메뉴 건너뛰기




Volumn 14, Issue 5, 2013, Pages 411-416

Regulation of the kinase RSK1 by arsenic trioxide and generation of antileukemic responses

Author keywords

Acute myeloid leukemia; Arsenic trioxide; Kinase; RSK1

Indexed keywords

ARSENIC TRIOXIDE; S6 KINASE;

EID: 84877846701     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.23760     Document Type: Article
Times cited : (11)

References (48)
  • 1
    • 77958456360 scopus 로고    scopus 로고
    • Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North american leukemia intergroup study c9710
    • PMID:20705755
    • Powell BL, Moser B, Stock W, Gallagher RE, Willman CL, Stone RM, et al. Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710. Blood 2010; 116:3751-7; PMID:20705755; http://dx.doi.org/10.1182/blood-2010-02-269621.
    • (2010) Blood , vol.116 , pp. 3751-3757
    • Powell, B.L.1    Moser, B.2    Stock, W.3    Gallagher, R.E.4    Willman, C.L.5    Stone, R.M.6
  • 2
    • 0035884639 scopus 로고    scopus 로고
    • United states multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia
    • PMID:11559723
    • Soignet SL, Frankel SR, Douer D, Tallman MS, Kantarjian H, Calleja E, et al. United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J Clin Oncol 2001; 19:3852-60; PMID:11559723.
    • (2001) J Clin Oncol , vol.19 , pp. 3852-3860
    • Soignet, S.L.1    Frankel, S.R.2    Douer, D.3    Tallman, M.S.4    Kantarjian, H.5    Calleja, E.6
  • 3
    • 0030610687 scopus 로고    scopus 로고
    • Use of arsenic trioxide (as2o3) in the treatment of acute promyelocytic leukemia (apl): Ii. Clinical efficacy and pharmacokinetics in relapsed patients
    • PMID:9129042
    • Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 1997; 89:3354-60; PMID:9129042.
    • (1997) Blood , vol.89 , pp. 3354-3360
    • Shen, Z.X.1    Chen, G.Q.2    Ni, J.H.3    Li, X.S.4    Xiong, S.M.5    Qiu, Q.Y.6
  • 4
    • 0033570955 scopus 로고    scopus 로고
    • Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: Remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients
    • PMID:10552940
    • Niu C, Yan H, Yu T, Sun HP, Liu JX, Li XS, et al. Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. Blood 1999; 94:3315-24; PMID:10552940.
    • (1999) Blood , vol.94 , pp. 3315-3324
    • Niu, C.1    Yan, H.2    Yu, T.3    Sun, H.P.4    Liu, J.X.5    Li, X.S.6
  • 5
    • 3242689062 scopus 로고    scopus 로고
    • Phase ii trial of arsenic trioxide in relapsed and refractory acute myeloid leukemia, secondary leukemia and/or newly diagnosed patients at least 65 years old
    • PMID:15234567
    • Parmar S, Rundhaugen LM, Boehlke L, Riley M, Nabhan C, Raji A, et al. Phase II trial of arsenic trioxide in relapsed and refractory acute myeloid leukemia, secondary leukemia and/or newly diagnosed patients at least 65 years old. Leuk Res 2004; 28:909-19; PMID:15234567; http://dx.doi.org/10.1016/j. leukres. 2003.12.012.
    • (2004) Leuk Res , vol.28 , pp. 909-919
    • Parmar, S.1    Rundhaugen, L.M.2    Boehlke, L.3    Riley, M.4    Nabhan, C.5    Raji, A.6
  • 6
    • 67650514338 scopus 로고    scopus 로고
    • Biological responses to arsenic compounds
    • PMID:19363033
    • Platanias LC. Biological responses to arsenic compounds. J Biol Chem 2009; 284:18583-7; PMID:19363033; http://dx.doi.org/10.1074/jbc. R900003200.
    • (2009) J Biol Chem , vol.284 , pp. 18583-18587
    • Platanias, L.C.1
  • 7
    • 77956898610 scopus 로고    scopus 로고
    • Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide
    • PMID:20656687
    • Goussetis DJ, Altman JK, Glaser H, McNeer JL, Tallman MS, Platanias LC. Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide. J Biol Chem 2010; 285:29989-97; PMID:20656687; http://dx.doi.org/10.1074/jbc. M109.090530.
