Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity

Journal of Biomedical Materials Research - Part A

Volumn 93, Issue 4, 2010, Pages 1312-1321

  Caicedo, Marco S ^a   Pennekamp, Peter H ^a   McAllister, Kyron ^a   Jacobs, Joshua J ^a   Hallab, Nadim J ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Costimulatory molecules; Cytokines; Inflammation; Ions; Macrophages

Indexed keywords

ADAPTIVE IMMUNE RESPONSE; ADAPTIVE RESPONSE; CELL LINES; COCRMO ALLOY; COSTIMULATORY MOLECULES; CYTOKINE PRODUCTION; CYTOKINES; HUMAN MONOCYTES; IMMUNE MECHANISM; INFLAMMATION; METAL IMPLANT DEBRIS; MOLYBDENUM IONS; MONOCYTES/MACROPHAGES; NICKEL IONS; OSTEOLYSIS; PROINFLAMMATORY CYTOKINES; PROINFLAMMATORY RESPONSE; RECEPTOR ANTAGONISTS; SOLUBLE IONS; T CELLS; UP-REGULATION;

ALLOYS; BODY FLUIDS; CELL CULTURE; CHROMIUM; COBALT; DEBRIS; MACROPHAGES; METAL IONS; METALS; MOLECULES; MOLYBDENUM; NICKEL ALLOYS; PATHOLOGY; POWDER METALLURGY;

MOLYBDENUM ALLOYS;

ALLOY; B7 ANTIGEN; CD86 ANTIGEN; CHROMIUM; COBALT; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; MOLYBDENUM; NICKEL; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ADULT; ARTICLE; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IMMUNOSTIMULATION; INFLAMMATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MALE; METAL IMPLANTATION; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROVOCATION TEST; REACTION ANALYSIS; T LYMPHOCYTE; UPREGULATION;

ALLOYS; ANTIGENS, CD80; ANTIGENS, CD86; COBALT; CYTOKINES; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1BETA; INTERLEUKIN-6; IONS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; METALS; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77951605369     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32627     Document Type: Article

References (44)

