Bioavailability of natural carotenoids in human skin compared to blood

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 76, Issue 2, 2010, Pages 269-274

  Meinke, Martina C ^a   Darvin, Maxim E ^a   Vollert, Henning ^b   Lademann, Jürgen ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b BioActive Food GmbH (HV)   (Germany)

Author keywords

Blood; Carotenoids; Human skin; Kale extract; Raman spectroscopy

Indexed keywords

BETA CAROTENE; CAROTENOID; FREE RADICAL; LYCOPENE; XANTHOPHYLL;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; BIOAVAILABILITY; BLOOD; COMPARATIVE STUDY; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; FOREHEAD; HAND PALM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; RAMAN SPECTROMETRY; SERUM; SKIN; SKIN PROTECTION;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; BRASSICA; CAROTENOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOUBLE-BLIND METHOD; FEMALE; FOREHEAD; HAND; HUMANS; MALE; MIDDLE AGED; PLANT EXTRACTS; SKIN; SPECTRUM ANALYSIS, RAMAN; TIME FACTORS; TISSUE DISTRIBUTION; YOUNG ADULT;

EID: 77957257128     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.06.004     Document Type: Article

References (38)

1. Dhalla N.S., Temsah R.M., Netticadan T. Role of oxidative stress in cardiovascular diseases. J. Hypertens. 2000, 18:655-673.
2. Hagen T.M., Huang S., Curnutte J., Fowler P., Martinez V., Wehr C.M., Ames B.N., Chisari F.V. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 1994, 91:12808-12812.
3. Halliwell B. Oxidative stress and neurodegeneration: where are we now?. J. Neurochem. 2006, 97:1634-1658.
4. Sander C.S., Chang H., Hamm F., Elsner P., Thiele J.J. Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis. Int. J. Dermatol. 2004, 43:326-335.
5. Heinen M.M., Hughes M.C., Ibiebele T.I., Marks G.C., Green A.C., van der Pols J.C. Intake of antioxidant nutrients and the risk of skin cancer. Eur. J. Cancer 2007, 43:2707-2716.
6. Lee J.E., Giovannucci E., Smith-Warner S.A., Spiegelman D., Willett W.C., Curhan G.C. Intakes of fruits, vegetables, vitamins A, C, and E, and carotenoids and risk of renal cell cancer. Cancer Epidemiol. Biomarkers Prev. 2006, 15:2445-2452.
7. Stahl W., Sies H. Bioactivity and protective effects of natural carotenoids. Biochim. Biophys. Acta 2005, 1740:101-107.
8. Aust O., Stahl W., Sies H., Tronnier H., Heinrich U. Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema. Int. J. Vitam. Nutr. Res. 2005, 75:54-60.
9. Stahl W., Sies H. Antioxidant activity of carotenoids. Mol. Aspects Med. 2003, 24:345-351.
10. Khachik F., Carvalho L., Bernstein P.S., Muir G.J., Zhao D.Y., Katz N.B. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Exp. Biol. Med. (Maywood) 2002, 227:845-851.
11. Heinrich U., Gartner C., Wiebusch M., Eichler O., Sies H., Tronnier H., Stahl W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J. Nutr. 2003, 133:98-101.
12. Palombo P., Fabrizi G., Ruocco V., Ruocco E., Fluhr J., Roberts R., Morganti P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol. Physiol. 2007, 20:199-210.
13. Darvin M.E., Gersonde I., Albrecht H., Meinke M., Sterry W., Lademann J. Non-invasive in vivo detection of the carotenoid antioxidant substance lycopene in the human skin using the resonance Raman spectroscopy. Laser Phys. Lett. 2006, 3:460-463.
14. Blume-Peytavi U., Rolland A., Darvin M.E., Constable A., Pineau I., Voit C., Zappel K., Schafer-Hesterberg G., Meinke M., Clavez R.L., Sterry W., Lademann J. Cutaneous lycopene and beta-carotene levels measured by resonance Raman spectroscopy: high reliability and sensitivity to oral lactolycopene deprivation and supplementation. Eur. J. Pharm. Biopharm. 2009, 73:187-194.
15. Darvin M., Zastrow L., Sterry W., Lademann J. Effect of supplemented and topically applied antioxidant substances on human tissue. Skin Pharmacol. Physiol. 2006, 19:238-247.
16. Schafer Z.T., Grassian A.R., Song L., Jiang Z., Gerhart-Hines Z., Irie H.Y., Gao S., Puigserver P., Brugge J.S. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009, 461:109-113.
17. Polidori M.C., Carrillo J.C., Verde P.E., Sies H., Siegrist J., Stahl W. Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels. Nutr. J. 2009, 8. 10-
