Dose-dependent vitamin C uptake and radical scavenging activity in human skin measured with in vivo electron paramagnetic resonance spectroscopy

Skin Pharmacology and Physiology

Volumn 26, Issue 3, 2013, Pages 147-154

  Lauer, Anna Christina ^a   Groth, Norbert ^b   Haag, Stefan F ^a   Darvin, Maxim E ^a   Lademann, Jürgen ^a   Meinke, Martina C ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Privatinstitut Galenus GmbH   (Germany)

Author keywords

Antioxidant; Raman resonance spectroscopy; Uptake kinetics

Indexed keywords

ASCORBIC ACID; CALCIUM ASCORBATE; PLACEBO; SCAVENGER; CAROTENOID;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG UPTAKE; ELECTRON SPIN RESONANCE; FEMALE; FOOD FREQUENCY QUESTIONNAIRE; HUMAN; IN VIVO STUDY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SKIN; TREATMENT DURATION; VITAMIN SUPPLEMENTATION; AMPLITUDE MODULATION; ANTIOXIDANT ACTIVITY; BODY MASS; HUMAN TISSUE; MAGNETIC FIELD; MICROWAVE RADIATION; SMOKING; SUN EXPOSURE;

ADMINISTRATION, ORAL; ADULT; ASCORBIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; MALE; MIDDLE AGED; SKIN; YOUNG ADULT;

EID: 84877843749     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000350833     Document Type: Article

References (50)

