A phase 2, double-blind, randomized, placebo-controlled trial of a novel nutritional supplement product to promote healthy skin

Journal of Drugs in Dermatology

Volumn 10, Issue 10, 2011, Pages 1106-1114

  Dayan, Steven H ^a   Arkins, John P ^b   Sharma, Vinny ^c   Paterson, Elaine ^d   Barnes, David ^d  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b DeNova Research   (United States)

^c LAKE ERIE COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^d Standard Process   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CAROTENOID; DERMATOLOGICAL AGENT; NICOTINIC ACID; OMEGA 3 FATTY ACID; PANTOTHENIC ACID; PLACEBO; PYRIDOXINE; SILICON; SKIN HEALTH EXPERIMENTAL PRODUCT; UBIDECARENONE; UNCLASSIFIED DRUG; XANTHOPHYLL;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYDRATION; MALE; NORMAL HUMAN; PHASE 2 CLINICAL TRIAL; RAMAN SPECTROMETRY; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SELF CONCEPT; SKIN CARE; SKIN WATER LOSS; WRINKLE;

ADMINISTRATION, ORAL; ADULT; AGED; CAROTENOIDS; CASE-CONTROL STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PATIENT SATISFACTION; SKIN; SPECTRUM ANALYSIS, RAMAN; TREATMENT OUTCOME; WATER LOSS, INSENSIBLE;

