Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 20, 2013, Pages 8164-8169

  Barber, John S ^a   Yokomizo, Lauren K ^a,g   Sheikh, Virginia ^b   Freeman, Alexandra F ^c   Garabedian, Elizabeth ^d   Van Dijk, Evert ^e   Sokolic, Robert ^d   Candotti, Fabio ^d   Weng, Nan Ping ^f   Sereti, Irini ^b   Milner, Joshua D ^a  

^a Laboratory of Clinical Infectious Diseases   (United States)

^b Laboratory of Immunoregulation   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^e Pepscan Presto BV   (Netherlands)

^f NATIONAL INSTITUTE ON AGING   (United States)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atopy; Immune deficiency

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; IMMUNOSURVEILLANCE; PEPTIDE LIBRARY; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH2 CELL;

ATOPY; IMMUNE DEFICIENCY;

ANTIGENS, CD14; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; COCULTURE TECHNIQUES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; HUMANS; IMMUNE SYSTEM DISEASES; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MODELS, STATISTICAL; PEPTIDE LIBRARY; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY; TH2 CELLS;

EID: 84877871065     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1302103110     Document Type: Article

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