    • (2010) J Biol Chem , vol.285 , pp. 29989-29997
    • Goussetis, D.J.1    Altman, J.K.2    Glaser, H.3    McNeer, J.L.4    Tallman, M.S.5    Platanias, L.C.6
  • 8
    • 77957716030 scopus 로고    scopus 로고
    • Autophagy contributes to therapy-induced degradation of the pmlrara oncoprotein
    • PMID:20574048
    • Isakson P, Bjørås M, Bøe SO, Simonsen A. Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood 2010; 116:2324-31; PMID:20574048; http://dx.doi.org/10.1182/blood-2010-01- 261040.
    • (2010) Blood , vol.116 , pp. 2324-2331
    • Isakson, P.1    Bjørås, M.2    Bøe, S.O.3    Simonsen, A.4
  • 9
    • 84868526475 scopus 로고    scopus 로고
    • Autophagic degradation of the bcr-Abl oncoprotein and generation of antileukemic responses by arsenic trioxide. [ epub ahead of print]
    • PMID:22898604
    • Goussetis DJ, Gounaris E, Wu EJ, Vakana E, Sharma B, Bogyo M, et al. Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. [Epub ahead of print]. Blood 2012; 120:3555-62; PMID:22898604; http://dx.doi.org/10.1182/blood-2012-01-402578.
    • (2012) Blood , vol.120 , pp. 3555-3562
    • Goussetis, D.J.1    Gounaris, E.2    Wu, E.J.3    Vakana, E.4    Sharma, B.5    Bogyo, M.6
  • 10
    • 22944432512 scopus 로고    scopus 로고
    • Beyond single pathway inhibition: Mek inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects
    • PMID:16101455
    • Milella M, Precupanu CM, Gregorj C, Ricciardi MR, Petrucci MT, Kornblau SM, et al. Beyond single pathway inhibition: MEK inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects. Curr Pharm Des 2005; 11:2779-95; PMID:16101455; http://dx.doi.org/10. 2174/1381612054546842.
    • (2005) Curr Pharm Des , vol.11 , pp. 2779-2795
    • Milella, M.1    Precupanu, C.M.2    Gregorj, C.3    Ricciardi, M.R.4    Petrucci, M.T.5    Kornblau, S.M.6
  • 11
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of flt3 and n-ras gene mutations in acute myeloid leukemia
    • PMID:10216104
    • Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood 1999; 93:3074-80; PMID:10216104.
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3    Yokota, S.4    Minami, S.5    Miyawaki, S.6
  • 12
    • 0028214608 scopus 로고
    • Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia
    • PMID:8123851
    • Neubauer A, Dodge RK, George SL, Davey FR, Silver RT, Schiffer CA, et al. Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia. Blood 1994; 83:1603-11; PMID:8123851.
    • (1994) Blood , vol.83 , pp. 1603-1611
    • Neubauer, A.1    Dodge, R.K.2    George, S.L.3    Davey, F.R.4    Silver, R.T.5    Schiffer, C.A.6
  • 13
    • 0141502208 scopus 로고    scopus 로고
    • Downmodulation of erk activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts
    • PMID:12970778
    • Lunghi P, Tabilio A, Dall'Aglio PP, Ridolo E, Carlo-Stella C, Pelicci PG, et al. Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts. Leukemia 2003; 17:1783-93; PMID:12970778; http://dx.doi.org/10.1038/sj.leu.2403032.
    • (2003) Leukemia , vol.17 , pp. 1783-1793
    • Lunghi, P.1    Tabilio, A.2    Dall'Aglio, P.P.3    Ridolo, E.4    Carlo-Stella, C.5    Pelicci, P.G.6
  • 14
    • 52449095361 scopus 로고    scopus 로고
    • The rsk family of kinases: Emerging roles in cellular signalling
    • PMID:18813292
    • Anjum R, Blenis J. The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol 2008; 9:747-58; PMID:18813292; http://dx.doi.org/10.1038/nrm2509.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 747-758
    • Anjum, R.1    Blenis, J.2
  • 15
    • 0037160016 scopus 로고    scopus 로고
    • Activation of rac1 and the p38 mitogen-Activated protein kinase pathway in response to arsenic trioxide
    • PMID:12239215
    • Verma A, Mohindru M, Deb DK, Sassano A, Kambhampati S, Ravandi F, et al. Activation of Rac1 and the p38 mitogen-Activated protein kinase pathway in response to arsenic trioxide. J Biol Chem 2002; 277:44988-95; PMID:12239215; http://dx.doi.org/10.1074/jbc.M207176200.
