Voltage-gated sodium channel Nav1.1, Nav1.3 and β1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat

Brain Research Bulletin

Volumn 75, Issue 1, 2008, Pages 179-187

  Guo, Feng ^a   Yu, Na ^a   Cai, Ji Qun ^a   Quinn, Tim ^b   Zong, Zhi Hong ^a   Zeng, Yan Jun ^c   Hao, Li Ying ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c BEIJING UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Epilepsy; Isoform; Spontaneously epileptic rat; Subunit; Voltage gated sodium channel

Indexed keywords

MESSENGER RNA; PROTEIN SUBUNIT; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPSY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; UPREGULATION; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; EPILEPSY; HIPPOCAMPUS; NERVE TISSUE PROTEINS; PROTEIN SUBUNITS; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; RNA, MESSENGER; SODIUM CHANNELS; UP-REGULATION;

EID: 37349043190     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2007.10.005     Document Type: Article

References (43)

1. Abdelmalik P.A., Avoli M., and Carlen P.L. Intractable epilepsies of the neocortex: basic mechanisms. Adv. Neurol. 97 (2006) 117-127
2. Amano H., Amano T., Matsubayashi H., Ishihara K., Serikawa T., and Sasa M. Enhanced calcium influx in hippocampal CA3 neurons of spontaneously epileptic rats. Epilepsia 42 (2001) 345-350
3. Audenaert D., Van Broeckhoven C., and De Jonghe P. Genes and loci involved in febrile seizures and related epilepsy syndromes. Hum. Mutat. 27 (2006) 391-401
4. Aronica E., Yankaya B., Troost D., van Vliet E.A., Lopes da Silva F.H., and Gorter J.A. Induction of neonatal sodium channel II and III α-isoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus. Eur. J. Neurosci. 13 (2001) 1261-1266
5. Copley R.R. Evolutionary convergence of alternative splicing in ion channels. Trends Genet. 20 (2004) 171-176
6. Ji-qun C., Ishihara K., Nagayama T., Serikawa T., and Sasa M. Long-lasting antiepileptic effects of levetiracetam against epileptic seizures in the spontaneously epileptic rat (SER): differentiation of levetiracetam from conventional antiepileptic drugs. Epilepsia 46 (2005) 1362-1370
7. Chen J., Sochivko D., Beck H., Marechal D., Wiestler O.D., and Becker A.J. Activity-induced expression of common reference genes in individual CNS neurons. Lab. Invest. 81 (2001) 913-916
8. 1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. Neuroscience 24 (2004) 4030-4042
9. Ellerkmann R.K., Remy S., Chen J., Sochivko D., Elger C.E., and Urban B.W. Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience 119 (2003) 323-333
10. Felts P.A., Yokoyama S., Dib-Hajj S., Black J.A., and Waxman S.G. Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system. Mol. Brain Res. 45 (1997) 71-82
11. Goldin A.L. Resurgence of sodium channel research. Annu. Rev. Physiol. 63 (2001) 871-894
12. + channels. J. Exp. Biol. 205 (2002) 575-584
13. 1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy. Eur. J. Neurosci. 16 (2002) 360-364
14. Isom L.L. Sodium channel beta subunits: anything but auxiliary. Neuroscientist 7 (2001) 42-54
15. Ito M., Shirasaka Y., Hirose S., Suqawara T., and Yamakawa K. Seizure phenotypes of a family with missense mutations in SCN2A. Pediatr. Neurol. 31 (2004) 150-152
16. Kitada K., Akimitsu T., Shigematsu Y., Kondo A., Maihara T., and Yokoi N. Accumulation of N-acetyl-l-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizures and spongiform degeneration in the central nervous system. J. Neurochem. 74 (2000) 2512-2519
17. Klein J.P., Khera D.S., Nersesyan H., Kimchi E.Y., Waxman S.G., and Blumenfeld H. Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Res. 1000 (2004) 102-109
18. McCormick D.A., and Contreras D. On the cellular and network bases of epileptic seizures. Annu. Rev. Physiol. 63 (2001) 815-846
19. Mantegazza M., Gambardella A., Rusconi R., Schiavon E., Annesi F., and Cassulini R.R. Identification of a Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 18177-18182
