An ex-vivo multiple sclerosis model of inflammatory demyelination using hyperbranched polymer

Biomaterials

Volumn 34, Issue 23, 2013, Pages 5872-5882

  Mathew, Asha ^a   Pakan, Janelle M P ^b   Collin, Estelle C ^a   Wang, Wenxin ^a   McDermott, Kieran W ^b   Fitzgerald, Una ^a   Reynolds, Richard ^c   Pandit, Abhay S ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Demyelination; Inflammation; Multiple sclerosis; Non viral gene delivery; Organotypic brain slice

Indexed keywords

BRAIN SLICES; DEMYELINATION; INFLAMMATION; MULTIPLE SCLEROSIS; NON-VIRAL GENE DELIVERY;

GENE TRANSFER; GENES; PATHOLOGY;

DENDRIMERS;

GAMMA INTERFERON; MYELIN; POLY (2 DIMETHYLAMINOETHYLMETHACRYLATE); POLY(METHYL METHACRYLATE); TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BRAIN SLICE; CELL SURVIVAL; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CYTOKINE RELEASE; DEMYELINATION; DRUG CYTOTOXICITY; EX VIVO STUDY; GENE EXPRESSION; MULTIPLE SCLEROSIS; NONVIRAL GENE DELIVERY SYSTEM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; CEREBRAL CORTEX; DEMYELINATING DISEASES; HUMANS; INFLAMMATION; INTERFERON-GAMMA; METHACRYLATES; MODELS, BIOLOGICAL; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEIN; MYELIN SHEATH; NEUROFILAMENT PROTEINS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84877821654     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.04.010     Document Type: Article

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