1. Lauer AC, Groth N, Haag SF, Darvin ME, Lademann J, Meinke MC: Radical scavenging capacity in human skin before and after vitamin C uptake: an in vivo feasibility study using electron paramagnetic resonance spectroscopy. J Invest Dermatol 2013; 133: 1102-1104.
2. Thiele JJ, Schroeter C, Hsieh SN, Podda M, Packer L: The antioxidant network of the stratum corneum. Curr Probl Dermatol 2001; 29: 26-42.
3. Sander CS, Chang H, Hamm F, Elsner P, Thiele JJ: Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis. Int J Dermatol 2004; 43: 326-335. (Pubitemid 38714593)
4. Vermeij WP, Alia A, Backendorf C: ROS quenching potential of the epidermal cornified cell envelope. J Invest Dermatol 2011; 131: 1435-1441.
5. Berger MM: Can oxidative damage be treated nutritionally? Clin Nutr 2005; 24: 172-183. (Pubitemid 40392800)
6. Vermeij WP, Backendorf C: Skin cornification proteins provide global link between ROS detoxification and cell migration during wound healing. Plos One 2010; 5:e11957.
7. Richelle M, Sabatier M, Steiling H, Williamson G: Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium. Br J Nutr 2006; 96: 227-238. (Pubitemid 46476322)
8. Packer L, Valacchi G: Antioxidants and the response of skin to oxidative stress: vitamin E as a key indicator. Skin Pharmacol Appl Skin Physiol 2002; 15: 282-290.
9. Mandl J, Szarka A, Banhegyi G: Vitamin C: update on physiology and pharmacology. Br J Pharmacol 2009; 157: 1097-1110.
10. Finkel T, Holbrook NJ: Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408: 239-247.
11. Buettner GR, Jurkiewicz BA: Catalytic metals, ascorbate and free radicals: combinations to avoid. Radiat Res 1996; 145: 532-541. (Pubitemid 26127160)
12. Moison RMW, Doerga R, Van Henegouwen GMJB: Increased antioxidant potential of combined topical vitamin E and C against lipid peroxidation of eicosapentaenoic acid in pig skin induced by simulated solar radiation. Int J Radiat Biol 2002; 78: 1185-1193. (Pubitemid 35462147)
13. Song Y, Xu Q, Park Y, Hollenbeck A, Schatzkin A, Chen H: Multivitamins, individual vitamin and mineral supplements, and risk of diabetes among older US adults. Diabetes Care 2011; 34: 108-114.
14. Rizzo MR, Abbatecola AM, Barbieri M, Vietri MT, Cioffi M, Grella R, Molinari A, Forsey R, Powell J, Paolisso G: Evidence for anti-inflammatory effects of combined administration of vitamin E and C in older persons with impaired fasting glucose: impact on insulin action. J Am Coll Nutr 2008; 27: 505-511.
15. Dayan SH, Arkins JP, Sharma V, Paterson E, Barnes D: A phase 2, double-blind, randomized, placebo-controlled trial of a novel nutritional supplement product to promote healthy skin. J Drugs Dermatol 2011; 10: 1106-1114.
16. Traikovich SS: Use of topical ascorbic acid and its effects on photodamaged skin topography. Arch Otolaryngol Head Neck Surg 1999; 125: 1091-1098. (Pubitemid 29473371)
17. Fitzpatrick RE, Rostan EF: Double-blind, halfface study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatol Surg 2002; 28: 231-236. (Pubitemid 34259749)
18. Meinke MC, Lauer A, Haag SF, Darvin ME, Groth N, Lademann J: Cutaneous radical scavenging effects of orally administered antioxidants measured by electron paramagnetic resonance spectroscopy. e-SPEN J 2012; 7:e160-e166.
19. Fuchs J, Groth N, Herrling T: In vivo measurement of oxidative stress status in human skin. Redox Cell Biol Genet A 2002; 352: 333-339. (Pubitemid 41103194)
20. Fuchs J, Groth N, Herrling T, Zimmer G: Electron paramagnetic resonance studies on nitroxide radical 2,2,5,5-tetramethyl-4-piperidin-1-oxyl (TEMPO) redox reactions in human skin. Free Radic Biol Med 1997; 22: 967-976. (Pubitemid 27084133)
21. Fuchs J, Freisleben HJ, Podda M, Zimmer G, Milbradt R, Packer L: Nitroxide radical biostability in skin. Free Radic Biol Med 1993; 15: 415-423. (Pubitemid 23283558)
22. Herrling T, Fuchs J, Rehberg J, Groth N: UVinduced free radicals in the skin detected by ESR spectroscopy and imaging using nitroxides. Free Radic Biol Med 2003; 35: 59-67. (Pubitemid 36782337)
23. Darvin ME, Gersonde I, Ey S, Brandt NN, Albrecht H, Gonchukov SA, Sterry W, Lademann J: Noninvasive detection of beta-carotene and lycopene in human skin using Raman spectroscopy. Laser Phys 2004; 14: 231-233.
24. Mayne ST, Cartmel B, Scarmo S, Lin HQ, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W: Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. Am J Clin Nutr 2010; 92: 794-800.
25. Krinsky NI: Carotenoids as antioxidants. Nutrition 2001; 17: 815-817. (Pubitemid 33001646)
26. Lademann J, Schanzer S, Meinke M, Sterry W, Darvin ME: Interaction between carotenoids and free radicals in human skin. Skin Pharmacol Physiol 2011; 24: 238-244.
