Ligand-triggered stabilization of vitamin D receptor/retinoid X receptor heterodimer conformations on DR4-type response elements

Journal of Molecular Biology

Volumn 296, Issue 3, 2000, Pages 743-756

  Quack, Marcus ^a   Carlberg, Carsten ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Gel shift clipping assay; Orphan nuclear receptors; Synergistic ligand interaction; Transcriptional regulation

Indexed keywords

BENZOIC ACID ESTER DERIVATIVE; CALCITRIOL; CELL NUCLEUS RECEPTOR; DIMER; LIGAND; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA BINDING; DNA RESPONSIVE ELEMENT; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; TRANSCRIPTION REGULATION;

EID: 0034711957     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3499     Document Type: Article

References (48)

1. 3
2. Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth
3. Orphan nuclear receptors: New ligands and new possibilities
4. BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites
5. SXR, a novel steroid and xenobiotic-sensing nuclear receptor
6. Crystal structure of the ligand binding domain of the human nuclear receptor RXR-α
7. 3: Interplay with retinoid and thyroid hormone signalling
8. The concept of multiple vitamin D pathways
9. 3
10. Two nuclear signalling pathways for vitamin D
11. 3 analogues MC903, EB1089 and KH1060 function as transcriptional activators: Vitamin D receptor homodimers show higher ligand sensitivity than heterodimers with retinoid X receptors
12. 3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers
13. The vitamin D system
14. Unique response pathways are established by allosteric interactions among nuclear hormone receptor
15. Promiscuous liaisons
16. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
17. 3 receptor binding site found in the rat atrial natriuretic factor promoter
18. 3 receptor and the retinoid X receptor on DNA
19. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
20. An orphan nuclear receptor activated by pregnanes defines a novel steroid signalling pathway
21. Ligand-dependent conformational changes in thyroid hormone and retinoic acid receptors are potentially enhanced by heterodimerization with retinoid X receptor
22. 9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
23. 3-activated expression of the rat osteocalcin gene
24. The RXR heterodimers and orphan receptors
25. The nuclear receptor superfamily: The second decade
26. The anti-proliferative and differentiation-inducing effects of vitamin D analogues are not determined by the binding affinity for the vitamin D receptor alone
27. 3 receptor
28. 3 analogues is not related to the AP-1 pathway, but related to promoter selectivity
29. 3 receptor is functionally linked to the transactivation domain 2 (AF-2)
30. The LXRs: A new class of oxysterol receptors
31. 3 and its A ring-modified analogs
32. 3 are associated with enhanced activation of the vitamin D receptor
33. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
34. 3 receptor homodimers
35. Selective recognition of the vitamin D receptor conformations mediates promoter selectivity of vitamin D
36. Structural variants of the vitamin D analogue EB1089 reduce its ligand sensitivity and promoter selectivity
37. The role of the T-box for the function of the vitamin D receptor on different types of response elements
38. Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid
39. A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene
40. The c-erb-A protein is a high-affinity receptor for thyroid hormone
41. 3 response elements formed by inverted palindromes: Polarity-directed ligand sensitivity of VDR-RXR heterodimer-mediated transactivation
42. 3 response element identified in the mouse c-fos promoter
43. A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter
44. 3 receptor
45. 3 receptors
46. Newly identified actions of the vitamin D endocrine system
47. Cloning of the human phospholipase C-γ1 promoter and identification of a DR6-type vitamin D-responsive element
48. 3