Paricalcitol Attenuates 4-Hydroxy-2-Hexenal-Induced Inflammation and Epithelial-Mesenchymal Transition in Human Renal Proximal Tubular Epithelial Cells

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Kim, Chang Seong ^a   Joo, Soo Yeon ^a   Lee, Ko Eun ^a   Choi, Joon Seok ^a   Bae, Eun Hui ^a   Ma, Seong Kwon ^a   Kim, Suhn Hee ^b   Lee, JongUn ^a   Kim, Soo Wan ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chonbuk National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; CONNECTIVE TISSUE GROWTH FACTOR; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PARICALCITOL; SMAD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1; VITAMIN D RECEPTOR; 4-HYDROXY-2-HEXENAL; ALDEHYDE; ERGOCALCIFEROL; NITRIC OXIDE SYNTHASE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; INFLAMMATION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; KIDNEY TUBULE EPITHELIUM; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RENAL PROTECTION; SIGNAL TRANSDUCTION; CELL LINE; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; METABOLISM; TOXICITY; WESTERN BLOTTING;

ALDEHYDES; BETA CATENIN; BLOTTING, WESTERN; CELL LINE; CYCLOOXYGENASE 2; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; ERGOCALCIFEROLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INFLAMMATION; KIDNEY TUBULES, PROXIMAL; NITRIC OXIDE SYNTHASE; SIGNAL TRANSDUCTION;

EID: 84877869622     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063186     Document Type: Article

References (35)

1. Esterbauer H, Schaur RJ, Zollner H, (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11: 81-128.
2. Ozbek E, (2012) Induction of oxidative stress in kidney. Int J Nephrol 2012: 465897.
3. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H, et al. (1994) Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci U S A 91: 2616-2620.
4. Lee JY, Je JH, Kim DH, Chung SW, Zou Y, et al. (2004) Induction of endothelial apoptosis by 4-hydroxyhexenal. Eur J Biochem 271: 1339-1347.
5. Bodur C, Kutuk O, Tezil T, Basaga H (2012) Inactivation of Bcl-2 through IkappaB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE). J Cell Physiol.
6. Abarikwu SO, Pant AB, Farombi EO, (2012) 4-Hydroxynonenal induces mitochondrial-mediated apoptosis and oxidative stress in SH-SY5Y human neuronal cells. Basic Clin Pharmacol Toxicol 110: 441-448.
7. Bae EH, Cho S, Joo SY, Ma SK, Kim SH, et al. (2011) 4-Hydroxy-2-hexenal-induced apoptosis in human renal proximal tubular epithelial cells. Nephrol Dial Transplant 26: 3866-3873.
8. Kim J, Seok YM, Jung KJ, Park KM, (2009) Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice. Am J Physiol Renal Physiol 297: F461-470.
9. Canty TG Jr, Boyle EM Jr, Farr A, Morgan EN, Verrier ED, et al. (1999) Oxidative stress induces NF-kappaB nuclear translocation without degradation of IkappaBalpha. Circulation 100: II361-364.
10. Tan X, Wen X, Liu Y, (2008) Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling. J Am Soc Nephrol 19: 1741-1752.
11. Tan X, Li Y, Liu Y, (2006) Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol 17: 3382-3393.
12. Mizobuchi M, Morrissey J, Finch JL, Martin DR, Liapis H, et al. (2007) Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats. J Am Soc Nephrol 18: 1796-1806.
13. He W, Kang YS, Dai C, Liu Y, (2011) Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol 22: 90-103.
14. Rosenau C, Emery D, Kaboord B, Qoronfleh MW, (2004) Development of a high-throughput plate-based chemiluminescent transcription factor assay. J Biomol Screen 9: 334-342.
15. Trotter KW, Archer TK, (2004) Reconstitution of glucocorticoid receptor-dependent transcription in vivo. Mol Cell Biol 24: 3347-3358.
16. Dai C, Stolz DB, Bastacky SI, St-Arnaud R, Wu C, et al. (2006) Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. J Am Soc Nephrol 17: 2164-2175.
17. Park JW, Bae EH, Kim IJ, Ma SK, Choi C, et al. (2010) Paricalcitol attenuates cyclosporine-induced kidney injury in rats. Kidney Int 77: 1076-1085.
18. Je JH, Lee JY, Jung KJ, Sung B, Go EK, et al. (2004) NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway. FEBS Lett 566: 183-189.
19. Lawrence T, (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1: a001651.
20. Boor P, Sebekova K, Ostendorf T, Floege J, (2007) Treatment targets in renal fibrosis. Nephrol Dial Transplant 22: 3391-3407.
21. Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, et al. (2010) Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 176: 85-97.
22. Koesters R, Kaissling B, Lehir M, Picard N, Theilig F, et al. (2010) Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol 177: 632-643.
23. Li L, Zepeda-Orozco D, Black R, Lin F, (2010) Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol 176: 1767-1778.
24. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, et al. (2002) Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110: 341-350.
25. Venkov CD, Link AJ, Jennings JL, Plieth D, Inoue T, et al. (2007) A proximal activator of transcription in epithelial-mesenchymal transition. J Clin Invest 117: 482-491.
26. Boor P, Ostendorf T, Floege J, (2010) Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol 6: 643-656.
27. Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, et al. (2003) BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9: 964-968.
28. Bottinger EP, Bitzer M, (2002) TGF-beta signaling in renal disease. J Am Soc Nephrol 13: 2600-2610.
29. Lan HY, (2011) Diverse roles of TGF-beta/Smads in renal fibrosis and inflammation. Int J Biol Sci 7: 1056-1067.
30. Hayashida T, Decaestecker M, Schnaper HW, (2003) Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells. FASEB J 17: 1576-1578.
31. Li F, Zeng B, Chai Y, Cai P, Fan C, et al. (2009) The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis. Biochem Biophys Res Commun 386: 289-293.
32. Chung AC, Zhang H, Kong YZ, Tan JJ, Huang XR, et al. (2010) Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling. J Am Soc Nephrol 21: 249-260.
33. Yang F, Chung AC, Huang XR, Lan HY, (2009) Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and-independent Smad pathways: the role of Smad3. Hypertension 54: 877-884.
34. Liu Y, (2010) New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 21: 212-222.
35. Palmer HG, Gonzalez-Sancho JM, Espada J, Berciano MT, Puig I, et al. (2001) Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol 154: 369-387.