-
1
-
-
0038497542
-
Molecular structure of nucleic acids: a structure for deoxyribose nucleic acid
-
Watson, J., and F. Crick. 1953. Molecular structure of nucleic acids: a structure for deoxyribose nucleic acid. Nature 171: 737.
-
(1953)
Nature
, vol.171
, pp. 737
-
-
Watson, J.1
Crick, F.2
-
2
-
-
0030849094
-
The influence of antisense oligonucleotide-induced RNA structure on E. coli RNase H1 activity
-
Lima, W.F., M. Venkatraman, and S.T. Crooke. 1997. The influence of antisense oligonucleotide-induced RNA structure on E. coli RNase H1 activity. J. Biol. Chem. 272 : 18191-18199.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18191-18199
-
-
Lima, W.F.1
Venkatraman, M.2
Crooke, S.T.3
-
3
-
-
0032750621
-
2′-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation
-
Manoharan, M. 1999. 2′-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation. Biochim. Biophys. Acta 1489 : 117-130.
-
(1999)
Biochim. Biophys. Acta
, vol.1489
, pp. 117-130
-
-
Manoharan, M.1
-
4
-
-
0034780950
-
Drug properties of second-generation antisense oligonucleotides: how do they measure up to their predecessors? Curr
-
Henry, S.P., R.S. Geary, R. Yu, and A.A. Levin. 2001. Drug properties of second-generation antisense oligonucleotides: how do they measure up to their predecessors? Curr. Opin. Invest. Drugs 2 : 1444-1449.
-
(2001)
Opin. Invest. Drugs
, vol.2
, pp. 1444-1449
-
-
Henry, S.P.1
Geary, R.S.2
Yu, R.3
Levin, A.A.4
-
5
-
-
0030797704
-
Antisense oligonucleotide inhibitors for the treatment of cancer: 1. Pharmacokinetic properties of phosphorothioate oligodeoxynucleotides
-
Geary, R.S., J.M. Leeds, S.P. Henry, D.K. Monteith, and A.A. Levin. 1997. Antisense oligonucleotide inhibitors for the treatment of cancer: 1. Pharmacokinetic properties of phosphorothioate oligodeoxynucleotides. Anti-Cancer Drug Design 12 : 383-393.
-
(1997)
Anti-Cancer Drug Design
, vol.12
, pp. 383-393
-
-
Geary, R.S.1
Leeds, J.M.2
Henry, S.P.3
Monteith, D.K.4
Levin, A.A.5
-
6
-
-
0030781238
-
Pharmacokinetic properties of phosphorothioate oligonucleotides
-
Leeds, J.M., R.S. Geary, S.P. Henry, J. Glover, W. Shanahan, J. Fitchett, T. Burckin, L. Truong, and A.A. Levin. 1997. Pharmacokinetic properties of phosphorothioate oligonucleotides. Nucleosides Nucleotides 16 : 1689-1693.
-
(1997)
Nucleosides Nucleotides
, vol.16
, pp. 1689-1693
-
-
Leeds, J.M.1
Geary, R.S.2
Henry, S.P.3
Glover, J.4
Shanahan, W.5
Fitchett, J.6
Burckin, T.7
Truong, L.8
Levin, A.A.9
-
7
-
-
0003099233
-
Pharmacokinetic properties in humans
-
In: S.T. Crooke (Ed.), Marcel Dekker, Inc., New York
-
Yu, R.Z., R.S. Geary, T. Ushiro-Watanabe, A.A. Levin, and S.L. Schoenfeld. 2001. Pharmacokinetic properties in humans. In: S.T. Crooke (Ed.), Antisense DrugTechnology: Principles, Strategies, and Applications. Marcel Dekker, Inc., New York, pp. 183-200.
-
(2001)
Antisense DrugTechnology: Principles, Strategies, and Applications
, pp. 183-200
-
-
Yu, R.Z.1
Geary, R.S.2
Ushiro-Watanabe, T.3
Levin, A.A.4
Schoenfeld, S.L.5
-
8
-
-
0028850751
-
Pharmacokinetics of antisense oligonucleotides
-
Agrawal, S., J. Temsamani, W. Galbraith, and J. Tang. 1995. Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinet. 28 : 7-16.
-
(1995)
Clin. Pharmacokinet.
, vol.28
, pp. 7-16
-
-
Agrawal, S.1
Temsamani, J.2
Galbraith, W.3
Tang, J.4
-
9
-
-
0028934855
-
Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (Gem 91) developed as a therapeutic agent for human immunodeficiency virus type-1
-
Zhang, R., R.B. Diasio, Z. Lu, T. Liu, Z. Jiang, W.M. Galbraith, and S. Agrawal. 1995. Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (Gem 91) developed as a therapeutic agent for human immunodeficiency virus type-1. Biochem. Pharmacol. 49 : 929-939.
-
(1995)
Biochem. Pharmacol.
, vol.49
, pp. 929-939
-
-
Zhang, R.1
Diasio, R.B.2
Lu, Z.3
Liu, T.4
Jiang, Z.5
Galbraith, W.M.6
Agrawal, S.7
-
10
-
-
0028241377
-
Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate
-
Sands, H., L.J. Gorey-Feret, A.J. Cocuzza, F.W. Hobbs, D. Chidester, and G.L.Trainor. 1994. Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate. Mol. Pharmacol. 45 : 932-943.
-
(1994)
Mol. Pharmacol.