    • (2002) J Biol Chem , vol.277 , pp. 44988-44995
    • Verma, A.1    Mohindru, M.2    Deb, D.K.3    Sassano, A.4    Kambhampati, S.5    Ravandi, F.6
  • 16
    • 33746178172 scopus 로고    scopus 로고
    • Role of the p38 mitogen-Activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses
    • PMID:16818652
    • Giafis N, Katsoulidis E, Sassano A, Tallman MS, Higgins LS, Nebreda AR, et al. Role of the p38 mitogen-Activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. Cancer Res 2006; 66:6763-71; PMID:16818652; http://dx.doi.org/10.1158/0008-5472.CAN-05-3699.
    • (2006) Cancer Res , vol.66 , pp. 6763-6771
    • Giafis, N.1    Katsoulidis, E.2    Sassano, A.3    Tallman, M.S.4    Higgins, L.S.5    Nebreda, A.R.6
  • 17
    • 45549109532 scopus 로고    scopus 로고
    • Regulation of arsenic trioxide-induced cellular responses by mnk1 and mnk2
    • PMID:18299328
    • Dolniak B, Katsoulidis E, Carayol N, Altman JK, Redig AJ, Tallman MS, et al. Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2. J Biol Chem 2008; 283:12034-42; PMID:18299328; http://dx.doi.org/10.1074/jbc. M708816200.
    • (2008) J Biol Chem , vol.283 , pp. 12034-1242
    • Dolniak, B.1    Katsoulidis, E.2    Carayol, N.3    Altman, J.K.4    Redig, A.J.5    Tallman, M.S.6
  • 18
    • 33747362918 scopus 로고    scopus 로고
    • Activation of the mitogenand stress-Activated kinase 1 by arsenic trioxide
    • PMID:16762916
    • Kannan-Thulasiraman P, Katsoulidis E, Tallman MS, Arthur JS, Platanias LC. Activation of the mitogenand stress-Activated kinase 1 by arsenic trioxide. J Biol Chem 2006; 281:22446-52; PMID:16762916; http://dx.doi.org/10.1074/jbc. M603111200.
    • (2006) J Biol Chem , vol.281 , pp. 22446-2252
    • Kannan-Thulasiraman, P.1    Katsoulidis, E.2    Tallman, M.S.3    Arthur, J.S.4    Platanias, L.C.5
  • 19
    • 77951055592 scopus 로고    scopus 로고
    • Arsenic trioxide-dependent activation of thousand-And-one amino acid kinase 2 and transforming growth factor-beta-Activated kinase 1
    • PMID:20159944
    • McNeer JL, Goussetis DJ, Sassano A, Dolniak B, Kroczynska B, Glaser H, et al. Arsenic trioxide-dependent activation of thousand-And-one amino acid kinase 2 and transforming growth factor-beta-Activated kinase 1. Mol Pharmacol 2010; 77:828-35; PMID:20159944; http://dx.doi.org/10.1124/mol.109.061507.
    • (2010) Mol Pharmacol , vol.77 , pp. 828-835
    • McNeer, J.L.1    Goussetis, D.J.2    Sassano, A.3    Dolniak, B.4    Kroczynska, B.5    Glaser, H.6
  • 20
    • 55249093243 scopus 로고    scopus 로고
    • Targeting mek/mapk signal transduction module potentiates ato-induced apoptosis in multiple myeloma cells through multiple signaling pathways
    • PMID:18583568
    • Lunghi P, Giuliani N, Mazzera L, Lombardi G, Ricca M, Corradi A, et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood 2008; 112:2450-62; PMID:18583568; http://dx.doi.org/10.1182/blood-2007-10-114348.