20. + channel function in the extracellular domain of the beta1 subunit. J. Biol. Chem. 273 (1998) 3954-3962
21. Momiyama T., Ishihara K., Serikawa T., Moritake K., and Sasa M. Effects of nicardipine on abnormal excitability of CA3 pyramidal cells in hippocampal slices of spontaneously epileptic rats. Eur. J. Pharmacol. 280 (1995) 119-123
22. Meisler M.H., and Kearney J.A. Sodium channel mutations in epilepsy and other neurological disorders. J. Clin. Inves. 115 (2005) 2010-2017
23. Moorman J.R., Kirsch G.E., VanDongen A.M., Joho R.H., and Brown A.M. Fast and slow gating of sodium channels encoded by a single mRNA. Neuron 4 (1990) 243-252
24. McEwen D.P., Meadows L.S., Chen C., Thyagarajan V., and Isom L.L. Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. J. Biol. Chem. 279 (2004) 16044-16049
25. 1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. J. Neurosci. 22 (2002) 10699-10709
26. Mann M.W., and Pons G. Various pharmacogenetic aspects of antiepileptic drug therapy: a review. CNS Drugs 21 (2007) 143-164
27. Madia F., Striano P., Gennaro E., Malacarne M., Paravidino R., and Biancheri R. Cryptic chromosome deletions involving SCN1A in severe myoclonic epilepsy of infancy. Neurology 67 (2006) 1230-1235
28. Morgan K., Stevens E.B., Shah B., Cox P.J., Dixon A.K., and Lee K. Beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 2308-2313
29. Ohmori I., Ouchida M., Ohtsuka Y., Oka E., and Shimizu K. Significant correlation of the SCN1A mutations and severe myoclonic epilepsy in infancy. Biochem. Biophys. Res. Commun. 295 (2002) 7-23
30. Striano P., Bordo L., Lispi M.L., Specchio N., Minetti C., and Vigevano F. A novel SCN2A mutation in family with benign familial infantile seizures. Epilepsia 47 (2006) 218-220
31. Scheffer I.E., Harkin L.A., Grinton B.E., Dibbens L.M., Turner S.J., and Zielinski M.A. Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. Brain 130 (2007) 100-109
32. Sasa M., Ohno Y., Ujihara H., Fujita Y., Yoshimura M., and Takaori S. Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant rat. Epilepsia 29 (1988) 505-513
33. Scalmani P., Rusconi R., Armatura E., Zara F., Avanzini G., and Franceschetti S. Effects in neocortical neurons of mutations of the Na(v)1.2 Na+ channel causing benign familial neonatal-infantile seizures. J. Neurosci. 26 (2006) 10100-10109
34. Serikawa T., and Yamada J. Epileptic seizures in rats homozygous for two mutations, zitter and tremor. J. Hered. 77 (1986) 441-444
35. Whitaker W.R., Faull R.L., Dragunow M., Mee E.W., Emson P.C., and Clare J.J. Changes in the mRNAs encoding voltage-gated sodium channel type II and III in human epileptic hippocampus. Neuroscience 106 (2001) 275-285
36. Wallace R.H., Scheffer I.E., Parasivam G., Barnett S., Wallace G.B., and Sutherland G.R. Generalized epilepsy with febrile seizures plus: mutation of the sodium channel subunit SCN1B. Neurology 58 (2002) 1426-1429
37. +-channel beta1 subunit gene SCN1B. Nat. Genet. 19 (1998) 366-370
38. Xu R., Thomas E.A., Jenkins M., Gazina E.V., Chiu C., and Heron S.E. A childhood epilepsy mutation reveals a role for developmentally regulated splicing of a sodium channel. Mol. Cell Neurosci. 35 (2007) 292-301
39. + exchanger 1 null mutant mouse. J. Neurophysiol. 89 (2003) 229-236
40. Yan H.D., Ji-qun C., Ishihara K., Naqayama T., Serikawa T., and Sasa M. Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER). Epilepsia 46 (2005) 1170-1177
41. Yan H.D., Ishihara K., Hanaya R., Kurisu K., Serikawa T., and Sasa M. Voltage-dependent calcium channel abnormalities in hippocampal CA3 neurons of spontaneously epileptic rats. Epilepsia 48 (2007) 758-764
42. Yu F.H., Mantegazza M., Westenbroek R.E., Robbins C.A., Kalume F., and Burton K.A. Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat. Neurosci. 10 (2007) 134
43. Yu F.H., Westenbroek R.E., Silos-Santiago I., McCormick K.A., Lawson D., and Ge P. Sodium channel beta 4, a new disulfide-linked auxiliary subunit with similarity to beta 2. J. Neurosci. 23 (2003) 7577-7585