2b compared with interferon-á2b alone for metastatic renal cell cancer
    • Flanigan, r. C. et al. Nephrectomy followed by interferon-á2b compared with interferon-á2b alone for metastatic renal cell cancer. N. Engl. J. Med. 345, 1655-1659 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1655-1659
    • Flanigan, R.C.1
  • 52
    • 0035934596 scopus 로고    scopus 로고
    • Radical nephrectomy plus interferon-á based immunotherapy compared with interferon-á alone in metastatic renal cell carcinoma: A randomised trial
    • Mickisch, G. H. et al. radical nephrectomy plus interferon-á based immunotherapy compared with interferon-á alone in metastatic renal cell carcinoma: a randomised trial. Lancet 358, 966-970 (2001).
    • (2001) Lancet , vol.358 , pp. 966-970
    • Mickisch, G.H.1
  • 53
    • 73849131264 scopus 로고    scopus 로고
    • The role of cytoreductive nephrectomy in metastatic renal cell cancer: A clinical practice guideline
    • [online]
    • Fleshner, N. et al. The role of cytoreductive nephrectomy in metastatic renal cell cancer: a clinical practice guideline. Cancer Care Ontario [online], http://www.cancercare.on.ca/pdf/ pebc3-8-3f.pdf (2006).
    • (2006) Cancer Care Ontario
    • Fleshner, N.1
  • 54
    • 62849127717 scopus 로고    scopus 로고
    • On behalf of the re04 investigators. Interferon-á (iFN), interleukin-2 (iL2) and 5-fluorouracil (5FU) vs iFN alone in patients with metastatic renal cell carcinoma (mrCC): Results of the randomized MrC/eOrTC reO4 trial [abstract]
    • Gore, M. e. on behalf of the re04 investigators. interferon-á (iFN), interleukin-2 (iL2) and 5-fluorouracil (5FU) vs iFN alone in patients with metastatic renal cell carcinoma (mrCC): results of the randomized MrC/eOrTC reO4 trial [abstract]. ASCO Meeting Abstracts 26, 5039 (2008).
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 5039
    • Gore, M.E.1
  • 55
    • 23044461230 scopus 로고    scopus 로고
    • Randomized phase ii/iii trial of interferon alfa-2a with and without 13-cis-retinoic acid in patients with progressive metastatic renal cell carcinoma: The european Organization for research and Treatment of Cancer Genito-Urinary Tract Cancer Group (eOrTC 30951)
    • Aass, N. et al. randomized phase ii/iii trial of interferon alfa-2a with and without 13-cis-retinoic acid in patients with progressive metastatic renal cell carcinoma: the european Organization for research and Treatment of Cancer Genito-Urinary Tract Cancer Group (eOrTC 30951). J. Clin. Oncol. 23, 4172-4178 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 4172-4178
    • Aass, N.1
  • 56
    • 35549006672 scopus 로고    scopus 로고
    • A randomized, controlled, double-blind phase III study (AvOreN) of bevacizumab/interferon-á2a vs placebo/ interferon-á2a as first-line therapy in metastatic renal cell carcinoma [abstract]
    • escudier, B. et al. A randomized, controlled, double-blind phase iii study (AvOreN) of bevacizumab/interferon-á2a vs placebo/ interferon-á2a as first-line therapy in metastatic renal cell carcinoma [abstract]. ASCO Meeting Abstracts 25, 3 (2007).
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 3
    • Escudier, B.1
  • 57
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • rini, B. i. et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J. Clin. Oncol. 26, 5422-5428 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5422-5428
    • Rini, B.I.1
  • 58
    • 64049084146 scopus 로고    scopus 로고
    • Update on AvOreN trial in metastatic renal cell carcinoma (mrCC): Efficacy and safety in subgroups of patients (pts) and pharmacokinetic (PK) analysis [abstract]
    • escudier, B. J. et al. Update on AvOreN trial in metastatic renal cell carcinoma (mrCC): efficacy and safety in subgroups of patients (pts) and pharmacokinetic (PK) analysis [abstract]. ASCO Meeting Abstracts 26, 5025 (2008).
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 5025
    • Escudier, B.J.1
  • 59
    • 14144252047 scopus 로고    scopus 로고
    • Validation and extension of the Memorial sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma
    • Mekhail, T. M. et al. validation and extension of the Memorial sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma. J. Clin. Oncol. 23, 832-841 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 832-841
    • Mekhail, T.M.1
  • 60
    • 10744230275 scopus 로고    scopus 로고
    • Adjuvant autologous renal tumor cell vaccine and risk of tumor progression in patients with rCC after radical nephrectomy: Phase III, randomized controlled trial
    • Jocham, D. et al. Adjuvant autologous renal tumor cell vaccine and risk of tumor progression in patients with rCC after radical nephrectomy: phase iii, randomized controlled trial. Lancet 363, 594-599 (2004).