    • (2008) Blood , vol.112 , pp. 2450-2462
    • Lunghi, P.1    Giuliani, N.2    Mazzera, L.3    Lombardi, G.4    Ricca, M.5    Corradi, A.6
  • 21
    • 42949169517 scopus 로고    scopus 로고
    • The rsk factors of activating the ras/mapk signaling cascade
    • PMID:18508509
    • Carriere A, Ray H, Blenis J, Roux PP. The RSK factors of activating the Ras/MAPK signaling cascade. Front Biosci 2008; 13:4258-75; PMID:18508509; http://dx.doi.org/10.2741/3003.
    • (2008) Front Biosci , vol.13 , pp. 4258-4275
    • Carriere, A.1    Ray, H.2    Blenis, J.3    Roux, P.P.4
  • 22
    • 38349165863 scopus 로고    scopus 로고
    • Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses
    • PMID:18048359
    • Altman JK, Yoon P, Katsoulidis E, Kroczynska B, Sassano A, Redig AJ, et al. Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses. J Biol Chem 2008; 283:1992-2001; PMID:18048359; http://dx.doi.org/10.1074/jbc.M705227200.
    • (2008) J Biol Chem , vol.283 , pp. 1992-2001
    • Altman, J.K.1    Yoon, P.2    Katsoulidis, E.3    Kroczynska, B.4    Sassano, A.5    Redig, A.J.6
  • 23
    • 33845190126 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin and the p70 s6 kinase by arsenic trioxide in bcr-Abl-expressing cells
    • PMID:17121928
    • Yoon P, Giafis N, Smith J, Mears H, Katsoulidis E, Sassano A, et al. Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL-expressing cells. Mol Cancer Ther 2006; 5:2815-23; PMID:17121928; http://dx.doi.org/10.1158/1535-7163.MCT-06-0263.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2815-2823
    • Yoon, P.1    Giafis, N.2    Smith, J.3    Mears, H.4    Katsoulidis, E.5    Sassano, A.6
  • 24
    • 67650514338 scopus 로고    scopus 로고
    • Biological responses to arsenic compounds
    • PMID:19363033
    • Platanias LC. Biological responses to arsenic compounds. J Biol Chem 2009; 284:18583-7; PMID:19363033; http://dx.doi.org/10.1074/jbc. R900003200.
    • (2009) J Biol Chem , vol.284 , pp. 18583-18587
    • Platanias, L.C.1
  • 26
    • 23844538053 scopus 로고    scopus 로고
    • The flt3 internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived baf3 cells due to protein kinase a and ribosomal s6 kinase 1-mediated bad phosphorylation at serine 112
    • PMID:16103085
    • Yang X, Liu L, Sternberg D, Tang L, Galinsky I, DeAngelo D, et al. The FLT3 internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived BaF3 cells due to protein kinase A and ribosomal S6 kinase 1-mediated BAD phosphorylation at serine 112. Cancer Res 2005; 65:7338-47; PMID:16103085; http://dx.doi.org/10.1158/0008-5472.CAN-04-2263.
    • (2005) Cancer Res , vol.65 , pp. 7338-73347
    • Yang, X.1    Liu, L.2    Sternberg, D.3    Tang, L.4    Galinsky, I.5    DeAngelo, D.6
  • 27
    • 42449146501 scopus 로고    scopus 로고
    • Targeting survival cascades induced by activation of ras/raf/mek/erk, pi3k/pten/akt/mtor and jak/stat pathways for effective leukemia therapy
    • PMID:18337766
    • McCubrey JA, Steelman LS, Abrams SL, Bertrand FE, Ludwig DE, Bäsecke J, et al. Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy. Leukemia 2008; 22:708-22; PMID:18337766; http://dx.doi.org/10.1038/leu.2008.27.
