메뉴 건너뛰기




Volumn 15, Issue 6, 2013, Pages 992-1011

Hcp and VgrG1 are secreted components of the Helicobacter hepaticus type VI secretion system and VgrG1 increases the bacterial colitogenic potential

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; HCP PROTEIN; UNCLASSIFIED DRUG; VGRG1 PROTEIN;

EID: 84877833363     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/cmi.12094     Document Type: Article
Times cited : (31)

References (52)
  • 2
    • 84864320130 scopus 로고    scopus 로고
    • Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation
    • Boulard, O., Kirchberger, S., Royston, D.J., Maloy, K.J., and Powrie, F.M. (2012) Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation. J Exp Med 209: 1309-1324.
    • (2012) J Exp Med , vol.209 , pp. 1309-1324
    • Boulard, O.1    Kirchberger, S.2    Royston, D.J.3    Maloy, K.J.4    Powrie, F.M.5
  • 3
    • 28444445594 scopus 로고    scopus 로고
    • Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis
    • Boutin, S.R., Shen, Z., Rogers, A.B., Feng, Y., Ge, Z., Xu, S., etal. (2005) Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis. Infect Immun 73: 8449-8452.
    • (2005) Infect Immun , vol.73 , pp. 8449-8452
    • Boutin, S.R.1    Shen, Z.2    Rogers, A.B.3    Feng, Y.4    Ge, Z.5    Xu, S.6
  • 4
    • 77953813317 scopus 로고    scopus 로고
    • Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes
    • Bryan, N.B., Dorfleutner, A., Kramer, S.J., Yun, C., Rojanasakul, Y., and Stehlik, C. (2010) Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. J Inflamm (Lond) 7: 23.
    • (2010) J Inflamm (Lond) , vol.7 , pp. 23
    • Bryan, N.B.1    Dorfleutner, A.2    Kramer, S.J.3    Yun, C.4    Rojanasakul, Y.5    Stehlik, C.6
  • 6
    • 0030794060 scopus 로고    scopus 로고
    • Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus
    • Cahill, R.J., Foltz, C.J., Fox, J.G., Dangler, C.A., Powrie, F., and Schauer, D.B. (1997) Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect Immun 65: 3126-3131.
    • (1997) Infect Immun , vol.65 , pp. 3126-3131
    • Cahill, R.J.1    Foltz, C.J.2    Fox, J.G.3    Dangler, C.A.4    Powrie, F.5    Schauer, D.B.6
  • 7
    • 0018956590 scopus 로고
    • Analysis of gene control signals by DNA fusion and cloning in Escherichia coli
    • Casadaban, M.J., and Cohen, S.N. (1980) Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. J Mol Biol 138: 179-207.
    • (1980) J Mol Biol , vol.138 , pp. 179-207
    • Casadaban, M.J.1    Cohen, S.N.2
  • 8
    • 48649107476 scopus 로고    scopus 로고
    • The type VI secretion toolkit
    • Cascales, E. (2008) The type VI secretion toolkit. EMBO Rep 9: 735-741.
    • (2008) EMBO Rep , vol.9 , pp. 735-741
    • Cascales, E.1
  • 10
    • 1842456892 scopus 로고    scopus 로고
    • The versatile bacterial type IV secretion systems
    • Cascales, E., and Christie, P.J. (2003) The versatile bacterial type IV secretion systems. Nat Rev Microbiol 1: 137-149.
    • (2003) Nat Rev Microbiol , vol.1 , pp. 137-149
    • Cascales, E.1    Christie, P.J.2
  • 11
    • 2442682800 scopus 로고    scopus 로고
    • Definition of a bacterial type IV secretion pathway for a DNA substrate
    • Cascales, E., and Christie, P.J. (2004) Definition of a bacterial type IV secretion pathway for a DNA substrate. Science 304: 1170-1173.
    • (2004) Science , vol.304 , pp. 1170-1173
    • Cascales, E.1    Christie, P.J.2
  • 12
    • 77954607064 scopus 로고    scopus 로고
    • A pathobiont of the microbiota balances host colonization and intestinal inflammation
    • Chow, J., and Mazmanian, S.K. (2010) A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe 7: 265-276.