    • (2004) Lancet , vol.363 , pp. 594-599
    • Jocham, D.1
  • 61
    • 73849116047 scopus 로고    scopus 로고
    • Prolongation of progression-free and overall survival following an adjuvant vaccination with reniale® in patients with non-metastatic renal cell carcinoma: Secondary analysis of a multicenter phase-iii trial
    • [online]
    • Doehn C., richter, A., Theodor, r. A., Lehmacher, w. & Jocham, D. Prolongation of progression-free and overall survival following an adjuvant vaccination with reniale® in patients with non-metastatic renal cell carcinoma: secondary analysis of a multicenter phase-iii trial. Deutscher Krebskongress [online], http://www.egms.de./en/meetings/ dkk2006/06dkk395.shtml (2006).
    • (2006) Deutscher Krebskongress
    • Doehn, C.1    Richter, A.2    Theodor, R.A.3    Lehmacher, W.4    Jocham, D.5
  • 62
    • 46749085802 scopus 로고    scopus 로고
    • An adjuvant autologous therapeutic vaccine (HsPCC-96; Vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: A multicentre, open-label, randomised phase III trial
    • wood, C. et al. An adjuvant autologous therapeutic vaccine (HsPCC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase iii trial. Lancet 372, 145-154 (2008).
    • (2008) Lancet , vol.372 , pp. 145-154
    • Wood, C.1
  • 63
    • 33646441904 scopus 로고    scopus 로고
    • Impact of immune parameters on long-term survival in metastatic renal cell carcinoma
    • 2006
    • Donskov, F. & von der Maase, H. impact of immune parameters on long-term survival in metastatic renal cell carcinoma. J. Clin. Oncol. 24, 1997-2005 (2006).
    • J. Clin. Oncol. , vol.24 , pp. 1997-2005
    • Donskov, F.1    Von Der Maase, H.2
  • 64
    • 34247524959 scopus 로고    scopus 로고
    • Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer
    • van der vliet, H. J. et al. effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clin. Cancer Res. 13, 2100-2108 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2100-2108
    • Van Der Vliet, H.J.1
  • 65
    • 33746864751 scopus 로고    scopus 로고
    • Gene expression and tissue microarray analysis of interleukin-2 complete responders in patients with metastatic renal cell carcinoma [abstract]
    • Pantuck, A. J. et al. Gene expression and tissue microarray analysis of interleukin-2 complete responders in patients with metastatic renal cell carcinoma [abstract]. ASCO Meeting Abstracts 23, 4535 (2005).
    • (2005) ASCO Meeting Abstracts , vol.23 , pp. 4535
    • Pantuck, A.J.1
  • 66
    • 33644947935 scopus 로고    scopus 로고
    • Cytokine therapy: A standard of care for metastatic renal cell carcinoma?
    • Hutson, T. e. & Quinn D. i. Cytokine therapy: a standard of care for metastatic renal cell carcinoma? Clin. Genitourin. Cancer 4, 181-186 (2005).
    • (2005) Clin. Genitourin. Cancer , vol.4 , pp. 181-186
    • Hutson, T.E.1    Quinn, D.I.2
  • 67
    • 37349072460 scopus 로고    scopus 로고
    • Ipilimumab (anti-CTLA antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
    • Yang, J. C. et al. ipilimumab (anti-CTLA antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J. Immunother. 30, 825-830 (2007).
    • (2007) J. Immunother. , vol.30 , pp. 825-830
    • Yang, J.C.1
  • 70
    • 34548125294 scopus 로고    scopus 로고
    • Vascular endothelial growth factortrap overcomes defects in dendritic cell differentiation but does not improve antigenspecific immune responses
    • Fricke, i. et al. vascular endothelial growth factortrap overcomes defects in dendritic cell differentiation but does not improve antigenspecific immune responses. Clin. Cancer Res. 13, 4840-4848 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 4840-4848
    • Fricke, I.1
  • 71
    • 33846882806 scopus 로고    scopus 로고
    • Update on the application of interleukin-2 in the treatment of renal cell carcinoma
    • McDermott, D. F. Update on the application of interleukin-2 in the treatment of renal cell carcinoma. Clin. Cancer Res. 13, 716s-720s (2007).