27. Fitzpatrick TB: The validity and practicality of sun-reactive skin type-I through type-VI. Arch Dermatol 1988; 124: 869-871.
28. Haag SF, Taskoparan B, Darvin ME, Groth N, Lademann J, Sterry W, Meinke MC: Determination of the antioxidative capacity of the skin in vivo using resonance Raman and electron paramagnetic resonance spectroscopy. Exp Dermatol 2011; 20: 483-487.
29. Fuchs J, Groth N, Herrling T: Cutaneous tolerance to nitroxide free radicals in human skin. Free Radic Biol Med 1998; 24: 643-648. (Pubitemid 28150482)
30. Haag SF, Fleige E, Chen M, Fahr A, Teutloff C, Bittl R, Lademann J, Schafer-Korting M, Haag R, Meinke MC: Skin penetration enhancement of core-multishell nanotransporters and invasomes measured by electron paramagnetic resonance spectroscopy. Int J Pharm 2011; 416: 223-228.
31. Fuchs J, Mehlhorn RJ, Packer L: Free-radical reduction-mechanisms in mouse epidermis skin homogenates. J Invest Dermatol 1989; 93: 633-640. (Pubitemid 19262824)
32. Fuchs J, Groth N, Herrling T: In vivo measurement of oxidative stress status in human skin. Methods Enzymol 2002; 352: 333-339. (Pubitemid 41103194)
33. Darvin ME, Gersonde I, Meinke M, Sterry W, Lademann J: Non-invasive in vivo determination of the carotenoids beta-carotene and lycopene concentrations in the human skin using the Raman spectroscopic method. J Phys D Appl Phys 2005; 38: 2696-2700. (Pubitemid 41067761)
34. Ermakov IV, Sharifzadeh M, Ermakova M, Gellermann W: Resonance Raman detection of carotenoid antioxidants in living human tissue. J Biomed Opt 2005; 10: 064028.
35. Meinke MC, Darvin ME, Vollert H, Lademann J: Bioavailability of natural carotenoids in human skin compared to blood. Eur J Pharm Biopharm 2010; 76: 269-274.
36. Hata TR, Scholz TA, Ermakov IV, McClane RW, Khachik F, Gellermann W, Pershing LK: Non-invasive Raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol 2000; 115: 441-448.
37. Darvin ME, Gersonde I, Albrecht H, Meinke M, Sterry W, Lademann J: Non-invasive in vivo detection of the carotenoid antioxidant substance lycopene in the human skin using the resonance Raman spectroscopy. Laser Phys Lett 2006; 3: 460-463.
38. Levine M, Conry Cantilena C, Wang YH, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR: Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 1996; 93: 3704-3709. (Pubitemid 26125678)
39. Duarte TL, Lunec J: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C. Free Radic Res 2005;39:671-686. (Pubitemid 40959655)
40. Steiling H, Longet K, Moodycliffe A, Mansourian R, Bertschy E, Smola H, Mauch C, Williamson G: Sodium-dependent vitamin C transporter isoforms in skin: distribution, kinetics, and effect of UVB-induced oxidative stress. Free Radic Biol Med 2007; 43: 752-762. (Pubitemid 47411489)
41. Shindo Y, Witt E, Packer L: Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light. J Invest Dermatol 1993; 100: 260-265. (Pubitemid 23083169)
42. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM: Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA 2008; 300: 2123-2133.
43. Guo B, Yuan Y, Wu Y, Xie Q, Yao S: Assay and analysis for anti-and pro-oxidative effects of ascorbic acid on DNA with the bulk acoustic wave impedance technique. Anal Biochem 2002; 305: 139-148. (Pubitemid 34666786)
44. Darvin ME, Fluhr JW, Schanzer S, Richter H, Patzelt A, Meinke MC, Zastrow L, Golz K, Doucet O, Sterry W, Lademann J: Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: enrichment strategies in a controlled in vivo study. J Dermatol Sci 2011; 64: 53-58.
45. Watzl B, Kulling SE, Moseneder J, Barth SW, Bub A: A 4-week intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men. Am J Clin Nutr 2005; 82: 1052-1058. (Pubitemid 43779764)
46. Darvin ME, Patzelt A, Knorr F, Blume-Peytavi U, Sterry W, Lademann J: One-year study on the variation of carotenoid antioxidant substances in living human skin: influence of dietary supplementation and stress factors. J Biomed Opt 2008; 13: 044028.
47. Thiele JJ, Weber SU, Packer L: Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. J Invest Dermatol 1999; 113: 1006-1010. (Pubitemid 30013345)
48. Lademann J, Caspers PJ, van der Pol A, Richter H, Patzelt A, Zastrow L, Darvin M, Sterry W, Fluhr JW: In vivo Raman spectroscopy detects increased epidermal antioxidative potential with topically applied carotenoids. Laser Phys Lett 2009; 6: 76-79.
49. Darvin ME, Sterry W, Lademann J: Resonance Raman spectroscopy as an effective tool for the determination of antioxidative stability of cosmetic formulations. J Biophoton 2010; 3: 82-88.
50. Meinke MC, Haag SF, Schanzer S, Groth N, Gersonde I, Lademann J: Radical protection by sunscreens in the infrared spectral range. Photochem Photobiol 2011; 87: 452-456.