, vol.45
, pp. 932-943
-
-
Sands, H.1
Gorey-Feret, L.J.2
Cocuzza, A.J.3
Hobbs, F.W.4
Chidester, D.5
Trainor, G.L.6
-
11
-
-
0031910668
-
Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion
-
Grindel, J.M., T.J. Musick, Z. Jiang, A. Roskey, and S. Agrawal. 1998. Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion. Antisense Nucleic Acid Drug Dev. 8 : 43-52.
-
(1998)
Antisense Nucleic Acid Drug Dev.
, vol.8
, pp. 43-52
-
-
Grindel, J.M.1
Musick, T.J.2
Jiang, Z.3
Roskey, A.4
Agrawal, S.5
-
12
-
-
0027786912
-
Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats
-
Cossum, P.A., H. Sasmor, D. Dellinger, L. Truong, L. Cummins, S.R. Owens, P.M.Markham, J.P. Shea, and S.T. Crooke. 1993. Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats. J. Pharmacol. Exp. Ther. 267 : 1181-1190.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.267
, pp. 1181-1190
-
-
Cossum, P.A.1
Sasmor, H.2
Dellinger, D.3
Truong, L.4
Cummins, L.5
Owens, S.R.6
Markham, P.M.7
Shea, J.P.8
Crooke, S.T.9
-
13
-
-
0028183175
-
Pharmacokinetics of a 14C-labeled phosphorothioate oligonucleotide, ISIS 2105, after intradermal administration to rats
-
Cossum, P.A., L. Troung, S.R. Owens, P.M.Markham, J.P. Shea, and S.T. Crooke. 1994. Pharmacokinetics of a 14C-labeled phosphorothioate oligonucleotide, ISIS 2105, after intradermal administration to rats. J. Pharmacol. Exp. Ther. 269 : 89-94.
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.269
, pp. 89-94
-
-
Cossum, P.A.1
Troung, L.2
Owens, S.R.3
Markham, P.M.4
Shea, J.P.5
Crooke, S.T.6
-
14
-
-
0035138215
-
Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey
-
Yu, R.Z., R.S. Geary, J.M. Leeds, T. Ushiro-Watanabe, M. Moore, J. Fitchett, J.Matson, T. Burckin, M.V. Templin, and A.A. Levin. 2001. Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey. J. Pharm. Sci. 90 : 182-193.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 182-193
-
-
Yu, R.Z.1
Geary, R.S.2
Leeds, J.M.3
Ushiro-Watanabe, T.4
Moore, M.5
Fitchett, J.6
Matson, J.7
Burckin, T.8
Templin, M.V.9
Levin, A.A.10
-
15
-
-
0030987678
-
Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302)
-
Glover, J.M., J.M. Leeds, T.G. Mant, D. Amin, D.L. Kisner, J.E. Zuckerman, R.S. Geary, A.A. Levin, and W.R. Shanahan, Jr. 1997. Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302). J. Pharmacol. Exp. Ther. 282 : 1173-1180.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.282
, pp. 1173-1180
-
-
Glover, J.M.1
Leeds, J.M.2
Mant, T.G.3
Amin, D.4
Kisner, D.L.5
Zuckerman, J.E.6
Geary, R.S.7
Levin, A.A.8
Shanahan Jr., W.R.9
-
16
-
-
0032921468
-
Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects
-
Sereni, D., R. Tubiana, C. Lascoux, C. Katlama, O. Taulera, A. Bourque, A. Cohen, B. Dvorchik, R.R. Martin, C. Tournerie, A. Gouyette, and P.J. Schechter. 1999. Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects. J. Clin. Pharmacol. 39 : 47-54.
-
(1999)
J. Clin. Pharmacol.
, vol.39
, pp. 47-54
-
-
Sereni, D.1
Tubiana, R.2
Lascoux, C.3
Katlama, C.4
Taulera, O.5
Bourque, A.6
Cohen, A.7
Dvorchik, B.8
Martin, R.R.9
Tournerie, C.10
Gouyette, A.11
Schechter, P.J.12
-
17
-
-
0002574175
-
Pharmacokinetic properties of phosphorothioate oligonucleotides in humans
-
In: S.T. Crooke (Ed.), Springer, Heidelberg
-
Leeds, J.M., and R.S. Geary. 1998. Pharmacokinetic properties of phosphorothioate oligonucleotides in humans. In: S.T. Crooke (Ed.), Antisense Research and Applications. Springer, Heidelberg, pp. 217-231.
-
(1998)
Antisense Research and Applications
, pp. 217-231
-
-
Leeds, J.M.1
Geary, R.S.2
-
18
-
-
0030776403
-
Pharmacokinetics, metabolism and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (CGP 69846A) after intravenous and subcutaneous administration
-
Phillips, J.A., S.J. Craig, D. Bayley, R.A. Christian, R.S. Geary, and P.L. Nicklin. 1997. Pharmacokinetics, metabolism and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (CGP 69846A) after intravenous and subcutaneous administration. Biochem. Pharmacol. 54 : 657-668.
-
(1997)
Biochem. Pharmacol.
, vol.54
, pp. 657-668
-
-
Phillips, J.A.1
Craig, S.J.2
Bayley, D.3
Christian, R.A.4
Geary, R.S.5
Nicklin, P.L.6
-
19
-
-
0029761186
-
Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice
-
Rifai, A., W. Byrsch, K. Fadden, J. Clark, and K.-H. Schlingensipen. 1996. Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice. Am. J. Pathol. 149 : 717-725.