    • (2008) Leukemia , vol.22 , pp. 708-722
    • McCubrey, J.A.1    Steelman, L.S.2    Abrams, S.L.3    Bertrand, F.E.4    Ludwig, D.E.5    Bäsecke, J.6
  • 28
    • 34547209343 scopus 로고    scopus 로고
    • Roles of the raf/mek/erk pathway in cell growth, malignant transformation and drug resistance
    • PMID:17126425
    • McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 2007; 1773:1263-84; PMID:17126425; http://dx.doi.org/10.1016/j.bbamcr.2006.10.001.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1263-1284
    • McCubrey, J.A.1    Steelman, L.S.2    Chappell, W.H.3    Abrams, S.L.4    Wong, E.W.5    Chang, F.6
  • 29
    • 42449165060 scopus 로고    scopus 로고
    • Contributions of the raf/mek/erk, pi3k/pten/akt/mtor and jak/stat pathways to leukemia
    • PMID:18337767
    • Steelman LS, Abrams SL, Whelan J, Bertrand FE, Ludwig DE, Bäsecke J, et al. Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia 2008; 22:686-707; PMID:18337767; http://dx.doi.org/10.1038/leu.2008.26.
    • (2008) Leukemia , vol.22 , pp. 686-707
    • Steelman, L.S.1    Abrams, S.L.2    Whelan, J.3    Bertrand, F.E.4    Ludwig, D.E.5    Bäsecke, J.6
  • 30
    • 79960235543 scopus 로고    scopus 로고
    • Roles of the ras/raf/mek/erk pathway in leukemia therapy
    • PMID:21494257
    • Steelman LS, Franklin RA, Abrams SL, Chappell W, Kempf CR, Bäsecke J, et al. Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. Leukemia 2011; 25:1080-94; PMID:21494257; http://dx.doi.org/10.1038/leu.2011.66.
    • (2011) Leukemia , vol.25 , pp. 1080-1094
    • Steelman, L.S.1    Franklin, R.A.2    Abrams, S.L.3    Chappell, W.4    Kempf, C.R.5    Bäsecke, J.6
  • 31
    • 79952704794 scopus 로고    scopus 로고
    • Role of rasrafmekerk signaling in physiological hematopoiesis and leukemia development
    • PMID:21170740
    • Chung E, Kondo M. Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development. Immunol Res 2011; 49:248-68; PMID:21170740; http://dx.doi.org/10.1007/s12026-010-8187-5.
    • (2011) Immunol Res , vol.49 , pp. 248-268
    • Chung, E.1    Kondo, M.2
  • 32
    • 84555189440 scopus 로고    scopus 로고
    • Regulation and function of the rsk family of protein kinases
    • PMID:22187936
    • Romeo Y, Zhang X, Roux PP. Regulation and function of the RSK family of protein kinases. Biochem J 2012; 441:553-69; PMID:22187936; http://dx.doi.org/ 10.1042/BJ20110289.
    • (2012) Biochem J , vol.441 , pp. 553-569
    • Romeo, Y.1    Zhang, X.2    Roux, P.P.3
  • 33
    • 79959501837 scopus 로고    scopus 로고
    • P90rsk2 is essential for flt3-itd-but dispensable for bcr-Abl-induced myeloid leukemia
    • PMID:21527514
    • Elf S, Blevins D, Jin L, Chung TW, Williams IR, Lee BH, et al. p90RSK2 is essential for FLT3-ITD-but dispensable for BCR-ABL-induced myeloid leukemia. Blood 2011; 117:6885-94; PMID:21527514; http://dx.doi.org/10.1182/blood-2010-10- 315721.
    • (2011) Blood , vol.117 , pp. 6885-6894
    • Elf, S.1    Blevins, D.2    Jin, L.3    Chung, T.W.4    Williams, I.R.5    Lee, B.H.6
  • 34
    • 1542677089 scopus 로고    scopus 로고
    • Phosphorylation of p27kip1 at threonine 198 by p90 ribosomal protein s6 kinases promotes its binding to 14-3-3 and cytoplasmic localization
    • PMID:14504289
    • Fujita N, Sato S, Tsuruo T. Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. J Biol Chem 2003; 278:49254-60; PMID:14504289; http://dx.doi.org/10.1074/jbc. M306614200.