    • (2010) Cell Host Microbe , vol.7 , pp. 265-276
    • Chow, J.1    Mazmanian, S.K.2
  • 13
    • 78650828652 scopus 로고    scopus 로고
    • Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
    • Fox, J.G., Ge, Z., Whary, M.T., Erdman, S.E., and Horwitz, B.H. (2011) Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol 4: 22-30.
    • (2011) Mucosal Immunol , vol.4 , pp. 22-30
    • Fox, J.G.1    Ge, Z.2    Whary, M.T.3    Erdman, S.E.4    Horwitz, B.H.5
  • 14
    • 84859911615 scopus 로고    scopus 로고
    • NLRC4-driven production of IL-1beta discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
    • Franchi, L., Kamada, N., Nakamura, Y., Burberry, A., Kuffa, P., Suzuki, S., etal. (2012) NLRC4-driven production of IL-1beta discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat Immunol 13: 449-456.
    • (2012) Nat Immunol , vol.13 , pp. 449-456
    • Franchi, L.1    Kamada, N.2    Nakamura, Y.3    Burberry, A.4    Kuffa, P.5    Suzuki, S.6
  • 15
    • 45849148064 scopus 로고    scopus 로고
    • Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice
    • Ge, Z., Sterzenbach, T., Whary, M.T., Rickman, B.H., Rogers, A.B., Shen, Z., etal. (2008) Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice. Microbes Infect 10: 726-733.
    • (2008) Microbes Infect , vol.10 , pp. 726-733
    • Ge, Z.1    Sterzenbach, T.2    Whary, M.T.3    Rickman, B.H.4    Rogers, A.B.5    Shen, Z.6
  • 16
    • 79953311518 scopus 로고    scopus 로고
    • Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins
    • Hachani, A., Lossi, N.S., Hamilton, A., Jones, C., Bleves, S., Albesa-Jove, D., and Filloux, A. (2011) Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins. J Biol Chem 286: 12317-12327.
    • (2011) J Biol Chem , vol.286 , pp. 12317-12327
    • Hachani, A.1    Lossi, N.S.2    Hamilton, A.3    Jones, C.4    Bleves, S.5    Albesa-Jove, D.6    Filloux, A.7
  • 17
    • 0020959710 scopus 로고
    • Studies on transformation of Escherichia coli with plasmids
    • Hanahan, D. (1983) Studies on transformation of Escherichia coli with plasmids. J Mol Biol 166: 557-580.
    • (1983) J Mol Biol , vol.166 , pp. 557-580
    • Hanahan, D.1
  • 18
    • 63149199451 scopus 로고    scopus 로고
    • Structural similarity of tailed phages and pathogenic bacterial secretion systems
    • Kanamaru, S. (2009) Structural similarity of tailed phages and pathogenic bacterial secretion systems. Proc Natl Acad Sci USA 106: 4067-4068.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4067-4068
    • Kanamaru, S.1
  • 19
    • 63849246525 scopus 로고    scopus 로고
    • Protein structure prediction on the Web: a case study using the Phyre server
    • Kelley, L.A., and Sternberg, M.J. (2009) Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc 4: 363-371.
    • (2009) Nat Protoc , vol.4 , pp. 363-371
    • Kelley, L.A.1    Sternberg, M.J.2
  • 20
    • 25444457497 scopus 로고    scopus 로고
    • Colonization of the cecal mucosa by Helicobacter hepaticus impacts the diversity of the indigenous microbiota
    • Kuehl, C.J., Wood, H.D., Marsh, T.L., Schmidt, T.M., and Young, V.B. (2005) Colonization of the cecal mucosa by Helicobacter hepaticus impacts the diversity of the indigenous microbiota. Infect Immun 73: 6952-6961.
    • (2005) Infect Immun , vol.73 , pp. 6952-6961
    • Kuehl, C.J.1    Wood, H.D.2    Marsh, T.L.3    Schmidt, T.M.4    Young, V.B.5
  • 21
    • 0032425062 scopus 로고    scopus 로고
    • Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism
    • Kullberg, M.C., Ward, J.M., Gorelick, P.L., Caspar, P., Hieny, S., Cheever, A., etal. (1998) Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun 66: 5157-5166.