-
(1996)
Am. J. Pathol.
, vol.149
, pp. 717-725
-
-
Rifai, A.1
Byrsch, W.2
Fadden, K.3
Clark, J.4
Schlingensipen, K.-H.5
-
20
-
-
0028568244
-
A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts
-
Crooke, S.T., L.R. Grillone, A. Tendolkar, A. Garrett, M.J. Fratkin, J. Leeds, and W.H. Barr. 1994. A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts. Clin. Pharmacol. Ther. 56 : 641-646.
-
(1994)
Clin. Pharmacol. Ther.
, vol.56
, pp. 641-646
-
-
Crooke, S.T.1
Grillone, L.R.2
Tendolkar, A.3
Garrett, A.4
Fratkin, M.J.5
Leeds, J.6
Barr, W.H.7
-
21
-
-
0035119622
-
Absolute bioavailability of 2′-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats
-
Geary, R.S., O. Khatsenko, K. Bunker, R. Crooke, M. Moore, T. Burckin, L. Truong, H. Sasmor, and A.A. Levin. 2001. Absolute bioavailability of 2′-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats. J. Pharmacol. Exp. Ther. 296 : 898-904.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, pp. 898-904
-
-
Geary, R.S.1
Khatsenko, O.2
Bunker, K.3
Crooke, R.4
Moore, M.5
Burckin, T.6
Truong, L.7
Sasmor, H.8
Levin, A.A.9
-
22
-
-
0035119936
-
Pharmacokinetic properties of 2′-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats
-
Geary, R.S., T. Ushiro-Watanabe, L. Truong, S.M. Freier, E.A. Lesnik, N.B. Sioufi, H. Sasmor, M.Manoharan, and A.A. Levin. 2001. Pharmacokinetic properties of 2′-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats. J. Pharmacol. Exp. Ther. 296 : 890-897.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, pp. 890-897
-
-
Geary, R.S.1
Ushiro-Watanabe, T.2
Truong, L.3
Freier, S.M.4
Lesnik, E.A.5
Sioufi, N.B.6
Sasmor, H.7
Manoharan, M.8
Levin, A.A.9
-
23
-
-
0030426849
-
Pharmacokinetics and tissue disposition of a chimeric oligodeoxynucleoside phosphorothioate in rats after intravenous administration
-
Zhang, R.W., R.P. Iyer, D. Yu, W.T. Tan, X.S. Zhang, Z.H. Lu, H. Zhao, and S. Agrawal. 1996. Pharmacokinetics and tissue disposition of a chimeric oligodeoxynucleoside phosphorothioate in rats after intravenous administration. J. Pharmacol. Exp. Ther. 278 : 971-979.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.278
, pp. 971-979
-
-
Zhang, R.W.1
Iyer, R.P.2
Yu, D.3
Tan, W.T.4
Zhang, X.S.5
Lu, Z.H.6
Zhao, H.7
Agrawal, S.8
-
24
-
-
0036896204
-
Phase I trial of ISIS 104838, a 2′-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha
-
Sewell, L.K., R.S. Geary, B.F. Baker, J.M. Glover, T.G.K. Mant, R.Z. Yu, J.A. Tami, and A.F. Dorr. 2002. Phase I trial of ISIS 104838, a 2′-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha. J. Pharmacol. Exp. Ther. 303 : 1334-1343.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 1334-1343
-
-
Sewell, L.K.1
Geary, R.S.2
Baker, B.F.3
Glover, J.M.4
Mant, T.G.K.5
Yu, R.Z.6
Tami, J.A.7
Dorr, A.F.8
-
25
-
-
14644410433
-
Novel antisense anti-MDM2 mixedbackbone oligonucleotides: Proof of principle, in vitro and in vivo activities, and mechanisms
-
Zhang, R., H. Wang, and S. Agrawal. 2005. Novel antisense anti-MDM2 mixedbackbone oligonucleotides: Proof of principle, in vitro and in vivo activities, and mechanisms. Curr. Cancer Drug Targets 5 : 43-49.
-
(2005)
Curr. Cancer Drug Targets
, vol.5
, pp. 43-49
-
-
Zhang, R.1
Wang, H.2
Agrawal, S.3
-
26
-
-
10744226217
-
Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2′-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species
-
Geary, R.S., R.Z. Yu, T. Watanabe, S.P. Henry, G.E. Hardee, A. Chappell, J. Matson, H. Sasmor, L. Cummins, and A.A. Levin. 2003. Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2′-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species. Drug Metab. Dispos. 31: 1419-1428.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 1419-1428
-
-
Geary, R.S.1
Yu, R.Z.2
Watanabe, T.3
Henry, S.P.4
Hardee, G.E.5
Chappell, A.6
Matson, J.7
Sasmor, H.8
Cummins, L.9
Levin, A.A.10
-
27
-
-
8844262560
-
RNA interference and chemically modified small interfering RNAs
-
Manoharan, M. 2004. RNA interference and chemically modified small interfering RNAs. Curr. Opin. Chem. Biol. 8: 570-579.