    • (2003) J Biol Chem , vol.278 , pp. 49254-49260
    • Fujita, N.1    Sato, S.2    Tsuruo, T.3
  • 35
    • 44349134920 scopus 로고    scopus 로고
    • Activation of pi3k/akt and mapk pathways regulates myc-mediated transcription by phosphorylating and promoting the degradation of mad1
    • PMID:18451027
    • Zhu J, Blenis J, Yuan J. Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proc Natl Acad Sci U S A 2008; 105:6584-9; PMID:18451027; http://dx.doi.org/10.1073/pnas.0802785105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6584-6589
    • Zhu, J.1    Blenis, J.2    Yuan, J.3
  • 36
    • 4544384577 scopus 로고    scopus 로고
    • Tumor-promoting phorbol esters and activated ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal s6 kinase
    • PMID:15342917
    • Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A 2004; 101:13489-94; PMID:15342917; http://dx.doi.org/10.1073/pnas.0405659101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13489-1394
    • Roux, P.P.1    Ballif, B.A.2    Anjum, R.3    Gygi, S.P.4    Blenis, J.5
  • 37
    • 51049083138 scopus 로고    scopus 로고
    • Oncogenic mapk signaling stimulates mtorc1 activity by promoting rsk-mediated raptor phosphorylation
    • PMID:18722121
    • Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Thibault P, et al. Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr Biol 2008; 18:1269-77; PMID:18722121; http://dx.doi.org/10.1016/j.cub.2008.07.078.
    • (2008) Curr Biol , vol.18 , pp. 1269-1277
    • Carrière, A.1    Cargnello, M.2    Julien, L.A.3    Gao, H.4    Bonneil, E.5    Thibault, P.6
  • 38
    • 77950434375 scopus 로고    scopus 로고
    • Targeting the translational machinery as a novel treatment strategy for hematologic malignancies
    • PMID:20075156
    • Hagner PR, Schneider A, Gartenhaus RB. Targeting the translational machinery as a novel treatment strategy for hematologic malignancies. Blood 2010; 115:2127-35; PMID:20075156; http://dx.doi.org/10.1182/blood-2009-09- 220020.
    • (2010) Blood , vol.115 , pp. 2127-2135
    • Hagner, P.R.1    Schneider, A.2    Gartenhaus, R.B.3
  • 39
    • 79951487809 scopus 로고    scopus 로고
    • Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by bcr-Abl
    • PMID:21299459
    • Redig AJ, Vakana E, Platanias LC. Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL. Leuk Lymphoma 2011; 52(Suppl 1):45-53; PMID:21299459; http://dx.doi.org/10.3109/ 10428194.2010.546919.
    • (2011) Leuk Lymphoma , vol.52 , Issue.SUPPL. 1 , pp. 45-53
    • Redig, A.J.1    Vakana, E.2    Platanias, L.C.3
  • 40
    • 84883146054 scopus 로고    scopus 로고
    • The evolution of the tor pathway and its role in cancer. [epub ahead of print]
    • PMID:23246968
    • Beauchamp EM, Platanias LC. The evolution of the TOR pathway and its role in cancer. [Epub ahead of print]. Oncogene 2012; PMID:23246968; http://dx.doi.org/10.1038/onc.2012.567.
    • (2012) Oncogene
    • Beauchamp, E.M.1    Platanias, L.C.2
  • 41
    • 0028982917 scopus 로고
    • Interferon-Alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase
    • PMID:7608146
    • Uddin S, Yenush L, Sun XJ, Sweet ME, White MF, Platanias LC. Interferon-Alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase. J Biol Chem 1995; 270:15938-41; PMID:7608146; http://dx.doi.org/10.1074/jbc.270.27.15938.
    • (1995) J Biol Chem , vol.270 , pp. 15938-15941
    • Uddin, S.1    Yenush, L.2    Sun, X.J.3    Sweet, M.E.4    White, M.F.5    Platanias, L.C.6
  • 42
    • 0037040869 scopus 로고    scopus 로고
    • Activation of the p38 mitogenactivated protein kinase mediates the suppressive effects of type i interferons and transforming growth factor-beta on normal hematopoiesis
    • PMID:11773065
    • Verma A, Deb DK, Sassano A, Uddin S, Varga J, Wickrema A, et al. Activation of the p38 mitogenactivated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis. J Biol Chem 2002; 277:7726-35; PMID:11773065; http://dx.doi.org/10.1074/jbc.M106640200.