    • (2007) Clin. Cancer Res. , vol.13
    • McDermott, D.F.1
  • 72
    • 73849098632 scopus 로고    scopus 로고
    • Bevacizumab (B) plus lowdoses immunotherapy (iT) plus chemotherapy (CT) (BiC) in metastatic renal cell cancer (mrCC): Antitumor effects and variations of T-regulator cells (Treg) and other T-lymphocytes subsets
    • A study of the italian Oncology Group for Clinical research (GOirC) [abstract]
    • Passalacqua, r. et al. Bevacizumab (B) plus lowdoses immunotherapy (iT) plus chemotherapy (CT) (BiC) in metastatic renal cell cancer (mrCC): Antitumor effects and variations of T-regulator cells (Treg) and other T-lymphocytes subsets. A study of the italian Oncology Group for Clinical research (GOirC) [abstract]. ASCO Meeting Abstracts 26, 5121 (2008).
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 5121
    • Passalacqua, R.1
  • 73
    • 33845594278 scopus 로고    scopus 로고
    • Sorafenib plus interferon-á2b (iFN) as first-line therapy for advanced renal cell carcinoma (rCC): SwOG 0412 [abstract]
    • ryan, C. w. et al. sorafenib plus interferon-á2b (iFN) as first-line therapy for advanced renal cell carcinoma (rCC): SwOG 0412 [abstract]. ASCO Meeting Abstracts 24, 4525 (2006).
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 4525
    • Ryan, C.W.1
  • 74
    • 73849102127 scopus 로고    scopus 로고
    • Clinical and molecular factors predictive of outcome with first-line sorafenib-based therapy in advanced renal carcinoma (rCC): An analysis of swOG 0412 [abstract]
    • Goldman, B. H. et al. Clinical and molecular factors predictive of outcome with first-line sorafenib-based therapy in advanced renal carcinoma (rCC): An analysis of swOG 0412 [abstract]. ASCO Meeting Abstracts 25, 5108 (2007).
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 5108
    • Goldman, B.H.1
  • 75
    • 47049127786 scopus 로고    scopus 로고
    • Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
    • Hipp, M. H. et al. sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. Blood 111, 5610-5620 (2008).
    • (2008) Blood , vol.111 , pp. 5610-5620
    • Hipp, M.H.1
  • 76
    • 11144354471 scopus 로고    scopus 로고
    • A phase ii trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patients
    • Bleumer, i. et al. A phase ii trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patients. Br. J. Cancer 90, 985-990 (2004).
    • (2004) Br. J. Cancer , vol.90 , pp. 985-990
    • Bleumer, I.1
  • 77
    • 29144503225 scopus 로고    scopus 로고
    • A clinical trial with chimeric monoclonal antibody wX-G250 and low dose interleukin-2 pulsing scheme for advanced renal cell carcinoma
    • Bleumer, i. et al. A clinical trial with chimeric monoclonal antibody wX-G250 and low dose interleukin-2 pulsing scheme for advanced renal cell carcinoma. J. Urol. 175, 57-62 (2006).
    • (2006) J. Urol. , vol.175 , pp. 57-62
    • Bleumer, I.1
  • 79
    • 73849152747 scopus 로고    scopus 로고
    • [online]
    • As1409 (huBC1-huiL12), Antisoma [online], http://www.antisoma.com/asm/ products/ as1409/ (2007).
    • (2007) As1409 (huBC1-huiL12)
  • 80
    • 50249176028 scopus 로고    scopus 로고
    • New insights into form and function of fibronectin splice variants
    • white, e. s., Baralle, F. e. & Muro, A. F. New insights into form and function of fibronectin splice variants. J. Pathol. 216, 1-14 (2008).
    • (2008) J. Pathol. , vol.216 , pp. 1-14
    • White, E.S.1    Baralle, F.E.2    Muro, A.F.3
  • 83
    • 73849101371 scopus 로고    scopus 로고
    • Vaccination of renal cell cancer (rCC) patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (Trovax [T]) administered + low dose interleukin-2 (iL-2): A phase ii trial [abstract]
    • Hernandez-McClain, J. et al. vaccination of renal cell cancer (rCC) patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (Trovax [T]) administered + low dose interleukin-2 (iL-2): A phase ii trial [abstract]. ASCO Meeting Abstracts 26, 5101 (2008).