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 570-579
-
-
Manoharan, M.1
-
28
-
-
0033555551
-
Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-γ expression
-
McKay, R.A., L.J. Miraglia, L.L. Cummins, S.R. Owens, H. Sasmor, and N.M. Dean. 1999. Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-γ expression. J. Biol. Chem. 274 : 1715-1722.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1715-1722
-
-
McKay, R.A.1
Miraglia, L.J.2
Cummins, L.L.3
Owens, S.R.4
Sasmor, H.5
Dean, N.M.6
-
29
-
-
0347124829
-
Tissue disposition of a 2′-O-(2-methoxy) ethyl modified antisense oligonucleotides in monkeys
-
Yu, R.Z., R.S. Geary, D.K. Monteith, J. Matson, L. Truong, J. Fitchett, and A.A. Levin. 2004. Tissue disposition of a 2′-O-(2-methoxy) ethyl modified antisense oligonucleotides in monkeys. J. Pharm. Sci. 93 : 48-59.
-
(2004)
J. Pharm. Sci.
, vol.93
, pp. 48-59
-
-
Yu, R.Z.1
Geary, R.S.2
Monteith, D.K.3
Matson, J.4
Truong, L.5
Fitchett, J.6
Levin, A.A.7
-
30
-
-
0036570927
-
Development of an ultrasensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma
-
Yu, R.Z., B. Baer, A. Chappel, R.S. Geary, E. Chueng, and A.A. Levin. 2002. Development of an ultrasensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma. Anal. Biochem. 304 : 19-25.
-
(2002)
Anal. Biochem.
, vol.304
, pp. 19-25
-
-
Yu, R.Z.1
Baer, B.2
Chappel, A.3
Geary, R.S.4
Chueng, E.5
Levin, A.A.6
-
31
-
-
59749095779
-
Terminal elimination rates for antisense oligonucleotides in plasma correlate with tissue clearance rates in mice and monkeys
-
In: Annual Meeting of American Association of Pharmaceutical Scientists, Denver, Colorado
-
Yu, R.Z., J. Matson, and R.S. Geary. 2001. Terminal elimination rates for antisense oligonucleotides in plasma correlate with tissue clearance rates in mice and monkeys. In: Annual Meeting of American Association of Pharmaceutical Scientists, Denver, Colorado.
-
(2001)
-
-
Yu, R.Z.1
Matson, J.2
Geary, R.S.3
-
32
-
-
0002328601
-
The pharmacokinetics and toxicity of phosphorothioate oligonucleotides
-
In: J.A. Thomas (Ed.), Taylor & Francis, Philadelphia, PA
-
Levin, A.A., R.S. Geary, J.M. Leeds, D.K. Monteith, R.Z. Yu, M.V. Templin, and S.P. Henry. 1998. The pharmacokinetics and toxicity of phosphorothioate oligonucleotides. In: J.A. Thomas (Ed.), Biotechnology and Safety Assessment. Taylor & Francis, Philadelphia, PA, pp. 151-175.
-
(1998)
Biotechnology and Safety Assessment
, pp. 151-175
-
-
Levin, A.A.1
Geary, R.S.2
Leeds, J.M.3
Monteith, D.K.4
Yu, R.Z.5
Templin, M.V.6
Henry, S.P.7
-
33
-
-
84889837156
-
In vitro protein binding and drug interaction studies of an antisense oligonucleotide (ASO)
-
Isis 113715, targeting human Ptb1b mRNA. In: AAPS Annual Meeting and Exposition. American Association of Pharmaceutical Scientists, Baltimore, MD
-
Watanabe, T.A., R.S. Geary, and A.A. Levin. 2004. In vitro protein binding and drug interaction studies of an antisense oligonucleotide (ASO), Isis 113715, targeting human Ptb1b mRNA. In: AAPS Annual Meeting and Exposition. American Association of Pharmaceutical Scientists, Baltimore, MD.
-
(2004)
-
-
Watanabe, T.A.1
Geary, R.S.2
Levin, A.A.3
-
34
-
-
0027275566
-
Physiological parameters in laboratory animals and humans
-
Davies, B., and T. Morris. 1993. Physiological parameters in laboratory animals and humans. Pharm. Res. 10 : 1093-1095.
-
(1993)
Pharm. Res.
, vol.10
, pp. 1093-1095
-
-
Davies, B.1
Morris, T.2
-
35
-
-
33746800852
-
Comparative singledose disposition of radiolabeled ISIS 104838 and ISIS 113715 in rat
-
In: Annual Meeting of Pharmaceutical Scientists, Toronto, Canada
-
Grundy, J.S., R.Z. Yu, R.S. Geary, A.A. Levin, S. Zhao, A. Keyhani, and G. Piccirilli. 2002. Comparative singledose disposition of radiolabeled ISIS 104838 and ISIS 113715 in rat. In: Annual Meeting of Pharmaceutical Scientists, Toronto, Canada.
-
(2002)
-
-
Grundy, J.S.1
Yu, R.Z.2
Geary, R.S.3
Levin, A.A.4
Zhao, S.5
Keyhani, A.6
Piccirilli, G.7
-
36
-
-
0030667690
-
Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression
-
Geary, R.S., J.M. Leeds, J. Fitchett, T. Burckin, L. Troung, C. Spainhour, M. Creek, and A.A. Levin. 1997. Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression. Drug Metab. Dispos. 25 : 1272-1281.
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 1272-1281
-
-
Geary, R.S.1
Leeds, J.M.2
Fitchett, J.3
Burckin, T.4
Troung, L.5
Spainhour, C.6
Creek, M.7
Levin, A.A.8
-
37
-
-
0026573498
-
Organ distribution and stability of phosphorothioated oligodeoxyribonucleotides in mice
-
Goodarzi, G., M. Watabe, and K. Watabe. 1992. Organ distribution and stability of phosphorothioated oligodeoxyribonucleotides in mice. Biopharm. Drug Dispos. 13 : 221-227.