    • (1998) Infect Immun , vol.66 , pp. 5157-5166
    • Kullberg, M.C.1    Ward, J.M.2    Gorelick, P.L.3    Caspar, P.4    Hieny, S.5    Cheever, A.6
  • 24
    • 33750530394 scopus 로고    scopus 로고
    • IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    • Kullberg, M.C., Jankovic, D., Feng, C.G., Hue, S., Gorelick, P.L., McKenzie, B.S., etal. (2006) IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med 203: 2485-2494.
    • (2006) J Exp Med , vol.203 , pp. 2485-2494
    • Kullberg, M.C.1    Jankovic, D.2    Feng, C.G.3    Hue, S.4    Gorelick, P.L.5    McKenzie, B.S.6
  • 25
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 26
    • 84865410008 scopus 로고    scopus 로고
    • Campylobacter jejuni type VI secretion system: roles in adaptation to deoxycholic acid, host cell adherence, invasion, and in vivo colonization
    • Lertpiriyapong, K., Gamazon, E.R., Feng, Y., Park, D.S., Pang, J., Botka, G., etal. (2012) Campylobacter jejuni type VI secretion system: roles in adaptation to deoxycholic acid, host cell adherence, invasion, and in vivo colonization. PLoS ONE 7: e42842.
    • (2012) PLoS ONE , vol.7
    • Lertpiriyapong, K.1    Gamazon, E.R.2    Feng, Y.3    Park, D.S.4    Pang, J.5    Botka, G.6
  • 27
    • 52549099416 scopus 로고    scopus 로고
    • Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
    • Lightfield, K.L., Persson, J., Brubaker, S.W., Witte, C.E., von Moltke, J., Dunipace, E.A., etal. (2008) Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol 9: 1171-1178.
    • (2008) Nat Immunol , vol.9 , pp. 1171-1178
    • Lightfield, K.L.1    Persson, J.2    Brubaker, S.W.3    von Witte, C.E.4    Moltke, J.5    Dunipace, E.A.6
  • 28
    • 77749297949 scopus 로고    scopus 로고
    • In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation
    • Ma, A.T., and Mekalanos, J.J. (2010) In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation. Proc Natl Acad Sci USA 107: 4365-4370.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4365-4370
    • Ma, A.T.1    Mekalanos, J.J.2
  • 29
    • 61849114089 scopus 로고    scopus 로고
    • Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells
    • Ma, A.T., McAuley, S., Pukatzki, S., and Mekalanos, J.J. (2009a) Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells. Cell Host Microbe 5: 234-243.
    • (2009) Cell Host Microbe , vol.5 , pp. 234-243
    • Ma, A.T.1    McAuley, S.2    Pukatzki, S.3    Mekalanos, J.J.4
  • 30
    • 67649415191 scopus 로고    scopus 로고
    • An IcmF family protein, ImpLM, is an integral inner membrane protein interacting with ImpKL, and its walker a motif is required for type VI secretion system-mediated Hcp secretion in Agrobacterium tumefaciens
    • Ma, L.S., Lin, J.S., and Lai, E.M. (2009b) An IcmF family protein, ImpLM, is an integral inner membrane protein interacting with ImpKL, and its walker a motif is required for type VI secretion system-mediated Hcp secretion in Agrobacterium tumefaciens. J Bacteriol 191: 4316-4329.
    • (2009) J Bacteriol , vol.191 , pp. 4316-4329
    • Ma, L.S.1    Lin, J.S.2    Lai, E.M.3
  • 31
    • 78650591211 scopus 로고    scopus 로고
    • The Vibrio cholerae type VI secretion system displays antimicrobial properties
    • MacIntyre, D.L., Miyata, S.T., Kitaoka, M., and Pukatzki, S. (2010) The Vibrio cholerae type VI secretion system displays antimicrobial properties. Proc Natl Acad Sci USA 107: 19520-19524.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 19520-19524
    • MacIntyre, D.L.1    Miyata, S.T.2    Kitaoka, M.3    Pukatzki, S.4
  • 32
    • 0037243827 scopus 로고    scopus 로고
    • CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    • Maloy, K.J., Salaun, L., Cahill, R., Dougan, G., Saunders, N.J., and Powrie, F. (2003) CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 197: 111-119.