18. Halvorsen B.L., Holte K., Myhrstad M.C., Barikmo I., Hvattum E., Remberg S.F., Wold A.B., Haffner K., Baugerod H., Andersen L.F., Moskaug O., Jacobs D.R., Blomhoff R. A systematic screening of total antioxidants in dietary plants. J. Nutr. 2002, 132:461-471.
19. Pellegrini N., Serafini M., Colombi B., Del R.D., Salvatore S., Bianchi M., Brighenti F. Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays. J. Nutr. 2003, 133:2812-2819.
20. Schmidt S., Zietz M., Schreiner M., Rohn S., Kroh L.W., Krumbein A. Genotypic and climatic influences on the concentration and composition of flavonoids in kale (Brassica oleracea var. sabellica). Food Chem. 2010, 119:1293-1299.
21. Olsen H., Aaby K., Borge G.I. Characterization and quantification of flavonoids and hydroxycinnamic acids in curly kale (Brassica oleracea L. Convar. acephala Var. sabellica) by HPLC-DAD-ESI-MSn. J. Agric. Food Chem. 2009, 57:2816-2825.
22. Andersson S.C., Olsson M.E., Johansson E., Rumpunen K. Carotenoids in sea buckthorn (Hippophae rhamnoides L.) berries during ripening and use of pheophytin a as a maturity marker. J. Agric. Food Chem. 2009, 57:250-258.
23. Suarez M., Macia A., Romero M.P., Motilva M.J. Improved liquid chromatography tandem mass spectrometry method for the determination of phenolic compounds in virgin olive oil. J. Chromatogr. A 2008, 1214:90-99.
24. Hata T.R., Scholz T.A., Ermakov I.V., McClane R.W., Khachik F., Gellermann W., Pershing L.K. Non-invasive Raman spectroscopic detection of carotenoids in human skin. J. Invest. Dermatol. 2000, 115:441-448.
25. Stahl W., Krutmann J. [Systemic photoprotection through carotenoids]. Hautarzt 2006, 57:281-285.
26. Fitzpatrick T.B. The validity and practicality of sun-reactive skin type-I through type-Vi. Arch. Dermatol. 1988, 124:869-871.
27. Darvin M.E., Gersonde I., Meinke M., Sterry W., Lademann J. Non-invasive in vivo determination of the carotenoids beta-carotene and lycopene concentrations in the human skin using the Raman spectroscopic method. J. Phys. D - Appl. Phys. 2005, 38:2696-2700.
28. Darvin M.E., Gersonde I., Albrecht H., Sterry W., Lademann J. In vivo Raman spectroscopic analysis of the influence of UV radiation on carotenoid antioxidant substance degradation of the human skin. Laser Phys. 2006, 16:833-837.
29. Schweigert F.J., Klingner J., Hurtienne A., Zunft H.J. Vitamin A, carotenoid and vitamin E plasma concentrations in children from Laos in relation to sex and growth failure. Nutr. J. 2003, 2:17.
30. Darvin M.E., Gersonde I., Albrecht H., Sterry W., Lademann J. Resonance Raman spectroscopy for the detection of carotenoids in foodstuffs. Influence of the nutrition on the antioxidative potential of the skin. Laser Phys. Lett. 2007, 4:452-456.
31. Stahl W., Heinrich U., Jungmann H., von L.J., Schietzel M., Sies H., Tronnier H. Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting Betatene. J. Nutr. 1998, 128:903-907.
32. Chung H.Y., Ferreira A.L., Epstein S., Paiva S.A., Castaneda-Sceppa C., Johnson E.J. Site-specific concentrations of carotenoids in adipose tissue: relations with dietary and serum carotenoid concentrations in healthy adults. Am. J. Clin. Nutr. 2009, 90:533-539.
33. Watzl B., Kulling S.E., Moseneder J., Barth S.W., Bub A. A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men. Am. J. Clin. Nutr. 2005, 82:1052-1058.
34. Darvin M.E., Patzelt A., Knorr F., Blume-Peytavi U., Sterry W., Lademann J. One-year study on the variation of carotenoid antioxidant substances in living human skin: influence of dietary supplementation and stress factors. J. Biomed. Opt. 2008, 13:044028.
35. Darvin M., Patzelt A., Gehse S., Schanzer S., Benderoth C., Sterry W., Lademann J. Cutaneous concentration of lycopene correlates significantly with the roughness of the skin. Eur. J. Pharm. Biopharm. 2008, 69:943-947.
36. Sander C.S., Hamm F., Elsner P., Thiele J.J. Oxidative stress in malignant melanoma and non-melanoma skin cancer. Br. J. Dermatol. 2003, 148:913-922.
37. Thiele J.J., Weber S.U., Packer L. Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. J. Invest. Dermatol. 1999, 113:1006-1010.
38. Thiele J.J., Schroeter C., Hsieh S.N., Podda M., Packer L. The antioxidant network of the stratum corneum. Curr. Probl. Dermatol. 2001, 29:26-42.