-
(1992)
Biopharm. Drug Dispos.
, vol.13
, pp. 221-227
-
-
Goodarzi, G.1
Watabe, M.2
Watabe, K.3
-
38
-
-
0034980195
-
Integration of pharmacokinetic and pharmacodynamic studies in the discovery, development, and review of protein therapeutic agents: a conference report
-
Galluppi, G.R., M.C. Rogge, L.K. Roskos, L.J. Lesko, M.D. Green, D.W. Feigal, Jr., and C.C. Peck. 2001. Integration of pharmacokinetic and pharmacodynamic studies in the discovery, development, and review of protein therapeutic agents: a conference report. Clin. Pharmacol. Ther. 69 : 387-399.
-
(2001)
Clin. Pharmacol. Ther.
, vol.69
, pp. 387-399
-
-
Galluppi, G.R.1
Rogge, M.C.2
Roskos, L.K.3
Lesko, L.J.4
Green, M.D.5
Feigal Jr., D.W.6
Peck, C.C.7
-
39
-
-
0036231778
-
Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice
-
Butler, M., R.A. McKay, I.J. Popoff, W.A. Gaarde, D. Witchell, S.F. Murray, N.M. Dean, S. Bhanot, and B.P. Monia. 2002. Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes 51: 1028-1034.
-
(2002)
Diabetes
, vol.51
, pp. 1028-1034
-
-
Butler, M.1
McKay, R.A.2
Popoff, I.J.3
Gaarde, W.A.4
Witchell, D.5
Murray, S.F.6
Dean, N.M.7
Bhanot, S.8
Monia, B.P.9
-
40
-
-
0034883854
-
Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O-(2-methoxy)ethyl chemistry
-
Zellweger, T., H. Miyake, S. Cooper, K. Chi, B.S. Conklin, B.P. Monia, and M.E. Gleave. 2001. Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O-(2-methoxy)ethyl chemistry. J. Pharmacol. Exp. Ther. 298 : 934-940.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.298
, pp. 934-940
-
-
Zellweger, T.1
Miyake, H.2
Cooper, S.3
Chi, K.4
Conklin, B.S.5
Monia, B.P.6
Gleave, M.E.7
-
41
-
-
0031782392
-
A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of steroid-dependent Crohn's disease
-
Yacyshyn, B.R., M.B. Bowen-Yacyshyn, L. Jewell, R.A. Rothlein, E. Mainolfi, J.A. Tami, C.F. Bennett, D.L. Kisner, and W.R. Shanahan. 1998. A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of steroid-dependent Crohn's disease. Gastroenterology 114 : 1133-1142.
-
(1998)
Gastroenterology
, vol.114
, pp. 1133-1142
-
-
Yacyshyn, B.R.1
Bowen-Yacyshyn, M.B.2
Jewell, L.3
Rothlein, R.A.4
Mainolfi, E.5
Tami, J.A.6
Bennett, C.F.7
Kisner, D.L.8
Shanahan, W.R.9
-
42
-
-
84889843185
-
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense to clusterin, in patients with localized prostate cancer prior to radical prostatectomy
-
In: 40th Annual Meeting of the American Society of Clinical Oncology, New Orleans, LA
-
Chi, K.N., E. Eisenhauer, L. Fazli, E.C. Jones, S.L. Goldenberg, J. Powers, and M.E. Gleave. 2004. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense to clusterin, in patients with localized prostate cancer prior to radical prostatectomy. In: 40th Annual Meeting of the American Society of Clinical Oncology, New Orleans, LA.
-
(2004)
-
-
Chi, K.N.1
Eisenhauer, E.2
Fazli, L.3
Jones, E.C.4
Goldenberg, S.L.5
Powers, J.6
Gleave, M.E.7
-
43
-
-
0032724911
-
Novel mechanisms for antisense-mediated regulation of gene expression
-
Baker, B.F., and B.P. Monia. 1999. Novel mechanisms for antisense-mediated regulation of gene expression. Biochim. Biophys. Acta 1489 : 3-18.
-
(1999)
Biochim. Biophys. Acta
, vol.1489
, pp. 3-18
-
-
Baker, B.F.1
Monia, B.P.2
-
44
-
-
0029791763
-
Second-generation antisense oligonucleotides: Structure-activity relationships and the design of improved signal transduction inhibitors
-
Altmann, K.-H., D. Fabbro, N.M. Dean, T. Geiger, B.P. Monia, M. Muuler, and P. Nicklin. 1996. Second-generation antisense oligonucleotides: Structure-activity relationships and the design of improved signal transduction inhibitors. Biochem. Soc. Trans. 24 : 630-637.
-
(1996)
Biochem. Soc. Trans.
