Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage

Dermatologic Surgery

Volumn 28, Issue 3, 2002, Pages 231-236

  Fitzpatrick, Richard E ^a,b   Rostan, Elizabeth F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Dermatol Assoc S Diego Co Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; COLLAGEN TYPE 1; DRUG VEHICLE; EOSIN; HEMATOXYLIN; MESSENGER RNA; PLACEBO; SILICONE GEL; TETRAHEXYLDECYL ASCORBATE; UNCLASSIFIED DRUG;

AGING; ARTICLE; CHEEK; CLINICAL ARTICLE; CLINICAL EXAMINATION; CLINICAL TRIAL; COLLAGEN SYNTHESIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG FORMULATION; HUMAN; HUMAN TISSUE; HYDRATION; IN SITU HYBRIDIZATION; LIGHT DAMAGE; MICROSCOPY; MOUTH; PRIORITY JOURNAL; PUNCH BIOPSY; REJUVENATION; SKIN INFLAMMATION; SKIN PIGMENTATION; SKIN PROTECTION; TOPICAL TREATMENT;

ADMINISTRATION, TOPICAL; ASCORBIC ACID; DOUBLE-BLIND METHOD; HUMANS; PILOT PROJECTS; SKIN AGING;

EID: 0036202045     PISSN: 10760512     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-4725.2002.01129.x     Document Type: Article

References (37)

1. Topical vitamin C in aging
2. The chemical nature of vitamin C
3. Isolation and identification of vitamin C
4. Vitamin C and wound healing: II. Ascorbic acid content and tensile strength of healing wounds in human beings
5. Catabolism of L-ascorbic-1-C acid as a measure of its utilization in the intact and wounded guinea pig on scorbutic, maintenance, and saturation diets
6. Cellular functions of ascorbic acid
7. Induction of collagen synthesis by ascorbic acid
8. Ascorbate induction of collagen synthesis as a means for elucidating a mechanism for quantitative control of tissue-specific function
9. The stimulation of collagen secretion by ascorbate as a result of increased proline hydroxylation in chick embryo fibroblasts
10. The role of hydroxylation in the secretion of collagen by mouse fibroblasts in culture
11. Light-stimulated formation of hydrogen peroxide and hydroxyl radical in the presence of uroporphyrin and ascorbate
12. The action of various drugs on the suprarenal response of the rat to total-body X-irradiation
13. Ascorbate is an outstanding anti-oxidant in human blood plasma
14. Toxicity, radiation sensitivity modification, and metabolic effects of dehydroascorbate and ascorbate in mammalian cells
15. Membrane damage due to lipid oxidation
16. The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E
17. Vitamin E interaction with free radicals and ascorbate
18. The role of ascorbate in anti-oxidant protection of biomembranes: Interaction with Vitamin E and co-enzyme Q
19. Partners in defense, vitamin E and vitamin C
20. Ultraviolet light-induced generation of vitamin E radicals and their recycling: A possible photosensitizing effect of vitamin E in skin
21. Role of reactive oxygen species and free radicals from melanins in photo-induced cutaneous inflammations
22. Potential involvement of free radical reactions in ultraviolet light-mediated cutaneous damage
23. Reactive oxygen species in photodermatology
24. The biology of oxygen free radicals and their relevance to dermatology
25. Cumulative effects from repeated exposure to suberythemal doses of UVB and UVA in human skin
26. Low doses of repetitive ultraviolet A induce morphologic changes in human skin
27. Epidermal trans-uronic acid and the UV-A-induced photoaging of the skin
28. Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage
29. The photoprotective and anti-inflammatory effects of topical ascorbyl palmitate
30. Photoprotective effect of superoxide-scavenging anti-oxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse
31. A double-blind randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis
32. 2 laser resurfacing of photoaged skin
33. Topical L-ascorbic acid: Percutaneous absorption studies