Melamine causes apoptosis of rat kidney epithelial cell line (NRK-52e cells) via excessive intracellular ROS (reactive oxygen species) and the activation of p38 MAPK pathway

Cell Biology International

Volumn 36, Issue 4, 2012, Pages 383-389

  Guo, Chengzhi ^a,b   Yuan, Hui ^b   He, Zuping ^a,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HUNAN AGRICULTURAL UNIVERSITY   (China)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Melamine; Normal rat kidney (NRK) 52e cells; p38 mitogen activated protein kinase (MAPK) pathway; reactive oxygen species (ROS)

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACRIDINE ORANGE; ETHIDIUM BROMIDE; LIPOCORTIN 5; MELAMINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; EPITHELIUM CELL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; INTRACELLULAR SIGNALING; KIDNEY EPITHELIUM; KIDNEY TUBULE; MOLECULAR MECHANICS; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; IMIDAZOLES; KIDNEY TUBULES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRIAZINES;

RATTUS;

EID: 84859254307     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20110504     Document Type: Article

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