, vol.24
, pp. 630-637
-
-
Altmann, K.-H.1
Fabbro, D.2
Dean, N.M.3
Geiger, T.4
Monia, B.P.5
Muuler, M.6
Nicklin, P.7
-
45
-
-
0031010177
-
2′-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells
-
Baker, B.F., S.S. Lot, T.P. Condon, S. Cheng-Flournoy, E.A. Lesnik, H.M. Sasmor, and C.F. Bennett. 1997. 2′-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells. J. Biol. Chem. 272 : 11994-12000.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11994-12000
-
-
Baker, B.F.1
Lot, S.S.2
Condon, T.P.3
Cheng-Flournoy, S.4
Lesnik, E.A.5
Sasmor, H.M.6
Bennett, C.F.7
-
46
-
-
0035142861
-
Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice
-
Yu, R.Z., H. Zhang, R.S. Geary, M. Graham, L. Masarjian, K. Lemonidis, R. Crooke, N.M. Dean, and A.A. Levin. 2001. Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice. J. Pharmacol. Exp. Ther. 296 : 388-395.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, pp. 388-395
-
-
Yu, R.Z.1
Zhang, H.2
Geary, R.S.3
Graham, M.4
Masarjian, L.5
Lemonidis, K.6
Crooke, R.7
Dean, N.M.8
Levin, A.A.9
-
47
-
-
0033891369
-
Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis
-
Zhang, H., J. Cook, J. Nickel, R. Yu, K. Stecker, K. Myers, and N.M. Dean. 2000. Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis. Nature Biotechnol. 18 : 862-867.
-
(2000)
Nature Biotechnol.
, vol.18
, pp. 862-867
-
-
Zhang, H.1
Cook, J.2
Nickel, J.3
Yu, R.4
Stecker, K.5
Myers, K.6
Dean, N.M.7
-
48
-
-
84889824123
-
Effect of treatment regimen on sub-organ pharmacodynamics of a 2′-MOE modified antisense oligonucleotide, Isis 116847, targeting putative protein tyrosine phosphatase (PTEN)mRNA in rats
-
In: AAPS Annual Meeting and Exposition. American Association of Pharmaceutical Scientists, Salt Lake City, UT
-
Yu, R.Z., G. Riley, K. Hoc, T.A.Watanabe, J.Matson, S.Murray, S. Booten, S. Bhanot, B. Monia, and R.S. Geary. 2003. effect of treatment regimen on sub-organ pharmacodynamics of a 2′-MOE modified antisense oligonucleotide, Isis 116847, targeting putative protein tyrosine phosphatase (PTEN)mRNA in rats. In: AAPS Annual Meeting and Exposition. American Association of Pharmaceutical Scientists, Salt Lake City, UT.
-
(2003)
-
-
Yu, R.Z.1
Riley, G.2
Hoc, K.3
Watanabe, T.A.4
Matson, J.5
Murray, S.6
Booten, S.7
Bhanot, S.8
Monia, B.9
Geary, R.S.10
-
49
-
-
84889764452
-
In vivo pharmacodynamics and sub-cellular distribution of a 2-MOE-modified antisense oligonucleotide (ASO), ISIS 116847, targeting putative protein tyrosine phosphatase (PTEN) mRNA in mice and rats
-
In: Annual Meeting of Society ofToxicology and Chemistry, Baltimore, Maryland
-
Yu, R.Y., E.J. McArdle, G. Riley, K. Hoc, K.C. Nishihara, T.A. Watanabe, S.K. Pandey, S. Bhanot, and R.S. Geary. 2002. In vivo pharmacodynamics and sub-cellular distribution of a 2-MOE-modified antisense oligonucleotide (ASO), ISIS 116847, targeting putative protein tyrosine phosphatase (PTEN) mRNA in mice and rats. In: Annual Meeting of Society ofToxicology and Chemistry, Baltimore, Maryland.
-
(2002)
-
-
Yu, R.Y.1
McArdle, E.J.2
Riley, G.3
Hoc, K.4
Nishihara, K.C.5
Watanabe, T.A.6
Pandey, S.K.7
Bhanot, S.8
Geary, R.S.9
-
50
-
-
84889852884
-
Synovial biomarker study of ISIS 104838, an antisense oligodeoxynucleotide targeting TNF-alpha, in rheumatoid arthritis
-
In: 67th Annual Meeting of the American College of Rheumatology (ACR). October 23-28, Orlando, Florida, USA
-
Wei, N., J. Fiechtner, D. Boyle, A. Kavanaugh, S. Delauter, S. Rosengren, G.S. Firestein, J. Tami, R. Yu, and L. Sewell. 2003. Synovial biomarker study of ISIS 104838, an antisense oligodeoxynucleotide targeting TNF-alpha, in rheumatoid arthritis. In: 67th Annual Meeting of the American College of Rheumatology (ACR). October 23-28, Orlando, Florida, USA.
-
(2003)
-
-
Wei, N.1
Fiechtner, J.2
Boyle, D.3
Kavanaugh, A.4
Delauter, S.5
Rosengren, S.6
Firestein, G.S.7
Tami, J.8
Yu, R.9
Sewell, L.10
-
51
-
-
0035427644
-
Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration
-
Graham, M.J., S.T. Crooke, K.M. Lemonidis, H.J. Gaus, M.V. Templin, and R.M. Crooke. 2001. Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration. Biochem. Pharmacol. 62 : 297-306.
-
(2001)
Biochem. Pharmacol.
