Toll-like receptor 4 signaling pathway mediates proinflammatory immune response to cobalt-alloy particles

Cellular Immunology

Volumn 282, Issue 1, 2013, Pages 53-65

  Potnis, Pushya A ^a   Dutta, Debargh K ^a   Wood, Steven C ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Co alloy particles; Cytokines; Metal on metal hips; Periprosthetic osteolysis; TLR4 signaling

Indexed keywords

ALLOY; COBALT; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 8; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL VIABILITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; METAL IMPLANTATION; METAL ON METAL JOINT PROSTHESIS; MONOCYTE; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; UPREGULATION;

ALLOYS; ANTIBODIES, BLOCKING; BLOTTING, WESTERN; CELL LINE, TUMOR; COBALT; HEK293 CELLS; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-1BETA; INTERLEUKIN-8; MACROPHAGES; MONOCYTES; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PARTICLE SIZE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84877917605     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2013.04.003     Document Type: Article

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