Abnormal changes in voltage-gated sodium channels NaV1.1, NaV1.2, NaV1.3, NaV1.6 and in calmodulin/calmodulin-dependent protein kinase II, within the brains of spontaneously epileptic rats and tremor rats

Brain Research Bulletin

Volumn 96, Issue , 2013, Pages 1-9

  Xu, Xiaoxue ^a   Guo, Feng ^a   Lv, Xintong ^a   Feng, Rui ^a   Min, Dongyu ^a   Ma, Lihua ^a   Liu, Yajing ^a   Zhao, Jinsheng ^a   Wang, Lei ^b   Chen, Tianbao ^b   Shaw, Chris ^b   Hao, Liying ^a   Cai, Jiqun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Calmodulin; Calmodulin dependent protein kinase II; Genetic epilepsy; Subtype; Voltage gated sodium channel

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.3; SODIUM CHANNEL NAV1.6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; EPILEPSY; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; IMMUNOFLUORESCENCE TEST; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TEMPORAL CORTEX; TREMOR;

CALMODULIN; CALMODULIN-DEPENDENT PROTEIN KINASE II; GENETIC EPILEPSY; SUBTYPE; VOLTAGE-GATED SODIUM CHANNEL;

ANIMALS; BRAIN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CALMODULIN; DISEASE MODELS, ANIMAL; EPILEPSY; FEMALE; ION CHANNEL GATING; MALE; NEURONS; RATS; RATS, WISTAR; SODIUM CHANNELS; TREMOR;

EID: 84877912903     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2013.04.003     Document Type: Article

References (46)