, vol.62
, pp. 297-306
-
-
Graham, M.J.1
Crooke, S.T.2
Lemonidis, K.M.3
Gaus, H.J.4
Templin, M.V.5
Crooke, R.M.6
-
52
-
-
0036303535
-
Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer
-
Morris, M.J., W.P. Tong, C. Cordon-Cardo, M. Drobnjak, W.K. Kelly, S.F. Slovin, K.L. Terry, K. Siedlecki, P. Swanson, M. Rafi, R.S. DiPaola, N. Rosen, and H.I. Scher. 2002. Phase I trial of BCL-2 antisense oligonucleotide (G3139) administered by continuous intravenous infusion in patients with advanced cancer. Clin. Cancer Res. 8 : 679-683.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 679-683
-
-
Morris, M.J.1
Tong, W.P.2
Cordon-Cardo, C.3
Drobnjak, M.4
Kelly, W.K.5
Slovin, S.F.6
Terry, K.L.7
Siedlecki, K.8
Swanson, P.9
Rafi, M.10
DiPaola, R.S.11
Rosen, N.12
Scher, H.I.13
-
53
-
-
0030065059
-
Quantitation of phosphorothioate oligonucleotides in human plasma
-
Leeds, J.M., M.J. Graham, L. Troung, and L.L. Cummins. 1996. Quantitation of phosphorothioate oligonucleotides in human plasma. Anal. Biochem. 235 : 36-43.
-
(1996)
Anal. Biochem.
, vol.235
, pp. 36-43
-
-
Leeds, J.M.1
Graham, M.J.2
Troung, L.3
Cummins, L.L.4
-
54
-
-
0025223297
-
High-performance liquid chromatographic analysis of phosphorothioate analogues of oligodeoxynucleotides in biological fluids
-
Bigelow, J.C., L.R. Chirin, L.A. Mathews, and J.J. McCormack. 1990. High-performance liquid chromatographic analysis of phosphorothioate analogues of oligodeoxynucleotides in biological fluids. J. Chromatogr. Biomed. Appl. 533 : 133-140.
-
(1990)
J. Chromatogr. Biomed. Appl.
, vol.533
, pp. 133-140
-
-
Bigelow, J.C.1
Chirin, L.R.2
Mathews, L.A.3
McCormack, J.J.4
-
55
-
-
0037143754
-
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
-
Zinker, B.A., C.M. Rondinone, J.M.Trevillyan, R.J. Gum, J.E. Clampit, J.F. Waring, N. Xie, D. Wilcox, P. Jacobson, L. Frost, P.E. Kroeger, R.M. Reilly, S. Koterski, T.J. Opgenorth, R.G. Ulrich, S. Crosby, M. Butler, S.F. Murray, R.A. McKay, S. Bhanot, B.P. Monia, and M.R. Jirousek. 2002. PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Proc. Natl. Acad. Sci. USA 99 : 11357-11162.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11357-11162
-
-
Zinker, B.A.1
Rondinone, C.M.2
Trevillyan, J.M.3
Gum, R.J.4
Clampit, J.E.5
Waring, J.F.6
Xie, N.7
Wilcox, D.8
Jacobson, P.9
Frost, L.10
Kroeger, P.E.11
Reilly, R.M.12
Koterski, S.13
Opgenorth, T.J.14
Ulrich, R.G.15
Crosby, S.16
Butler, M.17
Murray, S.F.18
McKay, R.A.19
Bhanot, S.20
Monia, B.P.21
Jirousek, M.R.22
more..
-
56
-
-
0842288445
-
Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice
-
Liang, Y., M.C. Osborne, B.P. Monia, S. Bhanot, W.A. Gaarde, C. Reed, P. She, T.L. Jetton, and K.T. Demarest. 2004. Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Diabetes 53 : 410-417.
-
(2004)
Diabetes
, vol.53
, pp. 410-417
-
-
Liang, Y.1
Osborne, M.C.2
Monia, B.P.3
Bhanot, S.4
Gaarde, W.A.5
Reed, C.6
She, P.7
Jetton, T.L.8
Demarest, K.T.9
-
57
-
-
20044384728
-
Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism
-
Watts, L.M., V.P. Manchem, T.A. Leedom, A.L. Rivard, R.A. McKay, D. Bao, T. Neroladakis, B.P. Monia, D.M. Bodenmiller, J.X. Cao, H.Y. Zhang, A.L. Cox, S.J. Jacobs, M.D. Michael, K.W. Sloop, and S. Bhanot. 2005. Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism. Diabetes 54 : 1846-1853.
-
(2005)
Diabetes
, vol.54
, pp. 1846-1853
-
-
Watts, L.M.1
Manchem, V.P.2
Leedom, T.A.3
Rivard, A.L.4
McKay, R.A.5
Bao, D.6
Neroladakis, T.7
Monia, B.P.8
Bodenmiller, D.M.9
Cao, J.X.10
Zhang, H.Y.11
Cox, A.L.12
Jacobs, S.J.13
Michael, M.D.14
Sloop, K.W.15
Bhanot, S.16
-
58
-
-
20544474017
-
An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis
-
Crooke, R.M., M.J. Graham, K.M. Lemonidis, C.P. Whipple, S. Koo, and R.J. Perera. 2005. An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis. J. Lipid Res. 46: 872-884.
-
(2005)
J. Lipid Res.
, vol.46
, pp. 872-884
-
-
Crooke, R.M.1
Graham, M.J.2
Lemonidis, K.M.3
Whipple, C.P.4
Koo, S.5
Perera, R.J.6
-
59
-
-
84889844032
-
Hypolipidemic effects of a novel inhibitor of human APO-B 100 in humans
-
In: The American Diabetes Association's 65th Annual Meeting, San Diego, California
-
Bradley, J.D., R. Crooke, L.L. Kjems, M. Graham, R. Leong, R. Yu, D. Paul, and M. Wedel. 2005. Hypolipidemic effects of a novel inhibitor of human APO-B 100 in humans. In: The American Diabetes Association's 65th Annual Meeting, San Diego, California.