    • (2008) ASCO Meeting Abstracts , vol.26 , pp. 5101
    • Hernandez-Mcclain, J.1
  • 84
    • 33645697721 scopus 로고    scopus 로고
    • A phase i trial of vaccination of CA9-derived peptides for HLA-A24-positive patients with cytokine-refractory metastatic renal cell carcinoma
    • Uemura, H. et al. A phase i trial of vaccination of CA9-derived peptides for HLA-A24-positive patients with cytokine-refractory metastatic renal cell carcinoma. Clin. Cancer Res. 12, 1768-1775 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1768-1775
    • Uemura, H.1
  • 85
    • 53749087081 scopus 로고    scopus 로고
    • Anti-CTLA4 Monoclonal Antibody ipilimumab in the Treatment of Metastatic Melanoma: Recent Findings
    • Lens, M., Ferrucci, P. F. & Testori, A. Anti-CTLA4 Monoclonal Antibody ipilimumab in the Treatment of Metastatic Melanoma: recent Findings. Recent Pat. Anti-Cancer Drug Discov. 3, 105-113 (2008).
    • (2008) Recent Pat. Anti-Cancer Drug Discov. , vol.3 , pp. 105-113
    • Lens, M.1    Ferrucci, P.F.2    Testori, A.3
  • 86
    • 58149179532 scopus 로고    scopus 로고
    • Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients
    • Finke, J. H. et al. sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients. Clin. Cancer Res. 14, 6674-6682 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6674-6682
    • Finke, J.H.1
  • 87
    • 53249111806 scopus 로고    scopus 로고
    • Sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival
    • van Cruijsen, H. et al. sunitinib-induced myeloid lineage redistribution in renal cell cancer patients: CD1c+ dendritic cell frequency predicts progression-free survival. Clin. Cancer Res. 14, 5884-5892 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5884-5892
    • Van Cruijsen, H.1
  • 88
    • 61449150659 scopus 로고    scopus 로고
    • Cytoreductive nephrectomy in metastatic clear-cell renal cell carcinoma: Perspectives in the tyrosine kinase inhibitor era
    • Biswas, s. et al. Cytoreductive nephrectomy in metastatic clear-cell renal cell carcinoma: perspectives in the tyrosine kinase inhibitor era. Oncologist 14, 52-59 (2009).
    • (2009) Oncologist , vol.14 , pp. 52-59
    • Biswas, S.1
  • 89
    • 73849120302 scopus 로고    scopus 로고
    • Adjuvant therapies in primary clear-cell renal carcinoma; In recent advances in renal cell carcinoma (rCC)
    • Biswas, s. et al. Adjuvant therapies in primary clear-cell renal carcinoma; in recent advances in renal cell carcinoma (rCC). Int. Oncol. Updat. 53-77 (2008).
    • (2008) Int. Oncol. Updat. , pp. 53-77
    • Biswas, S.1
  • 90
    • 85003758578 scopus 로고    scopus 로고
    • Allogenic stem-cell transplantation of rCC after non-myeloablative chemotherapy: Feasibility, engraftment, and clinical results
    • rini, B. i. et al. Allogenic stem-cell transplantation of rCC after non-myeloablative chemotherapy: feasibility, engraftment, and clinical results. J. Clin. Oncol. 20, 2017-2024 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2017-2024
    • Rini, B.I.1
  • 91
    • 40549137442 scopus 로고    scopus 로고
    • Regression of human kidney cancer following allogenic stem cell transplantation is associated with recognition of an Herv-e antigen by T-cells
    • Takahashi, Y. et al. regression of human kidney cancer following allogenic stem cell transplantation is associated with recognition of an Herv-e antigen by T-cells. J. Clin. Invest. 118, 1099-1109 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1099-1109
    • Takahashi, Y.1
  • 92
    • 73849102505 scopus 로고    scopus 로고
    • National Cancer institute Clinical Trials. National Cancer Institute [online]
    • National Cancer institute Clinical Trials. National Cancer Institute [online], http://www.cancer.gov/ CLiNiCALTriALs (2009).
    • (2009)
  • 93
    • 34249868241 scopus 로고    scopus 로고
    • Adoptive T-cell therapy for cancer in the clinic
    • June, C. H. Adoptive T-cell therapy for cancer in the clinic. J. Clin. Invest. 117, 1466-1476 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 1466-1476
    • June, C.H.1
  • 94
    • 50549084485 scopus 로고    scopus 로고
    • Randomized phase ii trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer
    • Manegold, C. et al. randomized phase ii trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer. J. Clin. Oncol. 26, 3979-3986 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3979-3986
    • Manegold, C.1
  • 95
    • 0345060466 scopus 로고    scopus 로고
    • Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies
    • Murillo, O. et al. Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies. Clin. Cancer Res. 9, 5454-5464 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5454-5464
    • Murillo, O.1


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