    • (2003) J Exp Med , vol.197 , pp. 111-119
    • Maloy, K.J.1    Salaun, L.2    Cahill, R.3    Dougan, G.4    Saunders, N.J.5    Powrie, F.6
  • 33
    • 33744974779 scopus 로고    scopus 로고
    • A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus
    • Mougous, J.D., Cuff, M.E., Raunser, S., Shen, A., Zhou, M., Gifford, C.A., etal. (2006) A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 312: 1526-1530.
    • (2006) Science , vol.312 , pp. 1526-1530
    • Mougous, J.D.1    Cuff, M.E.2    Raunser, S.3    Shen, A.4    Zhou, M.5    Gifford, C.A.6
  • 34
    • 34347404255 scopus 로고    scopus 로고
    • Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa
    • Mougous, J.D., Gifford, C.A., Ramsdell, T.L., and Mekalanos, J.J. (2007) Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Nat Cell Biol 9: 797-803.
    • (2007) Nat Cell Biol , vol.9 , pp. 797-803
    • Mougous, J.D.1    Gifford, C.A.2    Ramsdell, T.L.3    Mekalanos, J.J.4
  • 35
    • 77954758654 scopus 로고    scopus 로고
    • The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models
    • Nell, S., Suerbaum, S., and Josenhans, C. (2010) The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models. Nat Rev Microbiol 8: 564-577.
    • (2010) Nat Rev Microbiol , vol.8 , pp. 564-577
    • Nell, S.1    Suerbaum, S.2    Josenhans, C.3
  • 36
    • 38949168473 scopus 로고    scopus 로고
    • Diversifying selection and concerted evolution of a type IV secretion system in Bartonella
    • Nystedt, B., Frank, A.C., Thollesson, M., and Andersson, S.G. (2008) Diversifying selection and concerted evolution of a type IV secretion system in Bartonella. Mol Biol Evol 25: 287-300.
    • (2008) Mol Biol Evol , vol.25 , pp. 287-300
    • Nystedt, B.1    Frank, A.C.2    Thollesson, M.3    Andersson, S.G.4
  • 37
    • 31944433740 scopus 로고    scopus 로고
    • Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system
    • Pukatzki, S., Ma, A.T., Sturtevant, D., Krastins, B., Sarracino, D., Nelson, W.C., etal. (2006) Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci USA 103: 1528-1533.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1528-1533
    • Pukatzki, S.1    Ma, A.T.2    Sturtevant, D.3    Krastins, B.4    Sarracino, D.5    Nelson, W.C.6
  • 38
    • 34848882221 scopus 로고    scopus 로고
    • Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin
    • Pukatzki, S., Ma, A.T., Revel, A.T., Sturtevant, D., and Mekalanos, J.J. (2007) Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. Proc Natl Acad Sci USA 104: 15508-15513.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15508-15513
    • Pukatzki, S.1    Ma, A.T.2    Revel, A.T.3    Sturtevant, D.4    Mekalanos, J.J.5
  • 39
    • 59849101362 scopus 로고    scopus 로고
    • The type VI secretion system: translocation of effectors and effector-domains
    • Pukatzki, S., McAuley, S.B., and Miyata, S.T. (2009) The type VI secretion system: translocation of effectors and effector-domains. Curr Opin Microbiol 12: 11-17.
    • (2009) Curr Opin Microbiol , vol.12 , pp. 11-17
    • Pukatzki, S.1    McAuley, S.B.2    Miyata, S.T.3
  • 40
    • 79960648176 scopus 로고    scopus 로고
    • Type VI secretion delivers bacteriolytic effectors to target cells
    • Russell, A.B., Hood, R.D., Bui, N.K., LeRoux, M., Vollmer, W., and Mougous, J.D. (2011) Type VI secretion delivers bacteriolytic effectors to target cells. Nature 475: 343-347.
    • (2011) Nature , vol.475 , pp. 343-347
    • Russell, A.B.1    Hood, R.D.2    Bui, N.K.3    LeRoux, M.4    Vollmer, W.5    Mougous, J.D.6
  • 42
    • 78649326935 scopus 로고    scopus 로고
    • What is type VI secretion doing in all those bugs?
    • Schwarz, S., Hood, R.D., and Mougous, J.D. (2010a) What is type VI secretion doing in all those bugs? Trends Microbiol 18: 531-537.
