Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: Excellent substrates for NAD(P)H:quinone oxidoreductase 1

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 11, 2013, Pages 2999-3009

  Newsome, Jeffery J ^a   Hassani, Mary ^b   Swann, Elizabeth ^a   Bibby, Jane M ^a   Beall, Howard D ^b   Moody, Christopher J ^a,c  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b UNIVERSITY OF MONTANA   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Benzofuran; Benzothiophene; Indazole; NQO1; Quinone; Quinone reductase

Indexed keywords

2 ACETOXYMETHYL METHOXYBENZOTHIOPHENE 4,7 DIONE; 2 FORMYL 5 METHOXYBENZOTHIOPHENE 4,7 DIONE; 2 HYDROXYMETHYL 5 METHOXY 3 METHYLBENZOFURAN 4,7 DIONE; 2 HYDROXYMETHYL 5 METHOXY 3 METHYLBENZOTHIOPHENE 4,7 DIONE; 2 HYDROXYMETHYL 5 METHOXYBENZOTHIOPHENE 4,7 DIONE; 3 (1 HYDROXYETHYL) 5 METHOXY 2 METHYLBENZOFURAN 4,7 DIONE; 3 ACETYL 5 METHOXY 2 METHYL 4 NITROBENZOFURAN; 3 HYDROXYMETHYL 5 METHOXY 2 METHYLBENZOTHIOPHENE 4,7 DIONE; 4 AMINO 5 METHOXY 2 METHYLBENZOTHIOPHENE; 4 AMINO 5 METHOXY 3 METHYLBENZOTHIOPHENE 2 METHANOL; 4 AMINO 5 METHOXYBENZOTHIOPHENE 2 CARBOXALDEHYDE; 4 AMINO 5 METHOXYBENZOTHIOPHENE 2 METHANOL; 5 METHOXY 2 METHYLBENZOTHIOPHENE 3 CARBOXALDEHYDE; 5 METHOXY 2 METHYLBENZOTHIOPHENE 4,7 DIONE; 5,7 DIMETHOXY 1,3 DIMETHYL 4 NITROINDAZOLE; 5,7 DIMETHOXY 3 METHYL 4 NITROINDAZOLE; 5,7 DIMETHOXY 3 METHYLINDAZOLE; BENZISOXAZOLEQUINONE DERIVATIVE; BENZOFURANQUINONE DERIVATIVE; BENZOTHIOPHENEQUINONE DERIVATIVE; ETHYL 4 AMINO 5 METHOXY 3 METHYLBENZOTHIOPHENE 2 CARBOXYLATE; ETHYL 5 METHOXY 3 METHYL 4 NITROBENZOTHIOPHENE 2 CARBOXYLATE; INDAZOLEQUINONE DERIVATIVE; MENADIONE; METHYL 4 AMINO 5 METHOXYBENZOTHIOPHENE 2 CARBOXYLATE; METHYL 5 METHOXY 4,7 DIOXOBENZOTHIOPHENE 2 CARBOXYLATE; NAD(P)H:QUINONE OXIDOREDUCTASE 1; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ARTICLE; ENZYME METABOLISM; ENZYME SUBSTRATE; REDUCTION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BENZOFURANS; CELL LINE, TUMOR; ENZYME ASSAYS; HUMANS; INDAZOLES; NAD(P)H DEHYDROGENASE (QUINONE); OXAZOLES; OXIDATION-REDUCTION; QUINONES; THIOPHENES;

EID: 84877840063     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.071     Document Type: Article

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