Indolequinone antitumor agents: Correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity

Journal of Medicinal Chemistry

Volumn 41, Issue 24, 1998, Pages 4755-4766

  Beall, Howard D ^a,d   Winski, Shannon ^a   Swann, Elizabeth ^b   Hudnott, Anna R ^b   Cotterill, Ann S ^c   O'Sullivan, Noeleen ^c   Green, Stephen J ^b   Bien, Richard ^b   Siegel, David ^a   Ross, David ^a   Moody, Christopher J ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF MONTANA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHOXYINDOLEQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; NAD(P)H DEHYDROGENASE (QUINONE); QUINONES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 7844226621     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980328r     Document Type: Article

References (37)

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2. Some of the results herein have been presented in preliminary form: Ross, D.; Beall, H. D.; Bourne, J. T.; Bolton, E. M.; Cotterill, A. S.; Swann, E.; Moody, C. J. Indolequinones and cyclopropamitosenes as novel bioreductive anticancer agents. Metabolism and chemosensitivity studies. Proc. Am. Assoc. Cancer Res. 1996, 37, 295. Beall, H. D.; Griffin, A. M.; Poulet, C.; Swann, E.; Moody, C. J.; Ross, D. Bioactivation of novel indolequinones, mitosenes and cyclopropamitosenes by NAD-(P)H:quinone oxidoreductase (NQO1): structure-metabolism and structure-cytotoxicity studies. Proc. Am. Assoc. Cancer Res. 1997, 38, 6612. Beall, H. D.; Hudnott, A. R.; Winski, S.; Siegel, D.; Swann, E.; Ross, D.; Moody, C. J. Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1. Bioorg. Med. Chem. Lett. 1998, 8, 545-548.
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