Melamine activates NFκB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS production in macrophages and human embryonic kidney cells

Toxicology in Vitro

Volumn 27, Issue 6, 2013, Pages 1603-1611

  Kuo, Fu Chen ^a,b   Tseng, Yu Ting ^a   Wu, Sing Ru ^c   Wu, Ming Tsang ^a   Lo, Yi Ching ^c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b E DA HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Human embryonic kidney cell; Macrophage; Melamine; NADPH oxidase; NF B; Oxidative stress

Indexed keywords

APOCYNIN; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MELAMINE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA BINDING; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KIDNEY CELL; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TOXICITY TESTING;

HUMAN EMBRYONIC KIDNEY CELL; MACROPHAGE; MELAMINE; NADPH OXIDASE; NF-ΚB; OXIDATIVE STRESS;

ANIMALS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; HEK293 CELLS; HUMANS; MACROPHAGES; MICE; NADPH OXIDASE; NF-KAPPA B; REACTIVE OXYGEN SPECIES; TRIAZINES;

EID: 84877917762     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.04.011     Document Type: Article

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