EID: 80054762928     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Shils ME, Shike M. Modern nutrition in health and disease. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2006.
2. Hu FB, Willett WC. Optimal diets for prevention of coronary heart disease. JAMA. 2002;288(20):2569-2578. (Pubitemid 35386892)
3. Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106(21):2747-2757. (Pubitemid 35364932)
4. Belluzzi A. N-3 fatty acids for the treatment of inflammatory bowel diseases. Proc Nutr Soc. 2002;61(3):391-395. (Pubitemid 34982930)
5. Hofmeyr GJ, Lawrie TA, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. 2010;8:CD001059.
6. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997;337(10):670-676. (Pubitemid 27375473)
7. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993;328(20):1450-1456. (Pubitemid 23143847)
8. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. 1993;328(20):1444-1449. (Pubitemid 23143846)
9. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet. 1996;347(9004):781-786. (Pubitemid 26091640)
10. Miller ER, 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142(1):37-46.
11. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297(8):842-857. (Pubitemid 46333949)
12. Ryan AS, Goldsmith LA. Nutrition and the skin. Clin Dermatol. 1996;14(4):389-406. (Pubitemid 26274696)
13. Cesarini JP, Michel L, Maurette JM, Adhoute H, Bejot M. Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatol Photoimmunol Photomed. 2003;19(4):182-189. (Pubitemid 37038440)
14. Gensler HL, Magdaleno M. Topical vitamin E inhibition of immunosuppression and tumorigenesis induced by ultraviolet irradiation. Nutr Cancer. 1991;15(2):97-106.
15. Darr D, Combs S, Dunston S, Manning T, Pinnell S. Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. Br J Dermatol. 1992;127(3):247-253.
16. Darr D, Dunston S, Faust H, Pinnell S. Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants. Acta Derm Venereol. 1996;76(4):264-268. (Pubitemid 26246992)
17. Diffey BL. Human exposure to solar ultraviolet radiation. J Cosmet Dermatol. 2002;1(3):124-130.
18. CuDerm I. Replica Information Packet. 2004; http://www.cuderm.com/bionet/ reppacket.pdf. Accessed March, 10, 2010.
19. Hata TR, Scholz TA, Ermakov IV, et al. Non-invasive raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol. 2000;115(3):441-448.
20. Beer K. A randomized, evaluator-blinded comparison of efficacy of hyaluronic acid gel and avian-sourced hylan B plus gel for correction of nasolabial folds. Dermatol Surg. 2007;33(8):928-936. (Pubitemid 47106733)
21. Narins RS, Brandt F, Leyden J, Lorenc ZP, Rubin M, Smith S. A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatol Surg. 2003;29(6):588-595. (Pubitemid 36702442)
22. Silvers SL, Eviatar JA, Echavez MI, Pappas AL. Prospective, open-label, 18-month trial of calcium hydroxylapatite (Radiesse) for facial soft-tissue augmentation in patients with human immunodeficiency virus-associated lipoatrophy: one-year durability. Plast Reconstr Surg. 2006;118(3 Suppl):34S-45S. (Pubitemid 44319089)
23. Purba MB, Kouris-Blazos A, Wattanapenpaiboon N, et al. Skin wrinkling: can food make a difference? J Am Coll Nutr. 2001;20(1):71-80. (Pubitemid 32244968)
24. Segger D, Schonlau F. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. J Dermatolog Treat. 2004;15(4):222-226. (Pubitemid 39013675)
25. Podda M, Grundmann-Kollmann M. Low molecular weight antioxidants and their role in skin ageing. Clin Exp Dermatol. 2001;26(7):578-582. (Pubitemid 32989582)
26. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993;90(17):7915-7922. (Pubitemid 23260825)
27. Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect. 1985;64:111-126. (Pubitemid 16135783)
28. Martires KJ, Fu P, Polster AM, Cooper KD, Baron ED. Factors that affect skin aging: a cohort-based survey on twins. Arch Dermatol. 2009;145(12):1375- 1379.
29. Trouba KJ, Hamadeh HK, Amin RP, Germolec DR. Oxidative stress and its role in skin disease. Antioxid Redox Signal. 2002;4(4):665-673. (Pubitemid 35001451)
30. Antell DE, Taczanowski EM. How environment and lifestyle choices influence the aging process. Ann Plast Surg. 1999;43(6):585-588.
31. Guyuron B, Rowe DJ, Weinfeld AB, Eshraghi Y, Fathi A, Iamphongsai S. Factors contributing to the facial aging of identical twins. Plast Reconstr Surg. 2009;123(4):1321-1331.
32. Dalle Carbonare M, Pathak MA. Skin photosensitizing agents and the role of reactive oxygen species in photoaging. J Photochem Photobiol B. 1992;14(1-2):105-124.
33. Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462-1470. (Pubitemid 35315736)
34. Tinkler JH, Bohm F, Schalch W, Truscott TG. Dietary carotenoids protect human cells from damage. J Photochem Photobiol B. 1994;26(3):283-285. (Pubitemid 24378387)
35. Ermakov IV, Ermakova MR, McClane RW, Gellermann W. Resonance Raman detection of carotenoid antioxidants in living human tissues. Opt Lett. 2001;26(15):1179-1181. (Pubitemid 33693644)
36. Grubauer G, Elias PM, Feingold KR. Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res. 1989;30(3):323-333. (Pubitemid 19082061)
37. Agner T. Basal transepidermal water loss, skin thickness, skin blood flow and skin colour in relation to sodium-lauryl-sulphate-induced irritation in normal skin. Contact Dermatitis. 1991;25(2):108-114.
38. De Paepe K, Houben E, Adam R, Wiesemann F, Rogiers V. Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter. Skin Res Technol. 2005;11(1):61-69. (Pubitemid 40347610)
39. Nuutinen J, Alanen E, Autio P, Lahtinen MR, Harvima I, Lahtinen T. A closed unventilated chamber for the measurement of transepidermal water loss. Skin Res Technol. 2003;9(2):85-89. (Pubitemid 36603649)
40. Alanen E, Nuutinen J, Nicklen K, Lahtinen T, Monkkonen J. Measurement of hydration in the stratum corneum with the MoistureMeter and comparison with the Corneometer. Skin Res Technol. 2004;10(1):32-37. (Pubitemid 38195476)
41. Agarwal V, Godfrey M, Long S, Whitby D, Barton S, Desnos A. Variability in the physical properties of the stratum corneum - influences of chronological age and season. Abstracts from the stratum corneum V conference 2007. Held in Cardiff July 11th-13th in association with the ISBS. International Journal of Cosmetic Science. 2007;29(3):219-219.
42. Hatzis J. The wrinkle and its measurement - a skin surface Profilometric method. Micron. 2004;35(3):201-219. (Pubitemid 38225246)
43. Cook TH, Craft TJ, Brunelle RL, Norris F, Griffin WA. Quantification of the skin's topography by skin profilometry. Int J Cosmet Sci. 1982;4(5):195-205.
44. Hata R, Senoo H. L-ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissuelike substance by skin fibroblasts. J Cell Physiol. 1989;138(1):8-16. (Pubitemid 19038665)
45. Walker M, Vetter T. Portraits made to measure: manipulating social judgments about individuals with a statistical face model. J Vis. 2009;9(11):12 11-13.
46. Montoya RM. I'm hot, so i'd say you're not: the influence of objective physical attractiveness on mate selection. Pers Soc Psychol Bull. 2008;34(10):1315-1331.