    • (2002) J Biol Chem , vol.277 , pp. 7726-7735
    • Verma, A.1    Deb, D.K.2    Sassano, A.3    Uddin, S.4    Varga, J.5    Wickrema, A.6
  • 43
    • 0035958901 scopus 로고    scopus 로고
    • The p38 mapk pathway mediates the growth inhibitory effects of interferon-Alpha in bcr-Abl-expressing cells
    • PMID:11353767
    • Mayer IA, Verma A, Grumbach IM, Uddin S, Lekmine F, Ravandi F, et al. The p38 MAPK pathway mediates the growth inhibitory effects of interferon-Alpha in BCR-ABL-expressing cells. J Biol Chem 2001; 276:28570-7; PMID:11353767; http://dx.doi.org/10.1074/jbc.M011685200.
    • (2001) J Biol Chem , vol.276 , pp. 28570-28577
    • Mayer, I.A.1    Verma, A.2    Grumbach, I.M.3    Uddin, S.4    Lekmine, F.5    Ravandi, F.6
  • 44
    • 34249324822 scopus 로고    scopus 로고
    • Suppressive effects of statins on acute promyelocytic leukemia cells
    • PMID:17483369
    • Sassano A, Katsoulidis E, Antico G, Altman JK, Redig AJ, Minucci S, et al. Suppressive effects of statins on acute promyelocytic leukemia cells. Cancer Res 2007; 67:4524-32; PMID:17483369; http://dx.doi.org/10.1158/0008-5472.CAN- 06-3686.
    • (2007) Cancer Res , vol.67 , pp. 4524-4532
    • Sassano, A.1    Katsoulidis, E.2    Antico, G.3    Altman, J.K.4    Redig, A.J.5    Minucci, S.6
  • 45
    • 66449106631 scopus 로고    scopus 로고
    • Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins
    • PMID:19240159
    • Sassano A, Lo Iacono M, Antico G, Jordan A, Uddin S, Calogero RA, et al. Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins. Mol Cancer Ther 2009; 8:615-25; PMID:19240159; http://dx.doi.org/ 10.1158/1535-7163.MCT-08-1196.
    • (2009) Mol Cancer Ther , vol.8 , pp. 615-625
    • Sassano, A.1    Lo Iacono, M.2    Antico, G.3    Jordan, A.4    Uddin, S.5    Calogero, R.A.6
  • 46
    • 79960289322 scopus 로고    scopus 로고
    • Dual mtorc2mtorc1 targeting results in potent suppressive effects on acute myeloid leukemia (aml) progenitors
    • PMID:21415215
    • Altman JK, Sassano A, Kaur S, Glaser H, Kroczynska B, Redig AJ, et al. Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors. Clin Cancer Res 2011; 17:4378-88; PMID:21415215; http://dx.doi.org/10.1158/1078-0432.CCR-10-2285.
    • (2011) Clin Cancer Res , vol.17 , pp. 4378-4388
    • Altman, J.K.1    Sassano, A.2    Kaur, S.3    Glaser, H.4    Kroczynska, B.5    Redig, A.J.6
  • 47
    • 77955443001 scopus 로고    scopus 로고
    • Critical roles for mtorc2-And rapamycin-insensitive mtorc1-complexes in growth and survival of bcr-Abl-expressing leukemic cells
    • 12474; PMID:20616057
    • Carayol N, Vakana E, Sassano A, Kaur S, Goussetis DJ, Glaser H, et al. Critical roles for mTORC2-And rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proc Natl Acad Sci U S A 2010; 107:12469-74; PMID:20616057; http://dx.doi.org/10.1073/pnas.1005114107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12469-12107
    • Carayol, N.1    Vakana, E.2    Sassano, A.3    Kaur, S.4    Goussetis, D.J.5    Glaser, H.6
  • 48
    • 83455225509 scopus 로고    scopus 로고
    • Antileukemic effects of ampk activators on bcr-Abl-expressing cells
    • PMID:22021366
    • Vakana E, Altman JK, Glaser H, Donato NJ, Platanias LC. Antileukemic effects of AMPK activators on BCR-ABL-expressing cells. Blood 2011; 118:6399-402; PMID:22021366; http://dx.doi.org/10.1182/blood-2011-01-332783.
    • (2011) Blood , vol.118 , pp. 6399-6402
    • Vakana, E.1    Altman, J.K.2    Glaser, H.3    Donato, N.J.4    Platanias, L.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.