-
(2005)
-
-
Bradley, J.D.1
Crooke, R.2
Kjems, L.L.3
Graham, M.4
Leong, R.5
Yu, R.6
Paul, D.7
Wedel, M.8
-
60
-
-
0036288638
-
Double blind, placebo controlled trial of the remission inducing and steroid-sparing properties of an ICAM-1 antisense oligodeoxynucleotide alicaforsen (ISIS 2302) in active steroid-dependent Crohn's disease
-
Isis 2302-CS9 Investigators
-
Yacyshyn, B.R., W.Y. Chevy, J. Goff, B. Salzberg, R. Baerg, A.L. Buchman, J. Tami, R. Yu, E. Gibiansky, W.R. Shanahan, and Isis 2302-CS9 Investigators. 2002. Double blind, placebo controlled trial of the remission inducing and steroid-sparing properties of an ICAM-1 antisense oligodeoxynucleotide alicaforsen (ISIS 2302) in active steroid-dependent Crohn's disease. Gut 51(1):30-36.
-
(2002)
Gut
, vol.51
, Issue.1
, pp. 30-36
-
-
Yacyshyn, B.R.1
Chevy, W.Y.2
Goff, J.3
Salzberg, B.4
Baerg, R.5
Buchman, A.L.6
Tami, J.7
Yu, R.8
Gibiansky, E.9
Shanahan, W.R.10
-
61
-
-
0032730633
-
Phase I study of an antisense oligonucleotide to protein kinase C-γ (ISIS 3521/CGP 64128A) in patients with cancer
-
Yuen, A.R., J. Halsey, G.A. Fisher, J.T. Holmlund, R.S. Geary, T.J. Kwoh, A. Dorr, and B.I. Sikic. 1999. Phase I study of an antisense oligonucleotide to protein kinase C-γ (ISIS 3521/CGP 64128A) in patients with cancer. Clin. Cancer Res. 5 : 3357-3363.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 3357-3363
-
-
Yuen, A.R.1
Halsey, J.2
Fisher, G.A.3
Holmlund, J.T.4
Geary, R.S.5
Kwoh, T.J.6
Dorr, A.7
Sikic, B.I.8
-
62
-
-
0032730429
-
Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase c-alpha, in patients with advanced cancer
-
Nemunaitis, J., J.T. Holmlund, M. Kraynak, D. Richards, J. Bruce, N. Ognoskie, T.J. Kwoh, R.S. Geary, F.A. Dorr, D. Von Hoff, and S.G. Eckhardt. 1999. Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase c-alpha, in patients with advanced cancer. J. Clin. Oncol. 17 : 3586-3595.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 3586-3595
-
-
Nemunaitis, J.1
Holmlund, J.T.2
Kraynak, M.3
Richards, D.4
Bruce, J.5
Ognoskie, N.6
Kwoh, T.J.7
Geary, R.S.8
Dorr, F.A.9
Von Hoff, D.10
Eckhardt, S.G.11
-
63
-
-
84889824601
-
New targets for glycemic control protein-tyrosine-phosphatase-1B antisense inhibitor
-
In: American Diabetes Association's 65th Annual Meeting, San Diego, California
-
Kjems, L. 2005. New targets for glycemic control protein-tyrosine-phosphatase-1B antisense inhibitor. In: American Diabetes Association's 65th Annual Meeting, San Diego, California.
-
(2005)
-
-
Kjems, L.1
-
64
-
-
84889774461
-
Second-generation antisense drug for cardiovascular disease demonstrates significant and durable reduc tions in cholesterol
-
In: 9th Drug Discovery Technology World Congress, Boston, MA
-
Crooke, R. 2004. Second-generation antisense drug for cardiovascular disease demonstrates significant and durable reduc tions in cholesterol. In: 9th Drug Discovery Technology World Congress, Boston, MA.
-
(2004)
-
-
Crooke, R.1
-
65
-
-
59749093014
-
Population pharmacokinetics and pharmacodynamics of ISIS 2302 (Role of population analysis in drug development)
-
In: ASCPT Annual Meeting, Orlando, Florida
-
Yu, R., L. Gibiansky, E. Gibiansky, and R.S. Geary. 2001. Population pharmacokinetics and pharmacodynamics of ISIS 2302 (Role of population analysis in drug development). In: ASCPT Annual Meeting, Orlando, Florida.
-
(2001)
-
-
Yu, R.1
Gibiansky, L.2
Gibiansky, E.3
Geary, R.S.4
-
66
-
-
24144457229
-
Prediction of clinical responses in a simulated phase III trial of Crohn's patients administered the antisense phosphorothioate oligonucleotide ISIS 2302: comparison of proposed dosing regimens
-
Yu, R.Z., J.Q. Su, J.S. Grundy, R.S. Geary, K.L. Sewell, A. Dorr, and A.A. Levin. 2003. Prediction of clinical responses in a simulated phase III trial of Crohn's patients administered the antisense phosphorothioate oligonucleotide ISIS 2302: comparison of proposed dosing regimens. Antisense Nucleic Acid Drug Dev. 13 : 57-66.
-
(2003)
Antisense Nucleic Acid Drug Dev.
, vol.13
, pp. 57-66
-
-
Yu, R.Z.1
Su, J.Q.2
Grundy, J.S.3
Geary, R.S.4
Sewell, K.L.5
Dorr, A.6
Levin, A.A.7
|