    • (2010) Trends Microbiol , vol.18 , pp. 531-537
    • Schwarz, S.1    Hood, R.D.2    Mougous, J.D.3
  • 43
    • 77958145264 scopus 로고    scopus 로고
    • Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions
    • Schwarz, S., West, T.E., Boyer, F., Chiang, W.C., Carl, M.A., Hood, R.D., etal. (2010b) Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. PLoS Pathog 6: e1001068.
    • (2010) PLoS Pathog , vol.6
    • Schwarz, S.1    West, T.E.2    Boyer, F.3    Chiang, W.C.4    Carl, M.A.5    Hood, R.D.6
  • 44
    • 0028864668 scopus 로고
    • Identification of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay
    • Shames, B., Fox, J.G., Dewhirst, F., Yan, L., Shen, Z., and Taylor, N.S. (1995) Identification of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay. J Clin Microbiol 33: 2968-2972.
    • (1995) J Clin Microbiol , vol.33 , pp. 2968-2972
    • Shames, B.1    Fox, J.G.2    Dewhirst, F.3    Yan, L.4    Shen, Z.5    Taylor, N.S.6
  • 45
    • 23144452044 scopus 로고    scopus 로고
    • The HHpred interactive server for protein homology detection and structure prediction
    • Soding, J., Biegert, A., and Lupas, A.N. (2005) The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res 33: W244-W248.
    • (2005) Nucleic Acids Res , vol.33
    • Soding, J.1    Biegert, A.2    Lupas, A.N.3
  • 46
    • 0035132939 scopus 로고    scopus 로고
    • Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases
    • Solnick, J.V., and Schauer, D.B. (2001) Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases. Clin Microbiol Rev 14: 59-97.
    • (2001) Clin Microbiol Rev , vol.14 , pp. 59-97
    • Solnick, J.V.1    Schauer, D.B.2
  • 47
    • 34249905600 scopus 로고    scopus 로고
    • Inhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells
    • Sterzenbach, T., Lee, S.K., Brenneke, B., von Goetz, F., Schauer, D.B., Fox, J.G., etal. (2007) Inhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells. Infect Immun 75: 2717-2728.
    • (2007) Infect Immun , vol.75 , pp. 2717-2728
    • Sterzenbach, T.1    Lee, S.K.2    von Brenneke, B.3    Goetz, F.4    Schauer, D.B.5    Fox, J.G.6
  • 48
    • 52649112717 scopus 로고    scopus 로고
    • The role of the Helicobacter hepaticus flagellar sigma factor FliA in gene regulation and murine colonization
    • Sterzenbach, T., Bartonickova, L., Behrens, W., Brenneke, B., Schulze, J., Kops, F., etal. (2008) The role of the Helicobacter hepaticus flagellar sigma factor FliA in gene regulation and murine colonization. J Bacteriol 190: 6398-6408.
    • (2008) J Bacteriol , vol.190 , pp. 6398-6408
    • Sterzenbach, T.1    Bartonickova, L.2    Behrens, W.3    Brenneke, B.4    Schulze, J.5    Kops, F.6
  • 50
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
    • Towbin, H., Staehelin, T., and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 51
    • 41949130225 scopus 로고    scopus 로고
    • Secretome analysis uncovers an Hcp-family protein secreted via a type VI secretion system in Agrobacterium tumefaciens
    • Wu, H.Y., Chung, P.C., Shih, H.W., Wen, S.R., and Lai, E.M. (2008) Secretome analysis uncovers an Hcp-family protein secreted via a type VI secretion system in Agrobacterium tumefaciens. J Bacteriol 190: 2841-2850.
    • (2008) J Bacteriol , vol.190 , pp. 2841-2850
    • Wu, H.Y.1    Chung, P.C.2    Shih, H.W.3    Wen, S.R.4    Lai, E.M.5
  • 52
    • 80053349020 scopus 로고    scopus 로고
    • The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
    • Zhao, Y., Yang, J., Shi, J., Gong, Y.N., Lu, Q., Xu, H., etal. (2011) The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477: 596-600.
    • (2011) Nature , vol.477 , pp. 596-600
    • Zhao, Y.1    Yang, J.2    Shi, J.3    Gong, Y.N.4    Lu, Q.5    Xu, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.