1. Astman N., Gutnick M.J., Fleidervish I.A. Persistent sodium current in layer 5 neocortical neurons is primarily generated in the proximal axon. Journal of Neuroscience 2006, 26:3465-3473.
2. V1.6 in kindling epileptogenesis. Epilepsia 2009, 50:44-55.
3. Boiko T., Rasband M.N., Levinson S.R., Caldwell J.H., Mandel G., Trimmer J.S., Matthews G. Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron 2001, 30:91-104.
4. V1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:2283-2288.
5. V1.8 in DRG neurons. Journal of Neurophysiology 2006, 96:97-108.
6. Ebrahimi A., Houshmand M., Tonekaboni S.H., Fallah Mahboob Passand M.S., Zainali S., Moghadasi M. Two novel mutations in SCN1A gene in Iranian patients with epilepsy. Archives of Medical Research 2010, 41:207-214.
7. Escayg A., Goldin A.L. Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia 2010, 51:1650-1658.
8. V1.3 and induces hyperexcitability in hippocampal neurons. Experimental Neurology 2010, 224:362-368.
9. Feldkamp M.D., Yu L., Shea M.A. Structural and energetic determinants of apo calmodulin binding to the IQ motif of the Na(V)1.2 voltage-dependent sodium channel. Structure 2011, 19:733-747.
10. Freilich E.R., Jones J.M., Gaillard W.D., Conry J.A., Tsuchida T.N., Reyes C., Dib-Hajj S., Waxman S.G., Meisler M.H., Pearl P.L. Novel SCN1A mutation in a proband with malignant migrating partial seizures of infancy. Archives of Neurology 2011, 68:665-671.
11. V1.1 voltage-dependent sodium channel. Biochemical and Biophysical Research Communications 2011, 411:329-334.
12. Giese K.P., Fedorov N.B., Filipkowski R.K., Silva A.J. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science 1998, 279:870-873.
13. Gong B., Rhodes K.J., Bekele-Arcuri Z., Trimmer J.S. Type I and type II Na(+) channel alpha-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain. Journal of Comparative Neurology 1999, 412:342-352.
14. V1.3 and beta1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat. Brain Research Bulletin 2008, 75:179-187.
15. Guo F., Sun F., Yu J.L., Wang Q.H., Tu D.Y., Mao X.Y., Liu R., Wu K.C., Xie N., Hao L.Y., Cai J.Q. Abnormal expressions of glutamate transporters and metabotropic glutamate receptor 1 in the spontaneously epileptic rat hippocampus. Brain Research Bulletin 2010, 81:510-516.
16. V1.6 and differentially modulates their functional properties. Journal of Neuroscience 2003, 23:8261-8270.
17. Hund T.J., Koyal O.M., Li J., Wright P.J., Qian L., Snyder J.S., Gudmundsson H., Kline C.F., Davidson N.P., Cardona N., Rasband M.N., Anderson M.E., Mohler P.J. A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. Journal of Clinical Investigation 2010, 120:3508-3519.
18. Isom L.L. Sodium channel beta subunits: anything but auxiliary. Neuroscientist 2001, 7:42-54.
19. 2+ sensitivity of sodium channels. Journal of Biological Chemistry 2004, 279:45004-45012.
20. Kitada K., Akimitsu T., Shigematsu Y., Kondo A., Maihara T., Yokoi N., Kuramoto T., Sasa M., Serikawa T. Accumulation of N-acetyl-l-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system. Journal of Neurochemistry 2000, 74:2512-2519.
21. Klein J.P., Khera D.S., Nersesyan H., Kimchi E.Y., Waxman S.G., Blumenfeld H. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Research 2004, 1000:102-109.
22. Kuramoto T., Kitada K., Inui T., Sasaki Y., Ito K., Hase T., Kawaguchi S., Ogawa Y., Nakao K., Barsh G.S., Nagao M., Ushijima T., Serikawa T. Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:559-564.
23. 2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovascular Research 2007, 73:631-640.
24. Malenka R.C., Kauer J.A., Perkel D.J., Mauk M.D., Kelly P.T., Nicoll R.A., Waxham M.N. An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature 1989, 340:554-557.
25. Manno I., Macchi F., Caleo M., Bozzi Y. Environmental enrichment reduces spontaneous seizures in the Q54 transgenic mouse model of temporal lobe epilepsy. Epilepsia 2011, 52:113-117.
26. Mao X., Ma P., Cao D., Sun C., Ji Z., Min D., Sun H., Xie N., Cai J., Cao Y. Altered expression of GABA receptors (α4, γ2 subunit), potassium chloride cotransporter 2 and astrogliosis in tremor rat hippocampus. Brain Research Bulletin 2011, 86:373-379.
27. V1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. Journal of Biological Chemistry 2004, 279:16044-16049.
28. V1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. Epilepsia 2008, 49:1535-1545.
29. V1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. Journal of Neuroscience 2007, 27:5903-5914.
30. Otmakhov N., Griffith L.C., Lisman J.E. Postsynaptic inhibitors of calcium/calmodulin-dependent protein kinase type II block induction but not maintenance of pairing-induced long-term potentiation. Journal of Neuroscience 1997, 17:5357-5365.
31. Rojo Carranza D., Hamiwka L., McMahon J.M., Dibbens L.M., Arsov T., Suls A., Stödberg T., Kelley K., Wirrell E., Appleton B., Mackay M., Freeman J.L., Yendle S.C., Berkovic S.F., Bienvenu T., Jonghe De P., Thorburn D.R., Mulley J.C., Mefford H.C., Scheffer I.E. De novo SCN1A mutations in migrating partial seizures of infancy. Neurology 2011, 77:380-383.
32. V1.1 related epilepsies. Human Mutation 2009, 30:747-760.
33. Savio-Galimberti E., Gollob M.H., Darbar D. Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies. Frontiers in Pharmacology 2012, 3:124.
34. Serikawa T., Yamada J. Epileptic seizures in rats homozygous for two mutations, zitter and tremor. Journal of Heredity 1986, 77:441-444.
35. Theoharis N.T., Sorensen B.R., Theisen-Toupal J., Shea M.A. The neuronal voltage-dependent sodium channel type II IQ motif lowers the calcium affinity of the C-domain of calmodulin. Biochemistry 2008, 47:112-123.
36. van Woerden G.M., Hoebeek F.E., Gao Z., Nagaraja R.Y., Hoogenraad C.C., Kushner S.A., Hansel C., De Zeeuw C.I., Elgersma Y. betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses. Nature Neuroscience 2009, 12:823-825.
37. Veeramah K.R., O'Brien J.E., Meisler M.H., Cheng X., Dib-Hajj S.D., Waxman S.G., Talwar D., Girirajan S., Eichler E.E., Restifo L.L., Erickson R.P., Hammer M.F. De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP. American Journal of Human Genetics 2012, 90:502-510.
38. + channels. Journal of Clinical Investigation 2006, 116:3127-3138.
39. Wang W., Takashima S., Segawa Y., Itoh M., Shi X., Hwang S.K., Nabeshima K., Takeshita M., Hirose S. The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe. Brain Research 2011, 1389:61-70.
40. Xu R., Thomas E.A., Gazina E.V., Richards K.L., Quick M., Wallace R.H., Harkin L.A., Heron S.E., Berkovic S.F., Scheffer I.E., Mulley J.C., Petrou S. Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. Neuroscience 2007, 148:164-174.
41. Yamakawa K. Molecular and cellular basis: insights from experimental models of Dravet syndrome. Epilepsia 2011, (Suppl. 2):70-71.
42. 2 channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER). Brain Research Bulletin 2013, 90:142-148.
43. Yu F.H., Mantegazza M., Westenbroek R.E., Robbins C.A., Kalume F., Burton K.A., Spain W.J., McKnight G.S., Scheuer T., Catterall W.A. Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nature Neuroscience 2006, 9:1142-1149.
44. V1.3 in cortical lesions of patients with focal cortical dysplasia type IIb. Neuroreport 2012, 23:407-411.
45. + channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. Journal of Neuroscience 2005, 25:9704-9720.
46. Zhou L.W., Moyer J.A., Muth E.A., Clark B., Palkovits M., Weiss B. Regional distribution of calmodulin activity in rat brain. Journal of Neurochemistry 1985, 44:1657-1662.