1. Hallab N. Metal sensitivity in patients with orthopedic implants. J Clin Rheumatol 2001;7:215-218. (Pubitemid 32776270)
2. Looney RJ, Schwarz EM, Boyd A, O'Keefe RJ. Periprosthetic osteolysis: an immunologist's update. Curr Opin Rheumatol 2006;18:80-87.
3. Hallab NJ, Caicedo M, Finnegan A, Jacobs JJ. Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty. J Orthop Surg 2008;3:6:1-11.
4. Goodman SB. Wear particles, periprosthetic osteolysis and the immune system. Biomaterials 2007;28:5044-5048.
5. Jacobs JJ, Hallab NJ. Loosening and osteolysis associated with metal-on-metal bearings: A local effect of metal hypersensitivity? J Bone Joint Surg Am 2006;88:1171-1172.
6. Arora A, Song Y, Chun L, Huie P, Trindade M, Smith RL, Goodman S. The role of the TH1 and TH2 immune responses in loosening and osteolysis of cemented total hip replacements. J Biomed Mater Res A 2003;64:693-697. (Pubitemid 37517303)
7. Jacobs JJ, Roebuck KA, Archibeck M, Hallab NJ, Glant TT. Osteolysis: Basic science. Clin Orthop Relat Res 2001;393: 71-77.
8. Archibeck MJ, Jacobs JJ, Roebuck KA, Glant TT. The basic science of periprosthetic osteolysis. Instr Course Lect 2001;50: 185-195.
9. Sinha RK, Shanbhag AS, Maloney WJ, Hasselman CT, Rubash HE. Osteolysis: Cause and effect. Instr Course Lect 1998;47: 307-320.
10. Ren W, Wu B, Peng X, Hua J, Hao HN, Wooley PH. Implant wear induces inflammation, but not osteoclastic bone resorption, in RANK(-/-) mice. J Orthop Res 2006;24:1575-1586. (Pubitemid 44203289)
11. Shanbhag AS, Kaufman AM, Hayata K, Rubash HE. Assessing osteolysis with use of high-throughput protein chips. J Bone Joint Surg Am 2007;89:1081-1089. (Pubitemid 46724600)
12. Fritz EA, Glant TT, Vermes C, Jacobs JJ, Roebuck KA. Chemokine gene activation in human bone marrow-derived osteoblasts following exposure to particulate wear debris. J Biomed Mater Res A 2006;77:192-201.
13. Roebuck KA, Vermes C, Carpenter LR, Fritz EA, Narayanan R, Glant TT. Down-regulation of procollagen alpha1[I] messenger RNA by titanium particles correlates with nuclear factor kappaB (NF-kappaB) activation and increased rel A and NF-kappaB1 binding to the collagen promoter. J Bone Miner Res 2001;16:501-510.
14. Hallab NJ, Anderson S, Stafford T, Glant T, Jacobs JJ. Lymphocyte responses in patients with total hip arthroplasty. J Orthop Res 2005;23:384-391. (Pubitemid 40287865)
15. Sato K, Takayanagi H. Osteoclasts, rheumatoid arthritis, and osteoimmunology. Curr Opin Rheumatol 2006;18:419-426.
16. Takayanagi H. Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 2007;7:292-304. (Pubitemid 46480961)
17. Takayanagi H. Inflammatory bone destruction and osteoimmunology. J Periodontal Res 2005;40:287-293.
18. Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003;423:337-342.
19. Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliot R, Chiu L, Black T. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 1999;96:3540-3545. (Pubitemid 29168945)
20. Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 2002;20:795-823.
21. Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 1999;402: 304-309. (Pubitemid 129516268)
22. Bendre MS, Montague DC, Peery T, Akel NS, Gaddy D, Suva LJ. Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease. Bone 2003;33:28-37. (Pubitemid 36952685)
23. Gao Y, Morita I, Maruo N, Kubota T, Murota S, Aso T. Expression of IL-6 receptor and GP130 in mouse bone marrow cells during osteoclast differentiation. Bone 1998;22:487-493. (Pubitemid 28226862)
24. Ma T, Miyanishi K, Suen A, Epstein NJ, Tomita T, Smith RL, Goodman SB. Human interleukin-1-induced murine osteoclastogenesis is dependent on RANKL, but independent of TNF-alpha. Cytokine 2004;26:138-144. (Pubitemid 38596924)
25. Kitaura H, Sands MS, Aya K, Zhou P, Hirayama T, Uthgenannt B, Wei S, Takeshita S, Novack DV, Silva MJ, Abu-Amer Y, Patrick Ross F, Teitelbaum SL. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J Immunol 2004; 173:4838-4846. (Pubitemid 39387764)
26. bu-Amer Y, Abbas S, Hirayama T. TNF receptor type 1 regulates RANK ligand expression by stromal cells and modulates osteoclastogenesis. J Cell Biochem 2004;93:980-989.
27. Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 2004;428:758-763. (Pubitemid 38508286)
28. Stolina M, Dwyer D, Ominsky MS, Corbin T, Van G, Bolon B, Sarosi I, McCabe J, Zack DJ, Kostenuik P. Continuous RANKL inhibition in osteoprotegerin transgenic mice and rats suppresses bone resorption without impairing lymphorganogenesis or functional immune responses. J Immunol 2007;179:7497-7505.
29. Stolina M, Adamu S, Ominsky M, Dwyer D, Asuncion F, Geng Z, Middleton S, Brown H, Pretorius J, Schett G, Bolon B, Feige U, Zack D, Kostenuik PJ. RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis. J Bone Miner Res 2005;20:1756-1765. (Pubitemid 41361876)
30. Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, Tanaka S, Kodama T, Akira S, Iwakura Y, Cua DJ, Takayanagi H. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006;203:2673-2682. (Pubitemid 44833343)
31. Lewis JB, Randol TM, Lockwood PE, Wataha JC. Effect of subtoxic concentrations of metal ions on NFkappaB activation in THP-1 human monocytes. J Biomed Mater Res A 2003;64: 217-224.
32. Lewis JB, Wataha JC, McCloud V, Lockwood PE, Messer RL, Tseng WY. Au(III), Pd(II), Ni(II), and Hg(II) alter NF kappa B signaling in THP1 monocytic cells. J Biomed Mater Res A 2005;74:474-481.
33. Catelas I, Petit A, Zukor DJ, Antoniou J, Huk OL. TNF-alpha secretion and macrophage mortality induced by cobalt and chromium ions in vitro-qualitative analysis of apoptosis. Biomaterials 2003;24:383-391. (Pubitemid 35287511)
34. Kaufman AM, Alabre CI, Rubash HE, Shanbhag AS. Human macrophage response to UHMWPE, TiAlV, CoCr, and alumina particles: Analysis of multiple cytokines using protein arrays. J Biomed Mater Res A 2008;84:464-474.
35. Watanabe H, Gehrke S, Contassot E, Roques S, Tschopp J, Friedmann PS, French LE, Gaide O. Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization. J Immunol 2008;180:5826-5832.
36. Watanabe H, Gaide O, Petrilli V, Martinon F, Contassot E, Roques S, Kummer JA, Tschopp J, French LE. Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 2007;127:1956-1963. (Pubitemid 47075373)
37. Hallab NJ. Lymphocyte transformation testing for quantifying metal-implant-related hypersensitivity responses. Dermatitis 2004;15:82-90.
38. Koster R, Vieluf D, Kiehn M, Sommerauer M, Kahler J, Baldus S, Meinertz T, Hamm CW. Nickel and molybdenum contact allergies in patients with coronary in-stent restenosis. Lancet 2000;356:1895-1897.
39. Gao Y, Grassi F, Ryan MR, Terauchi M, Page K, Yang X, Weitzmann MN, Pacifici R. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest 2007;117:122-132. (Pubitemid 46048459)
40. Clohisy JC, Hirayama T, Frazier E, Han SK, bu-Amer Y. NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis. J Orthop Res 2004;22:13-20. (Pubitemid 38035440)
41. Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ. Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis. J Orthop Res 2000;18:472-480. (Pubitemid 30599625)
42. Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol 1990;144:4226-4230. (Pubitemid 20187761)
43. Caicedo M, Desai R, Reddy A, McAllister K, Jacobs J, Hallab N. Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity. J Orthop Res 2009;27:847-854.
44. Li H, Willingham SB, Ting JP, Re F. Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol 2008;181:17-21.